| Doctor
en Farmàcia (1987) per la Universitat de Barcelona.
Investigador
Associat C.N.R.S. (Marseille, França) (1987).
Professor Titular de l’àrea
de Química Física de la Universitat de Barcelona
(1990)
Investigador visitant a la Memorial
University of Newfoundland (Canada) (1991),
Investigador visitant University of
California Los Angeles (UCLA) (1995,1997).
Actiu en el camp dels models de membrana,
monocapes (des del 1985), liposomes (des del 1986). Ha treballat
en projectes sobre encapsulació i vectorització
de fàrmacs en liposomes, interacció de fosfolípids
amb colesterol i reconstitució de proteïnes integrals
de membrana en proteoliposomes.
Involved in research of membrane models,
monolayers (since 1985) and liposomes (since 1986). He has
been working in the encapsulation and targeting of drugs in
liposomes, phospholipid-cholesterol interactions and reconstitution
of transmembrane preoteins into proteoliposomes. Main techniques
used are fluorescence, diferential scanning calorimetry and
atomic force microscopy.
Most relevant recent work:
Noé, Ch.; Hernández-Borrell,
J.; Kinsky, S.C.; Matsuura, E.; Leserman, L. (1988) Inhibition
of cell proliferation with antibody-targeed liposomes containing
methotrexate-d-dimyristoyl-phospha tidylethanolamine Biochimica
et Biophysica Acta 946,253-260.
Hernández-Borrell, J.; Keough,
K.M.W. (1993) Heteroacid phosphatidylcholines are affected
to various extents by Cholesterol Biochimica et Biophysica
Acta 1153, 277 -282.
Voss, J.; Hubbell, W.L.; Hernández-Borrell,
J.; Kaback, H.R. (1997) Electron paramagnetic resonance investigation:
of lactose permease transmembrane domain VII structure by
nitroxide-scanning Biochemistry 36, 15055 -15061.
Merino, S.; Domemech, O.; Diez, I.;
Sanz, F.; Viñas, M.; Montero, M.T.; Hernández-Borrell,
J. (2003) Effects of ciprofloxacin on Escherichia coli lipid
bilayers: an atomic force microscopy study Langmuir 19, 6922-6927.
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