Members of the  Group:

• Joan Gil Santano, Full Professor , Biochemistry section. Principal Investigator
• Gabriel Pons Irazazábal, Associate  Professor, Biochemistry section .Principal Investigator
• Daniel Iglesias, Postdoctoral fellow
• Llorenç Coll Mulet, Postdoctoral Fellow
• Mercé de Frías Sánchez, Predoctotal fellow
• Anna Cosialls Castel, Predoctoral fellow
• Diana González i Gironés, Predoctoral fellow
• Alba Pérez Perarnau, Predoctoral fellow
• Camila Rubio Patiño, Ph D student

Research Lines:

Molecular bases of cel.lular proliferation and apoptosis. As a model we use B-chronic Lymphocytic leukemia cells type B( B-CLL)  We are studying: 
• Transduction signals involved in B-CLL cells differentiation and apoptosis
• The effect of several drugs on proliferation and apoptosis with cellular models.Special attention to aspirin, other NSAID and quimiotherapeutic drugs. 
• Molecular mechanisms of apoptosis induction in several cellular models: B-CLL cells , líneas celulares derivadas de LLC-B , Jurkart T cells, colon cancer cells (HT-29).
• Transcriptional control during apoptosis induced by several stimulus.

Financial Support:

Publications

• Antonio F. Santidrián, Ana M. Cosialls, Llorenç Coll-Mulet, Daniel Iglesias-Serret, Mercè de Frias, Diana M. González-Gironès, Clara Campàs, Alicia Domingo, Gabriel Pons, Joan Gil .  The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells(2007) Hematologica  92, 1631- 1638

• Gisela García-Alvarez , Verònica Ventura , Oriol Ros ,  Rosa Aligué , Joan Gil , Albert Tauler Glycogen synthase kinase-3β binds to E2F1 and regulates its transcriptional activity  (2007)  Biochim Biophys Acta,  1773, 375-382

• D Iglesias-Serret , M de Frias , AF Santidrián, L Coll-Mulet, AM Cosialls, M Barragán, A Domingo, J Gil and G Pons. Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells (2007) Leukemia 21, 281-287

• Montserrat Barragán, Mercè de Frias, Daniel Iglesias-Serret, Clara Campàs, Esther Castaño, Antonio F. Santidrián,  Llorenç Coll-Mulet, Ana M. Cosialls, Alicia Domingo,  Gabriel Pons,  and Joan Gil.  Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C  (2006) J. leucocyt. Biol.   80, 1473- 1479

• Clara Campàs, Ana M. Cosialls, Montserrat Barragán, Daniel Iglesias-Serret, Antonio F. Santidrián, Llorenç Coll-Mulet, Mercè de Frias^, Alicia Domingo, Gabriel Pons, Joan Gil.  Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells. (2006) Experimental hematology 34, 1663-1669

• Llorenç Coll-Mulet,1 Daniel Iglesias-Serret,1 Antonio F. Santidrián, Ana M. Cosialls,Mercè de Frias, Esther Castaño, Clara Campàs,1 Montserrat Barragán, Alberto Fernándezde Sevilla,Alicia Domingo, Lyubomir T. Vassilev, Gabriel Pons, and Joan Gil.   MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. (2006) Blood. 107,  4109-14

• Iglesias-Serret, D, Coll Mulet, LL.,  Santidrian, A., Navarro sabaté, A., Domingo, A., Pons G. and Gil, J. Re: Prognostic Signifi cance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia (2005) J. Natl Canc. Inst. 97, 1088-1095

• Campas C,  Santidrian AF, Domingo A,  Gil J. Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma. (2005) Leukemia  19, 292-294

• Molina-Arcas M, Marce S, Villamor N, Huber-Ruano I, Casado FJ, Bellosillo B, Montserrat E, Gil J, Colomer D, Pastor-Anglada M.  Equilibrative nucleoside transporter-2 (hENT2) protein expression correlates with ex vivo sensitivity to fludarabine in chronic lymphocytic leukemia (CLL) cells. (2005)  Leukemia. 19(1):64-8. 

• Lopez JM, Fernandez MA, Pique M, Gil J.   Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. (2004)  Mol Cell Biochem. Nov;266(1-2):57-63.

• Pastor-Anglada M, Molina-Arcas M, Casado FJ, Bellosillo B, Colomer D, Gil J.  Nucleoside transporters in chronic lymphocytic leukaemia.(2004) Leukemia. 18(3):385-93. 

• Montserrat Barragán, Clara Campás, Beatriz Bellosillo and Joan Gil. Protein Kinases in the Regulation of Apoptosis in B-cell Chronic Lymphocytic Leukemia. ( 2003). Leukemia & Lymphoma, Vol. 44, No. 11 , pp. 1865–1870

• Daniel Iglesias-Serret, Maria Piqué, Joan Gil, Gabriel Pons, and José M. López Transcriptional and translational control of Mcl-1 during apoptosis. (2003) Arch. Biochem. Biophys. 417  141–152.

• Miriam Molina-Arcas, Beatriz Bellosillo, F. Javier Casado, Emili Montserrat, Joan Gil, Dolors Colomer, and Marçal  Pastor-Anglada. Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. (2003) Blood 101:2328-2334.

• Clara Campàs, José Manuel López, Antonio F. Santidrián, Montserrat Barragán, Beatriz Bellosillo, Dolors Colomer, and Joan Gil. Acadesine activatesAMPK and induces apoptosis in B-cell chronic lymphocytic

leukemia cells but not in T lymphocytes. (2003) Blood101:3674-3680) 

• Castaño, Esther and Gil, Joan. 15-Deoxy-D12,14 Prostaglandin J2 Synergizes With Phorbol Ester to Induce Proliferation in Swiss 3T3 Cells Independently of Peroxisome Proliferator-Activated Receptor Gamma and PGD2 Receptors. (2003) J. Cell. Physiol.195:421–427.

• Cristina Gómez-Santos, Isidre Ferrer, Antonio F. Santidrián, Marta Barrachina,


Joan Gil,  and Santiago Ambrosio.  Dopamine Induces Autophagic Cell Death and -Synuclein Increase in Human Neuroblastoma SH-SY5Y Cells. (2003). J.Neurosci. Res.73:341–350 

• C Campà, M Dalmau, B Montaner, M Barragàn, B Bellosillo, D Colomer, G Pons, R Pérez-Tomás and J Gil.  Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. (2003) Leukemia 17, 746–750.

• José M. López, Antonio F. Santidrián, Clara Campàs and Joan Gil . 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells,

but the AMP-activated protein kinase is not involved. (2003) Biochem. J. 370, 1027-1032. 

• Villalonga P, Lopez-Alcala C, Chiloeches A, Gil J, Marais R, Bachs O, Agell N. Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts.  J Biol Chem (2002) 277(40):37929-35

• Montserrat Barragán, Beatriz Bellosillo, Clara Campás, Dolors Colomer, Gabriel Pons and Joan Gil.  Involvement of protein kinase C and phosphatidylinositol-3-kinase pathways in the survival of B-Cell Chronic Lymphocytic Leukemia Cells (2002) Blood 99, 2969-2976

• Villalonga P, Lopez-Alcala C, Bosch M, Chiloeches A, Rocamora N, Gil J Marais R, Marshall CJ, Bachs O, Agell N. Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling. Mol Cell Biol. 21:7345-54.(2001)  

• Piqué, M., Castaño, Esther, Bellosillo, B., Pons, G. & Gil, J. (2002) Aspirin induces apoptosis independently of p38 mitogen-activated protein kinase in hematopoietic cell lines .Analytical Pharmacology 3, 34-40

• Herrera,B., Fernández, M., Álvarez, A.M., Roncero, C., Benito, M., Gil, J. and Fabregat, I. . Activation of caspases occurs downstream from radical oxygen species production, Bcl-x_L down-regulation, and early cytochrome c release in apoptosis induced by transforming growth factor b in rat fetal hepatocytes. Hepatology 34:548-556 (2001)