- Role of CPT1 in the development of obesity-induced insulin resistance and type 2 diabetes. In vitro and in vivo studies of fatty-acid oxidation and inflammation in liver and white and brown adipose tissue.
- Appetite regulation. Role of fatty acids and CPT1A in the control of food intake.
- Bioinformatic modeling of CPT1 and its relationship with obesity, type 2 diabetes and cancer: in silico design of anti-obesity and anti-cancer drugs. Study of derivates from the potential anti-obesity and anti-cancer drug C75 and their interaction with CPT1 in vitro, and in vivo in the hypothalamus. Projects in cooperation with Dr. Paulino Gómez-Puertas from the “Molecular Modelling Group” at the Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Madrid, Dr. Jordi García and Dr. Xavier Ariza at the Department of Organic Chemistry, University of Barcelona, and Dr. Núria Casals from the International University of Catalonia (UIC).
Funding in Process
- 2019 - 2023Immunometabolic profiling in obesity-associated diabetes. Qatar National Research Fund (QNRF) (PI: Nicholas Van Panhuys)
- 2018 - 2020Next-generation RNA sequencing and single-cell RNAseq: novel opportunities for understanding human adipose tissue pathophysiology and obesity (ADIPOSEQ) CIBEROBN Intramural (PI: Francesc Villarroya)
- 2018 - 2020Regulation of central and peripheral lipid metabolism to reduce food intake and obesity Ministry of economy, industry and competitiveness of Spain (SAF2017-83813-C3-1-R) (PI: Dolors Serra; Co-PI: Laura Herrero)
- 2018 - 2020Drug delivery targeting Brain CPT1: a novel nanomedicine-based approach to fight obesity and cancer (CONCORD) Japanese Medical Research Agency (AMED) & National Research Agency (AEI) (PI: Rosalía Rodríguez-Rodríguez)
- 2012 - presentCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) CB06/03/0001. Instituto de Salud Carlos III, Ministerio de Sanidad. (PI: Xavier Remesar / Dolors Serra)
Past Funding
- 2017 - 2018Analysis of the Inflammatory Profile in Childhood Onset Diabetes Sidra Internal Research Fund (IRF). Qatar Foundation (PI: Meritxell Espino)
- 2015 - 2017Estudio de las carnitina palmitoiltransferasas en hipotálamo como potenciales dianas para el control de la ingesta y tratamiento de la obesidad. Ministry of economy and competitiveness of Spain. SAF2014-5223-C2-1-R (PI: Dolors Serra)
- 2015 - 2018Estudio de las carnitinas palmitoiltransferasas en hipotálamo como potenciales dianas para el control de la ingesta y el tratamiento de la obesidad Ministry of economy and competitiveness of Spain (SAF2014-52223-C2-1-R) (PI: Dolors Serra; Co-PI: Jordi García)
- 2014 - 2015Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. L’Oréal-UNESCO Research Fellowship. (PI: Laura Herrero)
- 2014 - 2016Consolidated research groups. Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR). (2014 SGR 465; 2014-2016) (PI: Dolors Serra)
- 2014 - 2017Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. Ministry of economy and competitiveness of Spain. SAF2013-45887-R (PI: Laura Herrero)
- 2013 - 2014Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. European Foundation for the Study of Diabetes (EFSD)/Lilly Research Fellowship (PI: Laura Herrero)
- 2013 - 2015Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. European Foundation for the Study of Diabetes (EFSD) and Janssen Research Fellowship. (PI: Laura Herrero)
- 2012 - 2014New strategies of fatty acid oxidation modulation for the treatment of obesity. Ref. SAF2011-30520-C02-01. MICINN (PI: Dolors Serra)
- 2011 - 2013Fatty acid oxidation in the adipose tissue to revert obesity and type 2 diabetes. Ministry of Science and Innovation of Spain. Ref. SAF2010-20039. (PI: Laura Herrero)