@article {199,
	title = {3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone},
	journal = {Bioorganic \& medicinal chemistry letters},
	volume = {15},
	year = {2005},
	month = {2005/12/01/},
	pages = {5197 - 5201},
	abstract = {Information from X-ray crystal structures of Hsp90 inhibitors bound to the human Hsp90 molecular chaperone was used to assist in the design of 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as novel inhibitors of Hsp90. Accessing an extra interaction with the protein via Phe138 gave a significant increase in binding potency compared to similar analogues that do not make this interaction.},
	keywords = {Amides/chemistry/pharmacology; Crystallography, X-Ray; Drug Design; HSP90 Heat-Shock Proteins/antagonists \& inhibitors; Humans; Molecular Structure; Oxamic Acid/chemistry; Pyrazoles/chemistry/pharmacology},
	author = {Brough,P. A. and Barril, Xavier and Beswick,M. and Dymock,B. W. and Drysdale,M. J. and Wright,L. and Grant,K. and Massey,A. and Surgenor,A. and Workman,P.}
}
