Patricia Blanco
PhD student

I am a first-year student enrolled in the Biomedicine Ph.D. program of the University of Barcelona.

I did a bachelor's degree in Biotechnology at the Polytechnic University of Madrid and afterwards I completed a master's degree in Computational Biology at the same university.

I developed my master’s thesis project about computational drug design with Nuria Campillo at the Biological Research Centre (CIB-CSIC) in Madrid. We studied the possible binding sites of promising molecules that could bind the GPCR CXCR4 to inhibit tumoral metastasis.

Once I finished my master's, I did a 6-month Erasmus + traineeship in Thierry Langer's group at the University of Vienna doing molecular dynamics simulations of the GABA receptor in complex with small molecules.

After that, I spent 1.5 years working at the pharma company Roche as Linux System Administrator while studying another postgraduate degree in IT and Business at the Universidad CEU San Pablo

The objective of my Ph.D. project is to develop a computational workflow for the rational design of mini-PROTAC molecules. PROTACs are heterobifunctional small molecules designed to induce intracellular protein degradation. We aim to demonstrate that it is possible to rationally design mini-PROTACs, which would be smaller, drug-like, molecules (<500Da) with a similar or better-targeted protein degradation capacity than standard PROTACs.