Faculty of Pharmacy:

• Dr. M. Isabel Vázquez Baanante, Assoc. Professor of Biochemistry and Molecular Biology
• Dr. Isidoro Metón Teijeiro, Assoc. Professor of Biochemistry and Molecular Biology
• Mari Carmen Salgado Martín, Ph. D. Fellow
• Ida G. Anemaet, Ph D. Fellow
• Juan Diego González, Ph. D. Fellow
• Anna-Helena Martínez Caro, Undergraduate student

   Faculty of Biology:

• Dr. Felipe Fernández González, Professor of Ecology
• Marlon Córdoba Tejada, Ph. D. Student
• Manuel Varas Schiavi, Ph. D. Student
• Benedicte Thienpont, Ph. D. Student
• Albert Caballero Solares, Predoctoral student

• Teleost fish (gilthead sea bream, Sparus aurata): An alternative model to study non-insulin-dependent diabetes mellitus (NIDDM).

• Cloning and transcriptional regulation of genes involved in carbohydrate (glucokinase, glucose-6-phosphatase, 6-PF-2-K/Fru-2,6-P₂ase) and protein (aminotransferases) metabolism in fish: Biotechnogical applications.

• Hormonal and dietary regulation of the expression of key enzymes in glycolysis/gluconeogenesis and protein metabolism in Sparus aurata.

• Diets, nutrition and growth in fish.

• Environmental damage related to fish culture.

• MEC (BIO2006-01857): Knocking-down alanine aminotransferase gene expression from gilthead sea bream (Sparus aurata): Basic research and biotechnological applications (01/10//2006 to 30/09//2009).

• MCYT (BIO2003-01098): Study of gene expression and over-expression to improve the use of dietary carbohydrates and protein in gilthead sea bream, Sparus aurata (1/12/2003 to 30/11/2006).

• MCYT (BMC2000-0761): Carbohydrate metabolism in fish: regulation of glucokinase expression in gilthead sea bream (Sparus aurata) (19/12/2000 to 19/12/2003).

• CICYT (PB96-1488): Nutritional and hormonal control of carbohydrate metabolism and growth in Sparus aurata (10/97 to 10/2000).

• Fundació Bosch i Gimpera (1999). Project Nº 3154. Study of diets to feed ornamental fish.

• University of Barcelona (1996): SGR

• DGICYT (PB93-0757): Regulation of glycolysis-gluconeogenesis and growth in relation to the diet in Sparus aurata. (7/94 to 7/97).

• PETRI-NIDO INDUSTRIAL S.A., Project PTR91-0067 (1992-94). Optimization of feeding stuffs for the gilthead seabream fish (Sparus aurata) with low environmental incidence.

• Pharmaceutical companies interested in diabetes, growth factors and metabolic alterations.

• Fish farms: Somatic, biochemical and molecular parameters to evaluate growth conditions.

• Feed-stuff related companies.

• Environmental impact of fish culture.

• Egea, M., Metón, I., Córdoba., M, Fernández, F., & Baanante, I.V. Role of Sp1 and SREBP-1a in the insulin-mediated regulation of glucokinase transcription in the liver of gilthead seabream (Sparus aurata). General and Comparative Endocrinology (2008) 155: 359-367. Abstract

• Mediavilla, D., Metón, I., & Baanante, I.V. Purification and kinetic properties of 6-phosphofructo-1-kinase from gilthead sea bream muscle. BBA-General Subjects (2007) 1770: 706-715. Abstract

• Egea, M., Metón, I., & Baanante, I.V. Sp1 and Sp3 regulate glucokinase gene transcription in the liver of gilthead sea bream (Sparus aurata). Journal of Molecular Endocrinology (2007) 38: 481-492. Abstract

• Fernández, F., Miquel, A.G., Córdoba, M., Varas, M., Metón, I., Caseras, A., & Baanante, I.V. Effects of diets with distinct protein-to-carbohydrate ratios on nutrient digestibility, growth performance, body composition and liver intermediary enzyme activity in gilthead sea bream (Sparus aurata) fingerlings. Journal of Experimental Marine Biology and Ecology (2007) 343: 1-10. Abstract

• Metón, I., Egea, M., Anemaet, I.G., Fernández, F., & Baanante, I.V. Sterol Regulatory Element Binding Protein-1a Transactivates 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Gene Promoter. Endocrinology (2006) 147: 3446-3456. Abstract

• Melo, J.F.B., Lundstedt, L.M., Metón, I., Baanante, I.V., & Moraes, G. Dietary levels of protein on nitrogenous metabolism of jundiá (Rhamdia quelen). Comparative Biochemistry and Physiology A- Molecular & Integrative Physiology (2006) 145: 181-187. Abstract

• Salgado, M.C., Metón, I., Egea, M., & Baanante, I.V. Transcriptional regulation of glucose-6-phosphatase catalytic subunit promoter by insulin and glucose in the carnivorous fish, Sparus aurata. Journal of Molecular Endocrinology (2004) 33: 783-795. Abstract

• I. Metón, M. Egea, F. Fernández, M. C. Eraso & I.V. Baanante. The N-terminal sequence directs import of mitochondrial alanine aminotransferase into mitochondria. FEBS Lett. (2004) 566: 251-254. Abstract

• I. Metón, A. Caseras, F. Fernández & I.V. Baanante. Molecular cloning of hepatic glucose-6-phosphatase catalytic subunit from gilthead sea bream (Sparus aurata): response of its mRNA levels and glucokinase expression to refeeding and diet composition. Comp. Biochem. Physiol. (2004) 138B: 145-153. Abstract

• I. Metón, M. Egea & I.V. Baanante. New insights into the regulation of hepatic glucose metabolism in fish. Recent Research Developments in Biochemistry, Vol. 4, Part I, pp. 125-149. S.G. Pandalai (Ed.), Reaearch Signpost, Kerala. 2003. Abstract

• I. Metón, F. Fernández & I.V. Baanante. Short- and long-term effects of refeeding on key enzyme activities in glycolysis-gluconeogenesis in the liver of gilthead seabream (Sparus aurata). Aquaculture (2003) 225: 99-107. Abstract

• M. Cormont, I. Metón, M. Mari, P. Monzo, F. Keslair, C. Gaskin, T.E. McGraw & Y. Le Marchand-Brustel. CD2AP/CMS Regulates Endosome Morphology and Traffic to the Degradative Pathway Through its Interaction with Rab4 and c-Cbl. Traffic (2003) 4: 97-112. Abstract

• A. Caseras, I. Metón, C. Vives, M. Egea, F. Fernández & I.V. Baanante. Nutritional regulation of glucose-6-phosphatase gene expression in liver of the gilthead sea bream (Sparus aurata). Br. J. Nutr. (2002) 88: 607-614. Abstract

• R.M. da Costa & F. Fernández. Feeding and survival rates of the copepods Euterpina acutifrons Dana and Acartia grani Sars on the dinoflagellates Alexandrium minutum Balech and Gyrodinium corsicum Paulmier and the Chryptophyta Rhodomonas baltica Karsten. J. Exp. Mar. Biol. Ecol. (2002) 273: 131-142. Abstract

• A. Caseras, I. Metón, F. Fernández & I.V. Baanante. Glucokinase gene expression is nutritionally regulated in liver of gilthead sea bream (Sparus aurata). BBA-Gene Struct. Expr. (2000) 1493: 135-141. Abstract

• I. Metón, A. Caseras, F. Fernández & I.V. Baanante. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression is regulated by diet composition and ration size in liver of gilthead sea bream, Sparus aurata. BBA-Gene Struct. Expr. (2000) 1491: 220-228. Abstract

• I. Metón, A. Caseras, E. Cantó, F. Fernández & I.V. Baanante. Liver insulin-like growth factor-I mRNA is not affected by diet composition or ration size but shows diurnal variations in regularly-fed gilthead sea bream (Sparus aurata). J. Nutr. (2000) 130: 757-760. Abstract

• I. Metón, D. Mediavilla, A. Caseras, E. Cantó, F. Fernández & I.V. Baanante. Effect of diet composition and ration size on key enzyme activities of glycolysis-gluconeogenesis, pentose phosphate pathway and amino acid metabolism in liver of gilthead sea bream (Sparus aurata). Br. J. Nutr. (1999) 82: 223-232. Abstract

• I. Metón, E.P.J. Boot, J.S. Sussenbach, P.H. Steenbergh. Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1a. FEBS Lett. (1999) 444: 155-159. Abstract

• I. Metón, A. Caseras, D. Mediavilla, F. Fernández & I.V. Baanante. Molecular cloning of a cDNA encoding 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver of Sparus aurata : nutritional regulation of enzyme expression. Biochim. Biophys. Acta (1999) 1444: 153-165. Abstract

• F. Fernández, A.G. Miquel, R. Martinez, E. Serra, J. Guinea, F.J. Narbaiza, A. Caseras & I.V. Baanante. Dietary Chromic oxide does not affect the utilization of organic compounds but can alter the utilization of mineral salts in Gilthead Sea Bream Sparus aurata. J. Nutr. (1999) 129: 1053-1059. Abstract

• F. Fernández, A.G. Miquel, J. Guinea & R. Martínez. Digestion and digestibility in gilthead sea bream (Sparus aurata): the effect of diet composition and ration size. Aquaculture (1998) 166: 67-84. Abstract

• J. Guinea & F. Fernández. Effect of feeding frequency, feeding level and temperature on energy metabolism in Sparus aurata. Aquaculture (1997) 148: 125 - 142. Abstract