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LABORATORY
OF ORGANIC CHEMISTRY 
Synthesis of Bioactive
Nitrogen-containing Compounds
Our research interests
are focused on the field of Organic Synthesis. The ultimate
goal of our basic research is the development of general synthetic methods and strategies, and their application to the synthesis
of natural products, particularly indole and piperidine alkaloids,
and other bioactive nitrogen compounds, both in the racemic
series and enantiopure form. Our experience in this area has
allowed us to tackle interdisciplinary research projects in
the field of Biomedicine, in collaboration with research groups
involved in other areas. Similarly, we are participating in
joint projects with Chemical and Pharmaceutical companies aimed
at the synthesis of compounds with therapeutical interest.
1.
Research topics
- New methodologies for the enantioselective synthesis of nitrogen
compounds
-General methodologies for the enantioselective synthesis
of piperidine-containing derivatives
- Use of aminoalcohol-derived bicyclic lactams as versatile
chiral synthons
- Cyclocondensation reactions involving dynamic kinetic resolution
processes or the desymmetrization of enantiotopic groups
- Enantioselective synthesis of piperidine and indole
alkaloids
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General methods
and strategies for the synthesis of alkaloids
- Biomimetic syntheses
- Synthesis of drugs and therapeutically active compounds
2. Areas of expertise
- Organic synthesis: design and
realization
- Synthesis of drugs and new therapeutically active substances
- Heterocyclic chemistry (synthesis of heterocyclic compounds)
- Fine chemistry
- Development of new synthetic routes for drugs and improvement
of processes
- Isolation, structural determination and synthesis of impurities
- Structural elucidation by spectroscopic methods
- Organometallics
3.
Recent ongoing projects
- Aminoalcohol-derived
bicyclic lactams as chiral synthons for the enantioselective
synthesis of piperidine-containing alkaloids and bioactive
compounds
- Synthesis of alkaloids:
general metods and strategies
- Oral antidiabetic
agents: new procedures for the synthesis of azasugars (Marató TV3 Foundation)
- New synthetic routes to
generic active pharmaceutical ingredients (Urquima, S. A.)
- Synthesis of platelet activating factor analogues
(Marató TV3 Foundation)
- Synthesis of COX-2 inhibitors (Laboratorios Salvat)
- Synthesis of new dopaminergic agents (Zambon group)
- Design and synthesis of new phenytoine pro-drugs (Laboratorios Rubió, S. A.)
- Synthesis of 5-HT1D
receptor agonists (Almirall Prodesfarma)
- Synthesis of new therapeutic agents (laboratorios Vita, S. A.)
4. Selected papers 
5.
Recent patents 
6.
Recent synthetic achievements
7.
Current collaborations 
8.
Group members
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