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Next IBUB Seminar " Understanding the Purinome: the Role of Nucleoside Transporters" |
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Date: June, 1st
Time:13:00 hours
Place: Aula 18 ( Aulari) ( Faculty of Biology)
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Next IBUB Seminar "La regulación del acetiloma por las sirtuinas y su relevancia en el envejecimiento" |
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Date: May, 30th
Time:12:00 hours
Place: Aula Magna ( Faculty of Pharmacy)
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The IBUB research group led by Francesc Villarroya participates in the discovery of a new mechanism of regulation of brown adipose tissue, as published in the May issue of the journal Cell. |
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The Bone morphogenetic protein B (BMP8B) plays a key role in the regulation of thermogenesis in brown adipose tissue, according to the conclusions, acting at both central and peripheral level. The finding was the result of investigations conducted by the research group of Antonio Vidal-Puig, University of Cambridge, UK, with the participation of laboratories from Iowa (USA), Stockholm (Sweden) and the team of Miguel Lopez from the University of Santiago de Compostela, a member of CIBERobn as the group of Francesc Villarroya.
For further information see:
http://www.ub.edu/web/ub/en/menu_eines/noticies/2012/05/077.html
http://www.ncbi.nlm.nih.gov/pubmed/22579288
www.ub.edu/tam
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Dr Eva-Estebanez Perpiñá from IBUB presents her research on Wednesday 23 May at a seminar of the series "Barcelona BioMed Seminars" on PCB |
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Date: May, 23rd
Time:9:30 hours
Place: Fèlix Serratosa Room (PCB)
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Mini-symposium IBUB: "Novel actors in the control of adiposity and energy metabolism." Friday June 22nd. Aula de Graus, Faculty of Biology. Morning (final program and schedule to confirm) |
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This is a mini-symposium on newly identified molecular agents that control metabolism and adiposity.
Speakers confirmed to date (preliminary titles)
- Andrew Whittle (Vidal-Puig lab)
University of Cambridge
Bmp8b, a novel regulator of brown tissue with central and peripheral adiposité action
- Lluís Fajas
IRCM, Institut de Recherche Cancérologie in Montpellier, Montpellier.
Cell cyle controllers and adiposity
- Manuel Serrano
CNIO Madrid
PTEN and the control of tissue biology and metabolism adiposité
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The research group led by Eva IBUB Estébanez-Perpiñá, has been selected to measure protein crystals in the ALBA Synchrotron, the largest scientific infrastructure of our country. |
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The scientific proposal of Eva Estébanez-Perpiñá has obatined synchrotron light time which will develop drug discovery projects against alternative for prostate cancer and o ther diseases in which nuclear receptors, the subject of her research group study, play a role (for ex. brain tumors and metabolic diseases). The ALBA synchrotron is an accelerator of electrons and the X-rays produced are used, among other applications, to determine the three dimensional structure of key proteins in normal and pathological biological processes.
Link
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The IBUB research team led by the Jordi Garcia-Fernandez, Department of Genetics, participates in the discovery, published in the journal Nature Communications, of a new family of six genes that regulate the movement and positioning of mitochondria in neurons. |
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This work was led by Eduardo Soriano of the Institute for Research in Biomedicine (IRB Barcelona). It is a cluster of six genes that could be altered in neurological diseases such as Parkinson's disease and Charcot-Marie-Tooth, which are caused by alterations in genes that regulate the transport of mitochondria, the organelles responsible for providing energy for cellular metabolism. For more information: http://www.ub.edu/web/ub/ca/menu_eines/noticies/2012/05/032.html
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CANCELLED Next IBUB Seminar "Rellevància de les interaccions tumor-estroma durant la progressió del càncer de mama i en resposta al tractament" |
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Date: April, 26th
Time:11:30 hours
Place: Aula 18 (Aulari, Faculty of Biology)
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The IBUB research group led by Daniel Grinberg and Susana Balcells, participant in a study of susceptibility genes for osteoporosis and fractures published in Nature Genetics. |
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Susana Balcells and Urreizti Roser, researchers from the IBUB and Department of Genetics of UB participated as co-authors in an extensive meta-analysis of Genomewide association (GWA) to identifysusceptibility genes for osteoporosis and fractures. In Barcelona, this group has done the research in collaboration with the Department of Internal Medicine, Hospital del Mar-IMIM-URFOA. This study has allowed the identification of 56 genetic loci associated with bone density and 14 loci associated with fracture risk. The study was conducted within the context of the consortium GEFOS (Genetic Factors forOsteoporosis Consortium) funded by the European Union .The article is accessible on the website of Nature Genetics as "Advanced online publication."
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A publication by the IBUB research team leaded by Francesc Villarroya, designated by the Journal of Biological Chemistry as one of the best papers published by the journal in 2011. |
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The paper is "Peroxisome Proliferator-activated Receptor-gamma Coactivator-alpha Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype” by Albert Giralt, Elayne Hondares, Francesc Ribas, Julieta Díaz-Delfín, Marta Giralt, Roser Iglesias and Francesc Villarroya.
The journal selected only 20 papers – out of the more than 4,000 that were published last year – to receive this special designation. They chose one paper for each of the jounral’s affinity groups, and the study by Albert Giralt and collaborators represents the best in the Bioenergetics affinity group.
Journal of Biological Chemistry will make a public announcement soon, and have made all of the Best of 2011 papers freely accessible at http://www.jbc.org/site/bestoftheyear.
The Journal of Biological Chemistry is the official journal of the American Society for Biochemistry and Molecular Biology (ASBBM), established in 1905, and it is among the international journals on Biochemistry with the highest international reputation.
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IBUB International Workshop on lipodystrophies organized in collaboration with the CIBER Physiopathology of Obesity and Nutrition, and the Spanish Society on Lipodystrophies
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The Institute of Biomedicine of the University of Barcelona (IBUB) has organized in collaboration with CIBER Physiopathology of Obesity and Nutrition and the Spanish Society on Lipodystrophies, the international research workshop "Lipodystrophies". Lipodystrohies are a group of genetic or acquired (eg as a result of treatment in patients infected with the AIDS virus) diseases. Patients suffer alterations in the distribution of fat in the body, often with loss in some areas and accumulation in other sites. Apart from the problems of disfigurement that may occur, there are also important metabolic abnormalities in patients, especially diabetes, liver steatosis and dyslipidemia, thus leading to a significant cardiovascular risk. The complexity in the origin and manifestation of these diseases make them poorly understood and treatment alternatives are scarce.
This session will bring together leading Spanish researchers in these diseases with the collaboration of international experts. |
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The Symposium is free open to the attendance of all interested researchers.
Complete Banner
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Researchers at IBUB, in collaboration with other research groups of the IBEC, Hospital Clinic and Vall d’Hebron, have made an important leap towards understanding the second most common neurodegenerative illness, Parkinson’s disease (PD) |
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Researchers at IBUB, in collaboration with other research groups of the IBEC, Hospital Clinic and Vall d’Hebron, have made an important leap towards understanding the second most common neurodegenerative illness, Parkinson’s disease (PD), which affects around 5% of the population by age 85. The identification of the pathophysiological mechanisms behind this neurodegenerative pathology has been particularly hampered by the lack of genuine in vitro models and animal models faithful to the human pathology. Parkinson’s, which can be either genetic or sporadic, is characterized by a selective loss of particular neurons located in the part of the brain responsible for controlling movement of the body. The recent work published in EMBO Molecular Medicine journal reports for the first time the generation of a new cellular model that recapitulates the Parkinson's disease in dopaminergic neurons derived from induced pluripotent stem cells (iPSC). "We obtained cells with similar features to embryonic stem cells from skin fibroblasts of genetic PD patients, sporadic PD patients and healthy control group", said Ángel Raya, who leads the Control of Stem Cell Potency group at IBEC. Then, the cells were differentiated to dopaminergic neurons, the type of cell which is degenerated in the pathology, and keeped in culture for three months in order to mimic the aging process that occurs in the brain of patients. "Surprisingly, we saw that the ones from both types of PD patients exhibited clear signs of neurodegeneration, including a decrease in number and size of neurites, and an increase in the number of apoptotic neurons, necessary to the development of the disease, but not the ones from the healthy patients.” said Antonella Consiglio, who leads the group of Neural Commitment and Differentiation at IBUB. |
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This reveals that susceptibility to sporadic (non-hereditary) PD should be coded in patients’ genomes just as clearly as other patients’ tendency to the hereditary kind, and it’s also the first time that the spontaneous phenotypes that lead to sporadic PD have been described. The researchers were also able to identify that the neuronal alteration leading to both types of PD are the result of altered autophagy (the process by which cells ‘spring clean’ themselves by degrading their toxic waste and damaged parts).
As well as shedding light on some of the key players and pathological mechanisms of the disease, the human experimental model generated, captures patients’ genetic complexity, displays the prominent features of PD, and can eventually enable the identification of new therapeutic strategies that may prevent or remedy PD-related neurodegeneration.
Sánchez-Danés A., et al (2012) Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson’s disease. EMBO Molecular Medicine, in press
http://onlinelibrary.wiley.com/doi/10.1002/emmm.201200215/pdf |
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IBUB HOT TOPIC SEMINAR "Neurophatic Pain" |
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Date: March, 9th
Time:10:00 hours
Place: Aula de Graus (Aulari, Faculty of Biology)
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IBUB Seminar "Regulation of gene expression during cellular differentiation" |
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Date: March, 7th
Time: 12:00 hours
Place: Aula de Graus (Aulari, Faculty of Biology)
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IBUB Seminar "RAGE: a pattern-recognition receptor" |
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Date: February, 22nd
Time: 12:00 hours
Place: Aula de Graus (Aulari, Faculty of Biology)
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Dr. Francesc Villarroya, was elected director of the IBUB for the next four years. |
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At the meeting of the executive council of IBUB, last January 13th, Dr. F.Villarroya was elected director for the next four years.
According to the regulation of IBUB, the elected director announced that Dr. Florenci Serras would remain as Secretary of IBUB for the next period. |
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Last IBUB Seminar "La glándula de Harder del hámster sirio. Un modelo de variaciones de estrés oxidativo y autofagia en condiciones fisiológicas" |
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Date: January 20th
Time: 13:00 hours
Place: Aula 10 (Aulari, Facultat de Biologia)
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A research on Nucleoside Transporter Proteins in placenta from the IBUB research team leaded by Dr. Marçal Pastor-Anglada, in the cover of the journal Molecular Pharmacology |
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New call for IBUB courses on Confocal Microscopy. |
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A new call has been opened to apply for IBUB courses on Confocal Microscopy. On this new offer there will be 4 editions: November 18th , November 25th, December 2nd and December 16th from 9 to 12 h.
Positions are open to all IBUB members and those who are interested should send an application via registration through "Confocal Microscopy Training" banner which you can find on the web page (bottom right) . |
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Last IBUB Seminar "Papel de adenosina sobre la disfunción de podocitos y células mesangiales en ratas diabéticas" |
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Date: September 30th
Time: 13:00 hours
Place: Aula de Graus (Faculty of Biology)
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Jordi García-Fernández, Ignacio Maeso, Manuel Irimia and Salvatore D’Aniello, from IBUB, participate in the discovery of the oldest DNA regulatory region. |
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The autors report in a recent publication in Proceedings of the National Academies of Sciences (PNAS) the identification of the oldest known DNA regulatory region, next to the soxB2 genes. The study is co-authored by the research groups of José Luis Gómez-Skarmeta (Centro Andaluz de Biología del Desarrollo, CSIC) and Eric H. Davidson (California Institute of Tehcnology, US). Advancement in the knowledge of the non-coding DNA regions involved in the control of gene expression is essential for biomedical research, as multiple genetic diseases are known to be caused by alterations in these regions.
For further information:
http://www.ub.edu/web/ub/en/menu_eines/noticies/2011/09/047.html
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Symposium "Nuclear hormone receptors: meet the family" next September 21st. |
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Date: September 21st
Time: 09:30 hours
Place: AULA MAGNA (Faculty of Biology)
program
FREE ENTRANCE |
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Four research groups from IBUB, in the Oncocat network |
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Oncocat network has been created to promote coordination between organizations and oncology research groups and promote synergies in research on cancer in Catalonia. IBUB groups led by Drs C. Ciutat, M. Pastor-Anglada, M. Cascante, A.Mazo and E. Estebanez are members of the newly created network.
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Last IBUB seminar "Adipocitos perivasculares y la señalización vía Receptores Toll-like: Papel en la patofisiología de aterosclerosis" |
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Date: June 16th
Time: 09:30 hours
Place: Aula 20- Aulari (Faculty of Biology)
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IBUB seminar " Mecanismos moleculares implicados en la resistencia a insulina asociada a la obesidad: papel del órgano adiposo" |
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Date: May 6th
Time: 13:00 hours
Place: Aula de Graus (Faculty of Biology)
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IBUB course on "Image Analysis: Introducing Fiji/Image J" |
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New call to attend the course on "Image Analysis: Introducing Fiji/Image J" for IBUB researchers. An offer of an intensive course of initiation treatment of Confocal Microscopy image analysis. The course will be held on April 28th and all the IBUB researchers interested in attending the course can make a request at the banner in red down right of the webpage ( Confocal microscopy training), option 3. ( Basic knowledge of confocal microscopy is not required)
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The order of submitting applications will be considered
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Marta Cascante, head of the research group on Integrative Systems Biology, metabolomics and Cancer of IBUB, awarded by ICREA Academy. |
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Dra Marta Cascante, Professor on Biochemistry and Molecular Biology department, has been awarded the ICREA incentive Academy of research excellence in the university system of Catalonia. Dra Cascante is a member of the Network of Cooperative Research on Cancer (RTICC) and of the R+D+i Reference Network in Theoretical and Computational Chemistry (XRQTC) of Catalonia. She has authored over 150 publications and her research focuses on the study of cancer and metabolic diseases with the aim of deepening, by the approach of systems biology, in the knowledge of networks and metabolic basic pathways that cause the development and progression of these diseases. |
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Andrés Iniesta supports research on Sanfilippo syndrome |
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The seventh edition of the book 'Stories of solidarity Sport” was presented as “ Sport Heroes “ and was sponsored by Andrés Iniesta. This initiative will spend its funds to the “Barcelona Sanfilippo Association” to help to study the congenital disease "Sanfilippo Syndrome". This disease is a form of mucopolysaccharidosis due to mutations in coding genes for some enzymes of the mucoplisacàrids degradation pathway. Symptoms appear after the first year of life, there is a lack of learning capacity in children affected and produces a deterioration in growth and mental state gradually.
The research group of IBUB "Human Molecular Genetics" directed by Daniel
Grinberg of the Department of Genetics of the University of Barcelona, and in particular the research line of lysosomal diseases conducted by Daniel Grinberg and Lluïsa Vilageliu, has made important contributions to the knowledge of the disease, having recently described and characterized seven new mutations in the Spanish population affected by Sanfilippo C ((Molecular analysis of Sanfilippo syndrome type C in Spain: seven novel HGSNAT mutations and characterization of the mutant alleles. Canals I, Elalaoui SC, Pineda M, Delgadillo V, Szlago M, Jaouad IC, Sefiani A, Chabás A, Coll MJ, Grinberg D, Vilageliu L.Clin Genet. 2010 Aug 2).
Isaac Canals (left in photo) is carrying out his doctoral thesis about this disease, under the direction of Drs Lluïsa Vilageliu and Daniel Grinberg (center in photo). |
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IBUB Seminar " The molecular basis of inflammation and cardiovascular diseases in aging" |
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Date: March 31st
Hour: 12:00 hours
Place: Aula 33 (Faculty of Biology)
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Key role of the protein NOVA in the assembly of complex gene networks during evolution, a new collaboration between the two groups of IBUB led by Dr. Jordi Garcia and Dr. Gemma Marfany, published this month in PNAS |
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The phenomena of maturation of alternative transcripts (differential splicing) have a critical role in differentiation, development and in many diseases. In fact, over 90% of human genes produce multiple transcripts and some splicing factors, such as protein NOVA that, through alternative splicing, regulates expression of a specific proteome, from tens to hundreds of genes, in the nervous central system of mammals. This paper shows how the network regulated by NOVA has been assembled step by step during the evolution of metazoans, first for the acquisition by protein NOVA of the capacity to produce specific splicing of vertebrates in the origins of chordates, second by restricting the expression of NOVA in the nervous central system just before the origins of vertebrates, and third by the acquisition of new exons and targets by NOVA during the evolution of vertebrates. This work shows that despite having a similar number of genes, the human proteome is much larger than those of invertebrates, and that the regulation of splicing factors and the creation of new exons are key in the assembly of specific gene networks of complex systems like the human nervous system, through the use of differential splicing.
Dr. Jordi Garcia
Evolution and development
Dra. Gemma Marfany
Human Molecular Genetics I
For more information +
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Next IBUB Seminar, HOT TOPIC SEMINARS "Cardiovascular Ion Channelopathies" |
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Date: March 18th
Time: 10:00 hours
Place: Aula de Graus (Faculty of Biology)
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IBUB researcher, Dra. Silvia Busquets, receives the "Antoni Caparrós" Award for the project "Formoterol: a new therapeutic strategy in the treatment of cachexia" |
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The fact that the Formoterol project is a product of Phase IIA advanced study in patients, as well as the continued collaboration and publications, are issues that have been valued to award with this “Antoni Caparrós” Prize to Dra. Silvia Busquets, lecturer of the Department of Biochemistry and Molecular Biology, Faculty of Biology and member of the research team of IBUB "Biochemistry and Molecular Biology of Cancer". The recipient of this knowledge transfer is a pharmaceutical company in Cambridge (UK), which elaborates products to treat the symptoms of patients with cancer. The patent was licensed in June 2008 to this pharmaceutical company that is now conducting a Phase IIA clinical study with patients in “Edinburgh Royal Infirmary Hospital” to verify the anti-cachectic efficacy in humans. |
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CANCELLED Next IBUB Seminar "Oxygen sensors and hypoxia-inducible factors in health and disease" |
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CANCELLED
Date: February 25th
Time: 13:00 hours
Place: Aula de Graus (Faculty of Biology)
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IBUB Researchers discovered a new factor with a key role in controlling dorsiventral body symmetry |
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The IBUB researchers M. Dolores Molina, Ignacio Maeso, Emili Saló and Francesc Cebrià discovered in planarian a new factor - the noggin-like protein - as a key role in the pathway that controls the pattern of dorsiventral body symmetry. The finding was published in an article in the journal "Current Biology" and the research has been carried out in collaboration with Ana Neto and José Luis Gómez-Skarmeta, of the "Centro Andaluz de Biologia del Desarrollo" CSIC.
For more information: http://www.ub.edu/web/ub/en/menu_eines/noticies/2011/02/07.html
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Last IBUB Seminar " mIGF-1/SirT1 signaling and epigenetics during cardiac stress" |
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Date: January 21st
Time: 12:00 hours
Place: Aula 18 (Aulari, Faculty of Biology)
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IBUB Seminar "Programas de Colaboración Académico-Científicos con la Universidad de Guadalajara (México). Oportunidades y Retos" |
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Date: January 19th
Time: 12:30 hours
Place: Aula Magna (Faculty of Pharmacy)
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IBUB offers 3 pre-doctoral fellowships for the realization of the thesis in interdisciplinary research projects in biomedicine. The projects selected by IBUB which will have these grants assigned are focused on basic experimental research on bioactive molecules with potential therapeutic application for human disease.
The scholarships are annually renewed with a maximum of 4 years and include the monthly salary and the expenses of the academic PhD at the University of Barcelona.
You can find details of the projects associated with the grants, the call features and application forms at the link:
http://convocatories.ub.es/bepj/56BB.html
Application Period: From January 3rd to January 17th |
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The group from IBUB led by Dr. Diego Muñoz-Torrero, Professor of the Department of Pharmacology and Therapeutic Chemistry from the Faculty of Pharmacy, has received financial support from the Spanish Genome Foundation to develop new compounds against Alzheimer’s disease. |
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This group has developed a patent for a group of multipotent compounds, with a pharmacological combined profile that includes beta-secretase inhibition and aggregation of beta-amyloid peptide, which should block the neurodegenerative cascade at various levels in initial stages. One of these compounds that has shown superior activity in vitro than the reference drug, donepezil, will be tested in model animals of Alzheimer's disease to obtain preliminary data of its efficacy and safety.
The Bosch i Gimpera Foundation manages a collaboration agreement between the research group and the Spanish Genome Foundation which will support and fund the proof of concept studies in animals and the optimitzation of preclinical development, as well as undertaking to help achieve the commercialization of these compounds.
Carles Galdeano, who made his PhD thesis with the financing of IBUB within the program to support interdisciplinary research projects in biomedical research in our Institute, has participated in this study, along with other members of the research team. He recently received an award from the pharmaceutical company Lilly in the eighth edition of its Research Awards for PhD students. |
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Last IBUB Seminar“miR-33: A New Master Regulator of Sterol Homeostasis” |
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Date: December 21st
Time: 12:00 hours
Place: Aula de Graus (Aulari, Faculty of Biology)
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IBUB Seminar “Epigenetics: from Cell Biology to Human Disease” |
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Date: December 20th
Time: 15:00 hours
Place: Aula Magna ( Faculty of Biology)
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IBUB Seminar “Metabolismo lipídico hipotalámico y regulación del balance energético” |
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Date: December 16th
Time: 16:00 hours
Place: Aula 18 (Aulari, Faculty of Biology)
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IBUB Seminar “Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids” |
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Date: December 10th
Time: 11:00 hours
Place: Aula de Graus (Aulari, Faculty of Biology)
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The IBUB scholarship holder, Carles Galdeano, among the ten winners of the VIII Lilly Research Award for Doctoral Students. |
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Carlos Galdeano Cantador has received one of the ten prizes awarded by the pharmaceutical company Lilly in the eighth edition of its Research Awards for PhD students, awards that recognize the research work of doctoral students in the areas of Organic Chemistry, Pharmaceutical and Analytical.
The work presented by Carlos Galdeano is entitled "Multi-target-directed drug design: a novel class of dual binding site acetylcholinesterase inhibitors against Alzheimer's disease". This work is framed within the doctoral thesis project that aims to develope new compounds with potential to prevent, stop or delay the neurodegenerative process of Alzheimer's disease, led by Drs. Diego Muñoz-Torrero and F. Javier Luque, researchers of our Institute. This project was one of the three projects that in 2008 received the support of IBUB within the program of support to interdisciplinary research in biomedicine. Congratulations! |
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The researcher Josep F. Abril from IBUB, among the elite of the most cited scientists in the world. |
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Josep F. April, IBUB researcher and professor of the Department of Genetics, is one of UB researchers who are among the most cited authors in the world, according to the ISI Web of Knowledge, an international free access database which analyzes the impact of scientific activity. Based on these data, Josep F. April and Joan Rodés from IDIBAPS, are among the group of twenty-six researchers from Spain that are in the elite of the most cited scientists worldwide.
Josep F. April is a member of the Bioinformatics Unit of IBUB since its creation. His research activity is focused on computational analysis of the signals involved in determining the exonic structures of eukaryotic genes (in processes such as cutting and splicing junction), predicting genes in genomic sequences using bioinformatic tools and the validation of these predictions.
Author of several scientific papers on computational analysis of eukaryotic genomes published in high impact scientific journals, he is one of the experts who participated in the visualization and analysis of the genomes of several model organisms such as Drosophila melanogaster, and the lab rat. He was part of the scientific team that produced a first draft of the human genome, published in the journal Science in 2001. More recently, he collaborated on the project of annotating the first haploid genome of an individual human being, the genome of J. Craig Venter (PLoS Biology, 2007).
Currently he is working on the integration of data obtained by different methods of genomics, transcriptomics and proteomics, to functionally annotate the genome of the planarian Mediterranean Schmidtea, an organism that may be essential for understanding the molecular mechanisms of the regeneration in metazoans.
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IBUB Symposium " From Stem Cells to Regeneration, Models in Tissue Regeneration" |
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Date: November 12th
Time: 09:15 hours
Place: Aula de Graus (Aulari, Faculty of Biology)
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News from our Confocal Microscopy Training program.. |
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The demand for courses on confocal Microscopy has been a great success. The sessions started again in late 2010 and 5 sessions at a basic level and also another advanced session were programmed.
We'll make a reminder to present the applications for those who have not yet been able to attend the course and also to new demands. Thanks for your interest. We hope this IBUB service would be a benefit for your research.
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The project "Identification of androgen receptor aggregates that cause Bulbar Spinal Muscular Atrophy ", presented by Dr. Eva Estébanez Perpiñá from IBUB, in coordination with teams from IRB and the University of Cambridge has been funded by the TV3 Marathon call for research in rare diseases. |
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In the 2009 edition of the TV3 Marathon, dedicated to rare diseases, 20 of the 287 projects presented have been awarded. The project funded is coordinated by Dr. Xavier Salvatella, Institute of Biomedical Research with two other sub-projects under the direction of Dr. Eva Estébanez from IBUB and Dra. Leila Luleshi from the University of Cambridge. The Bulbar Spinal Muscular Atrophy (AMSB) is a rare hereditary neurodegenerative disease that occurs only in males and has no treatment. The AMSB is due to the appearance of aggregates in motor neurons formed by androgen receptor molecules with poliglutamina extensions to the N-terminal domain. The aim of the project is based on establishing the nature and structural characteristics of the aggregates that cause the death of motor neurons and eventually the appearance of AMSB symptoms.
Dr. Estébanez Perpiñà leads the research group "Nuclear Receptors as Novel Therapeutic Targets Interaction Surfaces" from IBUB since January 2008, when she joined our Institute within the IBUB emergent researchers program. |
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IBUB Seminari "Rutas de Señalización reguladoras de la plasticidad metabólica en el músculo esquelético. Relevancia para la prevención y el tratamiento de la diabetes mellitus tipo 2" |
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Date: October 29th
Time: 12:30 hours
Place: Aula 19 (Aulari, Faculty of Biology)
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IBUB Conference "Transtornos de conducta y psicoestimulantes: aspectos neurobiológicos relacionados con su uso psicoterapéutico y su potencial adictivo" |
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Date: October 27th
Time: 12:00 hours
Place: Aula 7 ( Building A, Faculty of Pharmacy)
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IBUB Conference " De la ingeniería genética a la patente industrial: un caso de diseño y elaboración de una vacuna" |
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Date: October 21st
Time: 16:00 hours
Place: Aula A5 (Faculty of Pharmacy)
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IBUB Seminar "Simulaciones de proteínas a pH constante. A veces un pKa no es un pKa" |
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Date: October 20th
Time: 12:00 hours
Place: Aula Magna (Faculty of Pharmacy)
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IBUB Conference "Influenza Virus M2 Proteins: Progress Toward Finding a Useful Inhibitor" |
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Date: October 18th
Time: 12:30 hours
Place: Aula 4 (Faculty of Pharmacy)
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IBUB workshop "Ion Channels in Health and Disease" |
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Date: September 17th
Time: 10:00 hours
Place: Aula de Graus (Faculty of Biology)
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IBUB laboratories in Hèlix Building, participate in the program "Spend the Summer in the Park" organized by the Barcelona Science Park. |
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IBUB laboratories at the Barcelona Science Park
(Dra. Eva Estébanez and Dra. Antonella Consiglio)
For further information
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IBUB seminar "ATP Binding Cassette (ABC) Sterol Transporters: Roles in Inflammation, Apoptosis and Atherosclerosis" |
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Date: June 28th
Time: 12:00 hours
Place: Aula Magna (Faculty of Biology)
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Last June 21st, Dr. Joan Bosch, a IBUB researcher, leader of the group Synthesis of Nitrogen Bioactive Compounds joined the Royal Academy of Pharmacy of Catalonia as an Aademic Fellow Member. |
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| Last Monday 21st of June, at 7 pm, took place in the Hall of the Royal Academy of Pharmacy of Catalonia (C / Hospital, 56 Barcelona) the admission of Dr Joan Bosch Cartes as an Academic Fellow Member of this Royal Corporation. |
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IBUB seminar "How EFF-1 Fuses Cell Membranes and Sculpts Epithelia, Muscles and Neurons" |
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Date: June 15th
Time: 13:00 hours
Place: Aula de Graus (Faculty of Biology)
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Call for doctoral fellowships projects, IBUB 2010 |
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Please note :
The deadline for submitting applications has been opened |
(7-06-2010) In the framework of the contract-program IBUB 2010, applications may now be made for 2 doctoral fellowships for doctoral theses to be developed in collaboration between teams at the IBUB. Further information and the conditions of application can be consulted at the links below.
The deadline for all applications is July 1st, 2010.
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The audio visual about Research on Metabolic Diseases of IBUB in collaboration with St Joan de Déu foundation, cover of the UB Web Page
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Today, June 7 th , has appeared on the cover of the web page of UB (
www.ub.edu) a video that was made from the collaboration in research on metabolic diseases between the Institute of Biomedicine of University of Barcelona and the Fundació Sant Joan de Déu.
For more information:http://www.ub.edu/web/ub/ca/ |
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IBUB workshop "Nucleoside and Nucleobase Transporter Proteins in Biomedicine" |
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Date: June 3rd
Time: 10:00 hours
Place: Aula de Graus (Faculty of Biology)
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Last April 30th, Dra. Gemma Marfany presented the IBUB research at the Conference of Professional Orientation in the Faculty of Biology |
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In the context of the professional orientation session organized by the Student Support Service, UB employment and the Faculty of Biology, Dra. Marfany presented the professional prospects in the field of research in experimental biology and biomedicine, and the research lines of IBUB with potential host for young researchers in training.  |
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An article on the use of Drosophila as a model for studying tissue regeneration, performed by the team of Florenci Serras and Montserrat Corominas, from IBUB, on “Bioessays” cover. |
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The publication on BIOESSAYS reviews the major features of regeneration in Drosophila, including signaling pathways, cell behavior and genetic control of regeneration. This review is complemented with an article of the same authors in the journal “DEVELOPMENT” where they demonstrate the importance of the JNK signal transduction pathway in the processes of wound healing and regeneration after cell death. |
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Joint Seminar IBUB-Societat Catalana de Biologia "Systems biology analysis of a small bacterium; there is more than expected" |
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Date: May 6th
Time: 12:00 hours
Place: Aula Magna (Faculty of Biology)
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Joint Seminar IBUB-IRB-CSIC "Chemical Biology for the Elucidation of Structure and Funtion Strogen Receiver" |
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Date: May 5th
Time: 09:30 hours
Place: Aula Fèlix Serratosa (Parc Científic de Barcelona)
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IBUB Seminar “La vaca sagrada. Ciencia y cultura en la investigación biológica en bovinos” |
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Date: April 15th
Time: 13:00 hours
Place: Aula de Graus (Faculty of Biology)
poster
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IBUB Seminar“The molecular basis of inflammation and cardiovascular diseases in aging” |
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Date: April 13th
Time: 12:00 hours
Place: Aula de Graus (Faculty of Biology)
poster
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IBUB Seminar“Integrative genomics of ageing: New approaches for an "old" problem” |
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Date: March 26th
Time: 12:00 hours
Place: Aula 19 (Aulari) Faculty of Biology
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Open applications to attend the course BIOINFORMATICS FOR BIOLOGISTS. EASY MANAGEMENT OF GENOMICS INFORMATION organized by Consolider-Ingenio 2010 with the collaboration of IBUB. |
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Find attached the program and features of the course that will take place at the Faculty of Biology, University of Barcelona the next April 14th, 15th and 16th. This course is restricted to 20 places, some of which are reserved for IBUB applicants. IBUB members interested in attending the course please send to juditagusti@ub.edu before March 26th, the following documents:
- Brief CV.
- Summary in not more than 5 lines of why are you interested in the course.
- Name of the leader of the IBUB group which the applicant is attached and the reference of the last publication of the group where IBUB is mentioned as the place where the work has been carried out.
IBUB applicants who are admitted will have a 50% reduction in the registration fee. (IBUB co-finances 100 of 200 euros of total enrollment). |
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An article on the discovery of a new pathway of thermogenesis hormonal control, carried out by research team led by Dr. Francesc Villarroya’s from IBUB, on “Cell Metabolism” cover. |
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The publication, edited on “ Cell Metabolism” March issue, identifies the hormonal factor FGF21 as a new activator of brown adipose tissue and its metabolic consumption activity. FGF21 is produced by the liver that releases it into the circulation in response to the stimulation of fatty acids. The study, based on the use of neonatal mice as an experimental model which are exposed to milk fat for the first time in their development, identifies a new pathway of controlling the energy expenditure with potential therapeutic application in obesity and type II diabetes. |
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Experimental electrophysiology unit, a new scientific-technological unit promoted by IBUB |
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The IBUB , with the collaboration of the Department of Biochemistry and Molecular Biology from the Faculty of Biology, supports the creation by the laboratory of Molecular Physiology, led by Dr. Antonio Felipe, of a scientific and technological experimental electrophysiology unit. This unit, that will operate both for research and teaching, consists of an inverted epifluorescence microscope, a pipette puller, a micro-forge, a hydraulic micro-manipulator, a Faraday cage, a digital and analog image capturing unit for TV in real time, a pneumatic anti-vibration table of compressed air and a high-end signal amplifier. This equipment, which measures electrical currents generated by the activity of membrane proteins, allows the study of membrane potential and ion movements generated by the cardiac action potential and nerve impulse transmission, among other physiological phenomena. Such technologies are of great importance in interdisciplinary research in biomedicine in the areas of cardiovascular, neurobiology, immunology and metabolism diseases. The unit is located in the Faculty of Biology, in the new building. This type of equipment is unique on campus Diagonal of the UB and adds value to the development of the Barcelona Knowledge Campus, an initiative of concentration of maximum competitiveness in research and higher education in our campus.
IBUB researchers interested in the scientific and technological benefits of this unit please contact Dr. Antonio Felipe, who is in charge of it, to this address: afelipe@ub.edu.
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The international workshop "Channelopathies: from bench to bedside"
organized by the Spanish Ion Channel Initiative and Consolider, with the
support of IBUB, took place last February 2nd and 3rd. |
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The workshop, in which Dr Antonio Felipe, member of IBUB, participated
as member of the organizing committee, gathered international researchers
in the field of physiopathology of ion channels, and placed together the
contribution from laboratories involved in basic and biomedical research in
this area.
For more information
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Professor Walter J Gehring has received the Honoris Cause Doctorate by the University of Barcelona supported by Dr Emili Saló, member of IBUB. |
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Last 21st of January, professor Walter J Gehring received the Honoris Cause doctorate by the University of Barcelona supported by Dr Emili Saló, professor of the Department of Genetics of the Faculty of Biology and member of IBUB.
Walter J. Gehring is Professor at the Biozentrum of the University of Basel, Switzerland. He obtained his Ph.D. at the University of Zurich in 1965 and after two years as a research assistant of Professor Ernst Hadorn he joined Professor Alan Garen's group at Yale University in New Haven as a postdoctoral fellow.
In 1969 he was appointed as an associate professor at the Yale Medical School and 1972 he returned to Switzerland to become a professor of developmental biology and genetics at the Biozentrum of the University of Basel. He is a Foreign Member of the National Academy of the USA, Great Britain, France, Germany and Sweden. In 2000 he received the Kyoto Prize for Basic Science, and in 2002 the Balzan Prize for Developmental Biology.
Walter Gehring has mainly been involved in studies of Drosophila genetics and development, particularly in the analysis of determination in the embryo and transdetermination of imaginal discs. He has made significant contributions to the study of the heat shock genes, various transposons and the homeotic genes which are involved in the genetic control of development.
He and his group have discovered the homeobox, a DNA segment characteristic for homeotic genes which is not only present in arthropods and their ancestors, but also in vertebrates up to man. He has been involved in the development and application of enhancer trapping methods. He and his collaborators have identified Pax-6 as a master control gene for eye development, which led to a new theory about the monophyletic origin of the eyes in evolution.
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For more information
Wikipedia
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The IBUB research group led by Claudio Toma and Bru Cormand will develop the project "Molecular Genetics of autism: association studies, analysis of structural variants and mutational screening for identification of susceptibility genes", funded by the Marathon TV3 2008. |
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Thanks to the funding obtained from the “Call on Serious Mental Diseases” from Marathon 2008, they will develop this project whose main objective is the avaluation of the contribution to autism from several genes involved in synaptogenesis and the regulation of the synaptic release of neurotransmitters in a large cohort of Spanish patients. The study's methodology will include association studies of case-control, mutational screening and analysis of structural variants (CNVs) in candidate genes.
The project is headed by Claudio Toma, researcher CIBER-ER, and will be developed within the group led by Bru Cormand from the Department of Genetics of the University of Barcelona which belongs to the IBUB team “ Human Molecular Genetics” coordinated by Daniel Grinberg.
Good luck and success in this research ! |
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Computational Biology IBUB Symposium |
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On the occasion of the opening of the new IBUB Unit on Computational Biology of the Institute of Biomedicine of the University of Barcelona, an International Symposium was held last 20th November with the participation of IBUB researchers and other international scientists leaders in the area.
Dr. Francesc Villarroya, IBUB Director, Dr. Alex Aguilar, UB Vice-Rector for Innovation and Knowledge Transfer and Dr. Joaquin Gutierrez, Dean of the Faculty of Biology of the UB opened the event with a great success of assistance.
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IBUB Seminari “La Diabetes tipo 2 también es una enfermedad del sistema inmunológico: pérdida de células T reguladoras en el tejido adiposo de los obesos” |
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Date: November 13th
Time: 12:00 hours
Place: Aula 5 (Edif.A) Facultat de Farmàcia
poster
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The team of Professor Javier Luque, IBUB member, will coordinate the international project NOstress (Unraveling the molecular mechanism of nitrosative stress resistance in tuberculosis) within the Health Area of the 7th Framework Program of the European Union. |
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The project NOstress aims to identify the molecular basis of M. Tuberculosis resistance to nitrosative stress, that is to say, to the excessive formation of radical nitric oxide (NO). This molecule, which has antibacterial activity, is one of the factors of the immune system that reduces the growth of M. tuberculosis and is produced by the macrophages during the initial process of infection. The project, in which several European laboratories are involved, pretends to improve the design of new therapies to treat tuberculosis.
For more information
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Audiovisual on metabolic diseases (IBUB-FSJD) |
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Due to the recent collaboration in research on metabolic diseases between the Institute of Biomedicine of University of Barcelona and the Fundació Sant Joan de Déu, the University of Barcelona audiovisual department has elaborated a video which can be found in the following addressess:
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IBUB Symposium |
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Date: September 17th
Time: 09:30 hours
Place: Aula de Graus, Biology faculty
University of Barcelona
(Free Entrance)
poster
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The IBUB image design, awarded with the "LAUS National Design Awards 2009" |
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The IBUB image design, conducted by the cabinet study Natalia Cuadrado, has been awarded a bronze prize in the “LAUS design awards 2009”.
The challenge of an original design for IBUB within the framework of many research institutions of biomedical research in our enviroment, and its own unequivocal character of Institute of the University of Barcelona, has provided inspiration for the image of our Institute.
We thank to “Natalia Cuadrado” group, for their work, their understanding of the academic and nonprofit character of our Institute and their commitment to achieve a modern look which projects our character and aims.
1 1 1 1 1 Congratulations!
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"Curso práctico de Microscopía Optimizada" for IBUB researchers |
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The IBUB has participated in the organization of the course of microscopy by computer “Curso Práctico de Microscopía Optimizada por Ordenador" that it was carried out at the beggining of September and has sponsorized some free enrolments for researchers who are members of it. |
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The attendance at the course has been an overwhelming success and demand has far exceeded the supply of enrolments. Due to this, many of the applications could not be studied, even though will be considered for future editions. |
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IBUB is in "La Vanguardia" news |
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As a part of a special supplement on "Research & Technology", La Vanguardia has published an interview with the director, Francesc Villarroya, which has reviewed the objectives and activities of the IBUB for the general public.
Complete article
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IBUB seminari |
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Last May 13th took place in the Aula Magna of the Facultad de Biología of the Universitat de Barcelona the conference organized by IBUB titled «Proteases and their Regulation from Molecular Structures to Application» by Robert Huber, Max-Planck Institute fuer Biochemie (Germany). Prof. Huber received the Nobel Price in Chemistry 1988, shared with Johann Deisenhoffer and Hartmut Michel, for their studies on the atomic foundations of photosynthesis. His studies on cyanobacterial phycobilisomes, blue multi-copper oxidases, but in particular the purple bacteria reaction centre, the first 3D structure of a membrane protein ever solved, they all contributed to elucidate the structural basis for the transformation of light into chemical energy, and are already part of the History of Biology and Biochemistry. During his seminar, Prof. Huber talked about all the families of proteolytic enzymes and explained the 3D structures of a prepresentative member of each family as well as their function and regulatory mechanisms. The seminar´s host was Eva Estébanez-Perpiñá (RyC and Marie Curie fellow and member of the IBUB since 2008), who had done her PhD under Prof. Huber´s supervision. Many other ex-alumni from his lab were also present in the audience .
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| Picture legend. From right to left: Francesc Villarroya Gombau (Director of the IBUB), Eva Estébanez-Perpiñá (IBUB), Xavier Gomis-Rueth (CSIC), Robert Huber (Max-Planck-Institut), Marta Garrido-Franco (Leitat), Pablo Fuentes-Prior (Sant Pau), and Miquel Coll (IRB). |
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Day joint research on metabolic diseases |
Sant Joan de Déu foundation and the Institute of Biomedicine of the University of Barcelona (IBUB), biomedical research centers heavily involved in the study of metabolic diseases, have began an strategic partnership to promote translational research in this field, exploiting the potential of basic and clinical research of both institutions.
The meeting "Advances in Research on Metabolic Diseases", held on last April 17th, was a first initiative in this direction, as a forum of exchange of knowledge about the state of research in this area and its prospects.
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News from our Confocal Microscopy Courses |
The demand for courses on confocal Microscopy has been a great success. Six editions have already been carried out and more than thirty of our IBUB researchers have attended them.
It has to be said that the demand for these courses has totally overcome our expectations and it has been necessary to close their continuity by now. They will surely start again from the beggining of the new academic year, provided the necessary financial resources can be made available by the IBUB.
By next September a reminder will be sent for applications to those who have been unable to attend so far and also for new applicants.
We very much appreciate your interest and wish that this IBUB service may have been useful to your research.
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Successfully concluded the IBUB-TEC symposium “Real Time PCR y secuenciación masiva de DNA”, in collaboration with Roche |
The symposium IBUB-Roche, first symposium of the IBUB-TEC series of scientific and technological seminars promoted by IBUB, took place last November 12th at the Faculty of Biology with a multitudinous success. More than 500 people were attending the meeting and a peripheral site had to be established in order to provide service to the massive attendance. The experience of collaboration with the company (Roche, in this case) and with Serveis Cientifico-Tècnics has been optimal to provide the biomedical research community an updated offer for improvement and upgrading technological capacities. |
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Presentation of SINTEFARMA, center of the Network of Centers of Technological Innovation Support Network (IT) of the Generalitat of Catalonia, led by an IBUB group |
The Center for Research and Development in Organic Synthesis for the chemical-pharmaceutical Industry (SINTEFARMA) has been presented on 5th of December at a ceremony in Aula Magna of the Faculty of Pharmacy. SINTEFARMA, located at the Unit of Organic Chemistry, Department of Pharmacology and Therapeutics Chemistry of the Faculty of Pharmacy at the University of Barcelona, is a center of the Network of Centers of Technological Innovation Support Network (IT) of the Generalitat of Catalonia, created with the objective of promoting technology transfer and collaboration with the industrial sector, providing advice and services in the field of organic synthesis and conducting applied research projects of technological interest for companies . The research group promoting SINTEFARMA, led by Dr. Joan Bosch, is a founding member of the IBUB, and from our institute we welcome this initiative which once again shows the momentum and dynamism of biomedical research on campus Diagonal of our University. Congratulations and many successes with this initiative from the IBUB!
Further information at www.ub.edu/sintefarma |
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The Laboratory of Molecular Physiology, Department of Biochemistry and Molecular Biology- IBUB, the Spanish leader in research on ion channels |
The independent portal "Ion Channel, Patch Clamp and Electrophysiology
Research led by Ion Channel Media Group Ltd.
(http://www.ionchannels.org), which produces a ranking of the world
laboratories and research with impact in the area of the Ion Channels has
recognized the Laboratory of Molecular Physiology, Department of Biochemistry and
Molecular Biology of the Institute of Biomedicine (IBUB) led by Dr.
Antonio Felipe, in the 109 worldwide position during the year 2008 for its contributions to this scientific area. This position places the Laboratory of Dr.
Felipe at the first position in the ranking of the Spanish laboratories in this research field in 2008. One of the main scientific contributions leading to this recognition was the publication selected by the IBUB as “article of the month” recently (J Biol Chem. 2008; 283:8756-8764). |
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New IBUB laboratories in the building Helix PCB |
The IBUB, in its policy of promoting emerging research teams and encouraging biomedical research on campus, is establishing new laboratories to host such new research teams in the Helix building of PCB. The team of Dr Eva Estébanez, emerging group of IBUB, will begin its activities in these labs next month. |
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IBUB-TEC, a new series of IBUB seminaris on technology advances |
These seminars are meant to PhD students, postdocs or any lab people, in order to improve technological capacities for biomedical research.
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Several already programmed IBUB-TEC Seminars are:
1.- Basic Bioinformatics Analysis (next October 17)
2.- Advances in RT-PCR and high-throughput DNA sequencing (IBUB-Roche Symposium next november 12, see below))
3.- Basics of Confocal Microscopy (December, practical-tutorial)
4.- ChIP on Chip versus ChIP-seq (January)
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The first seminar of the series will be “ Basics on Bioinformatics Analysis”
by Dr. Enrique Blanco (Departament de Genetica / IBUB), next 17 October (see attached announcement).. The target audience is PhD students and Researchers in any area of Molecular Biology.
The audience in this short talk will be in contact with real examples that explain how to take advantage of current computational tools:
search for genes in the most popular genome browsers, perform comparisons between related sequences, study the conservation of genes in different genomes, identify clusters of co-regulated genes or represent graphically these results. |
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IBUB participates in science dissemination, article in Eureka |
The IBUB undertakes activities oriented towards an improvement in the presence of biomedical research areas in non-specialized social environments. In the last issue of Eureka (the magazine of science addressed to young students) Gemma Marfany, an IBUB genetics researcher, provides a stimulating, easy accessible, view of the fascinating task of gene discovery under the title: ”The Gene Hunters” (“Caçadors de gens”).
Full text can be viewed in the following link. |
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Sessió IBUB-ROCHE
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In line with the activities of promoting improvement in biomedical research
technologies, IBUB participates, in partnership with the company Roche, in a
seminar series on recent advances in Real-time PCR and massive DNA
sequencing technologies, to he held next november 12th in Facultat de
Biologia.
You'll find below the anouncement including the preliminary
program.
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