Signal transduction and transcriptional activation mechanisms induced by
Bone Morphogenetic proteins (BMP)
Members of the Group:
-
Francesc Ventura Pujol, Full professor of Biochemistry Unit and Chairman
of the group
-
Elisabet Chalaux, post-dcotoral fellow
-
Teresa López Rovira, Ph.D. student
-
Raquel Fernández, Ph.D. student
Research lines:
Bone morphogenetic proteins (BMPs) constitute a growing family of
growth and differentiation factors belonging to the Transforming
growth factor-beta superfamily. BMPs, acting as morphogens, are involved
in several developmental processes including cell proliferation,
diferenciacion and survival. Our group is
focused in analysis of those signal transduction and transcriptional
activation mechanisms induced by bone morphogenetic proteins involved
in osteoblast and neuronal differentiation.
Financial support:
"Análisis de los mecanismos de transducción de señales
y activación transcripcional inducidos por BMPs" (D,G.I.C.Y.T.)
PM98-0183. 1999-09-28
Publications:
-
"Interaction and Functional Cooperation of NF-kB with Smads" . Teresa López-Rovira,
Elisabet Chalaux, Jose Luis Rosa, Ramon Bartrons, and Francesc Ventura.
(2000)
J.
Biol. Chem.. 275, . 28937–28946. PDF
-
"Bone morphogenetic protein-2 promotes dissociated survival and differentiation
effects in cultured ventral mesencephalic dopaminergic neurons" Reiriz,
J., Espejo, M., Ventura, F., Ambrosio, S. and Alberch, J. (1999) J.
Neurobiology 38: 161-170
-
"A zinc-finger transcription factor induced by TGF-ß promotes apoptotic
cell death in epithelial Mv1Lu cells" Chalaux, E., López-Rovira,
T., Rosa, J.L., Pons, G., Boxer, L.M., Bartrons, R. and Ventura, F.
(1999) FEBS Lett. 457, 478-482. PDF
-
"Assignment of the human p532 gene (HERC1) to chromosome 15q22 by fluorescence
in situ hybridization" Cruz, C., Paladugu, A., Ventura, F., Bartrons, R.,
Aldaz, M. And Rosa, J.L. (1999) Cytogenet Cell Genet.
86, 68-69.
-
"Exposure of foetal mesencephalic cells to bone morphogenetic protein-2
enhances the survival of dopaminergic neurons" Espejo, M., Cutillas, B.,
Ventura, F. and Ambrosio, S. (1999) Neurosci. Lett. 275,
13-16
-
"JunB is involved in the inhibition of myogenic differentiation by Bone
morphogenetic protein-2" Chalaux, E., López-Rovira, T., Rosa, J.L.,
Bartrons, R. and Ventura, F. (1998) J. Biol. Chem. 273,
537-543. PDF
-
" Interaction of Transforming Growth Factor-b
receptor I with farnesyl- protein transferase-? in yeast and mammalian
cells" Ventura F., Liu, F., Doody J. and Massagué J. (1996) J.
Biol. Chem. 271, 13931-13934.
-
"Human type II receptor for bone morphogenic proteins" Liu, F., Ventura,
F., Doody, J. and Massagué, J. (1995) Mol. Cell Biol.
15, 3479-3486.
|
