NUTRITION, GROWTH AND INTERMEDIARY METABOLISM IN FISH: BIOTECHNOLOGY AND BIOMEDICAL APPLICATIONS

  
  Director: Dr.  M. Isabel V. Baanante

     Dept. Bioquímica i Biologia Molecular (Farmàcia)      
          Facultat de Farmàcia, Univ. de Barcelona            
               Diagonal 643, 08028 Barcelona

                 Phone  (+ 34) 93 402 45 21 
                  Fax:  (+ 34) 93 402 45 20
              E-mail: baanantevazquez@ub.edu

RESEARCH TEAM RESEARCH GOALS RESEARCH PROJECTS COLLABORATIVE EXPECTATIONS RECENT PUBLICATIONS

Faculty of Pharmacy: Dr. M. Isabel Vázquez Baanante, Assoc. Professor of Biochemistry and Molecular Biology  Dr. Isidoro Metón Teijeiro, Lecturer Professor Jose Fernando Bibiano Melo, Postdoc  Miriam Egea Liria, Ph. D. Fellow  Mª Carmen Eraso Bastidas, Ph. D. Fellow  Mª Carmen Salgado Martín, Student

 

Faculty of Biology: Dr. Felipe Fernández González, Professor of Ecology  Marlom Córdoba Tejada, Ph. D. Student  Manuel Varas Schiavi, Ph. D. Student  Rodrigo Almeda García, Ph. D. Fellow  Santiago Hamilton, Ph. D. Fellow

 

Biochemistry, Molecular Biology and Functional Genomics in teleost fish:

 
 
• Teleost fish (gilthead sea bream, Sparus aurata): An alternative model to study   non-insulin-dependent diabetes mellitus (NIDDM).

 
• Cloning and transcriptional regulation of genes involved in carbohydrate (glucokinase, glucose-6-phosphatase, 6-PF-2-K/Fru-2,6-P₂ase) and protein (aminotransferases) metabolism in fish: Biotechnogical applications.

 
• Hormonal and dietary regulation of the expression of key enzymes in glycolysis/gluconeogenesis and protein metabolism in Sparus aurata.

 
• Diets, nutrition and growth in fish.

 
• Environmental damage related to fish culture.

 

RESEARCH PROJECTS

 

• MCYT (BIO2003-01098): Study of gene expression and over-expression to improve the use of dietary carbohydrates and protein in gilthead sea bream, Sparus aurata (1/12/2003 to 30/11/2006).

 
• MCYT (BMC2000-0761): Carbohydrate metabolism in fish: regulation of glucokinase expression in gilthead sea bream (Sparus aurata) (19/12/2000 to 19/12/2003).

 
• CICYT (PB96-1488): Nutritional and hormonal control of carbohydrate  metabolism and growth in Sparus aurata (10/97 to 10/2000).

 
• Fundació Bosch i Gimpera (1999). Project Nº 3154. Study of diets to feed  ornamental fish.

 
• University of Barcelona (1996): SGR

 
• DGICYT (PB93-0757): Regulation of glycolysis-gluconeogenesis and growth in  relation to the diet in Sparus aurata. (7/94 to 7/97).

 
• PETRI-NIDO INDUSTRIAL S.A., Project PTR91-0067 (1992-94). Optimization of feeding stuffs for the gilthead seabream fish (Sparus aurata) with low incidence in the environment.

 
To index

• Pharmaceutical companies interested in diabetes, growth factors and metabolic alterations.

 
• Fish farms: Somatic, biochemical and molecular parameters to evaluate growth conditions.

 
• Feed-stuff related companies.

 
• Environmental impact of fish culture.

 
To index

 
• I. Metón, M. Egea, F. Fernández, M. C. Eraso & I.V. Baanante. The N-terminal sequence directs import of mitochondrial alanine aminotransferase into mitochondria. FEBS Lett. (2004) 566: 251-254. Abstract

 
• I. Metón, A. Caseras, F. Fernández & I.V. Baanante. Molecular cloning of hepatic glucose-6-phosphatase catalytic subunit from gilthead sea bream (Sparus aurata): response of its mRNA levels and glucokinase expression to refeeding and diet composition. Comp. Biochem. Physiol. (2004) 138B: 145-153. Abstract

 
• I. Metón, M. Egea & I.V. Baanante. New insights into the regulation of hepatic glucose metabolism in fish. Recent Research Developments in Biochemistry, Vol. 4, Part I, pp. 125-149. S.G. Pandalai (Ed.), Reaearch Signpost, Kerala. 2003. Abstract

 
• I. Metón, F. Fernández & I.V. Baanante. Short- and long-term effects of refeeding on key enzyme activities in glycolysis-gluconeogenesis in the liver of gilthead seabream (Sparus aurata). Aquaculture (2003) 225: 99-107. Abstract

 
• M. Cormont, I. Metón, M. Mari, P. Monzo, F. Keslair, C. Gaskin, T.E. McGraw & Y. Le Marchand-Brustel. CD2AP/CMS Regulates Endosome Morphology and Traffic to the Degradative Pathway Through its Interaction with Rab4 and c-Cbl. Traffic (2003) 4: 97-112. Abstract

 
• A. Caseras, I. Metón, C. Vives, M. Egea, F. Fernández & I.V. Baanante. Nutritional regulation of glucose-6-phosphatase gene expression in liver of the gilthead sea bream (Sparus aurata). Br. J. Nutr. (2002) 88: 607-614. Abstract

 
• R.M. da Costa & F. Fernández. Feeding and survival rates of the copepods Euterpina acutifrons Dana and Acartia grani Sars on the dinoflagellates Alexandrium minutum Balech and Gyrodinium corsicum Paulmier and the Chryptophyta Rhodomonas baltica Karsten. J. Exp. Mar. Biol. Ecol. (2002) 273: 131-142. Abstract

 
• A. Caseras, I. Metón, F. Fernández & I.V. Baanante. Glucokinase gene expression is nutritionally regulated in liver of gilthead sea bream (Sparus aurata). BBA-Gene Struct. Expr. (2000) 1493: 135-141. Abstract

 
• I. Metón, A. Caseras, F. Fernández & I.V. Baanante. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression is regulated by diet composition and ration size in liver of gilthead sea bream, Sparus aurata. BBA-Gene Struct. Expr. (2000) 1491: 220-228. Abstract

 
• I. Metón, A. Caseras, E. Cantó, F. Fernández & I.V. Baanante. Liver insulin-like growth factor-I mRNA is not affected by diet composition or ration size but shows diurnal variations in regularly-fed gilthead sea bream (Sparus aurata). J. Nutr. (2000) 130: 757-760. Abstract

 
• I. Metón, D. Mediavilla, A. Caseras, E. Cantó, F. Fernández & I.V. Baanante. Effect of diet composition and ration size on key enzyme activities of glycolysis-gluconeogenesis, pentose phosphate pathway and amino acid metabolism in liver of gilthead sea bream (Sparus aurata). Br. J. Nutr. (1999) 82: 223-232. Abstract

 
• I. Metón, E.P.J. Boot, J.S. Sussenbach, P.H. Steenbergh. Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1a. FEBS Lett. (1999) 444: 155-159. Abstract

 
• I. Metón, A. Caseras, D. Mediavilla, F. Fernández & I.V. Baanante. Molecular cloning of a cDNA encoding 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver of Sparus aurata : nutritional regulation of enzyme expression. Biochim. Biophys. Acta (1999) 1444: 153-165. Abstract

 
• F. Fernández, A.G. Miquel, R. Martinez, E. Serra, J. Guinea, F.J. Narbaiza, A. Caseras & I.V. Baanante. Dietary Chromic oxide does not affect the utilization of organic compounds but can alter the utilization of mineral salts in Gilthead Sea Bream Sparus aurata. J. Nutr. (1999) 129: 1053-1059. Abstract

 
• F. Fernández, A.G. Miquel, J. Guinea & R. Martínez. Digestion and digestibility in gilthead sea bream (Sparus aurata): the effect of diet composition and ration size. Aquaculture (1998) 166: 67-84. Abstract

 
• J. Guinea & F. Fernández. Effect of feeding frequency, feeding level and temperature on energy metabolism in Sparus aurata. Aquaculture (1997) 148: 125 - 142. Abstract

 
To index