Plan docente de la asignatura

 

 

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Datos generales

 

Nombre de la asignatura: Nanopartículas para Imagen Médica y Suministro de Fármacos

Código de la asignatura: 571453

Curso académico: 2019-2020

Coordinación: Silvia Pujals Riatos

Departamento: Departamento de Ingeniería Electrónica y Biomédica

créditos: 2,5

Programa único: S

 

 

Horas estimadas de dedicación

Horas totales 62.5

 

Actividades presenciales

28

 

-  Teoría

 

16

 

-  Teórico-práctica

 

12

Trabajo tutelado/dirigido

20

Aprendizaje autónomo

14.5

 

 

Recomendaciones

 

Attendance:

  • The course will be divided into theoretical master classes (minimum 80% compulsory attendance) and practical sessions in the laboratory (100% compulsory attendance).


Otras recomendaciones

Irregularities in evaluated activities

  • If any sign of plagiarism/copying is detected in an evaluated activity, the minimum penalty will be a grade of zero. If the same student plagiarizes/copies a second time during the same course, the teacher will grade the whole subject with a zero and the student will not have the right to re-evaluation.
  • That which is established in this paragraph is without prejudice to the disciplinary process that can be initiated as a result of the acts carried out. See also article 16.7 of the Regulations for the subjects teaching plans and the assessment and qualification of the learnings (approved by the Governing Council on May 8, 2012).

 

 

Competencias que se desarrollan

 

Basic


  • To possess and fully understand the knowledge that provides a base from which or an opportunity to make original progress in the development and/or application of ideas, often in a research context

  • That all students know how to apply the knowledge acquired and its capacity to resolve problems in new or unfamiliar settings within broader (or multidisciplinary) contexts related to the field of study

  • That all students are capable of integrating knowledge and dealing with the complexity of forming judgements based on information that, while incomplete or limited, includes reflections on social and ethical responsibilities linked to the application of their knowledge and judgements

  • That all students know how to communicate their conclusions, as well as the knowledge and reasons that support them, to both specialist and lay audiences in a clear and unambiguous way in written reports.

  • That all students have the learning skills that allow them to continue studying in a manner that will have to be to a great extent independent and for which they take responsibility.

 

General


  • To acquire skills related to research methods.

  • To be ethically, environmentally and professionally responsible in engineering undertakings

  • To work in a team and lead it.

  • To Work as part of multidisciplinary teams and collaborate with other colleagues in the area.

  • To be able to communicate in an efficient way in different linguistic, cultural and social settings, as well as globally.

  • To have the knowledge of the basic and technological material that enables the learning of new methods and technologies, together with the versatility to adapt to new situations

  • Integrate advanced technological knowledge and improve the skills and specific skills for work in an experimental laboratory in the field of R + D + C medicines

 

Specific


  • To manage personal bibliographies, documentation, databases, software and legislation that affects the area, as well as the specific documents related to medical technology and innovation in this area.

  • To define reasonable hypotheses and develop solutions to complex partially defined problems or those which could have multiple viable innovative alternative solutions.

  • To compare, analyze and use technological advances in biomedical engineering to meet clinical requirements and improve health management in all areas of prevention, follow-up and intervention.

  • To compare, classify and apply the concepts and methods of advanced technologies such as nanomedicine, drug delivery and nanodiagnostics.

  • To evaluate and meet the need for the transfer of technology and innovation, patents and an entrepreneurial culture in the field of biomedical engineering.


  • Be able to assimilate the current therapeutic approaches to diagnostic imaging and the controlled transport of drugs based on the use of nanoparticles.

  • Identify different strategies on the experimental and clinical use of nanomaterials for the treatment of different pathologies, as well as the main advances in the incorporation of drugs.

  • Be able to propose the synthesis and characterization of different classes of nanoparticles of interest in Nanomedicine.

  • Design and plan nanoparticle research for biomedical purposes.

  • Design and plan new nanostructured systems for the controlled release of drugs.

  • Apply the general knowledge in research, development and innovation of new pharmaceutical products based on nanomaterials

 

 

 

 

Objetivos de aprendizaje

 

Referidos a conocimientos


  • Knowing the different types of technologies and being able to select them for different tissue engineering applications

  • Analyzing the behavior and performance of technologies used in tissue engineering for clinical applications

  • The characteristics that nanoparticles must meet in order to be used for medical diagnosis by imaging and the controlled transport of drugs

  • The different methods of preparation of nanoparticles

  • The influence of synthesis on the properties of nanomaterials

 

Referidos a habilidades, destrezas


  • The ability to think beyond boundaries and systematically explore and generate new ideas’.

  • The ability to use cutting-edge research methods, processes and techniques towards new venture creation and growth and to apply these also in cross disciplinary teams and contexts’.

  • The ability to transform practical experiences into research problems and challenges.

  • Have a general view of the different types of nanoparticles that can be used for this purpose, being aware of the multidisciplinarity of this complex area

  • Be familiar with the various nanoparticle characterization techniques

  • Have a general vision and be familiar with several concrete examples of applications of nanoparticles in Nanomedicine

 

 

Bloques temáticos

 

1. Nanomaterials

1.1. Introduction to Nanomedicine

1.2. Nanomaterials

2. Nanoparticles

2.1. Types of nanoparticles

2.2. Fundamental aspects of nanoparticles design

3. Nanoparticle synthesis

3.1. Synthesis, stabilization, passivation and functionalization of each type of nanoparticle.

3.2. Nanoparticle characterization techniques

3.3. Bioavailability and toxicity

4. Nanoparticles for medical diagnostics

4.1. Nanoparticles as contrast agents for different imaging techniques

4.2. Nanoparticles for biosensing

5. Nanoparticles for controlled drug delivery

5.1. Drug loading

5.2. Drug release depending on nanoparticle type

5.3. Active targeting

6. Biological responses

6.1. Protein corona and immune response

6.2. Extravasation (EPR effect) and tissue penetration

6.3. Toxicity and clearance

7. Laboratory practices

*  Laboratory practices (12h)

  1. Preparation of a colloidal suspension of gold nanoparticles
  2. UV/Vis spectrophotometric measurements, DLS, Zeta potential and TEM of colloidal gold nanoparticles.
  3. Surface functionalization of gold nanoparticles and characterization with proteins.
  4. Formulation and drug encapsulation of polymeric nanoparticles.
  5. Silica nanoparticles characterization (DLS, TEM)
  6. Fluorescence imaging of nanoparticles intracellular transport

 

 

Metodología y actividades formativas

 

1. Face-to-face teaching
Theoretical classes

The theoretical classes are considered fundamentally as master classes, although the aim is to encourage the participation of the students as much as possible. These lessons will be complemented by recommended audiovisual material. Students may have a copy, printed or in electronic format, before the class.

Practical classes

It is expected the development of 6 practical sessions related to the preparation and characterization of nanomaterials with therapeutic applications: Preparation, surface functionalization and characterization of gold nanoparticles, formulation and drug encapsulation of polymeric nanoparticles, silica mesoporous nanoparticles characterization and fluorescence imaging of intracellular transport of nanoparticles.

2. Self-learning

Student outside class duties

The student will have to deepen in the subjects treated in the theoretical classes by means of the consultation of the bibliography that is suggested.

3. Supervised work

The student must submit two reports

a) a report from lab lectures

b) a report on a scientific article, chosen in a consensual manner with the professor related to the content of the subject.

 

 

 

Evaluación acreditativa de los aprendizajes

 

Evaluation
In this subject a continuous evaluation of the student will be carried by default.

The continuous evaluation of this subject will consist of:

1) Final exam (50% of the total grade) based on multichoice questions, short questions and / or comments of research articles, related to the theoretical and practical classes of the subject

2) Report related to practical sessions (25%);

3) Report related to a subject related scientific article (25%)

Reassessment:
All students are eligible to take the reassessment exam, which consists of a single written examination. Students who want to be reassessed should renounce to their previous grade, if any, before the test. The new obtained grade in this reassessment will replace the previous one.

 

Evaluación única

Single assessment
Single assessment comprises a final examination at the end of the semester, which represents 100% of the final grade for the subject. Students should deliver the suitable form to the secretary’s office within two weeks of the course’s start date. A signed copy of the form should also be delivered to the teacher.

Reassessment:
All students are eligible to take the reassessment exam, which consists of a single written examination. Students who want to be reassessed should renounce to their previous grade, if any, before the test. The new obtained grade in this reassessment will replace the previous one.

 

 

Fuentes de información básica

Consulteu la disponibilitat a CERCABIB

Libro

·       Edelstein, A.S., Cammarata C. (eds.), Nanomaterials: synthesis, properties and applications. Bristol : Institute of Physics Publishing, 1998.

·       Guozhong, C., Nanostructures & Nanomaterials: Synthesis, Properties & Applications, Imperial College Press, 2004.

·       Ozin, G., Arsenault, A., Nanochemistry: A Chemical Approach to Nanomaterials, Royal Society of Chemistry, Cambridge, UK, 2005.

·       Vogel, V. (ed.), Nanotechnology. V. 5: Nanomedicine. Wiley-VCH, Weinheim, 2009

·       Schmid, G. (ed.), Nanoparticles. From theory to application. Wiley-VCH, Weinheim, 2010

·       Nagarajan, R , Hatton. T. A. (eds.) Nanoparticles: Synthesis, Stabilization, Passivation, and Functionalization.  V 996 American Chemical Society Series, 2008. 

Revista

·       Journal of Nanoparticles Research

http://www.springer.com/materials/nanotechnology/journal/11051