Historial

• Professor titular d’universitat de l’àrea de Fisiologia (1991-)
• Professor associat, Facultat de Biologia, UB (1989-1991)
• Investigador responsable, Dept. de Farmacologia, Lab. Menarini SA (1989-1991)
• Investigador associat, Dept. de Farmacologia, Lab. SALVAT SL (1986-1989)
• Col·laborador d'investigació (1983-1986)
• Doctor en Farmàcia, UB (1988)
• Llicenciat en Farmàcia, UB (1983)

Perfil

• Director del grup de recerca Eicosanox (2001-)
• Interessos de recerca:
  • Paper de la cascada de l’àcid araquidònic i els eicosanoides sobre la inflamació, el creixement cel·lular i els processos de reparació tissular
  • Efectes de pèptids endògens i fàrmacs sobre la cascada de l’àcid araquidònic
  • Relació entre la cascada de l’àcid araquidònic i l’estrès oxidatiu

Publicacions representatives

• Ferrer R, Moreno JJ (2010) Role of eicosanoids on intestinal epithelial homeostasis. Biochemical Pharmacology, 80: 431-438.
• Rodríguez-Lagunas MJ, Martín-Venegas R, Moreno JJ, Ferrer R (2010) Prostaglandin E2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in caco-2 cell monolayers. American Journal of Physiology Cellular Physiology, 299: C324-C334.
• Moreno JJ (2009) New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochemical Pharmacology, 77:1-10.
• Moreno JJ (2009) Differential effects of arachidonic and eicosapentaenoic acid-derived eicosanoids on polymorphonuclear transmigration across endothelial cell cultures. The Journal of Pharmacology and Experimental Therapeutics, 331: 1111-1117.
• Vivancos M, Moreno JJ (2008) Effect of resveratrol, tyrosol and beta-sitosterol on oxidised low-density lipoprotein-stimulated oxidative stress, arachidonic acid release and prostaglandin E2 synthesis by RAW 264.7 macrophages. British Journal of Nutrition, 99: 1199-1207.
• Nieves D, Moreno JJ (2006) Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathways regulate 3T6 fibroblast growth. Journal of Lipid Research, 47: 2681-2689 (2006)
• Nieves D, Moreno JJ (2006) Effect of arachidonic and eicosapentaenoic acid metabolisn on RAW 264.7 macrophage proliferation. Journal of Cellular Physiology, 208: 428-434  (2006)
• Martín-Venegas R, Roig-Pérez S, Ferrer R, Moreno JJ (2006) Arachidonic acid cascade and epithelial barrier function during Caco-2 cell differentiation. Journal of Lipid Research, 47: 1416-1423
• Mitjavila MT, Moreno JJ (2003) Effect of unsaturated degree of fatty acids in the modulation of atherosclerosis, Journal of Nutritional Biochemistry 14:182-195
• Vivancos M, Moreno JJ (2005) Beta-sitosterol modulates antioxidant enzyme response in RAW 264.7, Free Radical Biology and Medicine 39: 91-97
• Moreno JJ (2003) Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7, Free Radicals in Biology and Medicine 35:1073-1081
• Sánchez T, Moreno JJ (2002) Calcium-independent phospholipase A2 through prostaglandin synthesis is involved in Caco-2 cell growth, Journal of Cellular Physiology 193: 293-298
• Vivancos M, Moreno JJ (2002) Role of Ca2+-independent phospholipase A2 and cyclooxygenase/lipoxygenase pathways in the nitric oxide production by murine macrophages stimulated by lipopolysaccharides, Nitric Oxide: Biology  and Chemistry 6: 255-262 (2002)
• Sánchez T, Moreno JJ (2002) Role of EP1 and EP4 prostaglandin E2 subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation, American  Journal of  Physiology  Cellular  Physiology 282: C280-C288
• Sánchez T, Moreno JJ (2001) Role of phospholipase A2 in growth-dependent changes in prostaglandin release from 3T6 fibroblasts, Journal of  Cellular Physiology189: 237-243
• Moreno JJ, Carbonell T, Sánchez T, Miret S, Mitjavila MT (2001) Olive oil decreases both the oxidative stress and the production of arachidonic acid metabolites by prostaglandin G/H synthase pathway in rat macrophages, Journal of  Nutrition 131: 2145-2149
• Martínez J, Moreno JJ (2001) Role of Ca2+-independent phospholipase A2 on arachidonic acid release induced by reactive oxygen species, Archives of Biochemistry and Biophysics 392: 257-262
• Sánchez T, Moreno JJ (2000) The effect of high molecular phospholipase A2 inhibitors on 3T6 fibroblast proliferation, Biochemical  Pharmacology 61:811-816
• Martínez J, Sánchez T, Moreno JJ (2000) Regulation of prostaglandin E2 production by the superoxide radical and nitric oxide in mouse peritoneal macrophages Free Radical  Research 32:303-311

jjmoreno@ub.edu

Departament de Fisiologia-Farmàcia
Edifici B, 3a planta
Av. Joan XXIII s/n
08028 Barcelona

Tel: (+34) 934 024 505
Fax: (+34) 934 035 901