Translational Microenvironment Research in Lung Cancer and Lung Fibrosis

Research interests overview


Tissue cells are social organisms that tune their behavior based on a continuous exchange of biochemical and biophysical information with their surrounding microenvironment, which includes neighbor cells, extracellular matrix components and soluble factors. Normal cell-microenvironment interactions are essential for the maintenance of tissue structure and function. Conversely, cell-microenvironment interactions become awry in many diseases such as cancer and fibrosis, leadign to a permanent loss of tissue structure and function, and too often to the death of the individual. We study how does the microenvironment control cell behavior and misbehavior in normal and diseased conditions, particularly in lung cancer and fibrosis. For this purpose, we use the state-of-the-art of cell biology, bioengineering and biophysical tools as well as our unique collection of cells derived from patients with lung cancer or lung fibrosis. We then apply these tools to study quantitatively the aberrant interactions between tissue cells -including epithelial cells, fibroblasts, endothelial cells and immune cells- and their microenvironment in these diseases. Our ultimate goal is to be translational by using our understanding of how cell-microenvironment interactions contribute to cancer and fibrosis to define new therapeutic strategies against these devastating diseases as well as to identify novel biomarkers. For this purpose, we work in close collaboration with clinical groups, and often with companies by using our know-how and preclinical models.











For more specifics about our past and current research, please browse the different sections below:


               [LAB MEMBERS]                 [RESEARCH]          [PUBLICATIONS]          [COLLABORATION WITH INDUSTRY]                   

           [NEWS&VIEWS]                [COLLABORATORS]           [OPENINGS]                   [TEACHING]                [CONTACT]


                             [SUPORT LUNG CANCER RESEARCH / DONAR SUPORT RECERCA CÀNCER DE PULMÓ]                        
















Jordi Alcaraz (Principal Investigator)




Brief CV


· Citizenship: Spain


· Education:

- Ph.D. in Biophysics, University of Barcelona, Barcelona (Spain) 2002

- M. Sc. in Cell Physiology, University of Barcelona, Barcelona (Spain) 2000

- B. Sc. in Physics, University of Barcelona, Barcelona (Spain) 1997


· Biosketch:

Jordi is a Serra-Húnter Associate Professor in the School of Medicine at the University of Barcelona (UB) since 2016. He graduated in Physics in 1997 at the UB, and attended graduate school at the same university, where he obtained his Ph.D. in the fields of Cellular Biophysics and Nanobioengineering in 2002. From 2002 until 2007 he was a joint postdoc between the Cancer Biology Laboratory of Dr Mina J Bissell at the Lawrence Berkeley National Laboratory and the Single Molecule Biophysics Laboratory of Prof Carlos Bustamante at UC Berkeley. During his postdoc he pursued research aiming to understand how biophysical cues from the tissue microenvironment control differentiation and cancer progression at the single cell level.


Office Ph: (+34) 934031148

Lab Ph: (+34) 934039764

Fax: (+34) 934035278


Unitat de Biofísica i Bioenginyeria

Facultat de Medicina                                                  Universitat de Barcelona

Casanova 143

08036 Barcelona, Spain

Graduate students (director/tutor)




Paula Duch



Brief CV


· Citizenship: Spain


· Education:

- M. Sc. in Integrative Physiology, University of Barcelona, Barcelona (Spain) 2015

- B. Sc. in Biochemistry, Universitat Autònoma de Barcelona, Barcelona (Spain), 2014


 (+34) 934039764





Alejandro Llorente



Brief CV


· Citizenship: Spain


· Education:

- M. Sc. in Biomedicine, University of Barcelona, Barcelona (Spain) 2020

- B. Sc. in Biology, University of Girona, Girona (Spain), 2019

- B. Sc. in Biotechnology, University of Girona, Girona (Spain), 2019


 (+34) 934039764





Elba Marín



Brief CV


· Citizenship: Spain


· Education:

- M. Sc. in Translational Medicine, University of Barcelona, Barcelona (Spain) 2018

- B. Sc. in Biomedical Sciences, , University of Barcelona, Barcelona (Spain) 2017                                                                                                                                                                

 (+34) 934039764





Postdoctoral Researchers




Marta Gabasa





Brief CV


· Citizenship: Spain


· Education:

- PhD in Biology, University of Barcelona, Barcelona (Spain) 2015   

- M. Sc. in Biomedicine, University of Barcelona, Barcelona (Spain) 2010   

- B. Sc. in Biology, University of Barcelona, Barcelona (Spain) 2008

 (+34) 934039764





Natalia Díaz





Brief CV


· Citizenship: Chile/Spain


· Education:

- PhD in Biochemistry, Universidad de Chile, Santiago (Chile) 2016   

- M. Sc. in Biochemistry, Pontificia Universidad Católica de Valparaíso, Valparaíso (Chile) 2010   

- B. Sc. In Science, Pontificia Universidad Católica de Valparaíso, Valparaíso (Chile) 2007

 (+34) 934039764





Rafael Ikemori





Brief CV


· Citizenship: Brazil


· Education:

- PhD in Sciences, Universidade de São Paulo, USP, Sao Paulo (Brazil) 2014

- M. Sc. in Genetics and Molecular Biology, Univ. Estadual de Campinas, Campinas, (Brazil) 2009   

- B. Sc. in Biological Sciences, Univ. Estadual de Campinas, Campinas, (Brazil) 2006

 (+34) 934039764





Marselina Arshekyan





Brief CV


· Citizenship: Armenia


· Education:

- PhD in Biochemical and Pharmacological Methodologies, University of Urbino Carlo Bo, Urbino (Italy) 2015   

- B. Sc. in Pharmaceutical Chemistry, Yerevan State University, Yerevan (Armenia) 2004  

 (+34) 934039764







Past Members



Current Position

Alícia Giménez (grad student), 2015

Pharmaceutical Industry

Roberto Lugo (grad student), 2014

Manager of Higher Education Institutions

Marta Puig (grad student), 2014

Product Manager, Pharmaceutical Industry

Roland Galgoczy (grad student), 2014

Associate at Prescient Healthcare Group

Sandra Genís (Master student), 2011

PhD student, IRTA (Spain)

Luis G. Rigat-Brugarolas (Master student), 2011

PhD student, IBEC (Spain)

Stefan Lops (Master student), 2011

Assistant Clinical Trial Innovation at Janssen, Pharmaceutical Companies of Johnson and Johnson

Irene Acerbi (grad student), 2010

Postdoc, University of California San Francisco (US)

Adai Colom (technician), 2010

PhD student, INSERM U1006 (France)

Sarai Rodríguez (Master student), 2010

PhD student, Vall d’Hebron Research Institute (Spain)

Marc Torres (internship), 2010


Álex Urgell (Master student), 2009

Construction Industry (Spain)

Irina Pavelescu (Master student), 2009

PhD student, CSIC (Spain)

Ferran Brunet (Master student), 2009

Application Product Manager at Roche Diagnostics (Spain)

























Current research projects and long-term research interests


Aberrant cancer-stroma interactions in lung cancer

Lung cancer remains the leading cause of cancer-related deaths worldwide, with a 5-year survival rate of only 18% that is much lower than other leading cancer types like breast (89%) or colon (65%). Lung tumors and other solid neoplasias are increasingly regarded as organs driven by the aberrant co-evolution of cancer and stromal cells. Based on the striking similarities between the stroma in tumors and wounds, tumors are often described as “wounds that never heal”, and the desmoplastic (wound-like) stroma is pointed as a major contributor to tumor progression and even resistance to therapies. However, the mechanisms underlying the effects of such tumor stroma on tumor-promotion and modulation of therapy responses remain poorly understood, particularly in lung cancer. To address this limitation, we started in 2010 a collection of tumor associated fibroblasts (TAFs) -the most abundant stromal cell type- from surgical patients of the Hospital Clínic de Barcelona diagnosed with non-small cell lung cancer (NSCLC), which is the most abundant lung cancer type. We use advanced pre-clinical culture models to study the aberrant cancer-fibroblast interactions in lung cancer to unveil key molecular alterations that can be useful to develop novel therapies, to identify novel biomarkers and to dissect the mode of action of therapies.


Role of abnormal tissue mechanics in fibrosis and cancer

It is well known that each tissue and organ in our body is characterized by a specific deformability or “stiffness”. Thus, our brain or lungs are soft organs, whereas our muscle and bones are stiff. In normal conditions, the stiffness of each tissue is maintained within its physiological range during adulthood. Occasionally, a region of a tissue may temporarily stiffen as part of the normal wound healing response to damage. Likewise, tissue stiffness becomes progressively altered during aging. None of these previously mentioned mechanical alterations compromise neither the integrity nor the normal function of the tissue. In contrast, a hallmark of numerous diseases is the permanent loss of normal tissue stiffness, concomitantly with an impairment of normal functions. In some cases, the tissue becomes abnormally soft as in arthritis, emphysema or osteoporosis. In other cases, the tissue becomes abnormally stiff as in sclerosis, fibrosis and cancer. We are particularly interested in how normal tissue stiffness is lost in fibrosis and cancer, and how this abnormal tissue hardening contributes to the progression of these devastating diseases. Moreover, we are interested in using tissue mechanics-associated features as novel diagnostic and/or prognostic biomarkers. To pursue these interests, we used advanced culture models based on biomaterials with tunable elasticity as well as Atomic force microscopy (AFM) and other nanomechanical tools that enable measuring cell and tissue mechanics with high resolution.


Understanding the language of cell shape in normal conditions and in tumors

Intuitively, it is clear that there is a tight connection between the shape of a cell and its specific biological functions, i.e. form and function are expected to fit for every biological system. In support of this connection, there are numerous examples that illustrate that both the expression of most if not all genes and the activity of proteins are regulated by the specific shape of the cell. The same principles apply to the architecture of the extracellular matrix and how they support normal and diseased conditions. However, our current understanding of how cell shape and ECM structure and organization signal to regulate cellular processes is still very poor. We take advantage of micropatterning and advanced imaging techniques and other engineering tools to unravel how changes in cell shape and ECM architecture are transduced into alterations in cellular processes.


Nanobiotechnology and Bioengineering

To understand how mechanical cues regulate cellular functions in normal and diseased conditions, we take advantage of Atomic Force Microscopy and other nanotechniques that enable direct mechanical manipulation of cells and tissues. For this purpose, we develop new nanobiotechnological applications and optimize current systems to fit our experimental needs.

Experimental approaches and areas of expertise

Our research is intrinsically multidisciplinary, as it integrates tools and techniques from a variety of scientific fields including molecular and cell biology, biomaterials, nanobiotechnology and biophysics.


We conduct most of our experiments ‘ex-vivo’ using cultured cells from soft tissues with a ductal-alveolar structure including lung and mammary tissue. The sources of our cells (both human and rodent) are either primary culture from donors or commercially available cell lines.


The main techniques we use in our research include the following (but are not restricted to):


· Cell culture: primary culture of fibroblasts from tissue explants, culture of cell lines of mesenchymal or epithelial origin

· Genetic tools for transcription manipulation: shRNA, siRNA

· Biomaterials: 2D and 3D gel assays in which both the biochemical composition and the mechanical properties can be controlled independently

· Molecular cell biology: qRT-PCR, Western-Blotting, Immunofluorescence, Immunohistochemistry, Zymmography, Flow Cytometry

· Tools to control cell shape: micropatterning

· Advanced optical microscopy: phase contrast microscopy, DIC, epifluorescence, polarized light microscopy, confocal microscopy and confocal reflection microscopy

· Image processing with Image J and Matlab

· Digital Pathology, with customized software to process histologic stainings from patients

· Bioinformatic analysis, including analysis of gene expression datasets available at TCGA or other databases, pathway enrichment analysis, interactome analysis etc.

· Nano- Microrheology (i.e. characterization of mechanical properties of soft samples, including cells, gels and tissues) with Atomic Force Microscopy

· Control of Optical Microscopy setups

· Digital Signal Processing and Data analysis with Matlab

· Theoretical Physics: Soft Condensed Matter and Contact Mechanics









Microenvironment in cancer and fibrosis


Epigenetic SMAD3 repression in tumor-associated fibroblasts impairs fibrosis and response to the antifibrotic drug nintedanib in lung squamous cell carcinoma. R. Ikemori, M. Gabasa, P. Duch, M. Vizoso, P. Bragado, M. Arshakyan, I-C. Benchea, A. Marín, S. Morán, M. Castro, G. Fuster, S. Gea-Sorli, T. Jauset, L. Soucek, L.M. Montuenga, M. Esteller, E. Monsó, V.I. Peinado, P. Gascón, C. Fillat, F. Hilberg, N. Reguart, J. Alcaraz. Cancer Res 2020 80:276-290 LINK


J. Alcaraz, J. Lluís Carrasco, L. Millares, I-C. Luis, F.J. Fernández-Porras, A. Martinez-Romero, N. Diaz-Valdivia, J. Sanchez De Cos, R. Rami-Porta, L. Seijo, J. Ramírez, M.J. Pajares, N. Reguart, E. Barreiro, E. Monsó. Stromal markers of activated tumor associated fibroblasts predict poor survival and are associated with necrosis in non-small cell lung cancer. Lung Cancer 2019, 135: 151–160  LINK


Esther Marhuenda, Noelia Campillo, Marta Gabasa, Miguel Angel Martínez-García, Francisco Campos-Rodríguez, David Gozal, Daniel Navajas, Jordi Alcaraz, Ramon Farré, Isaac Almendros. Effects of Sustained and Intermittent Hypoxia on Human Lung Cancer Cells. American Journal of Respiratory Cell and Molecular Biology 2019 (in press) LINK


Laura Sala, Héctor Franco-Valls, Jelena Stanisavljevic, Josue Curto, Jordi Vergés, Raúl Peña, Paula Duch,

      Jordi Alcaraz, Antonio G. de Herreros and Josep Baulida. Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition. International Journal of Cancer 2019 145:3064-3077  doi: 10.1002/ijc.32376. LINK


A. Giménez, P. Duch, M. Puig, M. Gabasa, A. Xaubet, J. Alcaraz. Dysregulated collagen homeostasis by matrix stiffening and TGF-β1 in fibroblasts from idiopathic pulmonary fibrosis patients: role of FAK/Akt. International Journal of Molecular Science 2017, 18(11), 2431; pii: E2431 LINK


M. Gabasa, P. Duch, I. Jorba, A. Giménez, R. Lugo, I. Pavelescu, F. Rodríguez-Pascual, M. Molina-Molina, A. Xaubet, J. Pereda, J. Alcaraz. Epithelial contribution to the pro-fibrotic stiff microenvironment and myofibroblast population in lung fibrosis. Molecular Biology of the Cell 2017, 28(26):3741-3755 LINK


M. Gabasa, R. Ikemori, F. Hilberg, N. Reguart, J. Alcaraz. Nintedanib selectively inhibits the activation and tumor-promoting effects of fibroblasts from lung adenocarcinoma patients. British Journal of Cancer 2017, 117:1128-1138  LINK


A. Labernadie, T.  Kato, A. Brugués, X. Serra-Picamal, S. Derzsi, V. Gonzalez, A. Elosegui-Artola, J. Alcaraz, P. Roca-Cusachs, E. Sahai, X. Trepat. A mechanically active heterophilic E-cadherin/N-cadherin adhesion enables cancer associated fibroblasts to drive cancer cell invasion. Nature Cell Biology 2017, 19: 224–237 LINK


R. Lugo, M. Gabasa, F. Andriani, M. Puig, F. Facchinetti, J. Ramírez, A. Gómez-Caro, U. Pastorino, G. Fuster, I. Almendros, P. Gascón, A. Davalos, N. Reguart, L. Roz, J. Alcaraz. Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung. Oncotarget 2016 7(50):82324-82337 LINK


M. Vizoso, M. Puig, F.J. Carmona, M. Maqueda, A. Velásquez, A. Gómez, A. Labernadie, R. Lugo, M. Gabasa, L.G. Rigat-Brugarolas, X. Trepat, J. Ramírez, N. Reguart, S. Moran, A. Perera, M. Esteller, J. Alcaraz. Aberrant DNA methylation in Non Small Cell Lung Cancer associated fibroblasts. Carcinogenesis 2015, 36:1453-63 LINK


E. Monsó, L.M. Montuenga, J. Sánchez de Cos, C. Villena, and Grupo Colaborativo en Cáncer de Pulmón

        CIBERES-RTICC-SEPAR-Plataforma Biobanco Pulmonar (J. Alcaraz et al.), Biological Marker Analysis as Part of the CIBERES-RTIC Cancer-SEPAR Strategic Project on Lung Cancer. Arch Bronconeumol, 2015 51(9):462-467 LINK


V. Vicens-Zygmunt, S. Estany, A. Colom, A. Montes-Worboys, C. Machahua, A.J. Sanabria, R. Llatjos, I. Escobar, F. Manresa, J. Dorca, D. Navajas, J. Alcaraz, M. Molina-Molina. Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices. Respiratory Research 2015 Jul 1;16:82 LINK


M. Puig, R. Lugo, M. Gabasa, A. Giménez, A. Velásquez, R. Galgoczy, J. Ramírez, A. Gómez-Caro, Ó. Busnadiego, F. Rodríguez-Pascual, P. Gascón, N. Reguart, J. Alcaraz. Matrix Stiffening and Beta1 integrin Drive Subtype-specific Fibroblast Accumulation in Lung Cancer. Mol Cancer Res 2015, 13:161-73. LINK


Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ. Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development. 2013, 140:343-52 LINK


I. Acerbi, T. Luque, A. Giménez, M. Puig, N. Reguart, R. Farré, D. Navajas, and J. Alcaraz. Integrin-Specific Mechanoresponses to Compression and Tension Probed by cylindrical Flat-Ended AFM Tips in Lung Cells. PLoS ONE 2012, 7: e32261 LINK


J. Alcaraz, H. Mori, C.M. Ghajar, D. Brownfield, R. Galgoczy and M.J. Bissell. Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening. Integr. Biol., 2011, 3:1153–1166 LINK


I. Acerbi, J. Pereda, M. Molina-Molina, D. Navajas, N. Reguart, J. Alcaraz. TGF-beta1 stiffens lung carcinoma cells in culture. J Thorac Oncol. 2009, 4:S602-S603 LINK


J. Alcaraz, R. Xu, H. Mori, C.M. Nelson, R. Mroue, V.A. Spencer, D. Brownfield, D.C. Radisky, C. Bustamante, M.J. Bissell. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia EMBO J.  2008, 27:2829-2838 LINK


J. Alcaraz, C.M. Nelson, M.J. Bissell. Biomechanical Approaches For Studying Integration of Tissue Structure and Function In Mammary Epithelia. J Mammary Gland Biol Neoplasia. 2004, 9:361-374 LINK



Understanding the language of cell shape


J. Alcaraz, H. Mori, C.M. Ghajar, D. Brownfield, R. Galgoczy and M.J. Bissell. Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening. Integr. Biol., 2011, 3:1153–1166 LINK


P. Roca-Cusachs, J. Alcaraz, R. Sunyer, J. Samitier, R. Farré, D. Navajas. Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation. Biophys J,  2008, 94:4984-4995 LINK


J. LeBeyec, R. Xu, S.Y. Moonlee, C.M. Nelson, A. Rizki, J. Alcaraz, M.J. Bissell. Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res. 2007,313:3066-3075 LINK



Nanobiotechnology and Bioengineering


Characterization of the elastic properties of extracellular matrix models by atomic force microscopy. J. Otero, D. Navajas, J. Alcaraz. Methods in Cell Biology: Cell-derived Matrices Part A 2019 LINK


J. Alcaraz, J. Otero, I. Jorba, D. Navajas. Bidirectional mechanobiology between cells and their local extracellular matrix probed by atomic force microscopy. Seminars in Cell and Developmental Biology 2017, S1084-9521(17)30328-2 LINK


A. Giménez, J.J Uriarte, J. Vieyra, D. Navajas, J. Alcaraz. Elastic properties of hydrogels and decellularized tissue sections used in mechanobiology studies probed by atomic force microscopy. Microsc Res Tech. 2017;80:85-96. LINK


R. Galgoczy, I. Pastor, A. Coloma, A. Giménez, F. Mas, J. Alcaraz. A spectrophotometer-based diffusivity assay reveals that diffusion hindrance of small molecules in extracellular matrix gels used in 3D cultures is dominated by viscous effects. Colloids and Surfaces B: Biointerfaces 2014, 120:200-7 LINK


Colom A, Galgoczy R, Almendros I, Xaubet A, Farré R, Alcaraz J. Oxygen diffusion and consumption in extracellular matrix gels: Implications for designing three-dimensional cultures. J Biomed Mater Res A. 2014, 102:2776-84 LINK


I. Acerbi, T. Luque, A. Giménez, M. Puig, N. Reguart, R. Farré, D. Navajas, and J. Alcaraz. Integrin-Specific Mechanoresponses to Compression and Tension Probed by cylindrical Flat-Ended AFM Tips in Lung Cells. PLoS ONE 2012, 7: e32261 LINK


F. Rico, J. Alcaraz, J.J. Fredberg, D. Navajas. Nanomechanics of lung epithelial cells. Int J of Nanotechnology. 2005, 2:180-194 LINK


J. Alcaraz, L. Buscemi, X. Trepat, M. Grabulosa, B. Fabry, R Farré, D. Navajas. Microrheology of cultured lung epithelial cells measured with Atomic Force Microscopy. Biophys J. 2003, 84:2071-79 LINK


J. Alcaraz, L. Buscemi, M. Puig-de-Morales, J. Colchero, A. Baró, D. Navajas. Correction of Microrheological Measurements of Soft Samples with Atomic Force Microscopy for the hydrodynamic Drag on the Cantilever. Langmuir. 2002, 18: 716-721 LINK


M. Puig-de-Morales, M. Grabulosa, J. Alcaraz,  J. Mullol, G.N. Maksym, J.J. Fredberg, D. Navajas. Microrheology of cultured airway epithelial cells measured by magnetic twisting cytometry with frequency domain demodulation. J.Appl.Physiol. 2001, 91: 1152-1159  LINK


D. Navajas, J. Alcaraz, R. Peslin, J. Roca, R. Farré. Evaluation of a method for assessing respiratory mechanics during non-invasive ventilation. Eur. Respir. J. 2000, 16: 704-709 LINK


Book chapters


J. Alcaraz, P. Roca-Cusachs. Shape and Mechanical Cues Underlying Cellular Homeostasis in Soft Organs. Chapter of Cells, Forces and the Microenvironment (English). Coordinated by C. M. Cuerrier and A.E. Pelling. Published by Pan Stanford and World Scientiphic Publishing (US), 2015. ISBN: 978-981-4613-36-1 LINK


J. Alcaraz. Microscopía de Fuerza Atómica. Chapter of Técnicas en Histología y Biología celular (Spanish). Coordinated by L. Montuenga. Published by Elsevier (Spain), 2014. ISBN: 978-84-458-2520-4 LINK


J. Alcaraz. Introducción a las aplicaciones biofarmacológicas y biotecnológicas de la bioingeniería. Chapter of Biotecnología y Biofármacos. Módulo II (Spanish). Coordinated by J. Piulats. Published by Plan Nacional de Formación Continuada. Consejo General de Colegios Oficiales de Farmacéuticos (Spain). 2010.  ISBN: 978-84-693-1789-1 Legal Deposit: M-20075-2010                          




                                    COLLABORATION WITH BIOMEDICAL INDUSTRY


• Boheringer-Ingelheim, Spain  LINK

• Boheringer-Ingelheim Inc., Austria  LINK

• Basilea Pharmaceutica, Switzerland

• Artidis, Switzerland

• Peptomyc, Spain










Research collaboration with Boehringer-Ingelheim Inc Austria, 2019 LINK


Research collaboration with Boehringer-Ingelheim Spain, 2015 LINK


Crowdfunding campaing: “New approaches in the fight against lung cancer”, 2014 LINK


Cover of the 12th issue of the journal of the Royal Society of Chemistry iBiology displays an image from our iBiology 2011 paper LINK


Nomination of our EMBO J 2008 by the Faculty of 1000 Biology LINK









· Research Groups (in alphabetic order):

Mina J Bissell, LBNL, Berkeley (US)

Albert Davalos, Buck Institute for Age Research, Novato (US)

Manel Esteller, PEBC, IDIBELL, Barcelona (Spain)

Pere Gascón, IDIBAPS, Barcelona (Spain)

Eduard Monsó, Hospital Parc Taulí, CIBERES, Sabadell (Spain)

Alexandre Perera, UPC, CREB, Barcelona (Spain)

Noemi Reguart, IDIBAPS, Barcelona (Spain)

Luca Roz, Istituto Nazionale dei Tumori, Milano (Italy)

Valerie Weaver, UCSF, San Francisco (US)

Derek Radisky, Mayo Clinic, Jacksonville FL (US)

Xavier Trepat, IBEC, Barcelona (Spain)

Josep Samitier, IBEC, Barcelona (Spain)



· Clinical & Biomedical Institutions

Functional Unit of Thoracic Tumors, Hospital Clínic, Barcelona (Spain)

Pathology Department, Hospital Clínic, Barcelona (Spain)






                                    DONAR SUPORT RECERCA CÀNCER DE PULMÓ

                        SUPPORT LUNG CANCER RESEARCH


El nostre grup de recerca accepta aportacions voluntàries per ajudar a finançar la seva recerca en càncer de pulmó.

Per fer-ho, es prega contactar amb l’investigador principal del grup (Jordi Alcaraz) per email ( o telèfon (93 403 1148). Així mateix, podeu també contactar-nos per a qualsevol dubte o inquietud relacionada amb la nostra recerca!


Podeu contribuir amb qualsevol aportació o fent difusió de la nostra recerca.


Moltes gràcies!



Our research group accepts volunteer donations to support our lung cancer research. For this purpose, please contact the principal investigator of this group (Jordi Alcaraz) by email ( or telephone (+3493 403 1148). Likewise, should you have any doubt or different request on our research, please contact us!         


You can help us by making a donation or spreading the word of our research.


Many thanks!








We are actively involved in the following academic programs:


· Degree in Medicine, UB


· Degree in Molecular Medicine, UB


· Degree in Biomedical Engineering, UB


· Master in Biomedical Engineering, UB, UPC


· Master in Biomedicine, UB


· Master in Pharmaceutical Industry and Biotechnology, UPF


· Bioengineering in the Pharmaceutical and Biotechnological Industry, IL3, UB








Our group is continuously open to students at the level of Master, Graduate (PhD) and Postdoctoral level. Please contact us to inquire about currently available positions and projects.








Christmas 2009

Christmas 2010






· email


· Phone

[Office Ph:           (+34) 93 403 1148]

[Lab Ph:                (+34) 934039764]

[Fax:                      (+34) 934035278]


· Office and Lab location

Unitat de Biofísica i Bioenginyeria

5th floor, Facultat de Medicina (School of Medicine)

Casanova 143, Barcelona


How to find us?