Selected recent publications

 

Respiratory Mechanics

Cellular and Molecular Nanomechanics

Biomedical Imaging

 

Respiratory Mechanics

Navajas D, Duvivier C, Farré R, Peslin R. A simplified method for monitoring respiratory impedance during continuous positive airway pressure. Eur Respir J, 2000; 15: 185-91.

Farré R, Gavela E, Rotger M, Ferrer M, Roca J, Navajas D. Non-invasive assessment of respiratory resistance in severe chronic respiratory patients with nasal CPAP. Eur Respir J, 2000; 15: 314-9.

Navajas D, Alcaraz J, Peslin R, Roca J, Farré R. Evaluation of a method for assessing respiratory mechanics during non-invasive ventilation. Eur Respir J, 2000; 16:704-9.

Hernandez L, Ballester E, Farré R, Badia JR, Lobelo R, Navajas D, Montserrat JM Performance of nasal prongs in sleep studies: spectrum of flow-related events. Chest, 2001; 119: 442-50.

Farré R, Rigau J, Montserrat JM, Ballester E, Navajas D. Relevance of linearizing nasal prongs for assessing hypopneas and flow limitation suring sleep. Am J Respir Crit Care Med, 2001; 163: 494-7.

Montserrat JM, Farré R, Navajas D. Automatic continuous positive airway pressure devices for the treatment of sleep apnea hypopnea syndrome. Sleep Med, 2001; 2: 95-8.

Farré R, Rigau J, Montserrat JM, Ballester E, Navajas D. Evaluation of a simplified oscillation technique for assessing airway obstruction in sleep apnea. Eur Respir J, 2001; 17: 456-61.

Montserrat JM, Ferrer M, Hernandez L, Farré R, Vilagut G, Navajas D, Badia JR, Carrasco E, De-Pablo J, Ballester E. Effectiveness of CPAP treatment in daytime function in sleep apnea syndromeA randomized controlled study with an optimized placebo. Am J Respir Crit Care Med, 2001; 164: 608-13.

Badia JR, Farré R, Rigau J, Uribe ME, Navajas D, Montserrat JM. Forced oscillation measurements do not affect upper airway muscle tone or sleep in clinical studies. Eur Respir J, 2001; 18: 335-9.

Navajas D, Farré R. Forced oscillation assessment of respiratory mechanics in ventilated patients. Crit Care, 2001; 5: 3-9.

Farré R, Mancini M, Rotger M, Ferrer M, Roca J, Navajas D. Oscillatory resistance measured during noninvasive proportional assist ventilation. Am J Respir Crit Care Med, 2001; 164: 790-4.

Montserrat JM, Farré R, Navajas D. New technologies to detect static and dynamic upper airway obstruction during sleep. Sleep Breath, 2001; 5: 193-206.

Navajas D, Farré R. Forced oscillation technique: From theory to clinical applications. Monaldi Arch Chest Dis, 2001; 56: 555-62.

Farré R, Montserrat R, Ballester E, Navajas D. Potential rebreathing after continuous positive airway pressure failure during sleep. Chest, 2002; 121: 196-200.

Rigau J, Farré R, Roca J, Marco S, Herms A, Navajas D. A portable forced oscillation device for respiratory home monitoring. Eur Respir J, 2002; 19: 146-50.

Farré R, Montserrat JM, Rigau J, Trepat X, Pinto P, Navajas D. Response of automatic CPAP devices to different sleep breathing paterns. A bench study. Am J Respir Crit Care Med, 2002; 166: 469-473.

Montserrat JM, Farré R. Breathing Flow Disturbances during Sleep. Can They Be Accurately Assessed by Nasal Prongs? Am J Respir Crit Care Med, 2002; 166: 259-260.

Farré R, Rotger M, Ferrer M, Torres A, Navajas D. Automatic regulation of the cuff pressure in endotracheally intubated patients. Eur Respir J, 2002; 20: 1010-1013.

Farré R, Giro E, Casolive V, Navajas D, Escarrabill J. Quality control of mechanical ventilation at the patient's home. Intensive Care Med, 2003; 29: 484-486.

Farré R, Rotger M, Montserrat JM, Calero G, Navajas D. Collapsible upper airway segment to study the obstructive sleep apnea/hypopnea syndrome in rats. Respir Physiol Neurobiol, 2003; 136:199-209.

Farré R, Rigau J, Montserrat JM, Buscemi L, Ballester E, Navajas D. Static and dynamic upper airway obstruction in sleep apnea. Role of the breathing gas properties. Am J Respir Crit Care Med, 2003; 168:659-663.

Rigau J, Burgos F, Hernández C, Roca J, Navajas D, Farré R. Unsupervised self-testing of airway obstruction by forced oscillation at the patients’ home. Eur Respir J, 2003; 22:668-671.

Oostveen E, McLeod D, Lorino H, Farré R, Hantos Z, Desager K, Marchal F. The forced oscillation technique in clinical practice: Methodology, recommendations and future developments. ERS task force. Eur Respir J, 2003; 22:1026-1041.

Farré R, Navajas D. Assessment of expiratory flow limitation in chronic obstructive pulmonary disease: a new approach. Eur Respir J, 2004; 23: 187-188.

Rigau J, Farré R, Trepat X, Shusterman D, Navajas D. Oscillometric assessment of airway obstruction in vocal cord dysfunction. A model study. J Biomech, 2004; 37:37-43.

Farre, R. Inspiratory flow limitation in obstructive sleep apnoea patients. Clinical Science, 2004; 106: 563-565.

Granell S, Serrano-Mollar A, Folch-Puy E, Navajas D, Farre R, Bulbena O, Closa D. Oxygen in the alveolar airspace mediates lung inflammation in acute pancreatitis. Free Radic Biol & Med 2004; 37: 1640-1647.

Polkey MI, Farré R, Dinh-Xuan AT. Respiratory monitoring: revisiting classical physiological principles with new tools. Eur Respir J, 2004; 24: 718-719.

Farre R, Montserrat JM, Navajas D. Noninvasive monitoring of respiratory mechanics during sleep. Eur Respir J, 2004; 24:1052-1060.

Farre R, Granell S, Rotger M, Serrano-Mollar A, Closa D, Navajas D.  Animal model of unilateral ventilator-induced lung injury. Intensive Care Med, 2005; 31: 487-490.

Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. General considerations for lung function testing. Eur Respir J, 2005; 26:153-161.

Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J. Standardisation of spirometry. Eur Respir J, 2005; 26: 319-338.

Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson D, Macintyre N, McKay R, Miller MR, Navajas D, Pellegrino R, Viegi G. Standardisation of the measurement of lung volumes. Eur Respir J, 2005; 26: 511-522.

Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Gustafsson P, Hankinson J, Jensen R, McKay R, Miller MR, Navajas D, Pedersen OF, Pellegrino R, Wanger J.  Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J, 2005; 26:720-735.

Montserrat JM, Rigau J, Navajas D, Ballester E, Farre R. Effect of using the flow or the volume signals on the measurement of nonapneic respiratory events. Sleep, 2005; 28: 990-992.

Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J. Interpretative strategies for lung function tests. Eur Respir J, 2005; 26: 948-968.

Farre R, Lloyd-Owen SJ, Ambrosino N, Donaldson G, Escarrabill J, Fauroux B, Robert D, Schoenhofer B, Simonds A, Wedzicha JA.  Quality control of equipment in home mechanical ventilation: a European survey. Eur Respir J, 2005; 26: 86-94.

Lloyd-Owen SJ, Donaldson GC, Ambrosino N, Escarabill J, Farre R, Fauroux B, Robert D, Schoenhofer B, Simonds AK, Wedzicha JA. Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey. Eur Respir J, 2005; 25: 1025-1031.

Dellaca RL, Rotger M, Aliverti A, Navajas D, Pedotti A, Farre R. Non-invasive detection of expiratory flow limitation in COPD patients during nasal CPAP. Eur Respir J, 2006; 27: 983-991.

Farre R, Navajas D, Prats E, Marti S, Guell R, Montserrat JM, Tebe C, Escarrabill J.  Performance of mechanical ventilators at the patient's home: a multicentre quality control study. Thorax, 2006; 61: 400-404.

Calero G, Farre R, Ballester E, Hernandez L, Navajas D, Montserrat Canal JM.  Physiological consequences of prolonged periods of flow limitation in patients with sleep apnea hypopnea syndrome. Respir Med, 2006; 100: 813-817.

Rigau J, Montserrat JM, Wöhrle H, Plattner D, Schwaibold M, Navajas D, Farré R. Bench model to simulate upper airway obstruction for analyzing automatic. Chest in press.

 

Cellular and Molecular Nanomechanics

Maksym GM, Fabry B, Butler JP, Navajas D, Tschumperlin DJ, Laporte JD, Fredberg JJ. Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz. J Appl Physiol, 2000; 89: 1619-1632.

Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, Fredberg JJ. Scaling the microrheology of living cells. Phys Rev Lett, 2001; 87: 1481021.

Puig-de-Morales M, Grabulosa M, Alcaraz J, Mullol J, Maksym GM, Fredberg JJ, Navajas D. Measurement of cell microrheology by magnetic twisting cytometry with frequency domain demodulation. J Appl Physiol, 2001; 91: 1152-1159.

Alcaraz J, Buscemi L, Puig-de-Morales M, Colchero J, Baró A, Navajas D. Correction of microrheological measurements of soft samples with atomic force microscopy for the hydrodynamic drag on the cantilever. Langmuir, 2002; 18: 716-21.

Alcaraz J, Buscemi L, Grabulosa M, Trepat X, Fabry B, Farré R, Navajas D. Microrheology of human lung epithelial cells measured by Atomic Force Microscopy. Biophys J, 2003; 84: 2071-79.

Trepat X, Grabulosa M, Buscemi L, Rico F, Fabry B, Fredberg JJ, Farré R. Oscillatory magnetic tweezers based on ferromagnetic beads and simple coaxial coils. Rev Sci Instrum, 2003; 74(9): 4012-20.

Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, Taback NA, Millet EJ, Fredberg JJ. Time-scale and other invariants of integrative mechanical behavior in living cells. Phys Rev E, 2003 ; 68: 041914 (18 pages).

Puig-de-Morales M, Millet E, Fabry B, Navajas D, Wang N, Butler JP, Fredberg JJ. Cytoskeletal mechanics in the adherent human airway smooth muscle cell: probe specificity and scaling of protein-protein dynamics.  Am J Physiol Cell Physiol, 2004; 287: C643-C654.

Trepat X, Grabulosa M, Puig F, Maksym GN, Navajas D, Farre R. Viscoelasticity of human alveolar epithelial cells subjected to stretch. Am J Physiol Lung Cell Mol Physiol, 2004; 287(5):L1025-34.

Trepat, X, M Grabulosa, L Buscemi, F Rico, R Farré, and D Navajas. Thrombin and histamine induce stiffening of alveolar epithelial cells. Journal of Applied Physiology, 2005, 98:1567-1574.

Rico, F, J Alcaraz, JJ Fredberg, and D Navajas. Nanomechanics of Lung Epithelial Cells. Int J Nanotechnology, 2005, 2 (1/2) 180–194.

Roca-Cusachs, P.; Rico, F.; Martínez, E.; Toset, J.; Farré, R.; Navajas, D. Stability of Microfabricated High Aspect Ratio Structures in Poly(dimethylsiloxane). Langmuir, 2005, 21 (12), 5542-5548.

Rico F, Roca-Cusachs, N Gavara, R Farré, M Rotger, and D Navajas. Probing Mechanical Properties of Living Cells by Atomic Force Microscopy with Blunted Pyramidal Cantilever Tips. Phys Rev E, 2005 72 (2) 021914.

Puig, F, F Rico, I Almendros, JM Montserrat, D Navajas, and R Farré. Vibration Enhances Interleukin-8 Release In A Cell Model Of Snoring-Induced Airway Inflammation. Sleep, 2005 28 (10) 1312-1316.

Trepat X, Puig F, Gavara N, Fredberg JJ, Farre R, Navajas D. Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin. Am J Physiol Lung Cell Mol Physiol, 2006; 290: L1104-L1110.

Gavara N, Sunyer R, Roca-Cusachs P, Farre R, Rotger M, Navajas D. Thrombin-induced contraction in alveolar epithelial cells probed by traction microscopy. J Appl Physiol in press.

 

Biomedical imaging

Piera C, Ros D, Pavía J, Fuster D, Muxí A. Estimation of MAG3 Clearance using a single blood sample obtained in a continuous time interval. Nucl Med Commun, 1997; 18: 60-5.

Falcón C, Juvells I, Pavía J, Ros D. Evaluation of a cross-validation stopping rule in MLE SPECT reconstruction. Phys Med Biol, 1998; 43: 1271-83.

Ros D, Espinosa M, Setoain JF, Falcón C, Lomeña FJ, Pavía J. Evaluation of algorithms for the registration of 99Tcm-HMPAO brain SPET studies. Nucl Med Comm, 1999; 20: 227-36.

Pareto D, Pavia J, Falcón C, Juvells I, Cots C, Ros D. Characterisation of fan-beam collimators. Eur J Nucl Med, 2001; 28: 144-9.

D.Pareto, A.Cot, C.Falcón, I.Juvells; J.Pavía, D.Ros. Geometrical response modeling in fan-beam collimators. A numerical simulation. IEEE T Nucl Sci, 2002; 49:12-16.

A.Cot, J.Sempau, D.Pareto, S.Bullich, J.Pavía, F.Calviño, D.Ros. Evaluation of the geometric, scatter and septal penetration components in fan-beam collimators using Monte Carlo simulation. IEEE T Nucl Sci, 2002; 49:17-24.

Bullich S, Ros D, Cot A,  Falcón C, Muxí A, Pavía J. Dynamic model of the left ventricle for use in simulation of myocardial perfusion SPECT and gated SPECT. Medical Physics, 2003; 30: 1969-1975.  

Pareto D, Cot A, Pavía J, Falcón C, Juvells I, Lomeña F, Ros D. Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission spet imaging. Eur J Nucl Med Mol Imag, 2003; 30: 1322-1329

Salgado-Pineda P, Junque C, Vendrell P, Baeza I, Bargallo N, Falcon C, Bernardo M. Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients. Neuroimage, 2004; 21: 840-847.

Cot A, Sempau J, Pareto D, Bullich S, Pavia J, Calviño F, Ros D. Study of the point spread function (PSF) for 123I SPECT imaging using Monte Carlo simulation. Phys Med Biol, 2004; 49: 3125-3136.

Cot A, Falcón C, Crespo C, Sempau J, Pareto D, Bullich S, Lomeña F, Calviño F, Pavía J, Ros D. Absolute Quantification in Dopaminergic Neurotransmission SPECT Using a Monte Carlo-Based Scatter Correction and Fully 3-Dimensional Reconstruction. J Nucl Med, 2005; 46:1497-504.

Gimenez M.; Junqué, C.; Vendrell, P.; Caldú, X.; Narberhaus, A.; Bargallo, N.; Falcon, C.; Botet, F.; Mercader, J.M. Hippocampal functional magnetic resonance imaging during face-name learning task in adolescents with antecedents of prematurity. Neuroimage, 2005; 25:561-569.

P.Aguiar, C.Falcón, C.Crespo, A.Cot, F.Lomeña, J.Pavía, D.Ros. Influencia de la dispersión de fotones en la cuantificación de cambios relativos en estudios longitudinales de PET cerebral con 18F-FDG. Rev Esp Med Nucl, 24:404-9, 2005

A.Cot, E.Jané, J.Sempau, C.Falcón, S.Bullich, J.Pavía, F.Calviño, D.Ros. Influencia de la dispersión de fotones en la cuantificación de cambios relativos en estudios longitudinales de PET cerebral con 18F-FDG. IEEE Trans Nucl Sci, 53:198-203, 2006

AM. Catafau, M. Danus, S. Bullich, J. Llop, J. Perich, VJ. Cunningham, P. Plaza, MM. Penengo, JLH. Eersels,L. Squassante, D. Ros, M. Barbanoj. Characterization of the SPECT 5HT2A Receptor Ligand 123I-R91150 in Healthy Volunteers. Part I:Pseudoequilibrium Interval and Quantification Methods. J Nucl Med,  47:919-28, 2006