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DNA-triplex stabilizing properties of 8-aminoguanine
Posted June 8th, 2010 by pschmidtke
| Title | DNA-triplex stabilizing properties of 8-aminoguanine |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Soliva, R, Garcia GR, Blas JR, Eritja R, Asensio JL, Gonzalez C, Luque FJ, Orozco M |
| Journal | Nucleic acids research |
| Volume | 28 |
| Issue | 22 |
| Pagination | 4531 - 4539 |
| Date Published | 2000/11/15/ |
| Keywords | Cytosine/chemistry; DNA/chemistry/genetics; Guanine/analogs & derivatives/chemistry; Magnetic Resonance Spectroscopy/methods; Models, Molecular; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Structure-Activity Relationship; Thermodynamics |
| Abstract | A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calculations, and demonstrated by melting experiments. NMR experiments confirm the triplex-stabilizing properties of 8-aminoguanine and demonstrate that few changes are found in the structure of the triplex due to the presence of this modified base. |
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