Departament de Genètica 


Montserrat Aguadé
Ricard Albalat
Elvira Juan
Francesc Mestres
Montserrat Papaceit
Marta Pascual
Julio Rozas
Carmen Segarra
Lluís Serra





Powell JR; Dion K; Papaceit M; Aguadé M; Vicario S; Garrick RC. (2011) Non-recombining Genes in a Recombination Environment: The Drosophila 'Dot' Chromosome. Mol Biol Evol 28: 25-33. Epub 2010 Oct 12.

Conceição IC; Aguadé M. (2010) Odorant Receptor (Or) Genes: Polymorphism and Divergence in the D. melanogaster and D. pseudoobscura Lineages. PLoS One 5(10): e13389.

Kirkness, E. F.; others (including M. Aguadé) . (2010) Genome sequences of the human body louse and its primary endosymbiont provides insights into the permanent parasitic lifestyle. Proc Natl Acad Sci U S A 107(27):12168-73. Epub 2010 Jun 21.

Orengo D. J.; Aguadé M. (2010) Uncovering the footprint of positive selection on the X chromosome of Drosophila melanogaster. Mol Biol Evol 27: 153-160.

Alvarez-Ponce, D.; Aguadé, M.; Rozas, J. (2009) Network-level molecular evolutionary analysis of the insulin/TOR signal transduction pathway across 12 Drosophila genomes. Genome Res. 19: 234 - 242.

Aguadé M. (2009) Nucleotide and copy-number polymorphism at the odorant receptor genes Or22a and Or22b in Drosophila melanogaster. Mol Biol Evol 26: 61-70.

Guirao-Rico S.; Aguadé M. (2009) Positive selection has driven the evolution of the Drosophila insulin-like receptor (InR) at different timescales. Mol Biol Evol 26: 1723-1732.

Schaeffer SW, Bhutkar A, McAllister BF, Matsuda M, Matzkin LM, O'Grady PM, Rohde C, Valente VL, Aguadé M, Anderson WW, Edwards K, Garcia AC, Goodman J, Hartigan J, Kataoka E, Lapoint RT, Lozovsky ER, Machado CA, Noor MA, Papaceit M, Reed LK, Richards S, Rieger TT, Russo SM, Sato H, Segarra C, Smith DR, Smith TF, Strelets V, Tobari YN, Tomimura Y, Wasserman M, Watts T, Wilson R, Yoshida K, Markow TA, Gelbart WM, Kaufman TC (2008) Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps. Genetics 179:1601-1655.

Nóbrega C, Khadem M, Aguadé M, Segarra C (2008) Genetic exchange versus genetic differentiation in a medium-sized inversion of Drosophila: the A2/Ast arrangements of Drosophila subobscura. Mol Biol Evol25:1534-1543.

Conceição IC, Aguadé M (2008) High incidence of interchromosomal transpositions in the evolutionary history of a subset of or genes in Drosophila. J Mol Evol 66:325-332.

Ramos-Onsins SE, Puerma E, Balañá-Alcaide D, Salguero D, Aguadé M (2008) Multilocus analysis of variation using a large empirical data set: phenylpropanoid pathway genes in Arabidopsis thaliana. Mol Ecol 17:1211-1223.

Orengo, D.J.; Aguadé, M. Genome Scans of Variation and Adaptive Change: Extended Analysis of a Candidate Locus Close to the phantom Gene Region in Drosophila melanogaster (2007) Molecular Biology and Evolution 24: 1122-1129

Papaceit, M.; Ávila, V.; Aguadé, M.; García-Dorado, A (2007) The Dynamics of the roo Transposable Element In Mutation-Accumulation Lines and Segregating Populations of Drosophila melanogaster. Genetics 177: 511-522

Drosophila 12 Genomes Consortium. Clark, et al. (2007) Evolution of genes and genomes on the Drosophila phylogeny. Nature 450: 203-218. Nature 450: 213-218

Quesada, H.; Ramos-Onsins, S.E.; Rozas, J.; Aguadé, M. (2006) Positive selection versus demography: evolutionary inferences based on an unusual haplotype structure in Drosophila simulans. Mol. Biol. Evol. 23: 1643-1647.

Balañá-Alcaide, D., Ramos-Onsins, S. E., Boone, Q. & Aguadé, M. (2006) Highly structured nucleotide variation within and among Arabidopsis lyrata populations at the FAH1 and DFR gene regions. Mol. Ecol. 15: 2059-2068.

Papaceit, M., Aguadé, M. & Segarra, C.  (2006) Chromosomal evolution of elements B and C in the Sophophora subgenus of Drosophila: evolutionary rate and polymorphism. Evolution 60: 768-78.

Braverman, J., Lazzaro, B., AguadÉ, M. & Langley, C. H. (2005) DNA Sequence Polymorphism and Divergence at the erect wing and suppressor of sable loci of Drosophila melanogaster and D. Simulans. Genetics 170: 1153-1165 (2005).

Munté, A., Rozas, J., Aguadé & M. Segarra, C. (2005) Chromosomal inversion polymorphism leads to extensive genetic structure: a multilocus survey in Drosophila subobscura. Genetics 169:1573-1581.

Quesada, H., Ramos-Onsins, S. E., & Aguadé, M. (2005) Birth-and-death evolution of the Cecropin multigene family in Drosophila. J. Mol. Evol. 60: 1-11.

Orengo, D. J. & M. Aguadé, M. (2004) Detecting the Footprint of Positive Selection in a European Population of Drosophila melanogaster: Multilocus Pattern of Variation and Distance to Coding Regions. Genetics 167: 1759-1766.

Piccinali, R., Aguadé, M., & Hasson, E. (2004) Comparative Molecular Population Genetics of the Xdh Locus in the Cactophilic Sibling Species Drosophila buzzatii and D. koepferae. Mol. Biol. Evol. 21: 141-152.

Ramos-Onsins, S. E., Stranger, B. E., Mitchell-Olds, T. & Aguadé, M. (2004) Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A. lyrata. Genetics 166: 373-388.

Sánchez-Gracia, A., Aguadé, M. & Rozas, J. (2003) Patterns of nucleotide polymorphism and divergence in the odorant-binding protein genes OS-E and OS-F: analysis in the melanogaster species subgroup of Drosophila. Genetics 165:

Quesada, H., Ramírez, U. E. M., Rozas, J. & Aguadé, M. (2003) Large-scale adaptive hitchhiking upon high recombination. Genetics 165: 895-900.

Pérez, J. A., Munté, A. Rozas, J., Segarra, C. & Aguadé, M. (2003) Nucleotide polymorphism in the RpII215 gene region of the insular species Drosophila guanche: reduced efficacy of weak selection on synonymous variation. Mol. Biol. Evol. 20: 1867-1875.

Navarro-Sabaté, A., Aguadé, M. & Segarra, C. (2003) Excess of nonsynonymous polymorphism at Acph-1 in different gene arrangements of Drosophila subobscura. Mol. Biol. Evol. 20: 1833-1843.

Kuittinen, H., Salguero, D. and Aguadé, M. (2002) Parallel patterns of sequence variation within and between populations at three loci of Arabidopsis thaliana. Mol. Biol. Evol. 19: 2030-2034.

Kuittinen, H., Aguadé, M., Charlesworth, D., de Haan, A., Lauga, B., Mitchell-Olds, T., Oikarinen, S., Ramos-Onsins, S., Stranger, B., van Tienderen, P. and Savolainen, O. (2002) Primers for 22 candidate genes for ecological adaptations in Brassicaceae. Mol. Ecol. Notes 2: 258-262.

Rozas. J., Gullaud, M., Blandin, G. and Aguadé, M. (2001) DNA variation at the rp49 gene region of Drosophila simulans: Evolutionary inferences from an unusual haplotype structure. Genetics 158: 1147-1155.

Munté, A., Aguadé, M. and Segarra, C. (2001) Changes in the recombinational environment affect divergence at the yellow gene in Drosophila. Mol. Biol. Evol. 18: 1045-1056.

Khadem, M., Rozas, J., Segarra, C., and Aguadé, M. (2001) DNA variation at the rp49 gene region in Drosophila madeirensis and D. subobscura from Madeira: inferences about the origin of an insular endemic species. J. Evol. Biol. 14: 379-387.

Aguadé, M. (2001) Nucleotide sequence variation of two genes of the phenylpropanoid pathway, the FAH-1 and F3H genes, in Arabidopsis thaliana Mol. Biol. Evol. 18: 1-9.

Munté, A., Aguadé, M. and Segarra, C. (2000) Nucleotide variation at the yellow gene region is not reduced in Drosophila subobscura: A study in relation to chromosomal polymorphism. Mol. Biol. Evol. 17: 1942-1955

Llopart, A. and Aguadé, M. (2000) Nucleotide polymorphism at the RpII215 gene in Drosophila subobscura: weak selection on synonymous mutations. Genetics 155: 1245-1252

Kuittinen, H. and Aguadé, M. (2000) Nucleotide variation at the Chalcone Isomerase locus in Arabidopsis thaliana. Genetics 155: 863-872.

Llopart, A. and Aguadé, M. (1999) Synonymous rates at the RpII215 gene of Drosophila: variation among species and across the coding region. Genetics 152: 269-280.

Navarro-Sabaté, À., Aguadé, M. and Segarra, C. (1999) The relationship between allozyme and chromosomal polymorphism inferred from nucleotide variation at the Acph-1 gene region of Drosophila subobscura. Genetics 153: 871-889.

Navarro-Sabaté, À., Aguadé, M. and Segarra, C. (1999) The Acid phosphatase-1 gene region in the Drosophila species of the subsobscura cluster. Hereditas 130: 65-75

Comeron, J.M., Kreitman, M. and Aguadé, M. (1999) Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila Genetics 151: 239-249

Rozas, J., Segarra, C., Ribó, G.and Aguadé, M. (1999) Molecular population genetics of the rp49 gene region in different chromosomal inversions of Drosophila subobscura Genetics 151: 189-202

Llopart,, A. and Aguadé, M. (1998) A new naturally occurring inversion in Drosophila subobscura. Dros. Inf. Service 81: 143-144

Aguadé, M. (1998) Different selective forces drive the evolution of the Acp26Aa and Acp26Ab accessory gland peptide regions in species of the Drosophila melanogster complex. Genetics 150: 1079-1089

Comeron, J.M. and Aguadé, M. (1998) An evaluation of measures of synonymous codon usage bias. J.Mol.Evol. 47: 268-274

Cirera, S., and Aguadé, M. (1998) Molecular Evolution of a duplication: the Sex-Peptide (Acp70A) gene region of Drosophila subobscura and D. madeirensis. Mol.Biol.Evol. 15: 986-996

Cirera, S. and Aguadé, M. (1998) The Sex-Peptide gene (Dm Acp70A) is duplicated in Drosophila subobscura. Gene 210: 247-254

Khadem, M., Rozas, J., Segarra, C., and Aguadé, M. (1998) Tracing the colonization of Madeira and the Canary Islands by Drosophila subobscura ancestors through the study of the rp49 gene region. J. Evol. Biol. 11: 439-452

Ramos-Onsins, S., Segarra, C., Rozas, J., and Aguadé, M. (1998) Molecular and chromosomal phylogeny of the obscura group of Drosophila inferred from sequences of the rp49 gene region. Mol. Phyl. Evol. 9: 33-41

Ramos-Onsins, S. and Aguadé, M. (1998) Molecular Evolution of the Cecropin multigene family in Drosophila: Functional genes vs. pseudogenes. Genetics 150: 157-171.

Munté, A., Aguadé, M. and Segarra, C. (1997) Divergence of the yellow gene between Drosophila melanogaster and D. subobscura: recombination rate, codon bias and synonymous substitutions. Genetics 147: 165-175

Cirera, S. and Aguadé, M. (1997) Evolutionary history of the sex-peptide (Acp70A) gene region in Drosophila melanogaster. Genetics 147: 189-1975.

Comeron, J. M. and Aguadé, M. (1996) Synonymous substitutions in the Xdh gene of Drosophila: Heterogeneous distribution along the coding region. Genetics 144: 1053-1062.

Segarra, C., Ribó, G. and Aguadé, M. (1996) Differentiation of Muller's chromosomal elements D and E in the obscura group of Drosophila. Genetics 144: 139-146

Segarra, C., Lozovskaya, E. R., Ribó, G., Aguadé, M. and Hartl, D. L. (1995) P1 clones from Drosophila melanogaster as markers to study the chromosomal evolution of Muller's A element in two species of the obscura group of Drosophila . Chromosoma 104: 129-136.

Rozas, J., Segarra, C., Zapata, C., Alvarez, G. and Aguadé, M. (1995) Nucleotide polymorphism at the rp49 region of Drosophila subobscura: Lack of geographic subdivision within chromosomal arrangements in Europe. J. Evol. Biol. 8: 355-367.

Clark, A. G., Aguadé, M., Prout, T., Harshman, L. G. and Langley, C. H. (1995) Variation in the sperm displacement and its association with accessory gland protein loci in Drosophila melanogaster. Genetics 139:189-201.

Cirera, S., Martín-Campos, J. M., Segarra, C. and Aguadé, M. (1995) Molecular characterization of the breakpoints of an inversion fixed between Drosophila melanogaster and D. subobscura. Genetics 139: 321-326.

Capítols de llibre

Aguadé, M., Rozas, J. and Segarra, C. (2004) Inferring the action of natural selection from DNA sequence comparisons: data from Drosophila. In Evolution: from Moleculaes to Ecosystems (eds. A. Moya and E. Font) pp. 11-19.

Schaeffer, S. and Aguadé, M. (2000) Evidence for balancing, directional and background selection in Molecular Evolution. Genetics, Evolution and Society. R. Singh and C. Krimbas (eds.).