@article {225,
	title = {Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures},
	journal = {Bioorganic \& medicinal chemistry letters},
	volume = {14},
	year = {2004},
	month = {2004/01/19/},
	pages = {325 - 328},
	abstract = {Multiple co-crystal structures of an adenine-based series of inhibitors bound to the molecular chaperone Hsp90 have been determined. These structures explain the observed SAR for previously described compounds and new compounds, which possess up to 8-fold improved potency against the isolated enzyme. Anti-tumour cell potency and mechanism of action data is also described for the most potent compounds. These data should enable the design of more potent Hsp90 inhibitors.},
	keywords = {Adenine/analogs \& derivatives/pharmacology; Cell Line, Tumor; Crystallography, X-Ray/methods; HSP90 Heat-Shock Proteins/antagonists \& inhibitors/metabolism; Humans; Molecular Chaperones/antagonists \& inhibitors/metabolism; Structure-Activity Relationship},
	author = {Dymock,B. and Barril, Xavier and Beswick,M. and Collier,A. and Davies,N. and Drysdale,M. and Fink,A. and Fromont,C. and Hubbard,R. E. and Massey,A. and Surgenor,A. and Wright,L.}
}
