Medicine, School of Medicine, University of Barcelona.
Biomedical Engineering, School of Medicine, University of Barcelona.
Biomedical Engineering, University of Barcelona – Polytechnic
University of Catalonia
Biomedicine. University of Barcelona.
function is primarily determined by the mechanical properties of airways and
parenchymal tissues. Mechanical dysfunction of the lung is associated with
prevalent respiratory diseases. The research of my group is aimed at
furthering our understanding of the mechanical behavior of the respiratory
system to improve the diagnosis and treatment of respiratory diseases. We use
basic and translational approaches in a multidisciplinary framework involving
close cooperation with clinical research groups working in the field of
respiratory medicine. We study respiratory mechanics with a multiscale approach extending from organ to molecule.
organ level, we study the mechanical properties of the airways and lung
tissues and the alterations of the mechanical function associated with
respiratory diseases. Our work is mainly focused on mechanics of the upper
airway in sleep apnea syndrome, and on mechanical ventilation in acute and
chronic respiratory failure.
cellular and molecular level, we develop and apply cutting edge
nanotechnologies and advanced biophysical techniques to probe the mechanical
behavior of the cells and their mechanical interactions with the
microenvironment. We study the mechanical properties of the cell and its
response to inflammation and mechanical stresses. We develop new approaches
to differentiate stem cells using mechanical stimuli. Our research also
focuses on the study of the biophysical mechanisms regulating the adhesion
and vascular transmigration of leukocytes.
One of the
projects we are currently developing is focused on the field of regenerative
medicine, specifically lung bioengineering. Our work
is aimed at the bioartificial fabrication of
functional lungs by recellularizing the organ
scaffold with stem cells and recreating the in vivo mechanical micro/nano-environment.
Decellularized rat lung
Probing mechanical properties of decellularized
alveolar scaffolds with AFM
Two photon / second harmonic generation image
of a vessel wall (tunica intima and tunica adventitia)
in a decellularized rat lung
models of mechanical ventilation
models of obstructive sleep apnea
marrow-derived mesenchymal stem cells