Departament de Genètica 


Josep Francesc Abril
David Bueno
Francesc Cebrià
Montserrat Corominas
Marta Morey
Rafael Romero
Emili Saló
Florenci Serras





M.E. Isolani; J.F. Abril; E. Saló; P. Deri; A.M. Bianucci; R. Batistoni Planarians as a Model to Assess In Vivo the Role of Matrix Metalloproteinase Genes during Homeostasis and Regeneration. PLOS ONE, 2013, 8(2):e55649

Emili Saló and Kiyokazu Agata. Planarian regeneration: a classic topic claiming new attention. Int. J. Dev. Biol. 56: 1-4, 2012

Alejandro Gonzalez-Sastre, Mª Dolores Molina and Emili Saló. Inhibitory Smads and Bone Morphogenetic Protein (BMP) modulate anterior photoreceptor cell number during planarian eye regeneration. Int. J. Dev. Biol. 56: 155-163, 2012

Almuedo-Castillo, M., Sureda-Gómez, M., Adell, T. Wnt signaling in planarians: new answers to old questions. Int. J. Dev. Biol. 56: 53 – 65, 2012

Auletta, G., Adell, T., Colagè, I., D’Ambrosio, P.; Salò, E. Space Research Program on Planarian Schmidtea mediterranea's Establishment of the Anterior-Posterior Axis in Altered Gravity Conditions. Microgravity 2012. ISSN 0938-0108.

Josep F. Abril, Francesc Cebrià, Gustavo Rodríguez-Esteban, Susanna Fraguas, Thomas Horn, Beatriz Calvo, Kerstin Bartscherer, and Emili Saló. Smed454 dataset: unravelling the transcriptome of Schmidtea mediterranea. BMC genomics [Highly Accessed mention], 11(731):e1-e19, 2010

Mª Dolores Molina, Ana Neto, Ignacio Maeso, José Luis Gómez-Skarmeta, Emili Saló and Francesc Cebrià. Noggins, a noggin-like gene and a BMP/ADMP organizer control the regeneration of the planarian DV axis. Current Biology 21:300-305, 2011

Maria Almuedo-Castillo, Emili Saló and Teresa Adell. Dishevelled is essential for neural connectivity and Planar Cell Polarity in planarians. Proc. Natl. Acad. Sci. 2011, 108; 2813-2818

Enrique Fernández-Taboada, Gustavo Rodríguez-Esteban, Emili Saló, Josep F Abril. A proteomics approach to unravel the molecular nature of planarian stem cells. BMC genomics [Highly Accessed mention], 12(133):e1-e13, 2011

Marta Iglesias, Maria Almuedo-Castillo, Aziz Aboobaker and Emili Saló. Early planarian brain formation is independent of regenerative polarity mediated by the Wnt/bcatenin pathway. Developmental Biology 358: 68-78, 2011

Mª Dolores Molina, Emili Saló and Francesc Cebrià. Organizing the DV axis during planarian regeneration. Communicative & Integrative Biology 4:4, 498-500, 2011

Guoliang Chai, Changxin Ma, Kai Bao, Liang Zheng, Xinguan Wang, Zhirong Sun, Emili Saló, Teresa Adell, Wei Wu. Complete functional segregation of planarian b-catenin1 and -2 in mediating Wnt signaling and cell adhesion. J Biol Chem 31: 24120-24130, 2010

Enrique Fernandéz-Taboada, Sören Moritz, Martin Stehling, Dagmar Zeuschner , Hans R. Schöler, Emili Saló and Luca Gentile. Smed-SmB, a member of the (L)Sm protein superfamily, is essential for chromatoid body organization and planarian stem cell proliferation. Development 137: 1055-1065, 2010

Cristina González-Estévez and Emili Saló. Autophagy and apoptosis in planarians. Apoptosis 15: 279-292, 2010

Adell, T., Saló, E., Boutros, M., and Bartscherer, K. Smed-Evi/Wntless is required for b-catenin dependent and -independent processes during planarian regeneration. Development 136: 905-910; 2009

Emili Saló, Josep F. Abril, Teresa Adell, Francesc Cebrià, Kay Eckelt, Enrique Fernández-Taboada, Mette Handberg-Thorsager, Marta Iglesias, María D. Molina and Gustavo Rodríguez-Esteban. Planarian regeneration: achievements and future directions after 20 years of research. International Journal of Developmental Biology, 53: 1317-1327; 2009

Maria Dolores Molina; Francesc Cebria; Emili Saló. Expression pattern of the expanded noggin gene family in the planarian Schmidtea mediterranea. Mech. Dev. Gene expression Pattern, en premsa, 2009

Mette Handberg-Thorsager, Enrique Fernandez and Emili Saló. Stem cells and regeneration in planarians. Frontiers in Bioscience 13:6374-6394; 2008

Marta Iglesias; Jose Luis Gomez-Skarmeta; Emili Saló; Teresa Adell. Silencing of Smed-β-catenin1 generates radial-like hypercephalized planarians. Development 135; 1215-1221; 2008

Teresa Adell, Maria Marsal and Emili Saló. Planarian GSK3s are involved in neural regeneration. Dev. Genes. & Evol. 218, 89-103; 2008

Gianluca Tettamanti1, Emili Saló, Cristina González-Estévez, Daniel A. Felix, Annalisa Grimaldi and Magda de Eguileor. Autophagy in Invertebrates: Insights Into Development, Regeneration and Body. Remodeling. Current Pharmaceutical Design 14, 116-125; 2008

Cristina González-Estévez, Daniel A. Felix, Aziz A. Aboobaker and Emili Saló. Gtdap-1 and the Role of Autophagy During Planarian Regeneration and Starvation. Autophagy 3; 6 ; 640-642; 2007

Maria Dolores Molina; Francesc Cebria; Emili Saló. The BMP pathway is essential for re-specification and maintenance of the dorsoventral axis in regenerating and intact planarians. Developmental Biology 311; 79-94; 2007

Cristina González-Estévez, Daniel A. Felix, Aziz A. Aboobaker and Emili Saló. Gtdap-1 promotes autophagy and is required for planarian remodelling during regeneration and starvation. Proc. Natl. Acad. Sci. 104; (33); 13373-13378; 2007

CONTACT _Con-4062F8461 \c \s \l Mette Handberg-Thorsager and Emili Saló. The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Dev. Genes. & Evol. 217(5);403-411; 2007

Araúz, P.A., E. Saló, F. Mestres, and L. Serra. New wing and eye mutations in D. subobscura. Mutation notes. DIS 89, 138- 139, 2006

Jiménez, E., Paps, J., García-Fernàndez J. & Saló, E. Hox and paraHox genes in nemertodermatida, a basal bilaterian clade. Int. J. Dev. Biol. 50; 675-679; 2006

Saló, E. The power of regeneration and the stem cells kingdom: The freshwater planarian Schmidtea mediterranea (Platyhelminth). Bioessays  28(5):546-559; 2006

Saló, E. Control genético del desarrollo del ojo. Investigación y Ciencia Noviembre 2004; ESP, Review

Mannini, L., Rossi, L.,  Deri, P., Gremigni, V., Salvetti, A.,  Saló, E. & Batistoni, R. Djeyes absent (Djeya) controls prototypic planarian eye regeneration by cooperating with the transcription factor Djsix-1. Developmental Biology 269; 346-359; 2004

Cook, C., Jiménez, E., Akam, M. & Saló, E. The Hox gene complement of Acoel flatworms, a basal bilaterian clade. Evol. & Dev. 6:3; 154-163; 2004

Gonzalez-Estevez, C., Momose, T., Gehring, W.J. & Saló, E. Planarian transgenic lines obtained by electroporation using transposon-derived vectors and eye-specific GFP marker. Proc. Natl. Acad. Sci. 100; no 24; 14046-14051; 2003

Marsal, M., Pineda, D.& Saló, E. Gtwint-5 a member of the wnt family expressed in the central nervous system of Platyhelminthes. Mech. Dev G E P 3; 489-495; 2003

Pasquinelli, A.E., McCoy, A., Jimenez, E., Saló, E., Ruvkum, G., Martindale, M.Q. & Baguñà, J. Expression of the 22 nucleotide let-7 heterocronic RNA throughout the Metazoa: A role in life history evolution?. Evol. & Dev. 5; 4; 372-378; 2003

Pineda, D., Saló, E. Planarian Gtsix3, a member of the Six/so gene family, is expressed in brain branches but not in eye cells Mech. Dev G E P. 2;169-173; 2002

Shagin, D.A., E.V. Barsova, E. Bogdanova, O.V. Britanova, N. Gurskaya, K.A. Lukyanov, M.V. Matz, N.I. Punkova, N.Y. Usman, E.P. Kopantzev, E. Saló, and S. Lukyanov. Identification and characterization of a new family of C-type lectin-like genes from planaria Girardia tigrina.  Glycobiology  12; 463-72; 2002

Saló , E., Pineda, D., Marsal, M., Gonzalez, J., Gremigni, V. & Batistoni, R. Eye genetic network in Platyhelminthes: Expression and functional analysis of some players during planarian regeneration Gene 287; 67-74; 2002; Ned; Review

Saló, E & Baguñà, J.  Regeneration in Planarians and other worms. New findings, new tools and new perspectives. J. Exp. Zool. 292: 528-539; 2002; USA ; Review

Pineda, D., Rossi, A., Batistoni, R., Salvetti, A., Marsal, M., Gremigni, V., Falleni, A., Gonzalez, J., Deri, P. & Saló , E. The genetic network of prototypic planarian eye regeneration is Pax-6 independent. Development 129: 1423-1434; 2002

Pineda, D., Gonzalez, J., Marsal, M. & Saló , E.  Functional analysis of the eye genetic network in planarian regeneration Int.J. Dev. Biol. 45 (Supplement 1): 123-124; 2001

Saló, E., Tauler, J., Jimenez, E., Bayascas, J.R., Gonzalez-Linares, J., Garcia-Fernàndez, J. & Baguñà, J. Hox and ParaHox genes in flatworms. Characterization and expression.. American Zoologist 41: 652-663; 2001

Pineda, D., Gonzalez, J., Marsal, M. & Saló , E. Evolutionary conservation of the initial eye genetic pathway in planarians. J. Bel. Zool. 131(Supplement 1): 77-82; 2001

Pineda, D., Gonzalez, J., Callaerts, P., Ikeo, K., Gehring, W.J. & Saló, E. Searching for the prototypic eye genetic network: sine oculis is essential for eye regeneration in planarians. Proc. Natl. Acad. Sci. 97: 9, 4525-4529; 2000

Callaerts, P., Munoz-Marmol, A.M., Glardon S., Castillo, E., Sun, H., Li, W-H ,  Gehring, W.J. & Saló, E. Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina. Proc. Natl. Acad. Sci. 96: 558-563; 1999

Bayascas-Ramírez, J. R.,Castillo, E., Muñoz-Mármol, A. M. Baguñà, J. & Saló,E. Synchronous and early activation of planarian Hox genes and re-specification of body axes during regeneration. Hydrobiologia. 383: 125-130; 1998

Stornaiuolo A, Bayascas JR, Saló E,  Boncinelli E. A homeobox gene of the orthodenticle family is involved in antero-posterior patterning of regenerating planarians. Int. J. Dev. Biol. 42: 1153-1158; 1998.

Bayascas, J. R., Castillo, E., and Saló, E. Platyhelminthes have a Hox code differentially activated during regeneration, with genes closely related to those of spiralian protostomes. Dev. Genes. Evol. 208; 467-473; 1998

Muñoz-Màrmol, A. M., Casali, A., Miralles, A., Bueno, D., Bayascas, J. R., Romero, R., and Saló, E..Characterization of Platyhelminth POU domain genes: ubiquitous and specific anterior nerve cell expression of different epitopes of GtPOU-1.  Mech. Dev 76; 127-140; 1998

Muñoz-Mármol, A. M., Bayascas-Ramírez, J. R.,Castillo, E., Casali, A. & Saló,E.. Planarian homeobox gene Dtprd-1 is expressed in specific gland cells, and belongs to a new family within the paired-like class. Dev. Genes Evol. 207 (5), 296-305, 1997

Bueno, D., Castillo, E., Vispo, M., Cebria, F., Bayascas-Ramírez, J. R., Saló, E.& Romero, R. New protocol to visualize gene expression in intact and regenerating adult planarians by whole-mount in situ hybridization. (t01222). Tech. Tips on line, 12/11/1997

Tauler, J., Baguñà, J.  Saló & Garcia-Fernàndez, J. Distox genes: A milestone in the evolution of Hox clusters? Int.J. Dev. Biol. Supplement 1; pp 69S-70S; 1997

Bayascas-Ramírez, J. R.,Castillo, E., Muñoz-Mármol, A. M. & Saló,E. Planarian Hox genes: novel patterns of expression during regeneration. Development 124; pp. 141-148; 1997

Saló E, Muñoz-Marmol, A.M., Bayascas-Ramirez J.R., García-Fernández J., Casali, A., Corominas, M., &Baguñà J. The freshwater planarian Dugesia(G)tigrina.contains a great diversity of homeobox genes. Hydrobiologia, 305, 269-275;1995

Garcia-Fernàndez, J., Bayascas-Ramírez, J. R., Marfany, G., Muñoz-Mármol, A. M., Casali,  A., Baguñà, J.  & Saló, E. High copy number of highly conserved mariner-like transposons in planarian (Platyhelminthe): Evidence for a trans-phyla horizontal transfer. Mol. Biol. Evol. 12, 421-431; 1995

Baguñà, J., Saló, E., Romero, R., Garcia-Fernàndez, J., Bueno, D., Muñoz-Mármol, A. M., Bayascas-Ramírez, J. R. & Casali, A. Regeneration and pattern formation in planarians: Cells, molecules and genes. Zool. Sci. 11, No6, 781-795; 1994; JPN; Review.

Burgaya F., García-Fernández J., Riutort M., Baguñà J., & Saló E. Structure and expression of spk-1, a src-related gene product found in the simple triblastic Dugesia(G)tigrina.. Oncogene  9, 1267-1272; 1994.

Garcia-Fernàndez, J., Marfany, G., Baguñà, J. & Saló E. . Mariner, ¿de simple transposón a vector general de integración? Investigación y Ciencia, Diciembre (1993), 32-35

García-Fernández J., Marfany, G., Baguñà J., Saló E. Infiltration of mariner elements. Nature(Lond).364, 109-110 (1993) (Scientific Correspondence)

García-Fernández J., Baguñà J.,  Saló E.. Genomic organization and expression of the planarian homeobox genes Dth-1 and Dth-2. Development. 118; pp. 241-253; 1993

García-Fernández J., Baguñà J., Saló E.. Planarian Homeobox genes: Cloning, sequence analysis, and expression. Proc. Natl. Acad. Sci. 88; pp. 7338-7342; 1991

Saló E, Baguñà J. Regenation and pattern formation in planarians. III. Evidence that neoblasts are tolipotent stem-cells and the source of blastema cells . Development. 107; pp. 77; 86; 1989

Saló E, Baguñà J. Regeneration and pattern formation in planarians. II. Local origin and role of cell movements in blastema formation. Development  107; pp. 69; 76; 1989

Baguñà J., Saló E. Romero R.. Effects of activators and antagonists of the neuropeptides substance P and substance K on cell proliferation in planarians. Int. J. Dev. Biol. 33 pp. 261; 264; 1989

Saló E., Baguñà J. Changes in ornithine decarboxilase activity and polyamine content and effects of polymine inhibitors in the regenerating planarian Dugesia (G)tigrina. J. Exp. Zool. 250; pp. 150; 161; 1989

Baguñà J., Saló E., Collet J., Auladell M.C., Ribes M. Cellular, molecular and genetic approaches to regeneration and pattern formation in planarians. Fortschr. Zool.. 36; pp. 65; 78; 1988

Saló E, Baguñà J. Stimulation of cellular proliferacion and diferentiation in the intact regenerating planarian D. tigrina by the neuropeptide Substance P. J. of Experimental Zoology . 237; 1; 129; 136; 1986

Robertis E.M. Fritz A, Goetz J, Martin G, Mattaj I.W., Saló E, Smith G.D, Wright C, Zeller R.. The Xenopus homeoboxes. Cold Spring Harbor Symposia on Quantitative Biology. 50; 271; 276; 1985

Saló E, Baguñà J. Proximal and distal transformation during intercalary regeneration in the planarian D. tigrina. Evidence using a chromosomal marker. Roux´Archives of Developmental Biology. 194; pp. 364; 368; 1985

Saló E, Baguñà J. Cell movement intact and regenerating planarians. Quantitation using chromosomal, nuclear and cytoplasmatic markers. J. Embryol. exper. Morphol. 89; pp. 57; 70; 1985

Saló E, Baguñà J. Regeneration and pattern formation in planarians. I. The pattern of mitosis in anterior and posterior regeneration in D. tigrina. J. Embryol. exper. Morphol. 83; pp. 63; 80; 1984

Capítols de llibre

Cebrià, F.; Adell, T.; Abril, J.F.; Saló, E. La regeneració i l’homeòstasi en les planàries, un model clàssic de biologia del desenvolupament. Book chapter in: Treballs de la Societat Catalana de Biología, “Organismes model en biología”, M. Corominas & M. Valls eds., Vol 62, pp: 93-106, 2011

Adell, T., Cebrià, F. Saló, E. Planarian totipotent stem cells.Stem Cells. In press (United States of America): Science Publishers, Inc., Enfield (NH), USA, Plymouth, UK, 2013

Francesc Cebrià, Teresa Adell, Emili Saló. Regenerative medicine: lessons from planarians. Book Chapter : Stem cells, regenerative medicine and cancer. Elsevier, 2010

Teresa Adell, Francesc Cebrià and Emili Saló. Gradients in planarian regeneration and homeostasis. Generation and Interpretation of Morphogenetic Gradients Editors: James Briscoe, Peter Lawrence, and Jean-Paul Vincent. Cold Spring Harbor Laboratory Press, 2010

Emili Saló and Renata Batistoni. Animal models in eye research ed. P.A. Tsonis Book Chapter: Planarian eye, a simple and plastic system with great regenerative capacity. Elsevier, 2008

Bueno, D. Romero, R. &Saló, E.RNAi techniques applied to freshwater planarians (Platyhelminthes) during regeneration. In J. Knight, M. Marí-Beffa (ed.), Key Techniques in Practical Developmental Biology. Cambridge University Press, Cambridge. In press; 2005

Saló, E., Watson, N. & Schockaert, E. Proceedings of the 9th International Symposium on The Biology of the Turbellaria. J. Bel. Zool. 131(Supplement 1); 2001;  236 pp.; Bel; E

Baguñà J., Romero R., Saló E. et al.. Growth /degrowth amd regeneration as development phenomena in adult freshwater planarians. "Experimental Embryology in aquatic Plant and Animal Organisms" NATO-ASI Series H.J. Marthy, Plenum Press. pp. 129-162; 1990;  New York; USA; Review