Ramon Farré, Ph.D.


Professor of Physiology, Unit of Biophysics and Bioengineering, Department of Biomedicine, School of Medicine, University of Barcelona.


Group Leader, Institute for Biomedical Research August Pi Sunyer (IDIBAPS).


Group Leader, Centro Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias.



Director of Education, Spanish node of EIT-Health.


Associate Editor of The European Respiratory Journal

Coordinator of Area 2: “Respiratory, cardiovascular and renal pathobiology and bioengineering of IDIBAPS.

Secretary of the Group “Sleep and Control of Breathing” of the European Respiratory Society.


* rfarre@ub.edu

( +(34) 934024515







Degree in Medicine, School of Medicine, University of Barcelona.

Degree in Biomedical Engineering, School of Medicine, University of Barcelona.

Master in Biomedical Engineering, University of Barcelona – Polytechnic University of Catalonia

Ph.D. on Biomedicine. University of Barcelona.



Lung function is primarily determined by the mechanical properties of airways and parenchymal tissues. Mechanical dysfunction of the lung is associated with prevalent respiratory diseases. The research of my group is aimed at furthering our understanding of the mechanical behavior of the respiratory system to improve the diagnosis and treatment of respiratory diseases. We use basic and translational approaches in a multidisciplinary framework involving close cooperation with clinical research groups working in the field of respiratory medicine. We study respiratory mechanics with a multiscale approach extending from organ to molecule.


At the organ level, we study the mechanical properties of the airways and lung tissues and the alterations of the mechanical function associated with respiratory diseases. Our work is mainly focused on mechanics of the upper airway in sleep apnea syndrome, and on mechanical ventilation in acute and chronic respiratory failure.


At the cellular and molecular level, we develop and apply cutting edge nanotechnologies and advanced biophysical techniques to probe the mechanical behavior of the cells and their mechanical interactions with the microenvironment. We study the mechanical properties of the cell and its response to inflammation and mechanical stresses. We develop new approaches to differentiate stem cells using mechanical stimuli. Our research also focuses on the study of the biophysical mechanisms regulating the adhesion and vascular transmigration of leukocytes.


One of the projects we are currently developing is focused on the field of regenerative medicine, specifically lung bioengineering. Our work is aimed at the bioartificial fabrication of functional lungs by recellularizing the organ scaffold with stem cells and recreating the in vivo mechanical micro/nano-environment.






Decellularized rat lung

Probing mechanical properties of decellularized alveolar scaffolds with AFM

Two photon / second harmonic generation image

of a vessel wall (tunica intima and tunica adventitia)

in a decellularized rat lung




Atomic Force Microscopy

Magnetic Tweezers

Cell stretching

Surface Micro/Nano-patterning

Live cell fluorescence microscopy

Traction Microscopy

Cell culture

Respiratory mechanics techniques

Animal models of mechanical ventilation

Animal models of obstructive sleep apnea

Organ decellularization

Bone marrow-derived mesenchymal stem cells

Murine embryonic stem cells



Publications: https://www.ncbi.nlm.nih.gov/sites/myncbi/1h_-alawKu3k7/bibliography/47999319/public/?sort=date&direction=descending


Recent publications


Campillo N, Falcones B, Montserrat JM, Obeso A, Gozal D, Navajas D, Almendros I, Farré R. Frequency and magnitude of intermittent hypoxia modulate endothelial wound healing in a cell culture model of sleep apnea. J Appl Physiol, in press.


Vilaseca A, Campillo N, Torres M, Musquera M, Montserrat JM, Alcaraz A, Touijer KA, Farre R, Almendros I. Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea. PLoS ONE 12(6): e0179444.


Urbano JJ, da Palma RK, Lopesa LG, Uriarte JJ, Alvarenga LH, Vieira RP, Prates RA, Navajas D, Farré R, Oliveira LVF. Effects of two different decellularization routes on the mechanical properties of decellularized lungs. PLoS ONE 12(6): e0178696.


Pamidi S, Redline S, Rapoport D, Ayappa I, Palombini L, Farre R, Kirkness J, Pepin JL, Polo O, Wellman A, Kimoff J; on behalf of the American Thoracic Society ad hoc committee on Inspiratory Flow Limitation. An Official American Thoracic Society Workshop Report: Non-invasive Identification of Inspiratory Flow Limitation in Sleep Studies. Annals of the ATS, in press.


Dellaca RL, Veneroni C, Farre R. Trends in mechanical ventilation - are we ventilating our patients in the best possible way? Breathe, 2017; 13: 84–98.


Jorba I, Menal MJ, Torres M, Gozal D, Piñol G, Colell A, Montserrat JM, Navajas D, Farré R, Almendros I. Ageing and chronic intermittent hypoxia mimicking sleep apnea do not modify local brain tissue stiffness in healthy mice. Journal of the Mechanical Behavior of Biomedical Materials, in press.


Campillo N, Torres M, Vilaseca A, Nonaka P, Gozal D, Roca-Ferrer J, Picado C, Montserrat JM, Farré R, Navajas D, Almendros I. Role of cycloxygenase-2 on intermittent hypoxia induced lung tumor malignancy in a mouse model of sleep apnea. Scientific Reports, 2017; 7: 44693.


Gallego-Martin T, Farré R, Almendros I, Gonzalez-Obeso E, Obeso A. Chronic intermittent hypoxia mimicking sleep apnea increases spontaneous tumorigenesis in a mouse model. Eur Respir J, 2017; 49 (2) 1602111.


Akbarpour M, Khalyfa A, Qiao Z, Gileles-Hillel A, Almendros A, Farré R, Gozal D. Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea. SLEEP, 2017 Feb 1; 40(2).


Isetta V, Torres M, Gonzalez, Ruiz C, Dalmases M, Embid C, Navajas D, Farré R, Montserrat JM. A new mHealth application for sleep apnea patients under CPAP treatment.  J Telemed Telecare. 2017; 23: 14-18.


Vilaseca A, Nguyen DP, Vertosickc EA, Corradi RB, Musquera M, Pérez M, Fossati N, Sjobergc DD, Farré R, Almendros I, Montserrat JM, Benfantea NE, Hakimi A, Skanderupf AJ, Russo P, Alcaraz A, Touijer KA. Obstructive sleep apnea and Fuhrman grade in patients with clear cell renal cell carcinoma treated with surgery. World J Urol. 2017; 35: 51-56.


Jorba I, Campillo C, Uriarte JJ, Farré R, Navajas D. Probing mechanical properties of extracellular matrix of soft tissues by atomic force microscopy. J. Cell. Physiol. 2017; 232(1):19-26.


Poroyko V, Carreras A, Khalyfa A, Khalyfa A, Leone V, Peris E, Almendros I, Gileles-Hillel A, Qiao Z, Farré R, Chang EB, Gozal D. Chronically Disrupted Sleep Alters Gut Microbiota, and Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Scientific reports. 2016; 6:35405.


Khalyfa A, Almendros I, Gileles-Hillel A, Akbarpour M, Trzepizur W, Mokhlesi B, Huang L, Andrade J, Farre R, Gozal D. Circulating Exosomes Potentiate Tumor Malignant Properties In A Mouse Model Of Chronic Sleep Fragmentation. Oncotarget, 2016; 7: 54676-54690.


Campos-Rodriguez F, Martinez-Garcia MA, Reyes-Nuñez N, Selma-Ferrer MJ, Punjabi NM, Farre R. Impact of different hypopnea definitions on Obstructive Sleep Apnea severity and cardiovascular mortality risk in women and elderly. Sleep Med. 2016; 27-28: 54-58.

Nonaka PN, Uriarte JJ, Campillo N, Oliveira VR, Navajas D, Farré R. Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ. Respiratory Research 2016; 17:161

Vilaseca I, Lehrer-Coriat E, Torres M, Aguilar F, Almendros I, Martínez-Vidal BM, Farré R, Montserrat JM. Early effects of continuous positive airway pressure in a rodent model of allergic rhinitis. Sleep Medicine 2016; 27-28 25-27.


Almendros I, Khalyfa A, Trzepizur W,  Gileles-Hillel A, Huang L, Akbarpour M, Andrade J, Farré R, Gozal D. Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea. CHEST 2016; 150: 1030-1041.


Campillo N, Jorba I, Schaedel L, Casals B, Gozal D, Farré R, Almendros I, Navajas D. A chip system for cyclic stretch and intermittent hypoxia cell exposures mimicking obstructive sleep apnea. Front Physiol. 2016 Jul 29;7:319..


Moreno-Indias I, Torres M, Sanchez-Alcoholado L, Cardona F, Almendros I, Gozal D, Montserrat JM, Queipo-Ortuño MI, Farré R. Normoxic recovery mimicking treatment of sleep apnea does not reverse intermittent hypoxia-induced bacterial dysbiosis and low-grade endotoxemia in mice. SLEEP 2016, 39: 1891-1897.


Farré R, Navajas D. Forced oscillation: a poorly exploited tool for simply assessing respiratory function in children.(Editorial). Respirology, 2016; 21: 982–983.


Almendros I, Montserrat JM, Farré R. Challenging multi-morbidities: obstructive sleep apnoea and cancer.  BRN Rev. 2016; 2:170-84.


Uriarte JJ, Nonaka PN, Campillo N, Mendizabal Y, Sarri E, Egea G, Navajas D, Farré R. Early impairment of lung mechanics in a murine model of Marfan syndrome. PLoS ONE 2016; 11(3): e0152124.


Isetta V, Montserrat JM, Santano R, Wimms, Ramanan D, Woehrle H, Navajas D, Farré R. Novel approach to simulate sleep apnoea patients for evaluating positive pressure therapy devices. PLoS ONE 2016; 11(3): e0151530.


Palma RK, Nonaka PN, Campillo N, Uriarte JJ, Urbano JJ, Navajas D, Farré R, Oliveira LV. Behavior of vascular resistance undergoing various pressure insufflation and perfusion on decellularized lungs. Journal of Biomechanics, 2016; 49: 1230–1232.


Farre R, Navajas D, Montserrat JM. Technology for noninvasive mechanical ventilation: looking into the black box. ERJ Open Res, 2016; 2: 00004.


Castro-Grattoni AL, Alvarez R, Torres M, Farré R, Barbé F, Montserrat JM, Dalmases M, Almendros I, Sánchez-de-la-Torre M. Intermittent hypoxia-induced cardiovascular remodeling is reversed by normoxia in a mouse model of sleep apneaCHEST 2016; 149(6):1400-1408.


Farré R, Martínez-García MA, Campos-Rodriguez F, Montserrat JM. A step forward for better interpreting the apnea-hypopnea index. Editorial. SLEEP 2015, 38: 1839-40.

Dalmases  M, Solé-Padullés C, Torres M, Embid C, Nuñez MD, Farré R, Bargalló N, Bartrés-Faz D, Montserrat JM. Effect of CPAP on Cognition, Brain Function, and Structure Among Elderly Patients With OSA: A Randomized Pilot Study.  CHEST 2015; 148: 1214-23.

Gozal D, Farré R, Nieto FJ. Putative links between sleep apnea and cancer: from hypotheses to evolving evidence. CHEST 2015; 148: 1140-1147.

Isetta V, Negrín MA, Monasterio C, Masa JF, Feu N, Álvarez A, Campos-Rodriguez F, Ruiz C, Abad J, Vázquez-Polo FJ, Farré R, Galdeano M, Lloberes P, Embid C, de la Peña M, Puertas J, Dalmases M, Salord N, Corral J, Jurado B, León C, Egea C, Muñoz A, Parra O, Cambrodi R, Martel-Escobar M, Arqué M, Montserrat JM. A Bayesian Cost-Effectiveness Analysis of a Telemedicine-based Strategy for the Management of Sleep Apnea: A Multicenter Randomized Controlled Trial. Thorax, 2015; 70 :1054-61.

Isetta V, Navajas D, Montserrat JM, Farré R. Comparative assessment of several automatic continuous positive airway pressure devices response: a bench test study. ERJ Open Res 2015; 1: 00031.

Martínez-García MA, Campos-Rodríguez F, Almendros I, Farré R. Relationship Between Sleep Apnea and Cancer. Archivos de Bonconeumología 2015, 51: 456-461.

Gozal D, Farré R, Nieto, FJ. Obstructive sleep apnea and cancer: epidemiologic links and biological plausibility. Sleep Medicine Reviews, 2015; 27:43-55.

Larramona H,  Marcus CL, McDonough JM, Oliva Morera JC, Huang J, Farré R, Montserrat JM. Negative Expiratory Pressure Technique: An Awake Test to Measure Upper Airway Collapsibility in Adolescents. SLEEP 2015;38(11):1783–1791..

Almendros I, Gileles-Hillel A, Khalyfa A, Wang Y, Zhang SX, Farré R, Gozal D. Adipose Tissue Macrophage Polarization by Intermittent Hypoxia in a Mouse Model of OSA: Effect of Tumor Microenvironment. Cancer Letters 2015, 361: 233-9.

Melo E, Kasper J, Unger RE, Farré R, Kirkpatrick CJ. Development of a bronchial wall model based on a decellularized porcine trachea transwell. A Bronchial in vitro Tripleculture on a Decellularized Trachea. Tissue Eng C, 2015; 21: 909-92.

Palma RK, Campillo N, Uriarte JJ, Oliveira LFV, Navajas D, Farré R. Pressure- and flow-controlled media perfusion differently modify vascular mechanics in lung decellularization. Journal of the Mechanical Behaviour of Biomedical Materials, 2015, 49: 69–79.

Perea-Gil I, Uriarte JJ, Prat-Vidal C, Gálvez-Montón C, Roura S, Llucià-Valldeperas A, Soler-Botija C, Farré R, Navajas D, Bayes-Genis A. In vitro comparative study of two decellularization protocols in search of an optimal myocardial scaffold for recellularization, Am J Transl Res 2015; 7: 558-573.

Palma RK, Farré R, Montserrat JM, Del Blanco DG, Egea G, Oliveira LVF, Navajas D, Almendros I. Increased Upper Airway Collapsibility in a Mouse Model of Marfan Syndrome. Respir Physiol Neurobiol 2015; 207: 58–60.

Moreno-Indias I, Torres M, Montserrat JM, Sanchez-Alcoholado, Cardona F, Tinahones FJ, Gozal D, Poroyko VA, Navajas D, Queipo-Ortuño MI, Farré R. Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnea, Eur Respir J, 2015, 45: 1055-65.

Torres M, Rojas M, Campillo N, Montserrat JM, Navajas D, Farré R. Parabiotic model for differentiating local and systemic effects of continuous and intermittent hypoxia. J Appl Physiol 2015; 118: 42-47.

Almendros I, Gozal D, Farré R. “Obstructive Sleep Apnea and Cancer: Biological Basis” in “Sleep Apnea”, edited by F. Barbé and J.L. Pepin, Eur Respir Monogr 2014; 67: 24-36.

Isetta V, Ruiz M, Farré R, Montserrat JM. “Supporting patients with obstructive sleep apnea receiving continuous positive airway pressure treatment: the role of training and telemedicine” in “Sleep Apnea”, edited by F. Barbé and J.L. Pepin,  Eur Respir Monogr 2014; 67: 280-292.

Torres M,  Laguna-Barraza R, Dalmases M, Calle A, Pericuesta E, Montserrat JM, Navajas D, Gutierrez-Adán A, Farré R. Male fertility is reduced by chronic intermittent hypoxia mimicking sleep apnea in mice. SLEEP 2014;37(11):1757-1765.

Accompanying Editorial: “Sleep Apnea as a Potential Threat to Reproduction”.

Uriarte JJ, Nonaka PN, Campillo N, da Palma RK, Melo E, Oliveira LV, Navajas D, Farré R. Mechanical properties of acellular mouse lungs after sterilization by gamma irradiation. J Mech Behav Biomed Mater, 2014; 40:168–177.

Torres M, Palomer X, Montserrat JM, Vazquez-Carrera M, Farré R. Effect of ovariectomy on inflammation induced by intermittent hypoxia in a mouse model of sleep apnea. Respir Physiol Neurobiol 2014; 202:71–74.

Garreta E, Melo E, Navajas D, Farré R. Low oxygen tension enhances the generation of lung progenitor cells from mouse embryonic and induced pluripotent stem cells. Physiol Rep, 2014, 2 (7): e12075.

Dalmases M, Planas A, Torres M, Marquez-Kisinousky L, Almendros I, Embid C, Martinez MA, Farre R, Montserrat JM. Obstructive apneas induce lower brain oxidative stress in old than in young rats. SLEEP 2014; 37: 1249-1256.

Accompanying Editorial: “Sleep Apnea: A Redox Edge with Aging?”.

Guerrero A, Embid C, Isetta V, Farre R, Duran-Cantolla J, Parra O, Barbe F, Montserrat JM, Masa JF. Management of Sleep Apnea without high pre-test probability or with comorbidities by three nights of portable sleep monitoring. SLEEP 2014;37: 1363-73.

Colom A, Galgoczy R, Almendros I, Xaubet A, Farré R, Alcaraz J. Oxygen diffusion and consumption in extracellular matrix gels: implications for designing 3D cultures. Journal of Biomedical Materials Research: Part A, 2014; 102: 2776-84.

Nonaka PN, Uriarte JJ, Campillo N, Melo E, Navajas D, Farré R, Franco Oliveira LV. Mechanical properties of mouse lungs along organ decellularization by sodium dodecyl sulfate. Respir Physiol Neurobiol 2014; 200: 1–5.

Martínez-García MA, Campos-Rodriguez F, Durán-Cantoll J, de la Peña M, Masdeu MJ, González M, del Campo F, Catalán-Serra P; Valero-Sánchez I, Selma-Ferrer MJ; Marín JM, Barbé F, Martínez M, Farré R, Montserrat JM. Obstructive sleep apnea is associated with cancer mortality in younger patients. Sleep Medicine 2014; 15: 742-8.

Melo E, Cardenes N, Garreta E, Luque T, Rojas M, Navajas D, Farré R. Inhomogeneity of local stiffness in the extracellular matrix scaffold of fibrotic mouse lungs. J Mech Behav Biomed Mater 2014; 37: 186–195.

Andreu I, Luque T, Sancho A, Pelacho B, Iglesias O, Melo E, Farré R, Prósper F, Elizalde MR, Navajas D. Heterogeneous micromechanical properties of the extracellular matrix in healthy and infarcted hearts. Acta Biomaterialia 2014; 10: 3235–3242.

Martinez-Garcia MA, Martorell-Calatayud A, Nagore E, Valero I, Selma MJ, Chiner E, Landete P, Montserrat JM, Carreras C, Campos-Rodriguez F, Pérez-Gil A, Farré R. Association between sleep disordered-breathing and aggressiveness of malignant cutaneous melanoma. Eur Respir J, 2014 43:1661-1668.

Accompanying Editorial: “Sleep apnoea and cancer: the new challenge”.

Ramos P, Rubies C, Torres M, Batlle M, Farre R, Montserrat JM, Almendros I, Mont M. Atrial fibrosis in a chronic murine model of obstructive sleep apnea. Mechanisms and prevention by mesenchymal stem cells. Respir Research, 2014; 15: 54.

Almendros I, Wang Y, Becker L, Lennon FE, Zheng J, Coats BR, Schoenfelt KS, Carreras A, Hakim F, Zhang SX, Farré R, Gozal D. Intermittent hypoxia-induced changes in tumor associated macrophages and tumor malignancy in a murine sleep apnea model. Am J Respir Crit Care Med. 2014; 189: 593-601.

Isetta V, León C, Torres M, Embid C, Roca J, Navajas D, Farré R, Montserrat JM. Telemedicine-based approach for Obstructive Sleep Apnea management: building evidence. Interact J Med Res, 2014; 1: e6.

Melo E, Garreta E, Luque T, Cortiella J, Nichols J, Navajas D, Farré R. Effects of the decellularization method on the local stiffness of acellular lungs. Tissue Engineering C, 2014; 20: 412-422.

Frontpage image.

Nonaka PN, Campillo C, Uriarte JJ, Garreta E, Melo E, de-Oliveira LVF, Navajas D, Farré R. Effects of freezing/thawing on the mechanical properties of decellularized lungs. J Biomed Mater Res A. 2014; 102: 413-9.

Navajas D, Dellacà RL, Farré R. Forced Oscillation Technique. Chapter 10 in “Mechanics of Breathing. New Insights from New Technologies”. Editors: A. Aliverti and A. Pedotti. Springer. ISBN 978-88-470-5646-6, 2014.

Dellacà RL, Pompilio PP, Farré R, Navajas D, Zannin E.  Use of FOT for Optimising Mechanical Ventilation. Chapter 25 in “Mechanics of Breathing. New Insights from New Technologies”. Editors: A. Aliverti and A. Pedotti. Springer. ISBN 978-88-470-5646-6, 2014.

Nieto FJ and Farré R. Association of Sleep Apnea and Cancer: From Animal Studies to Human Epidemiologic Data. Chapter 6 in S. Redline and N.A. Berger (eds.), Impact of Sleep and Sleep Disturbances on Obesity and Cancer, Energy Balance and Cancer, DOI 10.1007/978-1-4614-9527-7_6, Springer Science+Business Media New York 2014.

Torres M, Montserrat JM, Pavía J, Dalmases M, Ros D, Fernandez Y, Barbé F, Navajas D, Farré R. Chronic intermittent hypoxia preserves bone density in a mouse model of sleep apnea. Respir Physiol Neurobiol 2013; 189: 646–648.

Calverley PMA, Farré R. Putting non-invasive lung mechanics into context (Editorial). Eur Respir J 2013; 42: 1435–1437.

Quintero M, Gonzalez-Martin MC, Vega-Agapito V, Gonzalez C, Obeso A, Farré R, Agapito T, Yubero S. The effects of intermittent hypoxia on redox status, NFkB activation, and plasma lipid levels is dependent on the lowest oxygen saturation. Free Radical Biology Medicine 2013; 65C: 1142-1154.

Franquesa M, Hoogduijn MJ, Reinders ME, Eggenhofer E, Engela AU, Mensah FK, Torras J, Pileggi A, van Kooten C, Mahon B, Detry O, Popp FC, Benseler V, Casiraghi F, Johnson C, Ancans J, Fillenberg B, Delarosa O, Aran JM, Roemeling-Vanrhijn M, Pinxteren J, Perico N, Gotti E, Christ B, Reading J, Introna M, Deans R, Shagidulin M, Farré R, Rambaldi A, Sanchez-Fueyo A, Obermajer N, Pulin A, Dor FJ, Portero-Sanchez I, Baan CC, Rabelink TJ, Remuzzi G, Betjes MG, Dahlke MH, Grinyó JM; the MiSOT Study Group. Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons  learned from First Clinical Trials. Transplantation. 2013; 96: 234-238.

Peñuelas O, Melo E, Sánchez E, Sánchez I, Quinn K, Ferruelo A, Pérez-Vizcaíno F, Esteban A, Navajas D, Nin N, Lorente JA, Farré R. Antioxidant effect of human adult adipose-derived stromal stem cells in alveolar epithelial cells undergoing stretch. Respir Physiol Neurobiol, 188 (2013) 1– 8.

Almendros I, Montserrat JM, Torres M, Dalmases M, Cabañas ML, Campos-Rodríguez F, Navajas D, Farré R. Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea. Respir Physiol Neurbiol, 186 (2013) 303– 307.

Luque T, Melo E, Garreta E, Cortiella J, Nichols J, Farré R, Navajas D. Local micromechanical properties of decellularized lung scaffolds measured with atomic force microscopy. Acta Biomaterialia 9 (2013) 6852–6859.

Farré R, Navajas D, Montserrat JM. "Is there an optimal nasal pressure for treating obstructive sleep apnea – and if so, what is it? (Editorial). SLEEP, 2013; 36: 463-464.

Govoni L, Isetta V, Giacomelli P, Rosso R, Farré R, Dellaca R. Long Term Monitoring of Breathing Pattern Parameters by a Wearable System at COPD Patient's Home. ThinkMind // eTELEMED 2013, The Fifth International Conference on eHealth, Telemedicine, and Social Medicine. ISBN: 978-1-61208-252-3.

Isetta V, Montserrat JM, Thiebault G, Weber C, Navajas D, Farré R. Validation of a Telemonitoring System for Sleep Apnea Treatment.  ThinkMind // eTELEMED 2013, The Fifth International Conference on eHealth, Telemedicine, and Social Medicine, ISBN: 978-1-61208-252-3.

Puig F, Fuster G, Adda M, Blanch L, Farré R,  Navajas D, Artigas A. Barrier-protective effects of activated protein C in human alveolar epithelial cells.  PLoS ONE, 2013; 8(2): e56965.

Isetta V, López-Agustina C, López-Bernal E, Amat M, Vila M, Valls C, Navajas D, Farré R. Cost-Effectiveness of a New Internet-based Monitoring Tool for Neonatal Post-Discharge Home Care. J Med Internet Res, 2013; 15(2): e38.

Li Bassi G, Tavares O, Marti JD, Giunta V, Luque N, Isetta V, Ferrer M, Farre R, Leite G, Torres A. An in-vitro study to assess determinant features associated with fluid sealing in the design of endotracheal tube cuffs and exerted tracheal pressures. Critical Care Med 2013; 41: 518-526,

Kheirandish-Gozal L, Farré R. The Injury theory, endothelial progenitors and sleep apnea. (Editorial). Am J Respir Crit Care Med, 2013; 187: 5-7.

Campos-Rodriguez F, Martinez-Garcia MA, Martinez M, Duran-Cantolla J, de la Pena M, Masdeu MJ, Gonzalez M, del Campo F, Gallego I, Marin JM, Barbe F, Montserrat JM, Farre R. Association between Obstructive Sleep Apnea and Cancer Incidence in a large multicenter Spanish Cohort. Am J Respir Crit Med, 2013; 187: 99-105.

Govoni L, Dellaca RL, Peneulas O, Bellani G, Artigas A, Ferrer R, Navajas D, Pedotti A, Farré R. Actual performance of mechanical ventilators in ICU. A multicentric quality control study. Medical Devices: Evidence and Research, 2012; 5: 111-119.

Martínez-García MA, Campos-Rodríguez F, Farré R. Sleep apnoea and cancer: current insights and future perspectives (Editorial). Eur Respir J, 2012; 40: 1315-1317.

Almendros I, Montserrat JM, Torres M, Bonsignore MR, Chimenti L, Navajas D, Farré R. Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea. Sleep Medicine, 2012; 13:1254–1260.

Almendros I, Carreras A, Montserrat JM, Gozal D, Navajas D, Farré R. Potential role of adult stem cells in obstructive sleep apnea. Frontiers Neurology, 3: 112, 2012.

Nieto FJ, Peppard PE, Young T, Finn L, Hla KM, Farré R. Sleep disordered breathing and cancer mortality: results from the Wisconsin Sleep Cohort Study. Am. J. Respir. Crit. Care Med., 2012, 186: 190–194.

Accompanying Editorial: “Sleep Apnea: A Common Mechanism for the Deadly Triad—Cardiovascular Disease, Diabetes, and Cancer?”.

Jobin V, Rigau J, Beauregard J, Farre R, Monserrat JM, Bradley TD, Kimoff RJ. Evaluation of upper airway patency during Cheyne-Stokes breathing in heart failure patients. Eur Respir J, 2012; 40: 1523–1530.

Chimenti L, Luque T, Bonsignore MR, Ramírez J, Navajas D, Farré R. Pre-treatment with mesenchymal stem cells reduces ventilator-induced lung injury. Eur Respir J, 2012; 40: 939-948.

Acerbi I, Luque T, A. Gimenez A, Puig M, Farré R, Reguant N, Navajas D, Alcaraz J. Integrin-specific mechanoresponses to compression and tension probed by flat-ended AFM tips. PLos One, 2012;7(2):e32261.

Guerrero A, Montserrat JM, Farre R, Masa F, Duran J, Embid C.. Automatic CPAP Performance in Patients with Sleep Apnea Plus COPD. COPD, 2012, 9:382-389.

Sellares J; Loureiro H; Ferrer M; Amaro M; Farré R; Torres A. The effect of spontaneous breathing in systemic interleukin-6 during ventilator weaning. European Respiratory Journal, 2012;39: 654-60.

Tsapikouni T, Garreta E, Melo E, Navajas D, Farré R. A bioreactor for subjecting cultured cells to fast-rate intermittent hypoxia. Respir Physiol Neurobiol, 2012; 182: 47-52.

Guaman AV, Carreras A, Calvo D, Agudo A, Navajas D, Pardo A, Marco S, Farré R. Rapid detection of sepsis in rats through volatile organic compounds in breath. Journal of Chromatography B, 881-882: 76-82, 2012.

Almendros, I.; Montserrat, J.M.; Ramirez, J.; Torres, M.; Duran-Cantolla, J.; Navajas, D.; Farré, R. Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnea. European Respiratory Journal, 30: 215-217, 2012.

Isetta V, López-Agustina C, Vila M, Clemente A, Cucala M, Farré R. Telenursing Service for Neonatal Post-discharge Home Care. eTELEMED 2012: The Fourth International Conference on eHealth, Telemedicine, and Social Medicine , Valencia, Spain, January 30 - February 4, 2012. ISBN: 978-1-61208-179-3. http://www.thinkmind.org/index.php?view=article&articleid=etelemed_2012_3_20_40034.

Isetta V, Montserrat JM, Fonollosa D, Roca J, Leon C, Farré R. Multicenter Support Network for CPAP Therapy Follow-up in Sleep Apnea. eTELEMED 2012: The Fourth International Conference on eHealth, Telemedicine, and Social Medicine, Valencia, Spain, January 30 - February 4, 2012. ISBN: 978-1-61208-179-3. http://www.thinkmind.org/index.php?view=article&articleid=etelemed_2012_1_10_40045.

Almendros I, Farre R, Torres M, Bonsignore MR, Dalmases M, Ramirez J, Navajas D, Montserrat JM. Early and mid-term effects of obstructive apneas in myocardial injury and inflammation. Sleep Medicine 12; 1037-1040, 2011.

Bates JHT, Irvin CG, Farre R, Hantos Z. Oscillation Mechanics of the Respiratory System, Compr Physiol 1:1233-1272, 2011.

Navajas D, Farré R. Respiratory mechanics. In Chapter 3: Pulmonary function testing; ERS Handbook

Dellacà R; Montserrat JM; Govoni L; Pedotti A; Navajas D; Farré R. Telemetric CPAP titration at home in patients with sleep apnoea hypopnoea syndrome. Sleep Medicine, 12: 153-157. 2011

Cagido VR; Zin WA; Ramirez J; Navajas D; Farré R. Alternating ventilation in a rat model of increased abdominal pressure. Respiratory Physiology & Neurobiology; 175: 310-315, 2011

Masa JF; Gonzalez MT; Pereira R; Mota M; Riesco JA; Corral J; Zamorano J; Rubio M; Teran J; Farré R. Validity of spirometry performed online. European Respiratory Journal; 37: 911-918, 2011

Almendros I; Farré R; Planas AM; Torres M; Bonsignore MR; Navajas D; Montserrat JM. Tissue oxygenation in brain, muscle and fat in a rat model of sleep apnea: differential effect of obstructive apneas and intermittent hypoxia.  Sleep; 34: 1127-1133; 2011.

Carreras, A.; Almendros, I.; Farré, R. Potential Role of Bone Marrow Mesenchymal Stem Cells in Obstructive Sleep Apnea. International Journal of Stem Cells; 43: 49, 2011.

Carreras A, Wang Y, Gozal D, Montserrat JM, Navajas D, Farré R.  Non-invasive system for applying airway obstructions to model obstructive sleep apnea in mice.  Respir Physiol Neurobiol 175:164-168, 2011.

Almendros I, Montserrat JM, Torres M, González C, Navajas D, Farre R. Changes in oxygen partial pressure of brain tissue in an animal model of obstructive apnea. Resp Res 11:3, 2010.

Guerrero A, Embid C, Farré R, Navajas D, Masa JF, Duran J, Montserrat JM. Sleep breathing flow characteristics as a sign for the detection of wakefulness in patients with sleep apnea. Respiration 80:495-499, 2010.

Rigau J, Farré R.  Quality control of non-invasive ventilation: performance, service, maintenance and infection control of ventilators. Chapter 7 in “Non-invasive ventilation & Weaning. Principles and practice” Ed. By M- Elliott, S. Nava and B. Schonhofer, Hooder-Arnold, CRC Taylor & Francis, 2010. ISBN: 13: 978-1-4441-2858.

Iranzo A, Isetta V, Molinuevo JL, Serradell M, Navajas D, Farre R, Santamaria J.  Electroencephalographic slowing heralds mild cognitive impairment in idiophatic REM sleep behavior disorder. Sleep Med 11:534-539, 2010.

Carreras A, Almendros I, Montserrat JM, Navajas D, Farré, R.  Mesenchymal stem cells reduce inflammation in a rat model of obstructive sleep apnea. Respir Physiol Neurobiol 172:210-212, 2010.

Estrada L, Santamaria J, Isetta V, Iranzo A, NAvajas D, Farré R. Validation of an EEG-based algorithm for automatic detaction of sleep onset in the Multiple Sleep Latency Test. Proceedings of the World Congress on Engineering 2010 Vol I, ISBN: 978-988-17012-9-9.

Carreras A, Rojas M, Tsapikouni T, Montserrat JM, Navajas D, Farré R. Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing. Resp Res 11: 91, 2010.

Puig F, Gavara N, Sunyer R, Farré R, Navajas D. Stiffening and contraction induced by dexamethasone in alveolar epithelial cells. Exp Mech 49:47-55, 2009.

Nacher M, Farré R, Montserrat JM, Torres M, Navajas D, Bulbena O, Serrano-Mollar A. Biological consequences of oxygen desaturation and respiratory effort in an acute animal model of obstructive sleep apnea (OSA). Sleep Med 10:892-897, 2009.

Farré R, Escarrabill J, Montserrat JM. Noninvasive Ventilation Treatment of Sleep Related Breathing Disorders. In Handbook of Sleep disorders. Second Edition. Edited by CA. Kushida. Informa Healthcare. ISBN-13: 978-0-8493-7319-0.

Carreras A, Almendros I, Acerbi A, Montserrat JM, Navajas D, Farré R. Obstructive apneas induce early release of mesenchymal stem cells into circulating blood. Sleep 32:117-119, 2009.

Farré R, Navajas D. Quality control: A necessary – but sometimes overlooked – tool for improving respiratory medicine. Eur Respir J 33:722–723, 2009.

Sunyer R, Ritort F, Farré R, Navajas D. Thermal activation and ATP dependence of the cytoskeleton remodeling dynamics. Phys Rev E. 79:051920, 2009.

Sunyer R, Trepat X, Fredberg JJ, Farré R, Navajas D, Temperature dependence of cell mechanics measured by atomic force microscopy. Phys Biol 6:025009, 2009.

Sellares J,  Acerbi I, Loureiro H, Dellaca RL, Ferrer M, Torres A, Navajas D, Farré R. Respiratory impedance during weaning from mechanical ventilation in a mixed population of critically ill patients. Brit J Anaesth, 103: 828-832, 2009.

Dellaca R, Gobbi A, Govoni L, Navajas D, Pedotti A, Farre R. Título: A novel simple internet-based system for real time monitoring and optimizing home mechanical ventilation. International Conference on eHealth, Telemedicine and Social Medicine; 2009; 209.215. ISBN: 978-0-7695-3532-6.

Farré R, Papadopoulos A, Munaro  G, Rosso R. An Open, Ubiquitous and Adaptive Chronic Disease Management Platform for Chronic Respiratory and Renal Diseases (CHRONIOUS). International Conference on eHealth, Telemedicine and Social Medicine. Pages: 184-189, doi/10.1109/eTELEMED.2009.37; ISBN: 978-0-7695-3532-6, 2009.

Dellaca R, Gobbi A, Govoni L, Navajas D, Pedotti A, Farre R. A novel simple internet-based system for real time monitoring and optimizing home mechanical ventilation. International Conference on eHealth, Telemedicine and Social Medicine. Pages: 209-215, doi:10.1109/eTELEMED.2009.37; ISBN: 978-0-7695-3532-6, 2009.

Almendros I, Acerbi I, Vilaseca I, Montserrat JM, Navajas D, Farré R. Continuous positive airway pressure (CPAP) induces early nasal inflammation. Sleep 31:127-131, 2008.

Roca-Cusachs P, Alcaraz J, Sunyer R, Samitier J, Farré R, Navajas D. Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation. Biophys J  94:4984–4995, 2008.

Almendros I, Carreras A, Ramirez J, Montserrat JM, Navajas D, Farré R. Upper airway collapse and reopening induced inflammation in a sleep apnea model. Eur Respir J 32:399–404, 2008.

Accompanying Editorial: “Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age


Gavara N, Roca-Cusachs P, Sunyer R, Farré R, Navajas D. Mapping cell-matrix stresses during stretch reveals inelastic reorganization of the cytoskeleton. Biophys J  95:464–471, 2008.

Farre R, Montserrat JM, Navajas D. Morbidity due to obstructive sleep apnea: insights from animal models. Curr Opin Pulm Med 14:530–536, 2008.

Farre R, Montserrat JM, Navajas D. Assessment upper airway mechanics during sleep. Respir Physiol Neurobiol 163:74-81, 2008.

Almendros I, Gutierrez PT, Closa D, Navajas D, Farre R. One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung. Respir Physiol Neurobiol 162:100-102, 2008.

Trepat X, Farré R. Alveolar permeability and stretch: too far, too fast (Editorial). Eur Respir J 32: 826–828, 2008.

Farre R, Montserrat JM. Principles of CPAP and auto-adjusting CPAP devices. Breathe; 5: 43-50, 2008.

Sanders MH, Montserrat JM, Farré R, Givelber RJ. Positive pressure therapy. A perspective on evidence-based outcomes and methods of application. Proc Am Thorac Soc,  5:161-172, 2008.

Farré R, Nácher M, Serrano-Mollar A, Gáldiz JB, Alvarez FJ, Navajas D, Montserrat JM. Rat model of chronic recurrent airway obstructions to study the sleep apnea syndrome. Sleep 30:930-933, 2007.

Valencia M, Ferrer M, Farré R, Navajas D, Badia JR, Nicolas JM, Torres A. Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position. A randomized trial. Crit Care Med 35:1543-1549, 2007.

Almendros I, Acerbi I, Puig F, Montserrat JM, Navajas D, Farré R. Upper airway inflammation triggered by vibration in a rat model of snoring. Sleep 30: 225-227, 2007.

Rico F, Roca-Cusachs P, Sunyer R, Farré R, Navajas D. Cell dynamic adhesion and elastic properties probed with cylindrical atomic force microscopy cantilever tips. J Mol Recognit, 20:459466, 2007.

Pevernagie D, Masa JF, Meurice JC, Farré R, Marrone O, Rodenstein D. Treatment of obstructive sleep-disordered breathing with positive airway pressure systems. Eur Respir Rev 16:106, 125-131, 2007.

Nácher M, Serrano-Mollar A, Farré R, Panés J, Seguí J, Montserrat JM. Recurrent obstructive apneas trigger early systemic inflammation in a rat model of sleep apnea. Respir Physiol Neurobiol 155: 93-96, 2007

Rigau J, Montserrat JM, Wöhrle H, Plattner D, Schwaibold M, Navajas D, Farré R. Bench model to simulate upper airway obstruction for analyzing automatic continuous positive airway pressure devices. Chest 130:350-361, 2006.

Calero G, Farre R, Ballester E, Hernandez L, Navajas D, Montserrat Canal JM.  Physiological consequences of prolonged periods of flow limitation in patients with sleep apnea hypopnea syndrome. Respir Med 100:813-817, 2006.

Farre R, Navajas D, Prats E, Marti S, Guell R, Montserrat JM, Tebe C, Escarrabill J.  Performance of mechanical ventilators at the patient's home: a multicentre quality control study. Thorax 61:400-404, 2006.

Dellaca RL, Rotger M, Aliverti A, Navajas D, Pedotti A, Farre R. Non-invasive detection of expiratory flow limitation in COPD patients during nasal CPAP. Eur Respir J 27:983-991, 2006.

Roca-Cusachs P, Almendros I, Sunyer R, Gavara N, Farré R, Navajas D. Rheology of passive and adhesion-activated neutrophils probed by Atomic Force Microscopy. Biophys J 91:3508-3518, 2006.

Gavara N, Sunyer R, Roca-Cusachs P, Farre R, Rotger M, Navajas D. Thrombin-induced contraction in alveolar epithelial cells probed by traction microscopy. J Appl Physiol 101:512-520, 2006.

Trepat X, Puig F, Gavara N, Fredberg JJ, Farre R, Navajas D. Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin. Am J Physiol Lung Cell Mol Physiol 290:L1104-L1110, 2006.

Montserrat JM, Rigau J, Navajas D, Ballester E, Farre R. Effect of using the flow or the volume signals on the measurement of nonapneic respiratory events. Sleep 28: 990-992, 2005.

Accompanying Editorial: “Caveat emptor--because you get what you ask for”.

Farre R, Granell S, Rotger M, Serrano-Mollar A, Closa D, Navajas D.  Animal model of unilateral ventilator-induced lung injury. Intensive Care Med 31:487-490, 2005.

Puig, F, F Rico, I Almendros, JM Montserrat, D Navajas, R Farré. Vibration Enhances Interleukin-8 Release In A Cell Model Of Snoring-Induced Airway Inflammation. Sleep 28:1312-1316, 2005.

Rico F, Roca-Cusachs, N Gavara, R Farré, M Rotger, D Navajas. Probing Mechanical Properties of Living Cells by Atomic Force Microscopy with Blunted Pyramidal Cantilever Tips. Phys Rev E 72:021914, 2005.

Roca-Cusachs P, Rico F, Martínez E, Toset J, Farré R, Navajas D. Stability of Microfabricated High Aspect Ratio Structures in Poly(dimethylsiloxane). Langmuir 21:5542-5548, 2005.

Trepat, X, M Grabulosa, L Buscemi, F Rico, R Farré, D Navajas. Thrombin and histamine induce stiffening of alveolar epithelial cells. J Appl Physiol 98:1567-1574, 2005.

Lloyd-Owen SJ, Donaldson GC, Ambrosino N, Escarabill J, Farre R, Fauroux B, Robert D, Schoenhofer B, Simonds AK, Wedzicha JA. Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey. Eur Respir J, 25: 1025-1031, 2005.

Farre R, Lloyd-Owen SJ, Ambrosino N, Donaldson G, Escarrabill J, Fauroux B, Robert D, Schoenhofer B, Simonds A, Wedzicha JA.  Quality control of equipment in home mechanical ventilation: a European survey. Eur Respir J, 26: 86-94, 2005.

Polkey MI, Farré R, Dinh-Xuan AT. Respiratory monitoring: revisiting classical physiological principles with new tools. Eur Respir J, 24: 718-719, 2004.

Farre, R. Inspiratory flow limitation in obstructive sleep apnoea patients. Clinical Science, 106: 563-565, 2004.

Farre R, Montserrat JM, Navajas D. Noninvasive monitoring of respiratory mechanics during sleep. Eur Respir J 24:1052-1060, 2004.

Granell S, Serrano-Mollar A, Folch-Puy E, Navajas D, Farre R, Bulbena O, Closa D. Oxygen in the alveolar airspace mediates lung inflammation in acute pancreatitis. Free Radic Biol & Med 37:1640-1647, 2004.

Rigau J, Farré R, Trepat X, Shusterman D, Navajas D. Oscillometric assessment of airway obstruction in vocal cord dysfunction. A model study. J Biomech 37:37-43, 2004.

Farré R, Navajas D. Assessment of expiratory flow limitation in chronic obstructive pulmonary disease: a new approach. Eur Respir J 23:187-188, 2004.

Trepat X, Grabulosa M, Puig F, Maksym GN, Navajas D, Farre R. Viscoelasticity of human alveolar epithelial cells subjected to stretch. Am J Physiol Lung Cell Mol Physiol 287:L1025-34, 2004.

Rigau J, Burgos F, Hernández C, Roca J, Navajas D, Farré R. Unsupervised self-testing of airway obstruction by forced oscillation at the patients' home. Eur Respir J 22:668-671, 2003.

Farré R, Rigau J, Montserrat JM, Buscemi L, Ballester E, Navajas D. Static and dynamic upper airway obstruction in sleep apnea. Role of the breathing gas properties. Am J Respir Crit Care Med 168:659-663, 2003.

Farré R, Rotger M, Montserrat JM, Calero G, Navajas D. Collapsible upper airway segment to study the obstructive sleep apnea/hypopnea syndrome in rats. Respir Physiol Neurobiol 136:199-209, 2003.

Farré R, Giro E, Casolive V, Navajas D, Escarrabill J. Quality control of mechanical ventilation at the patient's home. Intensive Care Med 29: 484-486, 2003.

Alcaraz J, Buscemi L, Grabulosa M, Trepat X, Fabry B, Farré R, Navajas D. Microrheology of human lung epithelial cells measured by Atomic Force Microscopy. Biophys J 84: 2071-79, 2003.

Oostveen E, McLeod D, Lorino H, Farré R, Hantos Z, Desager K, Marchal F. The forced oscillation technique in clinical practice: Methodology, recommendations and future developments. ERS task force. Eur Respir J, 22:1026-1041, 2003.

Montserrat JM, Farré R. Breathing Flow Disturbances during Sleep. Can They Be Accurately Assessed by Nasal Prongs? Am J Respir Crit Care Med, 166: 259-260, 2002.

Farré R, Rotger M, Ferrer M, Torres A, Navajas D. Automatic regulation of the cuff pressure in endotracheally intubated patients. Eur Respir J 20:1010-1013, 2002.

Farré R, Montserrat JM, Rigau J, Trepat X, Pinto P, Navajas D. Response of automatic CPAP devices to different sleep breathing paterns. A bench study. Am J Respir Crit Care Med 166:469-473, 2002.

Rigau J, Farré R, Roca J, Marco S, Herms A, Navajas D. A portable forced oscillation device for respiratory home monitoring. Eur Respir J 19:146-50, 2002.

Farré R, Montserrat R, Ballester E, Navajas D. Potential rebreathing after continuous positive airway pressure failure during sleep. Chest 121:196-200, 2002.

Montserrat JM, Farré R, Navajas D. New technologies to detect static and dynamic upper airway obstruction during sleep. Sleep Breath, 5:193-206, 2001.

Farré R, Mancini M, Rotger M, Ferrer M, Roca J, Navajas D. Oscillatory resistance measured during noninvasive proportional assist ventilation. Am J Respir Crit Care Med 164:790-794, 2001.

Navajas D, Farré R. Forced oscillation assessment of respiratory mechanics in ventilated patients. Crit Care 5: 3-9, 2001.

Badia JR, Farré R, Rigau J, Uribe ME, Navajas D, Montserrat JM. Forced oscillation measurements do not affect upper airway muscle tone or sleep in clinical studies. Eur Respir J 18:335-339, 2001.

Montserrat JM, Ferrer M, Hernandez L, Farré R, Vilagut G, Navajas D, Badia JR, Carrasco E, De-Pablo J, Ballester E. Effectiveness of CPAP treatment in daytime function in sleep apnea syndromeA randomized controlled study with an optimized placebo. Am J Respir Crit Care Med 164:608-613, 2001.

Farré R, Rigau J, Montserrat JM, Ballester E, Navajas D. Evaluation of a simplified oscillation technique for assessing airway obstruction in sleep apnea. Eur Respir J 17:456-461, 2001.

Montserrat JM, Farré R, Navajas D. Automatic continuous positive airway pressure devices for the treatment of sleep apnea hypopnea syndrome. Sleep Med 2:95-98, 2001.

Farré R, Rigau J, Montserrat JM, Ballester E, Navajas D. Relevance of linearizing nasal prongs for assessing hypopneas and flow limitation suring sleep. Am J Respir Crit Care Med 163: 494-497, 2001.

Hernandez L, Ballester E, Farré R, Badia JR, Lobelo R, Navajas D, Montserrat JM Performance of nasal prongs in sleep studies: spectrum of flow-related events. Chest 119:442-450, 2001.