Gonzalez-Bellavista A, Atrian S, Muñoz M, Capdevila M, Fabregas E. Novel potentiometric sensors based on polysulfone immobilized metallothioneins as metal-ionophores. Talanta 2008; doi10.1016/j.talanta.2008.09.031

Domenech J, Bofill R, Tinti A, Torreggiani A, Atrian S, Capdevila M.Comparative insight into the Zn(II)-, Cd(II)- and Cu(I)-binding features of the protozoan Tetrahymena pyriformis MT1 metallothionein. Biochim Biophys Acta (Proteins and Proteomics) 2008;1784:693-704

Orihuela R, Domenech J, Bofill R, You C, Mackay EA, Kägi JHR, Capdevila M, Atrian S. The metal-binding features of the recombinant mussel Mytilus edulis MT-10-IV metallothionein. J Biol Inorg Chem 2008,13:801-812

Torreggiani A, Domenech J, Atrian S, Capdevila M, Tinti A. Raman study of in vivo synthesized Zn(II)-metallothionein complexes: structural insight into metal clusters and protein folding. Biopolymers 2008;89:1114-1124

Atrian S, Bobrowski K, Capdevila M, Chatgilialoglu C, Ferreri C, Houee-Levin C, Salzano AM, Scaloni A, Torreggiani A. Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress. Chimia 2008;62:721-727

Atrian S, Lopez-Viñas E, Gomez-Puertas P, Chabas A, Vilageliu L, Grinberg D. An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions. Relevance for Gaucher disease. Proteins: structure, function and bioinformatics 2008; 70:882-891

Pagani A, Villarreal L, Capdevila M, Atrian S. The S.cerevisiae Crs5 metallothionein metal binding abilities and its role in response to zinc overload. Mol Microbiol. 2007;63:256-269

Palacios O, Leiva-Presa A, Atrian S, Lobinski R. A study of the Pb(II) binding to recombinant Mouse Zn7-metallothionein 1 and its domains by ESI-TOF-MS. Talanta 2007;72:480-488

Domenech J, Tinti A, Capdevila M, Atrian S, Torreggiani A. Structural study of the zinc and cadmium complexes of a type 2 plant (Quercus suber) metallothionein: insights by vibrational spectroscopy. Biopolymers 2007;86:240-248

Domenech J, Orihuela R, Mir G, Molinas M, Atrian S, Capdevila M. The Cd(II)-binding abilities of recombinant Quercus suber metallothionein, QsMT: bridging the gap between phytochelatins and metallothioneins. J Biol Inorg Chem. 2007;12:867-882

Pagani A, Casamayor A, Serrano R, Atrian S, Ariño J. Disruption of iron homeostasis in Saccharomyces cerevisiae by high zinc levels: a genome-wide study. Mol Microbiol. 2007; 65:521-537

Atrian S. Las Metalotioneínas: importancia de estas proteínas en el tejido cutáneo. NCP (Boletín de la Sociedad Española de Químicos Cosméticos) 2007;294:5-12

Villarreal L, Tío L, Capdevila M, Atrian S. Comparative metal binding and Genomics analysis of the avian (chicken) Metallothionein vs. mammalian forms. FEBS Journal 2006; 273:523-535

Penkowa M, Tío L, Giralt M, Quintana A, Molinero A, Atrian S, Vasak M, Hidalgo J. Specificity and divergence in the neurobiological effects of different Metallothioneins after brain injury. J Neurosc Res. 2006;23:974-984

Egli D, Domenech J, Selvaraj A, Balamurugan K, Hua H, Capdevila M, Georgiev O, Schaffner W, Atrian S. The four members of the Drosophila Metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification. Genes to Cells 2006;11:647-658

Domenech J, Mir G, Huguet G, Capdevila M, Molinas M, Atrian S. Plant metallothionein domains: functional insight into physiological metal binding and protein folding. Biochimie 2006; 88:583-593

Tío L, Villarreal L, Atrian S, Capdevila M. The Zn- and Cd-clusters of recombinant mammalian MT1 and MT4 Metallothionein domains include sulfide ligands. Exp Biol Med 2006; 231:1522-1527

Capdevila M, Domenech J, Pagani A, Tío L, Villarreal L. Atrian S. Zn- and Cd-metallothionein recombinant species from the most diverse phyla may contain sulfide (S2-) ligands. Angewandte Chem Intern Ed. 2005;44:4618-4622

Villarreal L, Tio L, Atrian S, Capdevila M. Influence of chloride ligands on the structure of Zn- and Cd-metallothionein species. Arch Biochem Bioph. 2005;435:331-335

Benach J, Winberg JO, Svendsen JS, Atrian S, Gonzàlez-Duarte R, Ladenstein R. Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis. J Mol Biol. 2005;345:579-598

Mir G, Domènech J, Huguet G, Guo W, Goldsbrough P, Atrian S, Molinas M. A plant type 2 metallothionein (MT) from cork tissue responds to oxidative stress. J Exp Bot. 2004;55:2483-2493

Klassen RB, Crenshaw K, Kozyraki R, Verroust PJ, Tio L, Atrian S, Allen PL, Hammond TG. Megalin mediates the renal uptake of heavy metal Metallothionein complexes. Am J Physiol Ren Physiol 2004;287:393-403

Tio L, Villarreal L, Atrian S, Capdevila M. Functional differentiation in the mammalian Metallothionein gene family. J Biol Chem. 2004;279:24403-24413

Leiva-Presa A, Capdevila M, Cols N, Atrian S, Gonzàlez-Duarte P. Chemical foundation of the attenuation of methylmercury(II) cytotoxicity by metallothioneins. Eur J Biochem. 2004;271:1-6

Koumanov A, Benach J, Atrian S, Gonzàlez-Duarte R, Karshikoff A, Ladenstein R. The catalytic mechanism of Drosophila alcohol dehydrogenase: evidence for a proton relay modulated by the coupled ionisation of the active site Lysine/Tyrosine pair and a NAD+ ribose OH switch. Proteins 2003;51:289-298

Domènech J, Palacios O, Villarreal L, Gonzàlez-Duarte P, Capdevila M, Atrian S. MTO: the second member of a Drosophila dual copper-thionein system. FEBS Let. 2003;533:72-78

Valls M, Bofill R, Gonzàlez-Duarte R, Gonzàlez-Duarte P, Capdevila M, Atrian S. A new insight into metallothionein classification and evolution. The in vivo and in vitro metal binding features of Homarus americanus recombinant MT. J Biol Chem. 2001;276:32835-32843

Cols N, Roepstorff K, Gonzàlez-Duarte R, Atrian S. Secretion of mouse-metallothionein by engineered E.coli cells in metal-enriched media. J Mol Microb Biotech. 2001;3:507-512

Polec K, Szpunar J, Palacios O, Gonzàlez-Duarte P, Atrian S, Lobinski R. Investigation of metal binding capacity by recombinant and native metallothioneins capillary zone electrophoresis (CZE) coupled with inductively coupled plasma mass spectroscopy (ICP-MS) via a self aspirating total consumption micronebulizer. J Anal Atom Spect. 2001;16:567-574

Bofill R, Capdevila M, Cols N, Atrian S, Gonzàlez-Duarte P. Zn(II) is required for the in vivo and in vitro folding of mouse Cu-metallothionein in two domains. J Biol Inorg Chem. 2001;6:405-417

Benach J, Atrian S, Ladenstein R, Gonzàlez-Duarte R. Genesis of Drosophila ADH: the shaping of the enzymatic activity from a SDR ancestor. Chem Biol Inter. 2001;130-132:405-415

Benach J, Atrian S; Fibla J, Gonzàlez-Duarte R, Ladenstein R. Structure-function relationships in Drosophila melanogaster alcohol dehydrogenase allozymes ADHS, ADHF and ADHUF, and distantly related forms. Eur J Biochem. 2000;267:3613-3622

Valls M, de Lorenzo V, Gonzàlez-Duarte R, Atrian S. Engineering of Pseudomonas cell membranes for heavy-metal bioadsorption. J Inorg Biochem. 2000;79:219-223

Valls M, Atrian S, de Lorenzo V, Fernández LA. Engineering a mouse metallothionein on the cell surface of Ralstonia eutropha CH34 for immobilisation of heavy metals in soil. Nature Biotech. 2000;18:661-665

Valls M, Bofill R, Romero-Isart N, Gonzàlez-Duarte R, Abian J, Carrascal M, Gonzàlez-Duarte P, Atrian S. Drosophila MTN: a metazoan copper-thionein related to fungal forms. FEBS Let. 2000;467:189-194

Benach J, Atrian S; Gonzàlez-Duarte R, Ladenstein R. The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 Å resolution by X-ray crystallography. J Mol Biol. 1999; 289:335-355

Cols N, Romero-Isart N, Bofill R, Capdevila M, Gonzàlez-Duarte P, Gonzàlez-Duarte R, Atrian S. In vivo copper- and cadmium-binding ability of mammalian metallothionein ß domain. Prot Engin. 1999;12:265-269

Bofill R, Palacios O, Capdevila M, Cols N, Gonzàlez-Duarte R, Atrian S, Gonzàlez-Duarte P. A new insight into the Ag+ and Cu+ binding sites in metallothionein ß domain. J Inorg Biochem. 1999; 73:57-64

Atrian S, Gonzàlez-Duarte R. The Drosophila virilis alcohol dehydrogenase catalytic residues are conserved. J Mol Evol. 1999;48:262-263

Romero-Isart N, Cols N, Termansen MK, Gelpi JLl, Gonzàlez-Duarte R, Atrian S, Capdevila M, Gonzàlez-Duarte P. Replacement of terminal cysteine with histidine in the metallothionein a and ß domains maintains its binding capacity. Eur J Biochem. 1999;259:519-527

Valls M, Gonzàlez-Duarte R, Atrian S. & de Lorenzo V. Bioaccumulation of heavy metals with fusion proteins of metallothionein to bacterial OMPs. Biochimie 1998;80:855-86l

Benach J, Atrian S, Gonzàlez-Duarte R, Ladenstein R. The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 Å resolution. J Mol Biol. 1998;282:383-399

Atrian S, Sánchez-Pulido L, Gonzàlez-Duarte R, Valencia A. Shaping of Drosophila alcohol dehydrogenase through evolution. Relationship with enzyme functionality. J Mol Evol. 1998;47:211-221

Cols N, Atrian S, Benach J, Ladenstein R, Gonzàlez-Duarte R. Drosophila alcohol dehydrogenase: evaluation of Ser139 site-directed mutants. FEBS Let. 1997;413:191-193

Capdevila M, Cols N, Romero-Isart N, Gonzàlez-Duarte R, Atrian S, Gonzàlez-Duarte P. Recombinant synthesis of mouse Zn3-ß and Zn4-a metallothionein1 domains and characterization of their Cadmium(II) binding capacity. CMLS 1997;53:681-688

Cols N, Romero-Isart N, Capdevila M, Oliva B, Gonzàlez-Duarte P, Gonzàlez-Duarte R, Atrian S. Binding of excess Cadmium(II) to Cd7-metallothionein from recombinant mouse Zn7- metallothionein1. UV-VIS absorption and circular dichroism studies and theoretical location approach by surface accessibility analysis. J Inorg Biochem. 1997;68:157-166

Capdevila M, Romero N, Gonzàlez-Duarte P, Cols N, Atrian S, Gonzàlez-Duarte R. Cadmium(II) binding to recombinant mouse Zn3-ß metallothionein1. Intern Ed Anal Quím. 1996;92:199-201

Albalat R, Valls M, Fibla J, Atrian S, Gonzàlez-Duarte R. Involvement of the C-terminal tail in the activity of Drosophila alcohol dehydrogenase. Eur J Biochem. 1995;233:498-505

Atrian S, Capdevila M, Cols N, Gonzàlez-Duarte R, Gonzàlez-Duarte P, Romero N, Stillman MJ. Metal binding properties of recombinant metallothionein and related peptides. J Inorg Biochem. 1995;59:103

Jörnvall H, Persson B, Krook M, Atrian S, Gonzàlez-Duarte R, Jeffery J, Ghosh D. Short-Chain Dehydrogenases/Reductases (SDR). Biochemistry 1995;34:6003-6013

Ladenstein R, Tibbelin G, Karshikoff A, Atrian S, Gonzàlez-Duarte R. Well-ordered crystals of a short-chain alcohol dehydrogenase from Drosophila lebanonensis: re-evaluation of the crystrallographic data and rotation-function analysis. Acta Crystal. 1995;D51:69-72

Luque T, Atrian S, Danielsson O, Jörnvall H, Gonzàlez-Duarte R. Structure of the Drosophila melanogaster glutathione-dependent formaldehyde dehydrogenase/octanol dehydrogenase gene (class III alcohol dehydrogenase). Eur J Biochem. 1994;225:985-993

Danielsson O, Atrian S, Luque T, Hjelmqvist L, Gonzàlez-Duarte R, Jörnvall H. Fundamental molecular differences between alcohol dehydrogenase classes. Proc Nat Acad Sci USA 1994;91:4980-4984

Albalat R, Atrian S, Gonzàlez-Duarte R. Drosophila lebanonensis ADH: analysis of recombinant wild-type enzyme and site-directed mutants. FEBS Let. 1994;341:171-176

Cols N, Marfany G, Atrian S, Gonzàlez-Duarte R. Effect of site-directed mutagenesis on conserved positions of Drosophila alcohol dehydrogenase. FEBS Let. 1993;319:90-94

Fibla J, Atrian S, Gonzàlez-Duarte R. Evidence of serine-protease activity closely associated with Drosophila alcohol dehydrogenase. Eur J Biochem. 1993;211:357-365

Atrian S, Marfany G, Albalat R, Gonzàlez-Duarte R. Primary structure analysis of Drosophila alcohol dehydrogenase. Biochem Genet-Life Sci Adv. 1992;11:19-29

Krook M, Prozorovski V, Atrian S, Gonzàlez-Duarte R, Jörnvall H. Short-chain dehydrogenases: proteolysis and chemical modification of prokaryotic 3a/20ß-hydroxysteroid, insect alcohol, and human 15-hydroxyprostaglandin dehydrogenases. Eur J Biochem. 1992;209:233-239

Albalat R, Gonzàlez-Duarte R, Atrian S. Protein Engineering of Drosophila melanogaster alcohol dehydrogenase. FEBS Let. 1992;308:235-239

Gordon, EJ, Bury SM, Sawyer L, Atrian, S, Gonzàlez-Duarte R. Preliminary X-ray crystallographic studies on alcohol dehydrogenase from Drosophila. J Mol Biol. 1992;227:356-358

Prozorovski V, Krook M, Atrian S, Gonzàlez-Duarte, R, Jörnvall H. Identification of reactive tyrosine residues in cysteine-reactive dehydrogenases. FEBS Let. 1992;304:46-50

Ribas de Pouplana Ll, Atrian S, Gonzàlez-Duarte R, Fothergill-Gilmore LA, Kelly SM, Price NC. Structural properties of long- and short-chain alcohol dehydrogenases. Biochem J. 1991;276:433-438

Visa N, Marfany G, Vilageliu Ll, Albalat R, Atrian S, Gonzàlez-Duarte R. The Adh in Drosophila: Chromosomal location and restriction analysis in species with different phylogenetic relationships. Chromosoma 1991;100:315-322

Atrian S, Gonzàlez-Duarte R, Fothergill-Gilmore LA. Synthesis of Drosophila melanogaster alcohol dehydrogenase in yeast. Gene 1990;93:205-212

Gonzàlez-Duarte R, Atrian S. Metabolic response to alcohol ingestion in Drosophila hydei. Heredity 1986;56:123-128

Gonzàlez-Duarte R, Juan E, Vilageliu Ll, Atrian S. El sistema ADH en Drosophila. Investigación y Ciencia 1986;113:56-69

Atrian S, Gonzàlez-Duarte R. Purification and molecular characterization of alcohol dehydrogenase of Drosophila hydei. Conservation in biochemical features of the enzyme. Biochem Genet. 1985;23:891-911

Atrian S, Gonzàlez-Duarte R. An aldo-keto reductase activity in Drosophila melanogaster and Drosophila hydei: a possible function in alcohol metabolism. Comp Biochem and Physiol. 1985;81B:949-952

Benach J, Atrian S, Ladenstein R, Gonzàlez-Duarte R. Genesis of Drosophila ADH: the shaping of the enzymatic activity from a SDR ancestor. In: Enzymology and Molecular Biology of Carbonyl Metabolism. H. Weiner, X. Hurley, K. Lindahl (eds.). Elsevier. vol 10:405-415, 2001.

Armengol R, Benaiges A, Mayordomo L, Moliner M, Atrian S. Genetic Engineering: a tool for the obtention of human proteins useful as cosmetic ingredients. In: Cosmetic Science for the New Century. Fed. of Societies of Cosmetic Chemist (eds.): 403-414, 2000.

Atrian S, Bofill R, Capdevila M, Cols N, Gonzàlez-Duarte P, Gonzàlez-Duarte R, Leiva A, Palacios O, Romero-Isart N. Recombinant synthesis and metal-binding abilities of mouse metallothionein1 and its a- and ß- domains. In: Metallothionein IV. CD. Klaassen (ed.). Birkhauser: 55-61, 1999.

Pazos F, Sánchez-Pulido L, García-Ranea JA, Andrade M, Atrian S, Valencia A. Comparative analysis of different methods for the detection of specificity regions in protein families. In: Biocomputing and Emergent Computation. D. Lundh, B. Olsson, A. Narayanan (eds.). World Scientific. Singapore-London: 132-145, 1997.

Gonzàlez-Duarte P, Duran N, Romero N, Oliva B, Cols N, Gonzàlez-Duarte R, Atrian S. Bioproduction of optimized quelating peptides in order to remove heavy metals from water. In: Perspectives on Protein Engineering. R. Epton (ed.). Mayflower Worldwide Limited: 78-80, 1995.

Atrian S, Albalat R, Cols N, Marfany G, Valls M, Gonzàlez-Duarte R. Picturing Drosophila alcohol dehydrogenase by site-directed mutagenesis. In: Perspectives on Protein Engineering. R. Epton (ed.). Mayflower Worldwide Limited: 148-150, 1995.

Atrian S, Gonzàlez-Duarte R. Comparison of some biochemical features of the enzyme alcohol dehydrogenase in sixteen species of Drosophila. In: Advances in Genetics, Development and Evolution of Drosophila. S. Lakovaara (ed.). Plenum Press. NewYork & London: 251-262, 1982.