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Details

Position
Post Doc
First Name
Sergi
Last Name
Ruiz Carmona
Title
5 : PhD
Project
I am interested in the combination of computational and experimental techniques in Drug Discovery processes.
In particular, my PhD project involved different methodologies such as:
  • Molecular Docking.
  • High Throughput Virtual Screening.
  • Experimental techniques:
    • Surface Plasmon Resonance.
    • Differential Scanning Fluorimetry.
    • in vivo assays.
  • Molecular Dynamics.
  • Chemoinformatic tools.
My main project was focused in finding small-molecules capables of binding in Protein-Protein Interfaces which increase their affinity.
Thus, as a proof of concept, we worked in a system formed by two E.Coli proteins, CheA and CheY. This system was selected applying cavity detection algorithms and druggability prediction methodologies developed in our group. 
 
I have also participated in collaborative projects with pharmaceutical companies, applying computational techniques in real R&D campaigns for drug discovery.

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