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Triple helix stabilization properties of oligonucleotides containing 8-amino-2'-deoxyguanosine
Posted June 8th, 2010 by pschmidtke
| Title | Triple helix stabilization properties of oligonucleotides containing 8-amino-2'-deoxyguanosine |
| Publication Type | Journal Article |
| Year of Publication | 1998 |
| Authors | Garcia, GR, Bachi A, Eritja R, Luque FJ, Orozco M |
| Journal | Bioorganic & medicinal chemistry letters |
| Volume | 8 |
| Issue | 21 |
| Pagination | 3011 - 3016 |
| Date Published | 1998/11/03/ |
| Keywords | &, Bonding;, Deoxyguanosine/chemistry;, Derivatives/chemistry;, Drug, Guanine/analogs, Hydrogen, Oligonucleotides/chemistry, Stability; |
| Abstract | Analysis of the Hoogsteen base pairs of guanine and 8-aminoguanine with cytosine in the gase phase shows a strong stabilization of the 8-aminoguanine.cytosine base pair due to the formation of an extra H-bond. Melting profiles of oligonucleotides carrying 8-amino-2'-deoxyguanosine confirm the triple helix stabilization properties of 8-aminoguanine. |
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