Preliminary program

  Monday 26 Tuesday 27 Wednesday 28 Thursday 29 Friday 30
8:30  
9:00 Session M: CELL ALTERATIONS AND PATHOGENESIS.
Chair: David J. Evans.
Keynote lecture. Ann C. Palmenberg: Structure of the cardiovirus leader protein and its cellular interactions in the shutoff of NPC trafficking.

M1. Raymond Roos: A subgenomic segment of Theiler’s murine encephalomyelitis virus RNA causes demyelination.
M2. Thomas Michiels: Cell specificity of the responses to IFN-lambda and IFN-alpha, and implications for neuroinvasion.
M3. Nicole L. Le Lay: Tissue-specific deletion of the coxsackievirus and adenovirus receptor (CAR) protects mice from virus-induced pancreatitis and myocarditis.
M4. Laurent Andreoletti: Active coxsackieviral B infection is associated with disruption of dystrophin in endomyocardial tissue of patients with acute myocardial infarction.
9:15
9:30
9:45
10:00
10:15
10:30 Coffee break
10:45  
11:00 Session N: ANTIVIRAL STRATEGIES.
Chair: Tim Skern.
Keynote lecture. Marvin Grubman: Development of novel vaccine and antiviral strategies to control foot-and-mouth disease.

N1. Armando Arias: Inhibitory and mutagenic activities of 5-fluorouridine-triphosphate contributes to lethal mutagenesis of foot-and mouth disease virus.
N2. Armando de Palma: The thiazolobenzimidazole TBZE-029 inhibits enteroviral replication by targeting a short region immediately downstream motif C in the non-structural protein 2C.
N4. Hiroyuki Shimizu: A RAF-1 inhibitor GW5074 inhibits poliovirus and enterovirus 71 replication independently of the RAF-1 signaling pathway.
N5. Michaela Schmidtke: Pleconaril resistance of coxsackievirus B3 (CVB3) can be overcome by new derivatives with substitutions in the central ring.
11:15
11:30
11:45
12:00
12:15
12:30  
12:45 Lunch
13:00
13:15
13:30
13:45  
14:00 Session O: DISEASE PREVENTION AND CONTROL.
Chair: Martin Ryan.
Keynote lecture. Olen M. Kew: Navigating safe passage to polio eradication.

O1. Andrew Macadam: Progress towards safer IPV seeds.
O2. Konstantin Chumakov: Role of poliovirus epitopes in IPV and OPV-induced immunitY.
O3. Cecily P. Burrill: The role of genetic diversity in poliovirus pathogenesis and Sabin 1 attenuation.
O4. Steffen Mueller: Virus attenuation by genome-scale changes in codon-pair bias: a general method for developing viral vaccines.
O5. Cara C. Burns: Poliovirus codon deoptimization as a potential strategy for rational design of stable RNA virus vaccines.
14:15
14:30
14:45
15:00
15:15
15:30 Coffee break
15:45
16:00 Albert Sabin lecture.
Introduction of the lecturer by James M Hogle.
Vincent R. Racaniello.
Modification of the innate immune response during picornavirus infection.
16:15
16:30
16:45
17:00 Closing remark
17:15
17:30  
17:45  
18:00

Dinner and visit

at Cavas Codorniu

18:15
18:30
18:45
19:00
19:15
19:30
19:45
20:00
20:15
20:30
20:45
21:00
21:15
21:30
21:45
22:00
22:15
22:30