%0 Journal Article %J The Journal of pharmacy and pharmacology %D 1986 %T On the binding of cinmetacin and indomethacin to human serum albumin %A Montero,M. T. %A Pouplana,R. %A Valls,O. %A Garcia,S. %K Acids/blood; %K Albumin/metabolism %K Binding; %K Dialysis; %K Humans; %K Indoleacetic %K Indomethacin/blood; %K Kinetics; %K Protein %K Serum %N 12 %P 925 - 927 %V 38 %X The binding of two non-steroidal anti-inflammatory drugs, indomethacin and cinmetacin, to human serum albumin was studied by dynamic dialysis at 37 degrees C and pH 7.4. Cinmetacin is bound more than indomethacin. The affinity constant for the primary binding site is 4.28 X 10(6) M-1 for cinmetacin and 1.4 X 10(6) M-1 for indomethacin. The protein binding of indomethacin is decreased in the presence of cinmetacin. %8 1986/12//