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SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors

Posted June 8th, 2010 by pschmidtke
TitleSAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors
Publication TypeJournal Article
Year of Publication2005
AuthorsMartinez, A, Alonso M, Castro A, Dorronsoro I, Gelpi JL, Luque FJ, Perez C, Moreno FJ
JournalJournal of medicinal chemistry
Volume48
Issue23
Pagination7103 - 7112
Date Published2005/11/17/
KeywordsBinding Sites; Glycogen Synthase Kinase 3/antagonists & inhibitors/chemistry; Hydantoins/chemical synthesis/chemistry; Maleimides/chemical synthesis/chemistry; Models, Molecular; Protein Binding; Quantitative Structure-Activity Relationship; Rhodanine/analogs & derivatives/chemical synthesis/chemistry; Structure-Activity Relationship; Thiadiazoles/chemical synthesis/chemistry
AbstractThe 2,4-disubstituted thiadiazolidinones (TDZD) are described as the first ATP-noncompetitive GSK-3 inhibitors. Following an SAR study about TDZD, different structural modifications in the heterocyclic ring aimed to test the influence of each heteroatom on the biological study are here reported here. Various compounds such as hydantoins, dithiazolidindiones, rhodanines, maleimides, and triazoles were synthesized and screened as GSK-3 inhibitors. After an extensive SAR study among these different heterocyclic families, TDZDs have been revealed as a privileged scaffold for the selective inhibition of GSK-3. A CoMFA analysis was also performed highlighting the molecular electrostatic field interaction in the interaction of TDZDs with GSK-3. Moreover, first mapping studies indicate two binding modes which in turn might imply relevant differences in the mechanism that underly the inhibitory activity of TDZDs.