@article {303,
	title = {DNA-triplex stabilizing properties of 8-aminoguanine},
	journal = {Nucleic acids research},
	volume = {28},
	year = {2000},
	month = {2000/11/15/},
	pages = {4531 - 4539},
	abstract = {A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calculations, and demonstrated by melting experiments. NMR experiments confirm the triplex-stabilizing properties of 8-aminoguanine and demonstrate that few changes are found in the structure of the triplex due to the presence of this modified base.},
	keywords = {Cytosine/chemistry; DNA/chemistry/genetics; Guanine/analogs \& derivatives/chemistry; Magnetic Resonance Spectroscopy/methods; Models, Molecular; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Structure-Activity Relationship; Thermodynamics},
	author = {Soliva,R. and Garcia,R. Guimil and Blas,J. R. and Eritja,R. and Asensio,J. L. and Gonzalez,C. and F. J. Luque and M. Orozco}
}
