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Role of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study

Posted June 8th, 2010 by pschmidtke
TitleRole of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study
Publication TypeJournal Article
Year of Publication1999
AuthorsSoliva, R, Luque FJ, Alhambra C, Orozco M
JournalJournal of Biomolecular Structure & Dynamics
Volume17
Issue1
Pagination89 - 99
Date Published1999/08//
KeywordsCarbohydrates/chemistry; Computer Simulation; DNA/chemistry; Models, Molecular; Nucleic Acid Conformation; Solutions
AbstractState of the art molecular dynamic simulations show that simple modification of the sugar puckering of 2'deoxyriboses leads to a reversible change between two stable forms of DNA which resemble very closely the canonical A and B duplex forms. Analysis of the A-type and B-type structures reveals interesting, and previously unknown features of these two families of conformations of the DNA.