Our aim is to translate the knowledge about the properties of molecules to the interaction with macromolecular targets and the regulation of the biological response. This interest has been focused on the development of multitarget compounds targeting neurodegenerative diseases, where our studies have led to the development of compounds interacting with cholinesterases, beta-secretase, monoamino oxidase, and beta-amyloid aggregation.
Another area of interest has been the role of the truncated hemoglobin N from M. tuberculosis, which plays a key role in eliminating nitric oxide, thus contributing to the survival of the bacillus.
Current interests comprise the development of bioactive compounds able to interfere with two key targets in the influenza A virus, the M2 channel proton, and hemagluttinin, and the development of inhibitors againts P. falciparum glucose-6-phosphate dehydrogense as antimalarial strategy.