People
Fausto G. Hegardt
Dr. Dolors Serra
Dr. Guillermina Asins
Dr. Laura Herrero
Josep Maria Orellana-Gavaldà
Paula Mera
Maria Ida Malandrino
Macarena Pozo Ariza
Kamil Makowski
Joan F. Mir Bonnín
Mar Arasa
Lluis Miquel
Research
1.Role of CPTI in the development of obesity-induced insulin resistance and type 2 diabetes
2.Appetite regulation
3.Structural studies
Funding
Publications
2010
Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome.
Inflammation and adipose tissue macrophages in lipodystrophic mice.
2009
Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells.
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.
Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria.
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.
2008
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.
2007
A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells.
Molecular genetics of HMG-CoA lyase deficiency.
C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.
Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.
Obesity, inflammation, and insulin resistance.
Modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae.
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.
2006
Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.
2005
Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.
2004
Redesign of carnitine acetyltransferase specificity by protein engineering.
Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.
2003
Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
Alumni
Chandrashekaran Gurunathan
Irene Vázquez
Assia Bentebibel
Antonio Felipe García Cordente
David Sebastián Muñoz
Guillem Plasencia Gallofré
Laura Herrero Rodríguez
Montse Morillas
Blanca Rubi
Angel Millar