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| Unitat de Bioquímica |
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| Mecanismes de transducció de senyals i d´activació transcripcional induïts per les proteïnes morfògenes ósees (BMPs) i el TGFß |
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| Membres del Grup |
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- Dr. Francesc Ventura Pujol, Professor Titular i responsable del grup.
- Dra. Julia Reiriz, Professora de l' Escola Universitària d' Infermeria.
- Mª José Ortuño Romero, becària predoctoral.
- Edgardo Rodriguez Carballo, becari predoctoral.
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| Línia de Treball |
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Les proteïnes morfógenes óseas (BMPs) formen una família de factors multifuncionals de creixement i diferenciació que pertanyen a la superfamília del factor de creixement transformant-b (TGF-b). Tant les BMPs com el TGF-ß controlen diversos processos durant el desenvolupament que inclouen proliferació, diferenciació, supervivència o morfogènesi. L´objectiu del nostre grup és l´anàlisi dels mecanismes de transducció de senyals i d´activació transcripcional induits tant per les BMPs, que es troben implicades en els fenòmens de diferenciació ósea.
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| Financiació del Grup |
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| | Análisis de los mecanismos implicados en la diferenciación osteoblástica inducida por BMPs |
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| | | Programa: Programa Nacional de Biología fundamental |
| | | Empresa/Administració financiadora: Ministerio de Educación y Ciencia |
| | | Número de projecte: BFU2005-01474/BMC |
| | | Durada. Desde: 2006 Fins a: 2009 |
| | | Investigador Principal: Francesc Ventura Pujol. |
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| | Función de osterix y p38 en osteogénesis inducida por BMPs. |
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| | | Programa: Programa Nacional de Biología fundamental |
| | | Empresa/Administració financiadora: Ministerio de Ciencia e Innovación |
| | | Número de projecte:BFU2008-02010/BMC |
| | | Durada. Desde: 2008 Fins a: 2011 |
| | | Investigador Principal: Francesc Ventura Pujol. |
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| Publicacions |
| Trovareu sempre les últimes publicacions del grup al PubMed |
- "ERK and p38 pathways regulate amino acid signalling". Casas-Terradellas E, Tato I, Bartrons R, Ventura F, Rosa JL. (2008) Biochimica et Biophysica Acta-Molecular Cell Research 1783 (12) : 2241-2254.
- "BMP-2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activities." Gamell C, Osses N, Bartrons R, Rückle T, Camps, M., Rosa JL, Ventura F. (2008) Journal of Cell Science 121 (23) : 3960-3970.
- "BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells." Susperregui A.R.G., Viñals F., Ho P.W.M., Gillespie M.T., Martin T.J. and Ventura F. (2008) Journal of Cellular Physiology 216 (1) : 144-152.
- "BMP-2 induces osterix expression through upregulation of DLX5 and its phosphorylation by p38." Ulsamer A, Ortuño MJ, Ruiz S, Susperregui AR, Osses N, Rosa JL, Ventura F. (2008) Journal of Biological Chemistry 283 (7) : 3816-3826.
- "Identification of a novel mutation in the PAX9 gene in a family affected by oligodontia and other dental anomalies." Tallón-Walton, V.; Manzanares-Céspedes, M.C.; Arte, S.; Carvalho-Lobato, P.; Valdivia-Gandur, I.; Garcia-Susperregui, A.; Ventura, F.; Nieminen, P. (2007) European Journal of Oral Sciences 115 (6): 427-32.
- "Simultaneous electrophoretic analysis of proteins of very high and low molecular weights using low-percentage acrylamide gel and a gradient SDS-PAGE gel." Casas-Terradellas, E.; Garcia-Gonzalo, F.R.; Hadjebi, O.; Bartrons, R.; Ventura, F.; Rosa, J.L. (2006) Electrophoresis 27 (20): 3935-3938.
- "Relationship between subclinical rejection and genotype, renal messenger RNA, and plasma protein transforming growth factor-beta1 levels". Hueso, M.; Navarro, E.; Moreso, F.; Beltran-Sastre, V.; Ventura, F.; Grinyo, J.M.; Seron, D. (2006) Transplantation 81 (10):1463-1466.
- "Sulfation is required for bone morphogenetic protein 2-dependent Id1 induction." Osses, N.; Gutierrez, J.; Lopez-Rovira, T.; Ventura, F.; Brandan, E. (2006) Biochemical and Biophysical Research Communications 344 (5):1207-15.
- "Repression of SOX6 transcriptional activity by SUMO modification." Fernandez Lloris, R.; Osses, N.; Shen, L. N.; Vaughan, O. A.; Girwood, D.; Bartrons R.; Rosa J. L.; Hay, R. T.; Ventura, F. (2006) FEBS Letters 580: 1215-1221.
- "Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins." Garcia-Gonzalo, F.R.; Bartrons, R.; Ventura, F.; Rosa, J.L. (2005) FEBS Letters 579: 343-348.
- "6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia." Obach, M.; Navarro-Sabate, A.; Caro, J.; Kong, X.; Duran, J.; Gomez, M.; Perales, J.C.; Ventura, F.; Rosa, J.L.; Bartrons, R. (2004) Journal of Biological Chemistry 279 (51) 53562-53570.
- "Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1." Vinals F, Ventura F. (2004) J. Biol. Chem. 279:45766-72.
- "BMP-2 decreases Mash1 stability by increasing Id1 expression." Vinals F, Reiriz J, Ambrosio S, Bartrons R, Rosa JL, Ventura F. (2004) EMBO J. 23:3527-37.
- "cAMP inhibits TGFbeta1-induced in vitro angiogenesis." del Valle-Perez B, Martinez-Estrada OM, Vilaro S, Ventura F, Vinals F. (2004) FEBS Lett. 569 :105-11.
- "Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation." Comalada M, Cardo M, Xaus J, Valledor AF, Lloberas J, Ventura F, Celada A. (2003) J Immunol. 170:4450-6.
- "Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cells." Fernandez-Lloris R, Vinals F, Lopez-Rovira T, Harley V, Bartrons R, Rosa JL, Ventura F. (2003) Mol Endocrinol. 17:1332-43.
- "Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat." Ferrer I, Blanco R, Carmona M, Puig B, Dominguez I, Vinals F. (2002) Acta Neuropathol (Berl) Apr;103(4):391-407.
- "Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2." Vinals F, Lopez-Rovira T, Rosa JL, Ventura F. (2002) FEBS Lett. 510(1-2):99-104.
- "Direct binding of Smad1 and Smad4 to two distinct motifs mediates BMP-specific transcriptional activation of Id1 gene." Lopez-Rovira T, Chalaux E, Massague J, Rosa JL, Ventura F. (2002) J Biol Chem. Feb 1;277(5):3176-85.
- "Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling." Viñals F, Pouyssegur J. (2001) Mol Cell Biol. 21:7218-30.
- "Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration." Ferrer I, Blanco R, Carmona M, Ribera R, Goutan E, Puig B, Rey MJ, Cardozo A, Viñals F, Ribalta T. (2001) Brain Pathol. 11:144-158.
- "Growth factor-stimulated protein synthesis is inhibited by sodium orthovanadate." Viñals F, McKenzie FR, Pouyssegur J. (2001) Eur J Biochem. 268:2308-2314.
- "Interaction and Functional Cooperation of NF-kB with Smads" . Teresa López-Rovira, Elisabet Chalaux, Jose Luis Rosa, Ramon Bartrons, and Francesc Ventura. (2000) J. Biol. Chem. Sep 15;275(37):28937-46.
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