ChemBio Lab

    Chemistry Platform for the Development of New Drugs
 
         
 

MEDICINAL CHEMISTRY

Baringolin Analogs

   
     
         
 
 
 
 
 
The first de novo synthetic library of thiopeptide analogues permitted to assess the impact of the peptidic tail and the thiazoline ring present in Baringolin.
     
 
       
 
The installation of a cyclohexanoic acid moiety resulted in a boost to potency against various Gram positive bacteria strains.
 
         

Acetylcholinesterase Dual Inhibitors

In a collaboration with Prof D. Muñoz Torrero (UB), we have applied MCRs for the synthesis of dual inhibitors of acetylcholinesterase endowed with remarkable b-amyloid antiaggregation properties, thus potentially useful in the treatment of Alzheimer disease.

   
         
     
           
University of Barcelona (UB) - Barcelona Science Park (PCB) C/Baldiri Reixac, 10-12, 08028 Barcelona