The V Symposium of Medicinal Chemistry Young Researchers, organized by the Spanish Society of Therapeutic Chemistry (SEQT), took place on the 22nd of June at the Spanish National Research Council (CSIC) headquarters in Madrid. As in former editions, this symposium allowed young researchers to show and discuss the work carried out in their laboratories. Salvatore Scaffidi presented a talk entitled “Drugging the FBW7 E3 ligase with a combined computational and biophysical approach”.