Syllabus and Language of teaching
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AREA 1. Activation and regulation of the immune response (12.5 ECTS) This area is designed to cover the main topics and recent advances in immunology. The aim is to provide students with knowledge of the bases of the normal function of the immune system and its regulation at the graduate level before starting more specific and specialized studies for the Master. The module examines the the following contents:
- Anatomy of the immune system (2.5 ECTS): a full understanding of the location and topology of the different anatomical components of the immune system and its interconnection with the rest of the body.
- Activation and signal transduction (2.5 ECTS): understanding the cell signaling as an integrative process of multiple signals, the molecular mechanisms involved and the basis for its modulation in immune system cells.
- Regulation of the immune response (2.5 ECTS): understanding the induction and maintenance systems of central and peripheral tolerance, and the different mechanisms used by the immune system to prevent excessive response to pathogens.
- Immunogenetics (2.5 ECTS): knowledge of immune system genes, genetic polymorphisms, MHC locus and genes of the NK receptors, cytokines, and cytokine receptors. Methodologies for study.
- Immunopathology (2.5 ECTS): basic concepts. Immunopathological mechanisms: immunodeficiency, hypersensitivity and autoimmunity. Therapies based on stimulation or suppression of the immune response. Immunological barriers to transplantation: immunosuppression.
AREA 2. Advanced Techniques in Immunology (7.5 ECTS) This area is designed to put into perspective the traditional technologies and the most advanced ones, to study the immune system and its application to different areas of bioscience research, diagnostics and biotechnology.
- Antibodies (2.5 ECTS): understanding of different strategies for specific antibody production in vivo and in vitro evaluation of their specificity, the different approaches to obtain polyclonal and monoclonal antibodies and purification.
- Flow Cytometry (2.5 ECTS): knowledge of flow cytometry technology and its potential for multiple biological assays, for the expression of cellular markers, cell cycle phases, apoptosis, production of soluble factors (cytokines and chemokines), activation and cell proliferation cytotoxicity, cell viability, production of free radicals, etc.
- Advanced Techniques in Immunology (2.5 ECTS): Functional analysis of lymphocytes: knowledge of techniques for measuring the functional capacity of T and B lymphocytes Proliferation, cytotoxicity, cytokine production, intracellular Ca2+, immunoglobulin production. PCR techniques applied to Immunology: knowledge of the techniques of PCR, RT-PCR, in situ-PCR and real-time PCR in the application to the analysis of gene expression, genetic polymorphisms and rearrangements of immunoglobulin genes and T cell receptors.