Members of group:

• Ramon Bartrons Bach , Full professor of Biochemistry and Molecular Biology 
• José Carlos Perales Losa,  Post-Doctoral Fellow
• Áúrea Navarro Sabaté, Post-doctoral investigator
• Esther Castaño Boldú, Post-dctoral fellow
• Lluis Riera Sans, Ph.D. studentt 
• Maria Molas Laplana, Ph.D. student
• Joan Duran Ferrer, Ph.D. student
• Alicia García Gómez-Valadés, Ph.D. student 

Research Lines:

• Regulation of carbohydrate metabolism. Isozymes of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase . 
• Regulation of gene expression by growth factors and hormones.
• Gene therapy strategies with diabetic animals. 
• Mechanisms of induction of apoptosis by aspirin and other NSAID .

Financial support:

Publications:

• PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. David A. Okar, Ànna Manzano, Àurea Navarro-Sabatè, Lluìs Riera, Ramon Bartrons and Alex J. Lange. (2001) TIBS 26, 30-35. PDF
• Hepatic preconditioning preserves energy metabolism during sustained ischemia. C. Peralta, R. Bartrons, L. Riera, A. Manzano, C. Xaus, E. Gelpi  and  J. Roselló-Catafau. (2000) Am J Physiol Gastrointest Liver Physiol 279: G163–G171,.PDF
• Fructose-1,6-bisphosphate inhibits the expression of inducible nitric oxide synthase caused by oxygen-glucose deprivation through the inhibition of glutamate release in rat forebrain slices    Antonio Cárdenas, Olivia Hurtado , Juan C. Leza , Pedro Lorenzo , Ramón Bartrons , Ignacio Lizasoain and María A. Moro (2000) Naunyn-Schmiedeberg’s Arch Pharmacol  362 : 208–212 PDF
• Detection of mRNA encoding H receptor and iNOS by RT-PCR in  autoimmune myocarditis with special reference to changes in heart contractility .   Nora Goren , Leonor Sterin-Borda , Ramon Bartrons , Ricardo Gomez , Enri Borda   .(2000)  Int. J.  Card. 76  165–172 PDF
• "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development". N.Goren, A.Manzano, LL.Riera, S.Ambrosio, F.Ventura, R.Bartrons. Mol. Brain Res. 75: 138-142 (2000). (PDF)
• A zinc-finger transcription factor induced bt TGF-b promotes apoptotic cell death in epidermal MV1Lu cells. Chalaux, E., Lopez, T., Rosa, J.L., Pons, G., Boxer, L., Bartrons, R., Ventura, F. FEBS Lett. (1999) 457: 478-482.
• Assignment of the human p532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization. Cruz, C., Paladugu, A., Ventura, F., Bartrons, R., Aldaz, M., Rosa, J.L. Cytogenet. Cell Genet. (1999) 86: 68-69.
• Antiinflamatorios no esteroides en la prevención del cáncer de colon. R. Bartrons; En "Transducción de señales como diana farmacológica" J.M. Baeyens y A. Zorzano editores (1999). Monografías Dr A. Esteve, vol. 24, 99-107.
• Aspirina i antiinflamatoris no esteroïdals en la prevenció del càncer colorectal. Bartrons R., Castaño, E., Pueto, G., Gil, J.En "Patologia Molecular" R. Bartrons, Ed. (1999). Treballs de la Societat Catalana de Biologia, vol. 49, 97-111.
• Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells. E. Castaño, M. Dalmau, M. Barragán, G. Pueyo, R. Bartrons and J. Gil. British J Cancer (1999) 81: 294-299.
• Cloning, expression and chromosomal localization of human testis 6-phosphofructo-2-kinase/ fructose 2,6-bisphosphatase gene. Manzano, A., Perez, X., Nadal, M., Estivill, X., Lange, A., Bartrons, R. Gene (1999) 229: 83-89. PDF
• JunB is involved in the inhibition of myogenic differentiation by BMP-2. Chalaux, E., Lopez, T., Rosa, J.L., Bartrons, R., Ventura, F. J. Biol. Chem. (1998) 273: 537-543.
• Protective effect of nifedipine against carrageenan-induced inflammation. Sanchez, S., Bartrons, R., Rodriguez, L., Gonzalez, P., Planas, E. Pharmacology(1998) 56: 131-136.
• Effect of starvation on gene expression of regulatory enzymes of glycolysis/gluconeogenesis in genetically obese (fa/fa) Zucker rats. Perez, X., Manzano, A., Tauler, A., Bartrons, R. Int. J. Obesity (1998) 22: 667-672.
• Molecular cloning, expression and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose 2,6-bisphosphatase gene (PFKFB3). Manzano, A., Rosa, J.L., Ventura, F., Perez, X, Nadal, M, Estivill, X, Ambrosio, S., Gil, J., Bartrons, R. Cytogenet Cell Genet (1998) 83: 214-217.
• Expression of the F-type PFK-2/FBPase-2 mRNA during liver regeneration. Joaquin, M., Rosa, J.L., Bartrons, R., Tauler,.A Biochim. Biophys. Acta (1997) 1334: 256-260.
• Gene expression of glucokinase regulatory protein in regenerating rat liver.Rosa, J.L., Pérez, X., Detheux, M., Van Schaftingen, E., Bartrons, R. Hepatology (1997) 25: 324-328.
• Inhibition of DNA synthesis by aspirin in swiss 3T3 fibroblasts. Castaño, E., Dalmau, M., Martí, M., Berrocal, F., Bartrons, R., Gil, J. J. Pharm. Exp. Ther. (1997) 280: 366-372.
• Exogenous fructose 1,6-bisphosphate reduces K+ permeability in isolated rat hepatocytes. Roig, T., Bartrons, R., Bermudez, J. Am. J. Physiol. (1997) 273: C473-C478.
• Fluoride and Pilocarpine Reduce the risk of Caries Produced by Chronic Clomipramine treatment in rats J. J. Martínez-Gomis, M.E. Planas, X. Planelles, R. Bartrons, S. Sánchez. Caries Res (1997); 31:155-160
• Intracerebral applications of MPP+: why so many different responses versus MPTP-treatment?. Ambrosio, S., Espino, A., Cutillas, B., Espejo, M., Bartrons, R. Current Topics in Neurochemistry (1997) 1:113-121.
• Hepatocyte growth factor and transforming growth factor b regulate PFK-2/FBPase-2 gene expression in rat hepatocyte cultures. Joaquin, M., Rosa, J.L., Salvadó, C., López, S., Nakamura, T., Bartrons, R., Gil, J., Tauler, A. Biochem. J. (1996) 314: 235-240.
• Nitric oxide inhibits DNA synthesis and induces activation of poly(ADP-ribose) polymerase in cultured rat hepatocytes. Dalmau, M., Joaquin, M., Nakamura, T., Bartrons, R., Gil, J. Experimental Cell Research (1996) 228: 14-18.
• Effects of taxol on isolated rat hepatocyte metabolism. Manzano, A., Roig, T., Bermúdez, J., Bartrons, R. Am. J. Physiol. (1996) 271: C1957-C1962.