Title | Role of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study |
Publication Type | Journal Article |
Year of Publication | 1999 |
Authors | Soliva, R, Luque FJ, Alhambra C, Orozco M |
Journal | Journal of Biomolecular Structure & Dynamics |
Volume | 17 |
Issue | 1 |
Pagination | 89 - 99 |
Date Published | 1999/08// |
Keywords | Carbohydrates/chemistry; Computer Simulation; DNA/chemistry; Models, Molecular; Nucleic Acid Conformation; Solutions |
Abstract | State of the art molecular dynamic simulations show that simple modification of the sugar puckering of 2'deoxyriboses leads to a reversible change between two stable forms of DNA which resemble very closely the canonical A and B duplex forms. Analysis of the A-type and B-type structures reveals interesting, and previously unknown features of these two families of conformations of the DNA. |