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For further information:

The Institute of Biomedicine of the UB

mercerodriguez@ub.edu
(economic affairs)

g.moreno@ub.edu

(administration)


IBUB UNITS
 
 
 

 

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IBUB Seminar "Autofagia y lípidos en enfermedades neurodegenerativas"
 

Date: September, 30th 2016

Time: 13:00 hours

Place: Aula 18, Faculty of Biology

poster

Seminar IBUB José A. Rodríguez PhD
IBUB Seminar "Role of Cardiotrophin-1: From liver protection to metabolic properties"
 

Date: September, 16th 2016

Time: 13:00 hours

Place: Aula 18, Faculty of Biology

poster

IBUB Seminar "Tracing adipocyte origins and metabolism"
 

Date: September, 14th 2016

Time: 13:00 hours

Place: Aula Graus, Faculty of Biology

poster

Bru Cormand and the collaborator Cèlia Sintas, IBUB researchers, identify around 40 migraine-related genes

 

The study identifies a genetic risk factor on chromosome X in a pathology which is more common in women than men.

Bru Cormand Cèlia Sintas
  Professor Bru Cormand and the collaborator Cèlia Sintas  

Migraine is one of the most common neurological disorders and it affects 1 out of 7 people in the world. Painful and incapacitating, it has multi-factor origins, with the participation of environmental triggering factors and several altered genes in each individual. Up to this date only 13 migraine-related genes were known and now a study of Nature Genetics proves the contribution of these 10 genes and adds 28 more to the candidate list. In the international work, focused on the analysis of common genetic migraine variants on people, there is the participation of Professor Bru Cormand and the collaborator Cèlia Sintas, from the Institute of Biomedicine of the University of Barcelona (IBUB.

Dr Marçal Pastor Anglada, elected new director of IBUB
 

 

On April 12th, 2016 the Directory Board elected Dr Marçal Pastor Anglada as 'IBUB director.

IBUB

The new director communicated that Dr Santiago Vazquez will be the new Secretary, and the members of "Comissió Permanat" will be  Dr Bru Cormand, Dr Anna Grandas, Dr Laura Herrero, Dr Diego Muñoz-Torrero, Dr Florenci Serras, and Dr Francesc Villarroya.

http://www.ub.edu/web/ub/en/menu_eines/noticies/2016/04/049.html
http://www.ub.edu/web/ub/en/index.html

MetNet annual Meeting: Adipose tissue metabolism in obesity
 

Barcelona, May 27th 2016

 

Registration:

http://scb.iec.cat/

MetNet annual meeting

Meeting location:

Sala Prat de la Riba, IEC

C/ del Carme, 47, Barcelona

 

Meeting organizers:

Pablo García-Rovés

Laura Herrero

IBUB Seminar "Soluble Amyloid Precursor Protein Beta Links Type 2 Diabetes and Alzheimer’s Disease Through Partial Agonism of Insulin Receptor"
 

Date: April, 13th 2016

Time: 12:00 hours

Place: Aula Graus, Faculty of Biology

poster

Seminar Olivier Bezy
IBUB Seminar "Mitochondria adipose tissue health and insulin resistance"
 

Date: April, 11th 2016

Time: 12:00 hours

Place: Aula Graus, Faculty of Biology

poster

Seminar Cecile V.
Montserrat Corominas and Marta Cascante, investigators of IBUB, awarded with the 2015 ICREA Academia Award by the Institució Catalana de Recerca i Estudis Avançats (ICREA)
 

The ICREA Academia Awards are given for a period of five years in recognition of the scientific trajectory of university professors. Awardees receive funds over this period to support their lines of research, support teaching activities and allow awardees to concentrate on research.

Montserrat Corominas and Marta Cascante join F.Xavier Luque and Francesc Villarroya, previous ICREA Academia awardees from IBUB. Marta Cascante was already awarded in the previous 5 year-period and Montserrat Corominas is a novel awardee.

Congratulations!

Dra. Corominas

Dra. Cascante

IBUB Seminar "Mechanisms of Action of Clinically Relevant NMDA Receptor Channel Blockers"
 

Date: March, 11th 2016

Time: 12:30 hours

Place: Aula IV, Faculty of Pharmacy

poster

Seminari Dr Vázquez
"Emerging model systems and obesity research" mini-symposium
 

IBUB supports the mini-symposium organized by CIBERobn next March 4th with the participation of researchers from the Max Planck Institute and the German Cancer Research Center (Germany) and Centro Andaluz de Biologia del Desarrollo, Sevilla (see attached announcement).

Mini-symposium

No registration required.

IBUB Seminar "Evolution and Functional Diversity of Animal Aquaporins"
 

Date: December, 12th 2015

Time: 12:00 hours

Place: Aula Magna, Faculty of Biology

poster

Seminar Roderick Nigel
International symposium: Genomic bases of disease
 

IBUB and CIBERER, organize under the coordination of Dr. Daniel Grinberg, the International Symposium: "Genomic bases of disease", which will be held on 16 and 17 December in Aula de Graus, Faculty of Biology, UB.

International symposium

For further information see:

poster

 

IBUB Seminar "Transcriptional (Dys) Regulation of Epithelial Homeostasis"
 

Date: December, 9th 2015

Time: 12:00 hours

Place: Aula Graus, Faculty of Biology

poster

International Symposium “Understanding human disease: New tools for new challenges”
 

CIBERER and Departament de Genètica de la Universitat de Barcelona, with the support of IBUB, organize under the coordination of Dr. Roser Gonzàlez the International Symposium “Understanding human disease: New tools for new challenges”, which will take place next Monday, November 23rd in Aula Magna, Faculty of Biology, UB. 

Free entrance, no registration required.

International Symposium

For further information see:

poster

Mini-Course IBUB: Physicochemical Profiling in Drug Discovery
 

Date:

Thursday 12th november 2015
Monday 16th november 2015

Time:

9:30 - 13:30h

Place:

Aula del Departament de Química Analítica

Faculty of Chemistry, 3rd floor

poster

Anna Planavila i Manel Vàzquez-Carrera, IBUB researchers, awarded by Fundació Marató TV3 for developing research projects on cardiac diseases.
 

The projects" Role of the new cardiomyokines FGF21 and Metrl in cardiac damage caused by alcoholism and hypertension", leaded by Anna Planavila, and "Diabetic cardiomyopathy: towards the identification of a new target for therapy" leaded by Manel Vàzquez,  have been awarded after selection among the 121 applications to this call.

Researchers received their awards last November 5th at Acadèmia de Ciències Mèdiques i de la Salut de Catalunya i Balears.

Marató TV3
Anna P.

Dra. Anna Planavila

 

Dr. Manuel Vázquez

Manuel V.              
IBUB Seminar "Human obesity: learning from the flies"
 

Date: November, 13th 2015

Time: 12:00 hours

Place: Aula Magna, Faculty of Biology

poster

CANCELLED

IBUB Seminar "Papel del microambiente en la regulación de la quiescencia de las células tumorales diseminadas"
 

Date: November, 10th 2015

Time: 12:30 hours

Place: Aula 35 (Aulari), Faculty of Biology

poster

The IBUB researchers Marta Cascante, Loudres Fañanas and Francesc Villarroya lead "Xarxes Temàtiques d'Excel.lència" funded by MINECO.
 

Three research networks leaded by IBUB researchers have been awarded by MINECO in the 2015 call.

"Medicina de Sistemas e Integración de Tecnologias Ómicas: Transcriptómica, Proteómica, Metabolómica y Fluxómica", coordinated by Marta Cascante, orientred towards the study of human body physiological regulation using the interdisplinary Systems Medicine approaches.

"Desarrollo cerebral y condicoons estresantes tempranas en salud mental: el rol mediador de mecanismos epigenétics y correlatos de neuroimagen" coordinated by Lourdes Fañanas, to study  how epigenetic mechanisms mediate permanent long-term effects of stress before birth and in childhood on on mental health and behavior.

"Plasticidad adiposa y sus patologías" coordinated by Francesc Villarroy,  focused to research on the processes of altered adipose tissue occurring in obesity and lipodystrophy, and the use of adipose tissue as a source for tissue transplantation and isolation of precursor cells for regenerative medicine.

Around  25 Spanish research tems will coordinate their research on these areas from IBUB.
IBUB Seminar "Molecular basis underlying the association between Gaucher Disease and Parkinson’s disease"
 

Date: October, 28th 2015

Time: 12:00 hours

Place: Aula Graus, Faculty of Biology

poster

Shaking up the foundations of epigenetics
 

Cells of multicellular organisms contain identical genetic material (the genome) yet can have drastic differences in their structural arrangements and functions. This variation of the distinct cell types comes from the differential expression of genes, which is controlled by interplay between different regulators within the cells, such as transcription factors, the transcription machinery, and the “epigenetic” modifications (which do not change the underlying genetic code) that occur on the DNA and protein factors within chromatin.

 

 

In a study co-directed by Roderic Guigó, a CRG principal investigator and a UPF professor, and Montserrat Corominas, at the Department of Genetics of the University of Barcelona (UB) and the Institute of Biomedicine of the UB (IBUB), the scientists show that the chromatin marks are irrelevant for regulating genes that are expressed in a punctual manner during development. The results of this study contrast sharply with the generally accepted view of the key roles that these epigenetic marks play in regulating gene expression.

    The work is published in the October issue of the journal Nature Genetics and is featured on the cover with an illustration by Luisa Lens, which was inspired by the results of the Catalan teams as well as by the Salvador Dali painting “Paisaje de mariposa. El gran masturbador en paisaje surrealista con ADN(Butterfly landscape. The great masturbator in a surrealist landscape with DNA).”

The project was based on gene expression data from the modENCODE project, which aims to provide the scientific community with a comprehensive encyclopedia of functional elements of the genome of model organisms. In this case, the researchers used data about the genomic expression from the nematode worm C. elegans and the fruit fly D. melanogaster.

"We didn’t set out to study the relationship between the epigenetic chromatin marks and gene expression during development, but rather to analyze the function of these marks in DNA processing. But we soon saw that there were some highly-expressed genes that did not have the epigenetic marks on their chromatin—which are thought to be required to maintain such high levels of expression. We first considered that this could be an experimental artifact, since it is common for developmental genes to be expressed only in a few specific cells, which could lead to the signals from the marks being diluted out and not detected. However, when we analyzed the data from the modENCODE project, we realized that the genes that were regulated during development were indeed expressed even though they lacked the chromatin marks one would expect. A lot of our work has focused on experimentally confirming these results," explains Montserrat Corominas.

Embryonic development is a well-studied process in which the precise regulation of gene expression is critical, since many genes are expressed simultaneously and in a punctual manner. The work from these two research groups in Barcelona now offers novel information for understanding this process, by focusing on a set of genes that act during development and are specific to certain tissues.

"At the present, we already have computer models that help us to predict the patterns of expression for genes based on their chromatin modifications. Our work now adds a new aspect that was previously not even contemplated, which will help us to make predictive models even more reliable," said Roderic Guigó. "Our results are based on the expression of genes in two model organisms. Now we have to see whether what we observed in these two organisms also holds true for humans. If so, the results from our study will be useful for improving approaches to manipulate or modulate the levels of gene expression—which would be extremely useful for studying and treating those diseases that we know are caused by the expression of specific genes,” concluded Guigó.

The proposal “Drugs for inflammatory and cardiovascular disorders”, promoted by IBUB researchers, has been selected in the first call of the CaixaImpulse programme. This initiative, jointly organized by “La Caixa” Foundation and Caixa Capital Risc, has the aim of fostering the transformation of scientific knowledge in companies and has a total budget of 1.3 million €.
 

The research project, led by the IBUB researcher Rosana Leiva (Project Leader), involves three staff members of the IBUB, professors. F. Javier Luque, Manuel Vázquez-Carrera and Santiago Vázquez.

The aim of the project is to further develop a series of compounds synthesized and tested in the context of the PhD Thesis of Elena Valverde (a pre-doctoral IBUB Grant holder) that have recently been the subject of a European patent application. The compounds, inhibitors of the soluble epoxide hydrolase, have potential interest for the treatment of inflammatory and cardiovascular disorders.

For further information:

http://www.fbg.ub.edu/post/ca/221/dues-iniciatives-de-la-ub-presentades-a-travs-de-lfbg-han-estat-seleccionades-pel-programa-caixaimpulse

 

International Symposium organized by the Spanish Network of Ion Channels.
 

The Spanish Network of Ion Channels opening session was held in "Paranimf" of the University of Barcelona on Sunday, October 4th, with the support of IBUB.

PhD students from the IBUB pre-doc programs awarded by Lilly Research Award.
 

On September 25th took place in Alcobendas, headquater in Spain of the multinational pharmaceutical company Lilly, the thirteenth Edition of the Research Awards for PhD students, which recognize excellence, effort and dedication demonstrated by young researchers in the fields of Analytical, Organic and Medicinal Chemistry. A committee of experts chose, depending on the quality and quantity of scientific publications, three winners and seven finalists. Two of the finalists were PhD students from the Department of Pharmacology and Medicinal Chemistry and grants holders of IBUB.



Marta Barniol-Xicota, who currently holds a scholarship from the IBUB for finishing the PhD Thesis, was selected finalist for her work “Stopping flu in its tracks: new approaches to influenza A inhibition”, related to her Thesis, supervised by Prof. Santiago Vázquez, member of the IBUB.

Elena Valverde Murillo, who enjoyed a PhD Grant from IBUB (2011-15), was selected finalist for her work “Exploring adamantane-like scaffolds for a wide range of therapeutical targets”, related to her Thesis, supervised by Prof. Manuel Vázquez-Carrera and Santiago Vázquez, members of the IBUB.

A scientific study led by Roderic Guigó form the Centre for Genomic Regulation (CRG), University Pompeu Fabra, in collaboration with Montserrat Corominas and Florenci Serras from the Department of Genetics of the University of Barcelona (UB) and of the Institute of Biomedicine of the UB (IBUB), illustrates the evolution of selenophosphate synthetase genes, involved in the synthesis of selenoproteins through prokaryotes and eukaryotes.
 

Selenoproteins are proteins that incorporate selenocysteine (Sec), a nonstandard amino acid analogous to cysteine, but containing the essential trace element selenium (from Greek σελήνη selene meaning “Moon”) instead of sulfur. Although is not very abundant, selenium is considered an important nutrient in the diet.

 

Synthesis and insertion of selenocysteine ​​requires several factors, among others, a specific tRNA, RNA and ribosome binding proteins, a specific elongation factor or the enzyme selenophosphate synthetase (SPS). The study reports the evolutionary history of sps genes, providing a map of selenoprotein function spanning the whole tree of life. SPS is itself a selenoprotein in many species, although functionally equivalent homologs that replace the Sec site with cysteine (Cys) are common. Many metazoans, however, possess sps genes with substitutions other than Sec or Cys (collectively referred to as SPS1). Using complementation assays in fly mutants, the investigation shows that these genes share a common function, which appears to be distinct from the synthesis of selenophosphate carried out by the Sec- and Cys- SPS genes (termed SPS2), and unrelated to Sec synthesis.

 

The figure that appears on the cover of the magazine depicts the selenoprotein genes SPS2 (moons) paired with their paralogous SPS1 (leaves, colored to indicate different Sec substitutions) emerged in various branches of the metazoan tree of life. At the bottom, an event of gene duplication and subfunctionalization is represented, with the duplicated genes then following on separate evolutionary trails. (Cover illustration in acrylic paint on paper by Milena Biolcati Rinaldi, with biological concepts by Marco Mariotti).

The results are published in the journal Genome Research and highlighted in the cover of September.

Genome Res. 2015 Sep;25(9):1256-67. doi: 10.1101/gr.190538.115.

The IBUB team  leaded by Daniel Grinberg participates in the discovery of a novel gene implicated in osteoporosis recently published in Nature.
 

Susana Balcells and Daniel Grinberg, professors in the Department of Genetics and members of the Institute of Biomedicine of the UB (IBUB).

An uncommon variant of the gene EN1 contributes to bone mineral density and osteoporotic fractures, according to a study recently published in the journal Nature. Daniel Grinberg, expert in the Department of Genetics of the University of Barcelona (UB) and member of the Institute of Biomedicine of the UB (IBUB), has participated in the study. Xavier Nogués and Natàlia Garcia Giralt, experts at the Service of Internal Medicine of the Hospital del Mar and the Hospital del Mar Medical Research Institute (IMIM) also participate in the study, which is led by Brent Richards, professor at McGill University (Montreal, Canada).

The study is also part of a research line on bone pathologies developed by the Centre for Biomedical Network Research on Rare Diseases (CIBERER), led by professors Daniel Grinberg and Susana Balcells (Department of Genetics of the UB and IBUB) with the collaboration of experts on internal medicine from the Hospital del Mar and the IMIM. 

A multi-focus study with worldwide participation

This is the first international study —a multi-focus study in which research centres from all over the world participate— that linksEN1 with the origin and development of osteoporosis, a common disease that will lead to fractures in between one-third and one-half of all women over the course of their lives. According to study conclusions, this uncommon genetic variant has a major influence on bone mineral density, which is major predictor of osteoporosis and osteoporotic fractures.


The research study has analysed the genome of more than 50,000 people from all over the world in order to identify new genes that have an influence in the risk of developing osteoporosis and osteoporotic fractures. The study, carried out by applying the most advanced genome sequencing technologies, proves that uncommon variants may play a major role in the development of diseases like osteoporosis.


The study is part of the international project Genetic Factors for Osteoporosis Consortium (GEFOS), funded by the European Union. The research team emphasizes the importance of sharing results of studies developed all over the world in order to “come to reliable conclusions”.


The research activity carried out by experts from the Department of Genetics of the UB and the IMIM, who have strongly collaborated with the project GEFOs to study the genetic basis of osteoporosis, has provided new data about genetic architecture and pathophysiological mechanisms linked with bone density variation and fracture susceptibility, a key factor to design new therapeutic strategies.

The IBUB research team leaded by F.Villarroya publishes the results on the presence of FGF21 in breast milk and its beneficial effects on intestinal maturation of newborn.
 

The work demonstrates that the hormonal factor FGF2 has a key role in the absorption of nutrients and regulating intestine function in newborns, and helps improve neonatal growth and metabolic profile during the first weeks of life. The results of the work have been published in the journal Scientific Reports. This work has been largely a result of the project "FGF21 as a new factor present in milk, involved in the beneficial effects of breastfeeding" awarded to the research team in the frame of the research program RecerCaixa,  Obra Social La Caixa, in collaboration with the Catalan Association of Public Universities (ACUP).

 

 

FGF21 is a hormone with anti-obesity and anti-diabetic properties. The research carried out has shown that FGF21 is present in human milk and rodents, and passing the baby through breast milk, acts on the gut, where it stimulates the production of enzymes that promote absorption lactose and other gastrointestinal hormones that help absorb nutrients properly.

 

 

After these results, the research team is currentlyt investigating the long-term effects effects on metabolism of having been exposed to FGF21 from milk or not, and if this factor is present and in what percentage in formula milk, with the support of a project recently awarded to the lab by Instituto Danone.

Research supported by the pre-doc IBUB fellowship program gives rise to a European patent for a potential drug.

 

On 28 July, the University of Barcelona presented to the European Patent Office (EPO, EPO) a patent application for new epoxide hydrolase inhibitors soluble compounds with therapeutic interest for cardiovascular disease, processes of inflammation and pain, and for the treatment of metabolic syndrome.

The patent application includes part of the results of the thesis of the IBUB predoctoral fellow Elena Valverde Murillo, conducted under the direction of the IBUB researchers Santiago Vázquez Cruz and Manel Vázquez Carrera, from the Department of Pharmacology and Medicinal Chemistry at the Faculty of Pharmacy.

The main interest of these new compounds is related to their physicochemical properties more suited to become future drugs than inhibitors of the soluble epoxide hydrolase enzyme previously available.

Marta Cascante, awarded with Medalla Narcís Monturiol al mèrit científic i tecnològic
 

Marta Cascante, research group leader at IBUB, has been awarded with one of the 2015 awards. These awards were established by Generalitat de Catalunya in 1982 and recognize individuals and organizations with strong contributions to the development of science and technology in Catalonia. Congratulations!

   
Xavier Barril, group leader at the Computational Biology of IBUB, and colleagues from academia and SMEs from Hungary, The Netherlands, Sweden, Switzerland, and UK, granted the FRAGNET by EU.
 

The EU has granted 3.9 M euro to explore new research methods and applications in the emerging field of fragment-based drug discovery. The funds granted to the international consortium will allow the recruitment of 15 PhD for the duration of the project.

In the last ten years, fragment-based drug discovery has established itself as a robust and powerful approach to identify good quality hits that can bind to a biological target. In this approach, much smaller investment is required in terms of automation and development of compounds in comparison to those required by High Throughput Screening (HTS), thereby enabling small companies and academic groups to participate in the drug hunting efforts.
 

More recently, fragment-based approaches are also used to interrogate biological systems, helping to unravel cellular processes and identify new drug targets. The FRAGNET project complements and reinforces Prof. Barril’s research, which focuses on the chemical validation of new therapeutic targets and the development of computational methods to assist this process. Prof. Barril commented: “As a computational chemist with more than 10 years experience in fragment screening, it is evident that both fields are highly synergistic but still insufficiently integrated. FRAGNET offers an ideal opportunity to train the next generation of scientist, who will take Fragment Screening to new heights”.

Xavier Barril and Francesc Xavier Luque, from IBUB, participate in the organization of the 4th workshop "New Trends in Computational Chemistry for Industry Applications", in association with  Xarxa de Recerca en Química Teòrica.
 

This workshop will be held in Barcelona on Oct 1st & 2nd and will consist on two days of talks focused on computational advances in materials science and life science. The workshop aims to highlight the latest scientific advances within the broad field of computational chemistry in academia and industry.


It will also be a suitable platform for researchers from different fields to meet so that fresh, innovative ideas for new interdisciplinary research can emerge.

IBUB Seminar "Cell Signaling By Receptor Tyrosine Kinases; From Basic Principles to Cancer Therapy"
 

Date: June, 26th 2015

Time: 15:00 hours

Place: Aula Magna, Faculty of Biology

poster

IBUB Seminar "Combicult and Brown adipose tissue as a cell therapy treatment for metabolic disorders"
 

 

Date: June, 26th 2015

Time: 12:00 hours

Place: Aula 18, Faculty of Biology

CANCELLED

poster

 

IBUB Seminar “Novel strategies for development of cholinesterase inhibitors: combination with GPCR ligands, photoswitchable compounds and natural products"
 

Date: April, 8th 2015

Time: 12:30 hours

Place: Aula Magna, Faculty of Pharmacy

poster

Applications to IBUB fellowhips for completion of doctoral thesis now open
 

The features and award criteria have been forwarded to the PIs of the Institute.

The deadline for applications is April 8, 2015.

 

Hot Topic Seminars: Ion channels in rare diseases
 

The IBUB, with Hospital Sant Joan de Déu and the Biomedicine Master program, has organized under the coordination of Dr. Antonio Felipe the scientific session "Ion channels in rare diseases." The seminar will take place next Friday, March 20th in Aula de Graus, Faculty of Biology, UB.

Poster

 

Call for a Course on Image Analysis ImageJ/FIJI by IBUB
 

The IBUB grants a course on Introduction to Image Analysis for all researchers of IBUB groups who are interested.

Applications can be made through the banner "Confocal Microscopy Training" at the bottom right of the website.

Applications will be processed in order of arrival.

You can view the course program on the following link:

"Course: Introduction to Image Analysis"

 

Francesc Villarroya, investigator of IBUB, awarded with the 2015 ICREA Academia Award by the Institució Catalana de Recerca i Estudis Avançats (ICREA)
 

The ICREA Academia Awards are given for a period of five years in recognition of the scientific trajectory of university professors. Awardees receive funds over this period to support their lines of research, support teaching activities and allow awardees to concentrate on research. Francesc Villarroya joins Jordi Garcia-Fernández, F.Xavier Luque and Marta Cascante, previous  ICREA Academia awardees from IBUB.

 

 

IBUB Seminar “Adenosine signalling and brown fat”
 

Date: February, 10th 2015

Time: 10:00 hours

Place: Aula de Graus (Aulari) Faculty of Biology

poster

Second Metnet meeting
 

The MetNet local network is an initiative of researchers in metabolism from several research labs in our city environment. The goal is to promote interactions among researchers in metabolism, especially among pre- and post-doc researchers, to interchange information, research models and technology advancements. The next meeting will take place next Friday, January 30th. It is organized by Laura Herrero from IBUB in Facultat de Farmàcia.

For further information see:

Program and attendance

 

IBUB Seminar " Analysis of early tumorigenic events in Drosophila epithelia"
 

Date: February, 2nd 2015

Time: 15:00 hours

Place: Aula de Graus (Aulari) Faculty of Biology

poster

IBUB Seminar "Structural studies of membrane transporters"
 

Date: January, 13th 2015

Time: 12:00 hours

Place: Faculty of Pharmacy, Edifici B, Aula B-106

poster

Two research teams from IBUB and INSA, research Institutes at the University of Barcelona, received the research grants awarded by the Danone Institute in the fields of food, nutrition and health in the 2014 call.
 

The IBUB team leaded by Francesc Villarroya will receive funds to develop the project “FGF21, a new bioactive factor of breast milk”, whereas the research team leaded by Rosa M. Lamuela, from the UB Institute on Nutrition INSA, will develop the project “Els aliments probiòtics augmenten la presència de compostos bioactius fenòlics en l’organisme i disminueixen els paràmetres de risc cardiovascular“.

The award ceremony took place on Thursday 18 December at the Royal Academy of Medicine, in Madrid. The personalities who participate in the event were Teresa Robledo de Dios, adviser of the Spanish Strategy for Nutrition, Physical Activity and Prevention of Obesity of the Spanish Agency of Consumption, Food Security and Nutrition; Joaquín Poch, president of the Royal Academy of Medicine; Manuel Serrano, honorary president of the Danone Institute; Luis A. Moreno, president of the Danone Institute, and Joao Paulo Andorinha, R&D director of Danone.

For further information see:

http://www.ub.edu/web/ub/en/menu_eines/noticies/2014/12/043.html?

 

Ibub Seminar "MicroRNAs, lipoproteínas, y transporte reverso de colesterol. Nueva oportunidad terapéutica?"
 

Date: December 17th , 2014

Time: 12:00 hours

Place: Aula 19 ( Aulari ) ( Faculty of Biology )

poster

IBUB mini-symposium " Metabolism and adipose tissue, at the core of disease" next december, 19th.
 

The IBUB, together with CIBERobn and St Joan de Déu Foundation, organizes the symposium "Adipose tissue and Metabolism, at the core of disease" at the Faculty of Biology of the University of Barcelona on December, 19th.

Among others participating S.Enerback, University of Gothenburg, C.Wolfrum the ETH Zurich and other specialists from the University of Córdoba, Santiago, Sant Joan de Déu Hospital, and UB.

Admission is free.

Poster

 

IBUB seminar "5'-nucleotidases as cancer drug targets"

Date: December 3rd , 2014

Time: 13:00 hours

Place: Aula 20 ( Aulari ) ( Faculty of Biology )

poster

Enric Canela, Rafael Franco and Roser Gonzalez, researchers of IBUB, have been awarded by the TV3 Marathon Foundation to develop research projects on neurodegenerative diseases.
 

44 research projects on neurodegenerative diseases have been awarded among those who applied to the TV3 Marathon Foundation in 2013 call for funds to investigation. The principal investigators of the projects received the awards on October, 30th.

Congratulations to all!

 

IBUB Seminari "Interfaces between metabolism and inflammation"
 

Date: Novembre 10th, 2014

Time: 12:00 hours

Place: Aula de Graus( Faculty of Biology )

poster

IBUB Seminari "Nutrient sensing pathways and the regulation of energy homeostasis"
 

Date: November 6th, 2014

Time: 11:30 hours

Place: Aula de Graus( Faculty of Biology )

poster

IBUB Seminari "Patient derived tumour models for drug screening in breast cancer"
 

Date: October 29th, 2014

Time: 12:00 hours

Place: Aula de Graus( Faculty of Biology )

poster

IBUB Seminar "Drug discovery in academia: the development of 11β-HSD1 inhibitors, from target to clinic"
 

Date: October 20th,, 2014

Time: 12:00 hours

Place: Aula Magna ( Faculty of Pharmacy )

poster

Professor Antonio Felipe from IBUB receives SECF’s award for the best science dissemination work
 

The Spanish Society for Physiological Sciences (SECF) has honoured Antonio Felipe Campo, professor from the Department of Biochemistry and Molecular Biology of the University of Barcelona (UB) and the Institute for Research in Biomedicine of UB (IBUB), for the science dissemination work he has carried out. Felipe received the prize on SECF’s general assembly, which took place on 26 September, at the auditorium of the Granada Science Park.

 

International Workshop on "Ion Channels in Health and Disease" on Friday,October 3, in the morning at the Faculty of Biology.
 

On Friday morning, October 3, will take place at the Faculty of Biology, the International Workshop on "Ion Channels in Health and Disease".

The event is organized by Dr. Felipe of IBUB, and the researchers attending come from the University of Oxford (F. Ashcroft), Max Planck (W.Stühmer) Drebecen University, Hungary (G.Panyi) and Institute of Neuroscience , Alicante (J. Lerma).

For more information see the poster on the following link:

Poster

 

IBUB Seminar " Oncostatina m, una citoquina gp130 secretada en tejido adiposo y regulada en condiciones de obesidad y diabetes tipo 2"
 

Date: September 23rd, 2014

Time: 12:00 hours

Place: Aula de Graus( Faculty of Biology )

poster

Call for a Basic Course on Confocal Microscopy sponsored by IBUB
 

The IBUB grants a basic course on Confocal Microscopy for all researchers of IBUB groups who are interested.

Applications can be made through the banner "Confocal Microscopy Training" at the bottom right of the website.

Applications will be processed in order of arrival.

You can view the course program on the following link:

"Basics on Confocal Microscopy "

IBUB Seminar "Nuclear receptors and Gene Specificity: Structural and Functional Insights"
 

Date: September 8th, 2014

Time: 12:00 hours

Place: Aula Magna ( Faculty of Biology )

poster

IBUB Seminar "Ru(III) complexes for anticancer therapy: when nucleolipids make the difference"
 

Date: September 4th, 2014

Time: 16:00 hours

Place: Sala de Graus Eduard Fontserè

(Aulari Física, planta 1)

( Faculty of Phisics )

poster

IBUB Seminar "¿Qué produce la deficiencia en la expresión de pleiotrofina en el hipocampo?"
 

Date: July 28th, 2014

Time: 12:00 hours

Place: Aula 3( Faculty of Pharmacy )

poster

IBUB Seminar "SISTEMA FGF23/Klotho"
 

Date: July 23rd, 2014

Time: 13:00 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology )

poster

IBUB Seminar"Una visión actualizada sobre canales y hemicanales y su posible role en transporte transmembranal"
 

Date: July 11th, 2014

Time: 13:00 hours

Place: Aula 18 (Aulari) ( Faculty of Biology )

poster

The IBUB researcher Antonella Consiglio, participating in the discovery of N-cadherin as a protein that can generate new neurons from brain stem cells
 

Antonella Consiglio, researcher at the Institute of Biomedicine of the University of Barcelona (IBUB), participated in a study that could shed light on the normal programme of activation of stem cells in the adult brain to produce new neurons throughout life. The work, published on the online edition of the journal Nature Cell Biology, was coordinated by Isabel Fariñas, head of the Molecular Neurobiology Unit of the University of Valencia (UV).

Experts Carlos López-Otín (University of Oviedo) and Robert Kypta (CIC bioGUNE, Bilbao) also participated in the study. Our tissues are constantly being renewed thanks to the stem cells that generate new cells to replace old cells. These stem cells are located in very specific locations within tissues, known as microenvironments or niches and in which stem cells are related to other types of cells. Although the regulation of these cellular interactions is poorly understood in general, stem cells in the adult brain are attached to other cells of its niche by a cell adhesion protein called N-cadherin, acting as a link. This study, carried out with mice, has shown that there is a protein, called MT5-MMP, which is able to cut this link totally releasing stem cells from the control of the niche.

Antonella Consiglio carried out the in vivo manipulation of the N-cadherin protein by means of a lentivector. She participated in the production of the lentivector, its cellular validation and the stereotactic injection into mice brain necessary to carry out the study. “This technique was used in order examine the direct effects of N-cadherin without affecting the formation of adult brain stem cell niche, which may happen when transgenic mice are used”, explains the neurobiologist who is expert on gene therapy. “The work allows us to better understand the relationship between stem cells and their environment and identifies molecular targets on which to act to enhance the activation of these cells during the renewal of tissues or in regenerative processes”, says Eva Porlan (UV), first author of the work. Furthermore, it is important to take into account that the uncontrolled activation of stem cells can give rise to tumours.

Therefore, the study is related to other research questions addressed to understand how stem cell normal activation is controlled in order to find therapeutic solutions to tumours caused by this loss of control. In addition, new data in the study can contribute to regenerative medicine, a field of science which seeks therapeutic solutions based on stem cells for degenerative processes, such as the Alzheimer or Parkinson. The research developed by Antonella Consiglio is focused on stem cells and regenerative medicine. Her lab at IBUB is specialized in the development of experimental gene transfer and profits technology to better know the fundamental biological processes of molecular biology, for instance stem cell activity and neurogenesis.

 

IBUB Seminar "Polygenic burden in schizophrenia and other mental disorders"
 

Date: June 30th, 2014

Time: 12:00 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology )

poster

IBUB-tech Seminar : presentation of a computer system for data analysis and experimental design.
 

Date: June 6th, 2014

Time: 13:00 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology )

poster

IBUB Seminar "Mapping autophagy to integrative metabolism"
 

Date: May 28th, 2014

Time: 13:00 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology )

poster

An IBUB team describes a key gene in early brain regeneration in the planarian
 

You can find all the information on the following link

http://www.ub.edu/web/ub/ca/menu_eines/noticies/2014/05/045.html

 

IBUB-tech Seminar "The Horrid History of Cell Culture, Best Practices of Cell Culture, STR profiling for Cell Line Authentication"
 

Date: May 15th, 2014

Time: 12:30 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology )

poster

Ricardo Moure, pre-doc researcher in IBUB, winner of FameLab Spain

 

Ricardo Moure, a pre-doc researcher at IBUB, has been announced as winner of FameLab Spain in the final which took place on May 14th, in Madrid.

FameLab is an international scientific talks competition which started up in 2005 from an original idea at Cheltenham Science Festival, with the main purpose of nurturing the communication of science by identifying, training and introducing new talents – new spokespeople working in science - with an innovative format: short scientific talks.

Since 2007, thanks to a partnership with the British Council, FameLab has gone global, with competitions now held in more than 20 countries across Europe, Asia, Africa and also the US. Globally more than 5,000 people have taken part in FameLab competitions. After the successful first competition in Spain in 2013, the Spanish Foundation for Science and Technology (FECYT) and British Council Spain have launched Spain’s FameLab 2014.

Ricardo Moure made a three-minute monologue about the effects of the fat in our body when we have obesity and how it favors type II diabetes. With this victory,  Ricardo has secured participation in the international final of the Cheltenham Festival, to be held from 3rd to 8th of June.

Good luck, Ricardo




IBUB Seminar "Regulation of the ERK cascade in cancer and developmental disorders"
 

Date: April 10th, 2014

Time: 12:00 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology )

poster

IBUB Seminar "Gene therapy strategies for rare skin diseases"
 

Date: March, 6th, 2014

Time: 17:00 hours

Place: Aula 17 (Aulari) ( Faculty of Biology )

poster

Hot Topic Seminars: Ion channels in nervous system disorders
 

The IBUB, whithin the Neuroscience and Biomedicine Master seminars, has organized under the coordination of Dr. Antonio Felipe the scientific session "Ion channels in nervous system disorders."

Poster

The researchers of IBUB Roger Torres and Adriana Sànnchez  Danès win the 6th edition of "Fotorecerca".
 

Today December 18th, it was announced the jury's decision of the 6th edition of "Fotorecerca" award, a scientific photography annual competition summoned by the Barcelona Scientific Park (PCB) in order to show the research that is carried out through an artistic vision. This year's winning photograph was submitted by Roger Torres and Adriana Sànchez Danès, predoctoral researchers of the lab “Stem cells and neural plasticity” of the Institute of Biomedicine, University of Barcelona (IBUB), directed by Dr.Antonella Consiglio.

"A busy neuronal network"

Joan Bosch, Peter McCormick and Francesc Villarroya, IBUB investigators, awarded by Fundació Marató TV3 for developing research projects on cancer.
 

 



42 projects had been awarded among 318 projects applying for support to the 2012 Fundació Marató de TV3 call for research on cancer. The principal investigators of the projects received the awards at PRBB auditorium the last November 12th. Congratulations to everybody!

 

Laura Herrero, IBUB researcher, awarded with a fellowship of the 8th L’Oréal-UNESCO For Women in Science Programme.
 

 

Laura Herrero, IBUB researcher, is one of the five Spanish women scientists awarded with a fellowship of the 8th L’Oréal-UNESCO For Women in Science Programme, created in 2000. The Programme is supported by the State Secretary for Research, Development and Innovation of the Spanish Ministry for Economics and Competitiveness. Its main objective is to support and promote the research developed by Spanish young women scientists. Congratulations to Laura Herrero (the second women on the right in the picture below)


IBUB Seminar "Drug interactions with canalicular export/detoxification transporters"
 

Date: December 2nd, 2013

Time: 12:00 hours

Place: Aula 25 (Aulari)( Faculty of Biology )

poster

Mini symposium IBUB " METABOLISM, AT THE CORE OF DISEASE" On occasion of the 50th anniversary of SEBBM next 22 november, at Aula Magna, Faculty of BIology, University of Barcelona.
 

 

The Simposium is organized by SEBBM and the Institute of Biomedicine, University of Barcelona (IBUB), with the collaboration of CIBERobn.

Full poster

 

IBUB Seminar "The hypothalamic lipid metabolism-BAT axis: a key modulator of energy balance"
 

Date: November 15th, 2013

Time: 12:00 hours

Place: Aula 25 (Aulari)( Faculty of Biology )

poster

IBUB Seminar "The phosphatase and tensin homolog PTEN in non-alcoholic fatty liver diseases"

 

Date: November 12th, 2013

Time: 12:00 hours

Place: Aula de Graus( Faculty of Biology )

poster

One of the groups of IBUB participates in a research that identifies novel autism candidate genes
 

 

You can find more information in the following link:

 

IBUB Seminar "Pheocromocytoma  as a source of novel stem cell populations from ectopic brown adipose tissue in the adult"
 

Date: October 29th, 2013

Time: 12:00 hours

Place: Aula de Graus( Faculty of Biology )

poster

IBUB Seminar Junction-mediated spindle orientation maintains epithelial architecture and prevents EMT effects
 

Date: October 21st, 2013

Time: 12:00 hours

Place: Aula 25 ( Aulari) ( Faculty of Biology )

poster

IBUB participates in the most important European conference on `Drosophila’ 
 

From 16 to 19 October, more than 700 international scientists will attend the European Drosophila Research Conference (EDRC 2013), the most important European conference focused on basic and biomedical research that uses the fly fruit, Drosophila melanogaster, as a model system. The biennial conference, which takes place in Barcelona’s Palau de Congressos, includes 7 plenary lectures, 300 talks, 20 sessions and 400 posters.

More info

IBUB Seminar "Drug transporters in tumor resistance, their roles in personalized chemotherapy"
 

Date: October 4th, 2013

Time: 16:30 hours

Place: Aula 19 ( Aulari) ( Faculty of Biology )

poster

 

IBUB Seminar"Mecanismos neuroendocrinos de interacción entre estado energetico del organismo, la pubertad y la función reproductora: Implicaciones fisiológicas y fisiopatológicas"

 

Date: October 2nd, 2013

Time: 12:30 hours

Place: Aula 20 ( Aulari) ( Faculty of Biology )

poster

IBUB Seminar "Oportunidades de proyectos colaborativos con la Universidad de Guadalajara (Mexico) a nivel Botánico, Biodeversidad  Marina, Neurociencias"
 

Date: September 23rd, 2013

Time: 12:00 hours

Place: Aula 3 ( Faculty of Pharmacy )

poster

Information note on the punctuation criteria for the APIF grants of IBUB
 

The last pre-doctoral call awarded two grants APIF to be assigned to IBUB. This is good news on the line of consolidation of institutes at UB. According to the regulation, the punctuation of the candidates included two points on the basis of indicators of the Institute.

After the Permanent Comission meeting, we inform you that the criteria which IBUB will use to award the punctuation will be:

• quality mustidisciplinaritat and cross-scientific thesis proposal in accordance with the objectives of the IBUB

• history of collaboration and intra-mural activity of the receiving group inside IBUB

• equal in merit, priority will be given to proposals made by the thesis groups that have so far not received support from its own pre-doctoral program of IBUB fellowships.

It is obviously necessary condition that the supervisor is a member of the IBUB.

The application of the criteria togenerate the punctuation for each particular applicant will be made by the Permanent Comission, excluding members who may present a conflict of interest.

IBUB Seminar "Metabolic regulation of macrophage polarization"
 

Date: September 20th, 2013

Time: 12:00 hours

Place: Aula 19, Aulari ( Faculty of Biology )

poster

IBUB Conference "Sexual dimorphism in Rat Aortic and Mesenteric Endothelial Function under Hyperglycemic Conditions and in Streptozotocin-induced Diabetes"
 

Date: September 18th, 2013

Time: 12:00 hours

Place: Aula A5 Edifici històrici ( Faculty of Pharmacy )

poster

IBUB Seminar "The recent advances in omega-3 PUFA action:  Metabolic flexibility and adaptation mechanisms"
 

Date: July 17h, 2013

Time: 12:00 hours

Place: Aula de Graus, Aulari ( Faculty of Biology )

poster

Mini-Symposium on Retinal morphogenesis and degenerative eye diseases (IBUB and BKC)
 

Date: September 16th, 2013

Time:from 10:30 hours

Place: Aula 35

poster

IBUB Seminar "The lysosome as a control center for cellular clearance and energy metabolism"
 

Date: September 4th, 2013

Time:15:00 hours

Place: Sala Fèlix Serratosa, PCB

poster

IBUB Seminar"Biological roles of the imprinted microRNA genes at the Dlk1-Dio3 chromosomal domain"
 

Date: July 17h, 2013

Time:13:00 hours

Place: Aula de Graus, Aulari ( Faculty of Biology )

poster

IBUB Seminar"How do Hox Proteins find their Target Genes in the living Cell"
 

Date: July 16th, 2013

Time:12:00 hours

Place: Aula 25, Aulari ( Faculty of Biology )

poster

IBUB Seminar“Characterization of the energy metabolism of mammalian cell lines in culture”
 

Date: June 28th, 2013

Time:12:00 hours

Place: Aula 20, Aulari ( Faculty of Biology )

poster

IBUB Seminar "5’ splice sites and alternative splicing: the problems of too many choices"
 

Date: June 18th, 2013

Time:13:00 hours

Place: Aula de Graus ( Faculty of Biology )

poster

IBUB Seminar "The role of ERK5 in cancer"
 

Date: June 14th, 2013

Time:12:00 hours

Place: Aula de Graus ( Faculty of Biology )

poster

IBUB collaborates in the 23rd European Drosophila Research Conference ( EDRC) in Barcelona, October 2013
 
IBUB Seminar "Trim17, a novel E3 ubiquitin-ligase for Mcl-1, that is essential to neuronal apoptosis"
 

Date: April 30th, 2013

Time:12:00 hours

Place: Aula de Graus ( Faculty of Biology )

poster

IBUB Seminar “Implications of personalized medicine”
 

Date: April 22nd, 2013

Time:12:30 hours

Place: Aula Magna ( Faculty of Pharmacy)

poster

IBUB Seminar “Palmitoylation is a key regulator of intracellular trafficking”
 

Date: April 22nd, 2013

Time:10:00 hours

Place: Aula de Graus ( Faculty of Biology )

poster

IBUB Seminar "Tools for analytical data interpretation and prediction for academic teaching and for research"
 

Date: April 9th

Time:11:00 hours

Place: Aula 101 ( Faculty of Chemistry)

poster

IBUB Seminar “SPRET/Ei mice reveal new players is sepsis: GILZ and a miRNA”
 

Date: April 4th

Time:17:00 hours

Place: Aula de Graus, Aulari ( Faculty of Biology)

poster

The IBUB research group leaded by Antonella Consiglio, in a research publication in Nature Neurosciences.
  Antonella Consiglio and Irene Fernandez-Carasa co-author a recent publication in Nature Neurosciences dealing with the role of leucine-rich repeat kinase 2 (LRRK2) and its degradation by chaperone-mediated autophagy (CMA). A new LRRK2 self-perpetuating inhibitory effect on CMA that could underlie toxicity in Parkinson's disease by compromising the degradation of α-synuclein, another Parkinson's disease-related protein degraded by this pathway, is reported.
IBUB Seminar "The KCNN4 channel regulates the function of cells of the immune system in cystic fibrosis"
 

Date: March, 14th

Time:12:00 hours

Place: Aula de Graus, Aulari, Faculty of Biology

poster

Hot Topic Seminars: Ion channels in cancer.
 

The IBUB, along with the Biomedicine Master and the Consolider program, have organized, under the leadership of Dr. Antonio Felipe, the scientific session "Ion channels in cancer", with the participation of researchers from the University of Padova (Italy), the Imperial College of London (UK) and the University of Barcelona. The talks will begin at 10:00 on Friday March 8th.


Program details

Admission is free and no registration is required

 

IBUB Seminar"New transition-metal catalysis for heterocycle synthesis"
 

Date: February 15th

Time:12:00 hours

Place: Aula Magna( Faculty of Pharmacy)

poster

IBUB Seminar "Papel del estómago en la regulación del balance energético. Desarrollo de un sistema de explantes de tejido gástrico ex vivo"
 

Date: February 1st

Time:13:00 hours

Place: Aula de Graus( Faculty of Biology)

poster

Internal IBUB symposium was held on Friday 25th at the Palau de les Heures.
 



Final program

  IBUB Seminar"Selective autophagy: giving cleaning a new spin"
 

Date: December 21st

Time:13:00 hours

Place: Aula de Graus( Faculty of Biology)

poster

   
IBUB Seminar"Pyrimidine transporters and metabolism in Trypanosoma brucei - where are the drug targets?"
 

Date: December 21st

Time:11:00 hours

Place: Aula de Graus( Faculty of Biology)

poster

   
IBUB Seminar "New modulators of the anti-tumoural functions of p53"
 

Date: December 19th

Time:13:00 hours

Place: Aula 19, Aulari ( Faculty of Biology)

poster

   
Last IBUB Seminar "Spatio-temporal dynamics of Akt subcellular localization and cell fate"
 

Date: November 28th

Time:11:00 hours

Place: Aula 33 ( Faculty of Biology)

poster

International Symposium "From whole body metabolism to cell dysfunction in diabetes," in collaboration withIBUB, on 29 November morning in the Great Hall, Faculty of Biology.
 

The symposium takes place on the occasion of the international conference of the European consortium BetaBat in Barcelona, and will feature presentations by scientific researchers in top international field research in diabetes ((M.Cnop, Universitat de Bruseles; A. Vidal-Puig i E.Ron, Universitat de Cambridge, B.Thorens, Universitat de Lausanne; L.Groop, Universitat de Lund; F. Levine, Sanford's Research Center, USA). Attendance is free and no registration is needed.


See the program attached.

 

IBUB Seminar "Designer nucleases for genome editing in stem cells of mice and man"
 

Date: November 12th

Time:11:00 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology)

poster

New call for IBUB courses on Confocal Microscopy.
 

A new call has been opened to apply for IBUB courses on Confocal Microscopy. On this new offer there will 3 editions: November 30, December 14 and February 1 from 15 to 18 h. There is provided another edition on February 8 for a course of treatment of Confocal Microscopy image analysis.

Positions are open to all IBUB members and those who are interested in the basic course should send an application via registration through "Confocal Microscopy Training" banner which you can find on the web page (bottom right), option 1. If you want to apply for the Image analysis course, click option 3. It is NO necessary to have basic knowledge, in any case.

The order of receipt of applications will be considered.

Roderic Guigó conference on the results of the ENCODE project.
 

On Tuesday 6, at 3 pm, the IBUB together with the Department of Genetics at the University of Barcelona, has organized a talk by Dr. Guigó on the main findings of the ENCODE project. The results of this project were recently published in Nature, Genome Research, and so, and has resulted in a revolution in our concepts about the structure and mechanisms of regulation of gene expression. The conference of Dr. Guigó is an excellent opportunity to know on first hand the investigation. The conference is held in the Aula Magna of the Faculty of Biology.

Poster

Laura Herrero, from IBUB, has been the unique State researcher honored with the Rising Star Award of the European Foundation for the Study of Diabetes (EFSD) and the Jansen pharmaceutical.
 

This recognition , the more relevant that EASD grants to young researchers from all over Europe in the field of diabetes research, has also awarded the experts Joline Beulens (Netherlands) Bonnefond Amélie (France) and Henrike Sell (Germany) . Laura Herrero is part of the Group of the regulation of lipid metabolism from UB, member of CIBER Physiopathology of Obesity and Nutrition (CIBERobn). The Rising Star Award, in particular, has been given her for the project Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes, which analyzes how you can eliminate the excess fat present in obesity, for enhancing the action of brown adipose tissue, the main body responsible for energy expenditure. The project also earned an aid sponsored by the pharmaceutical company Lilly in the call of grants for EFSD in 2012. The Rising Star awards were given on October 2nd , as part of the 48th Meeting of the EASD in Berlin. During the awards ceremony, Laura Herrero gave the lecture «Adipose tissue inflammation in obesity and lipodystrophy» focused in her research on the relationship between obesity and insulin-resistant diabetes and new therapeutic strategies to fight these metabolic alterations.

 

Antonella Consiglio, researcher of the Institute of Biomedicine at the University of Barcelona (IBUB) has received one of the prestigious grants from the European Research Council (European Research Council, ERC) for research projects of young researchers (Starting Grants).
 

The project is titled "Elucidating early pathogenic mechanisms of neurodegeneration in Parkinson's disease through humanized dynamic in vitro model", and want to further in the fundamental knowledge of neurodegenerative disease of Parkinson, the most common in Alzheimer's disease, using for the first time an innovative model of disease compared with those who had used so far. The team led by researcher Consiglio has developed a cellular model generated from Parkinson's patients, using pluripotent stem cells created and induced in the laboratory. The interdisciplinary nature of this biotechnologist technique.will allow to further the understanding of Parkinson and the process of neurodegeneration, and also will provide a new model as a platform for exploring new therapeutic strategies.

 The grant is awarded one of 12 grants obtained by researchers of Catalonia within the 29 grants awarded starting in Spain and one of 4 obtained by researchers around UB.

 Dr. Consiglio IBUB runs a lab in the building of the Helix PCB that operates within the framework of the promotion of emerging researchers of IBUB.

We announce the celebration of  the "II International Workshop on Ion Channels in health and disease", on  Septembre 14th, organized by Dr. Antonio Felipe from IBUB.
 



With the participation, among others, of USA researchers (MM Tamkun, Colorado State University; WACatterall, University of Washington), Germany (TJ Jentsch, Leibniz-Institut für Molekulare Pharmakologie, Berlin) and Madrid (E. Barroso  Institute of Molecular and Medical Genetics, Hospital Universitario La Paz)

 Attendance is free and no registration is requiered.

For more information

A technology patented by Dr. Xavier Barril’s group of IBUB, has led to a license agreement between the University of Barcelona, ICREA and Minoryx to develop a new generation of pharmacological chaperones.
 

The pharmacological chaperones are drugs that base their mechanism of action in the rescue of the functionality of proteins that have lost it due to genetic defects. This is a very common situation in rare diseases, and pharmacological chaperones are presented as one of the most promising and innovative approaches to treat them. This potential is especially important in cases of diseases with neurological components that do not respond to usual therapies. The technology developed by Xavier Barril helps to identify pharmacological chaperones that exceed the limitations which these type of drugs have found so far, allowing a qualitative leap in this approach. Minoryx has initiated several projects where this technology is exploited and they expect to have the first candidate for development during 2014. Dr. Xavier Barril, from the Department of Physical Chemistry of the University of Barcelona, leads a research group in the Computational Biology Unit of IBUB, one of the strategic IBUB units, established in 2009.

Unitat de Biologia Computacional



IBUB Seminar "Voluntary versus forced metamorphosis of glia into neurons"
 

Date: July, 18th

Time:15:00 hours

Place: Aula Magna ( Faculty of Biology)

poster

Dr. Antoni Camins, from IBUB, together with Dr. Carlos Beza of the University of Guadalajara, Mexico, organized the "International Seminar on epilepsy and neurodegeneration," which will take place on Friday 13 July at the Great Hall of the Faculty of Pharmacy.
 

The seminar, with the participation of several international researchers, has been organized with the participation of the GENIAR net (Group of Latin American Study of Neuroscience in Red), the CIBER on neurodegenerative Diseases, the Faculty of Pharmacy, and IBUB. The assistance is open to all interested and admission is free.The detailed program can be found on the poster attached.

 

Date: July, 13th

Time: 09:45 hours

Place: Aula Magna (Faculty of Pharmacy)

poster

We announce the celebration of the Mini-Symposium "Novel actors in the control of adiposity and energy balance", jointly organized by IBUB and CIBERobn
 

The event will take place next Friday, June 22nd at the Faculty of Biology, and attendance is open and free.

Poster

Dr Eva-Estebanez Perpiñá from IBUB presents Dr David G Lloyd research on friday 22nd at a seminar of the series "Barcelona BioMed Seminars" on PCB
 

Date: June, 22nd

Time:10:00 hours

Place: Fèlix Serratosa Room (PCB)

poster

Next IBUB Seminar " The prion diseases"
 

Date: June, 19th

Time:12:00 hours

Place: Aula A3 ( Bbuilding A) ( Faculty of Pharmacy)

poster

The researchers of IBUB Bru Cormand and his collaborator Celia Sintas, co-authored a scientific paper published in Nature Genetics, which has identified 4 new genes susceptible to migraine.
 

An international scientific consortium has identified some genetic risk factors for migraine without aura, which is the most common subtype of migraine in the population. The research, published in the online edition of Nature Genetics, involved Professor Bruno Cormand and his collaborator Celia Sintas, members of the research group led by Dr. Daniel Grinberg from IBUB. The scientific work that has identified 4 new genes susceptible to migraine without aura, is based on a case-control association study in genomic scale conducted with 5000 patients with common migraine (without aura) and 7000 control indiciduals. Specifically, the study reveals that several polymorphisms of genes MEF2D, TGFBR2, and PHACTR1 ASTN2 increase the risk of migraine, a neurological disorder that affects 1 in 6 women and 1 in 12 men. In addition, this new research has confirmed the association between this disease and TRPM8 and LRP1 genes, described and related to migraine in previous works by the same consortium.



IBUB Seminar "Bases Estructurales y Funcionales de la Regulación Alostérica de los Receptores P2X"
 

Date: June, 11th

Time: 13:00 hours

Place: Aula de Graus (Aulari) ( Faculty of Biology)

poster

IBUB Seminar "Novel Therapeutic strategies for oncogenic KRAS-driven cancers"
 

Date: June, 8th

Time: 13:00 hours

Place: Aula Magna ( Faculty of Biology)

poster

The IBUB participates in the celebration of the "XXVIII Annual Meeting of the Reference Network R & D in Theoretical and Computational Chemistry" next June 11th and 12th, at the Aula Magna of the Faculty of Biology.
 

Date: June, 11th and 12th

Place: Aula Magna ( Faculty of Biology)

poster

 

Last IBUB Seminar " Understanding the Purinome: the Role of Nucleoside Transporters"
 

Date: June, 1st

Time:13:00 hours

Place: Aula 18 ( Aulari) ( Faculty of Biology)

poster

   
IBUB Seminar "La regulación del acetiloma por las sirtuinas y su relevancia en el envejecimiento"
 

Date: May, 30th

Time:12:00 hours

Place: Aula Magna ( Faculty of Pharmacy)

poster

   
The IBUB research group led by Francesc Villarroya participates in the discovery of a new mechanism of regulation of brown adipose tissue, as published in the May issue of the journal Cell.
 

The Bone morphogenetic protein B (BMP8B) plays a key role in the regulation of thermogenesis in brown adipose tissue, according to the conclusions, acting at both central and peripheral level. The finding was the result of investigations conducted by the research group of Antonio Vidal-Puig, University of Cambridge, UK, with the participation of laboratories from Iowa (USA), Stockholm (Sweden) and the team of Miguel Lopez from the University of Santiago de Compostela, a member of CIBERobn as the group of  Francesc Villarroya.

 

For further information see:

http://www.ub.edu/web/ub/en/menu_eines/noticies/2012/05/077.html

 http://www.ncbi.nlm.nih.gov/pubmed/22579288

www.ub.edu/tam

 

Dr Eva-Estebanez Perpiñá from IBUB presents her research on Wednesday 23 May at a seminar of the series "Barcelona BioMed Seminars" on PCB
 

Date: May, 23rd

Time:9:30 hours

Place: Fèlix Serratosa Room (PCB)

poster

The research group led by Eva IBUB Estébanez-Perpiñá, has been selected to measure protein crystals in the ALBA Synchrotron, the largest scientific infrastructure of our country.

 

 The scientific proposal of Eva Estébanez-Perpiñá has obatined synchrotron light time which will develop drug discovery projects against alternative for prostate cancer and o ther diseases in which nuclear receptors, the subject of her research group study, play a role (for ex. brain tumors and metabolic diseases). The ALBA synchrotron is an accelerator of electrons and the X-rays produced are used, among other applications, to determine the three dimensional structure of key proteins in normal and pathological biological processes.

Link

 

The IBUB research team led by the Jordi Garcia-Fernandez, Department of Genetics, participates in the discovery, published in the journal Nature Communications, of a new family of six genes that regulate the movement and positioning of mitochondria in neurons.
 

This work was led by Eduardo Soriano of the Institute for Research in Biomedicine (IRB Barcelona). It is a cluster of six genes that could be altered in neurological diseases such as Parkinson's disease and Charcot-Marie-Tooth, which are caused by alterations in genes that regulate the transport of mitochondria, the organelles responsible for providing energy for cellular metabolism. For more information: http://www.ub.edu/web/ub/ca/menu_eines/noticies/2012/05/032.html

CANCELLED Next IBUB Seminar "Rellevància de les interaccions tumor-estroma durant la progressió del càncer de mama i en resposta al tractament"
 

Date: April, 26th

Time:11:30 hours

Place: Aula 18 (Aulari, Faculty of Biology)

poster

The IBUB research group led by Daniel Grinberg and Susana Balcells, participant in a study of susceptibility genes for osteoporosis and fractures published in Nature Genetics.
 

Susana Balcells and Urreizti Roser, researchers from the IBUB and Department of Genetics of UB participated as co-authors in an extensive meta-analysis of Genomewide association (GWA) to identifysusceptibility genes for osteoporosis and fractures. In Barcelona, this group has done the research in collaboration with the Department of Internal Medicine, Hospital del Mar-IMIM-URFOA. This study has allowed the identification of  56 genetic loci associated with bone density and 14 loci associated with fracture risk. The study was conducted within the context of the consortium GEFOS (Genetic Factors forOsteoporosis Consortium) funded by the European Union .The article is accessible on the website of Nature Genetics as "Advanced online publication."

 

A publication by the IBUB research team leaded by Francesc Villarroya,  designated by the Journal of Biological Chemistry  as one of the best papers published by the journal in 2011.
 

The paper is  "Peroxisome Proliferator-activated Receptor-gamma Coactivator-alpha Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype”  by Albert Giralt, Elayne Hondares, Francesc Ribas, Julieta Díaz-Delfín, Marta Giralt, Roser Iglesias and Francesc Villarroya.

The journal selected only 20 papers – out of the more than 4,000 that were published last year – to receive this special designation. They chose one paper for each of the jounral’s affinity groups, and the study by Albert Giralt and collaborators represents the best in the Bioenergetics affinity group.

Journal of Biological Chemistry will make a public announcement soon, and have made all of the Best of 2011 papers freely accessible at http://www.jbc.org/site/bestoftheyear.

The Journal of Biological Chemistry is the official journal of the American Society for Biochemistry and Molecular Biology (ASBBM), established in 1905,  and it is among the international journals on Biochemistry with the highest international reputation.  

IBUB International Workshop on lipodystrophies organized in collaboration with the CIBER Physiopathology of Obesity and Nutrition, and the Spanish Society on Lipodystrophies
 

The Institute of Biomedicine of the University of Barcelona (IBUB) has organized in collaboration with CIBER Physiopathology of Obesity and Nutrition and the Spanish Society on Lipodystrophies, the international research workshop "Lipodystrophies". Lipodystrohies are a group of genetic or acquired (eg as a result of treatment in patients infected with the AIDS virus) diseases. Patients suffer alterations in the distribution of fat in the body, often with loss in some areas and accumulation in other sites. Apart from the problems of disfigurement that may occur, there are also important metabolic abnormalities in patients, especially diabetes,  liver steatosis and dyslipidemia, thus leading to a significant cardiovascular risk. The complexity in the origin and manifestation of these diseases make them poorly understood and treatment alternatives are scarce.
This session will bring together leading Spanish researchers in these diseases with the collaboration of international experts.

 


The Symposium is free open to the attendance of all interested researchers.

Complete Banner

Researchers at IBUB, in collaboration with other research groups of the IBEC, Hospital Clinic and Vall d’Hebron, have made an important leap towards understanding the second most common neurodegenerative illness, Parkinson’s disease (PD)
  Researchers at IBUB, in collaboration with other research groups of the IBEC, Hospital Clinic and Vall d’Hebron, have made an important leap towards understanding the second most common neurodegenerative illness, Parkinson’s disease (PD), which affects around 5% of the population by age 85. The identification of the pathophysiological mechanisms behind this neurodegenerative pathology has been particularly hampered by the lack of genuine in vitro models and animal models faithful to the human pathology. Parkinson’s, which can be either genetic or sporadic, is characterized by a selective loss of particular neurons located in the part of the brain responsible for controlling movement of the body. The recent work published in EMBO Molecular Medicine journal reports for the first time the generation of a new cellular model that recapitulates the Parkinson's disease in dopaminergic neurons derived from induced pluripotent stem cells (iPSC). "We obtained cells with similar features to embryonic stem cells from skin fibroblasts of genetic PD patients, sporadic PD patients and healthy control group", said Ángel Raya, who leads the Control of Stem Cell Potency group at IBEC. Then, the cells were differentiated to dopaminergic neurons, the type of cell which is degenerated in the pathology, and keeped in culture for three months in order to mimic the aging process that occurs in the brain of patients. "Surprisingly, we saw that the ones from both types of PD patients exhibited clear signs of neurodegeneration, including a decrease in number and size of neurites, and an increase in the number of apoptotic neurons, necessary to the development of the disease, but not the ones from the healthy patients.” said Antonella Consiglio, who leads the group of Neural Commitment and Differentiation at IBUB.
 

This reveals that susceptibility to sporadic (non-hereditary) PD should be coded in patients’ genomes just as clearly as other patients’ tendency to the hereditary kind, and it’s also the first time that the spontaneous phenotypes that lead to sporadic PD have been described. The researchers were also able to identify that the neuronal alteration leading to both types of PD are the result of altered autophagy (the process by which cells ‘spring clean’ themselves by degrading their toxic waste and damaged parts).
As well as shedding light on some of the key players and pathological mechanisms of the disease, the human experimental model generated,  captures patients’ genetic complexity, displays the prominent features of PD, and can eventually enable the identification of new therapeutic strategies that may prevent or remedy PD-related neurodegeneration.

Sánchez-Danés A., et al (2012) Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson’s disease. EMBO Molecular Medicine, in press
http://onlinelibrary.wiley.com/doi/10.1002/emmm.201200215/pdf

IBUB HOT TOPIC SEMINAR "Neurophatic Pain"
 

Date: March, 9th

Time:10:00 hours

Place: Aula de Graus (Aulari, Faculty of Biology)

poster

IBUB Seminar "Regulation of gene expression during cellular differentiation"
 

Date: March, 7th

Time: 12:00 hours

Place: Aula de Graus (Aulari, Faculty of Biology)

poster

IBUB Seminar "RAGE: a pattern-recognition receptor"
 

Date: February, 22nd

Time: 12:00 hours

Place: Aula de Graus (Aulari, Faculty of Biology)

poster

Dr. Francesc Villarroya, was elected director of the IBUB for the next four years.
 

At the meeting of the executive council of IBUB, last January 13th, Dr. F.Villarroya was elected director for the next four years.

According to the regulation of IBUB, the elected director announced that Dr. Florenci Serras would remain as Secretary of IBUB for the next period.

Last IBUB Seminar "La glándula de Harder del hámster sirio. Un modelo de variaciones de estrés oxidativo y autofagia en condiciones fisiológicas"
 

Date: January 20th

Time: 13:00 hours

Place: Aula 10 (Aulari, Facultat de Biologia)

poster

A research on Nucleoside Transporter Proteins in placenta from the IBUB research team leaded by Dr. Marçal Pastor-Anglada, in the cover of the journal Molecular Pharmacology
 
New call for IBUB courses on Confocal Microscopy.
 

A new call has been opened to apply for IBUB courses on Confocal Microscopy. On this new offer there will be 4 editions: November 18th , November 25th, December 2nd  and December 16th   from 9 to 12 h.

Positions are open to all IBUB members and those who are interested should send an application via registration through "Confocal Microscopy Training" banner which you can find on the web page (bottom right) .
   
Last IBUB Seminar "Papel de adenosina sobre la disfunción de podocitos y células mesangiales en ratas diabéticas" 
 

Date: September 30th

Time: 13:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

Jordi García-Fernández, Ignacio Maeso, Manuel Irimia and Salvatore D’Aniello, from IBUB,  participate in the discovery of the oldest DNA regulatory region.
 

The autors report in a recent publication in Proceedings of the National Academies of Sciences (PNAS) the identification of the oldest known DNA regulatory region, next to  the soxB2 genes. The study is co-authored by the research groups of José Luis Gómez-Skarmeta (Centro Andaluz de Biología del Desarrollo, CSIC) and Eric H. Davidson (California Institute of Tehcnology, US). Advancement in the knowledge of the non-coding DNA regions involved in the control of gene expression is essential for biomedical research, as multiple genetic diseases are known to be caused by alterations in these regions.

For further information:

http://www.ub.edu/web/ub/en/menu_eines/noticies/2011/09/047.html

Symposium "Nuclear hormone receptors: meet the family" next September 21st.
 

Date: September 21st

Time: 09:30 hours

Place: AULA MAGNA (Faculty of Biology)

program

FREE ENTRANCE

   
Four research groups from IBUB, in the Oncocat network
 

Oncocat network has been created to promote coordination between organizations and oncology research groups and promote synergies in research on cancer in Catalonia. IBUB groups led by Drs C. Ciutat, M. Pastor-Anglada, M. Cascante, A.Mazo and E. Estebanez are members of the newly created network.

Last IBUB seminar "Adipocitos perivasculares y la señalización vía Receptores Toll-like: Papel en la patofisiología de aterosclerosis"
 

Date: June 16th

Time: 09:30 hours

Place: Aula 20- Aulari (Faculty of Biology)

poster

   
IBUB seminar " Mecanismos moleculares implicados en la resistencia a insulina asociada a la obesidad: papel del órgano adiposo"
 

Date: May 6th

Time: 13:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

IBUB course on "Image Analysis: Introducing Fiji/Image J"
 

New call to attend the course on "Image Analysis: Introducing Fiji/Image J" for IBUB researchers. An offer of an intensive course of initiation treatment of Confocal Microscopy image analysis. The course will be held on April 28th and all the IBUB researchers interested in attending the course can make a request at the banner in red down right of the webpage ( Confocal microscopy training), option 3. ( Basic knowledge of confocal microscopy is not required)

The order of submitting applications will be considered

Marta Cascante, head of the research group on Integrative Systems Biology, metabolomics and Cancer of IBUB, awarded by ICREA Academy.
 

 Dra Marta Cascante, Professor on Biochemistry and Molecular Biology department, has been awarded the ICREA incentive Academy of research excellence in the university system of Catalonia. Dra Cascante is a member of the Network of Cooperative Research on Cancer (RTICC) and of the R+D+i Reference Network in Theoretical and Computational Chemistry (XRQTC) of Catalonia. She has authored over 150 publications and her research focuses on the study of cancer and metabolic diseases with the aim of deepening, by the approach of systems biology, in the knowledge of networks and metabolic basic pathways that cause the development and progression of these diseases.

Andrés Iniesta supports research on Sanfilippo syndrome
 

The seventh edition of the book 'Stories of solidarity Sport” was presented as “ Sport Heroes “ and was sponsored by Andrés Iniesta. This initiative will spend its funds to the “Barcelona Sanfilippo Association” to help to study the congenital disease "Sanfilippo Syndrome". This disease is a form of mucopolysaccharidosis due to mutations in coding genes for some enzymes of the mucoplisacàrids degradation pathway. Symptoms appear after the first year of life, there is a lack of learning capacity in children affected and produces a deterioration in growth and mental state gradually.
The research group of IBUB "Human Molecular Genetics" directed by Daniel Grinberg of the Department of Genetics of the University of Barcelona, and in particular the research line of lysosomal diseases conducted by Daniel Grinberg and Lluïsa Vilageliu, has made important contributions to the knowledge of the disease, having recently described and characterized seven new mutations in the Spanish population affected by Sanfilippo C ((Molecular analysis of Sanfilippo syndrome type C in Spain: seven novel HGSNAT mutations and characterization of the mutant alleles. Canals I, Elalaoui SC, Pineda M, Delgadillo V, Szlago M, Jaouad IC, Sefiani A, Chabás A, Coll MJ, Grinberg D, Vilageliu L.Clin Genet. 2010 Aug 2).
Isaac Canals (left in photo) is carrying out his doctoral thesis about this disease, under the direction of Drs Lluïsa Vilageliu and Daniel Grinberg (center in photo).

IBUB Seminar " The molecular basis of inflammation and cardiovascular diseases in aging"
 

Date: March 31st

Hour: 12:00 hours

Place: Aula 33 (Faculty of Biology)

poster

Key role of the protein NOVA in the assembly of complex gene networks during evolution, a new collaboration between the two groups of IBUB led by Dr. Jordi Garcia and Dr. Gemma Marfany, published this month in PNAS
 

The phenomena of maturation of alternative transcripts (differential splicing) have a critical role in differentiation, development and in many diseases. In fact, over 90% of human genes produce multiple transcripts and some splicing factors, such as protein NOVA that, through alternative splicing, regulates expression of a specific proteome, from tens to hundreds of genes, in the nervous central system of mammals. This paper shows how the network regulated by NOVA has been assembled step by step during the evolution of metazoans, first for the acquisition by protein NOVA of the capacity to produce specific splicing of vertebrates in the origins of chordates, second by restricting the expression of NOVA in the nervous central system just before the origins of vertebrates, and third by the acquisition of new exons and targets by NOVA during the evolution of vertebrates. This work shows that despite having a similar number of genes, the human proteome is much larger than those of invertebrates, and that the regulation of splicing factors and the creation of new exons are key in the assembly of specific gene networks of complex systems like the human nervous system, through the use of differential splicing.

Dr. Jordi Garcia
Evolution and development

Dra. Gemma Marfany
Human Molecular Genetics I

For more information +

 

Next IBUB Seminar, HOT TOPIC SEMINARS "Cardiovascular Ion Channelopathies"
 

Date: March 18th

Time: 10:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

IBUB researcher, Dra. Silvia Busquets, receives the "Antoni Caparrós" Award for the project "Formoterol: a new therapeutic strategy in the treatment of cachexia"
 

The fact that the Formoterol project is a product of Phase IIA advanced study in patients, as well as the continued collaboration and publications, are issues that have been valued to award with this “Antoni Caparrós” Prize to Dra. Silvia Busquets, lecturer of the Department of Biochemistry and Molecular Biology, Faculty of Biology and member of the research team of IBUB "Biochemistry and Molecular Biology of Cancer". The recipient of this knowledge transfer is a pharmaceutical company in Cambridge (UK), which elaborates products to treat the symptoms of patients with cancer. The patent was licensed in June 2008 to this pharmaceutical company that is now conducting a Phase IIA clinical study with patients in “Edinburgh Royal Infirmary Hospital” to verify the anti-cachectic efficacy in humans.

CANCELLED Next IBUB Seminar "Oxygen sensors and hypoxia-inducible factors in health and disease"
 

 

CANCELLED

Date: February 25th

Time: 13:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

IBUB Researchers discovered a new factor with a key role in controlling dorsiventral body symmetry
 

The IBUB researchers M. Dolores Molina, Ignacio Maeso, Emili Saló and Francesc Cebrià discovered in planarian a new factor - the noggin-like protein - as a key role in the pathway that controls the pattern of dorsiventral body symmetry. The finding was published in an article in the journal "Current Biology" and the research has been carried out in collaboration with Ana Neto and José Luis Gómez-Skarmeta, of the "Centro Andaluz de Biologia del Desarrollo" CSIC.

For more information: http://www.ub.edu/web/ub/en/menu_eines/noticies/2011/02/07.html

 

Last IBUB Seminar " mIGF-1/SirT1 signaling and epigenetics during cardiac stress"
 

Date: January 21st

Time: 12:00 hours

Place: Aula 18 (Aulari, Faculty of Biology)

poster

IBUB Seminar "Programas de Colaboración Académico-Científicos con la Universidad de Guadalajara (México). Oportunidades y Retos"
 

Date: January 19th

Time: 12:30 hours

Place: Aula Magna (Faculty of Pharmacy)

poster

   
 

IBUB offers 3 pre-doctoral fellowships for the realization of the thesis in interdisciplinary research projects in biomedicine. The projects selected by IBUB which will have these grants assigned are focused on basic experimental research on bioactive molecules with potential therapeutic application for human disease.

The scholarships are annually renewed with a maximum of 4 years and include the monthly salary and the expenses of the academic PhD at the University of Barcelona.

You can find details of the projects associated with the grants, the call features and application forms at the link:

http://convocatories.ub.es/bepj/56BB.html

Application Period: From January 3rd to January 17th

 
The group from IBUB led by Dr. Diego Muñoz-Torrero, Professor of the Department of Pharmacology and Therapeutic Chemistry from the Faculty of Pharmacy, has received financial support from the Spanish Genome Foundation to develop new compounds against Alzheimer’s disease.
 

This group has developed a patent for a group of multipotent compounds, with a pharmacological combined profile that includes beta-secretase inhibition and aggregation of beta-amyloid peptide, which should block the neurodegenerative cascade at various levels in initial stages. One of these compounds that has shown superior activity in vitro than the reference drug, donepezil, will be tested in model animals of Alzheimer's disease to obtain  preliminary data of its efficacy and safety.

The Bosch i Gimpera Foundation manages a collaboration agreement between the research group and the Spanish Genome Foundation which will support and fund the proof of concept studies in animals and the optimitzation of preclinical development, as well as undertaking to help achieve the commercialization of these compounds.

Carles Galdeano, who made his PhD thesis with the financing of IBUB within the program to support interdisciplinary research projects in biomedical research in our Institute,  has participated in this study, along with other members of the research team. He recently received an award from the pharmaceutical company Lilly in the eighth edition of its Research Awards for PhD students.

 
Last IBUB Seminar“miR-33: A New Master Regulator of Sterol Homeostasis”
 

Date: December 21st

Time: 12:00 hours

Place: Aula de Graus (Aulari, Faculty of Biology)

poster

IBUB Seminar “Epigenetics: from Cell Biology to Human Disease”
 

Date: December 20th

Time: 15:00 hours

Place: Aula Magna ( Faculty of Biology)

poster

IBUB Seminar “Metabolismo lipídico hipotalámico y regulación del balance energético”
 

Date: December 16th

Time: 16:00 hours

Place: Aula 18 (Aulari, Faculty of Biology)

poster

   
IBUB Seminar “Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids”
 

Date: December 10th

Time: 11:00 hours

Place: Aula de Graus (Aulari, Faculty of Biology)

poster

   
The IBUB scholarship holder,  Carles Galdeano, among the ten winners of the VIII Lilly Research Award for Doctoral Students.
 

Carlos Galdeano Cantador has received one of the ten prizes awarded by the pharmaceutical company Lilly in the eighth edition of its Research Awards for PhD students, awards that recognize the research work of doctoral students in the areas of Organic Chemistry, Pharmaceutical and Analytical.

The work presented by Carlos Galdeano  is entitled "Multi-target-directed drug design: a novel class of dual binding site acetylcholinesterase inhibitors against Alzheimer's disease". This work is framed within the doctoral thesis project that aims to develope new compounds with potential to prevent, stop or delay the neurodegenerative process of Alzheimer's disease, led by Drs. Diego Muñoz-Torrero and F. Javier Luque, researchers of our Institute. This project was one of the  three projects that in 2008 received the support of IBUB within the program of support to interdisciplinary research in biomedicine. Congratulations!

 
The researcher Josep F. Abril from IBUB, among the elite of the most cited scientists in the world.
 

Josep F. April, IBUB researcher and professor of the Department of Genetics, is one of UB researchers who are among the most cited authors in the world, according to the ISI Web of Knowledge, an international free access database which analyzes the impact of scientific activity. Based on these data,  Josep F. April and Joan Rodés from IDIBAPS, are among  the group of twenty-six researchers from Spain that are in the elite of the most cited scientists worldwide.

Josep F. April is a member of the Bioinformatics Unit of IBUB since its creation. His research activity is focused on computational analysis of the signals involved in determining the exonic structures of eukaryotic genes (in processes such as cutting and splicing junction), predicting genes in genomic sequences using bioinformatic tools and the validation of these predictions.

Author of several scientific papers on computational analysis of eukaryotic genomes published in high impact scientific journals, he is one of the experts who participated in the visualization and analysis of the genomes of several model organisms such as Drosophila melanogaster,  and the lab rat. He was part of the scientific team that produced a first draft of the human genome, published in the journal Science in 2001. More recently, he collaborated on the project of annotating the first haploid genome of an individual human being, the genome of J. Craig Venter (PLoS Biology, 2007).

Currently  he is working on the integration of data obtained by different methods of genomics, transcriptomics and proteomics, to functionally annotate the genome of the planarian Mediterranean Schmidtea, an organism that may be essential for understanding the molecular mechanisms of the regeneration in metazoans.

   
IBUB Symposium " From Stem Cells to Regeneration, Models in Tissue Regeneration"
 

Date: November 12th

Time: 09:15 hours

Place: Aula de Graus (Aulari, Faculty of Biology)

poster

   
News from our Confocal Microscopy Training program..
 
The demand for courses on confocal Microscopy has been a great success. The sessions started again in late 2010 and 5 sessions at a basic level and also another advanced session were programmed.

We'll make a reminder to present the applications for those who have not yet been able to attend the course and also to new demands. Thanks for your interest. We hope this IBUB service would be a benefit for your research.

 

 

The project "Identification of androgen receptor aggregates that cause Bulbar Spinal Muscular Atrophy ", presented by Dr. Eva Estébanez Perpiñá from IBUB, in coordination with teams from IRB and the University of Cambridge has been funded by the TV3 Marathon call for research in rare diseases.
 

In the 2009 edition of the TV3 Marathon, dedicated to rare diseases, 20 of the 287 projects presented have been awarded. The project funded is coordinated by Dr. Xavier Salvatella, Institute of Biomedical Research with two other sub-projects under the direction of Dr. Eva Estébanez from IBUB and Dra. Leila Luleshi from the University of Cambridge. The Bulbar Spinal Muscular Atrophy (AMSB) is a rare hereditary neurodegenerative disease that occurs only in males and has no treatment. The AMSB is due to the appearance of aggregates in motor neurons formed by androgen receptor molecules with poliglutamina extensions to the N-terminal domain. The aim of the project is based on establishing the nature and structural characteristics of the aggregates that cause the death of motor neurons and eventually the appearance of AMSB symptoms.

Dr. Estébanez Perpiñà leads the research group "Nuclear Receptors as Novel Therapeutic Targets Interaction Surfaces" from IBUB since January 2008, when she joined our Institute within the IBUB emergent researchers program.

IBUB Seminari "Rutas de Señalización reguladoras de la plasticidad metabólica en el músculo esquelético. Relevancia para la prevención y el tratamiento de la diabetes mellitus tipo 2"
 

Date: October 29th

Time: 12:30 hours

Place: Aula 19 (Aulari, Faculty of Biology)

poster

   
IBUB Conference "Transtornos de conducta y psicoestimulantes: aspectos neurobiológicos relacionados con su uso psicoterapéutico y su potencial adictivo"
 

Date: October 27th

Time: 12:00 hours

Place: Aula 7 ( Building A, Faculty of Pharmacy)

poster

   
IBUB Conference " De la ingeniería genética a la patente industrial: un caso de diseño y elaboración de una vacuna"
 

Date: October 21st

Time: 16:00 hours

Place: Aula A5 (Faculty of Pharmacy)

poster

   
IBUB Seminar "Simulaciones de proteínas a pH constante. A veces un pKa no es un pKa"
 

Date: October 20th

Time: 12:00 hours

Place: Aula Magna (Faculty of Pharmacy)

poster

IBUB Conference "Influenza Virus M2 Proteins: Progress Toward Finding a Useful Inhibitor"
 

Date: October 18th

Time: 12:30 hours

Place: Aula 4 (Faculty of Pharmacy)

poster

IBUB workshop "Ion Channels in Health and Disease"
 

Date: September 17th

Time: 10:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

IBUB laboratories in Hèlix Building, participate in the program "Spend the Summer in the Park" organized by the Barcelona Science Park.
 

 

IBUB laboratories at the Barcelona Science Park

(Dra. Eva Estébanez and Dra. Antonella Consiglio)

For further information

 

 

IBUB seminar "ATP Binding Cassette (ABC) Sterol Transporters: Roles in Inflammation, Apoptosis and Atherosclerosis"
 

Date: June 28th

Time: 12:00 hours

Place: Aula Magna (Faculty of Biology)

poster

   
Last June 21st, Dr. Joan Bosch, a IBUB researcher, leader of the group Synthesis of Nitrogen Bioactive Compounds joined the Royal Academy of Pharmacy of Catalonia as an Aademic Fellow Member.
 


Last Monday 21st of June, at 7 pm, took place in the Hall of the Royal Academy of Pharmacy of Catalonia (C / Hospital, 56 Barcelona) the admission of Dr Joan Bosch Cartes as an Academic Fellow Member of this Royal Corporation.
IBUB seminar "How EFF-1 Fuses Cell Membranes and Sculpts Epithelia, Muscles and Neurons"
 

Date: June 15th

Time: 13:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

Call for doctoral fellowships projects, IBUB 2010
 

 

Please note :
The deadline for submitting applications has been opened

(7-06-2010) In the framework of the contract-program IBUB 2010, applications may now be made for 2 doctoral fellowships for doctoral theses to be developed in collaboration between teams at the IBUB. Further information and the conditions of application can be consulted at the links below.

The deadline for all applications is July 1st, 2010.

 

The audio visual about Research on Metabolic Diseases of IBUB in collaboration with St Joan de Déu foundation, cover of the UB Web Page

 


Today, June 7 th , has appeared on the cover of the web page of UB ( www.ub.edu) a video that was made from the coll
aboration in research on metabolic diseases between the Institute of Biomedicine of University of Barcelona and the Fundació Sant Joan de Déu.

For more information:http://www.ub.edu/web/ub/ca/

   
IBUB workshop "Nucleoside and Nucleobase Transporter Proteins in Biomedicine"
 

Date: June 3rd

Time: 10:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

   
Last April 30th, Dra. Gemma Marfany presented the IBUB research at the Conference of Professional Orientation in the Faculty of Biology
 
In the context of the professional orientation session organized by the Student Support Service, UB employment and the Faculty of Biology, Dra. Marfany presented the professional prospects in the field of research in experimental biology and biomedicine, and the research lines of IBUB with potential host for young researchers in training.
   
An article on the use of Drosophila as a model for studying tissue regeneration, performed by the team of Florenci Serras and Montserrat Corominas, from  IBUB, on “Bioessays” cover.
 

The publication on BIOESSAYS reviews the major features of regeneration in Drosophila, including signaling pathways, cell behavior and genetic control of regeneration. This review is complemented with an article of the same authors in the journal “DEVELOPMENT” where they demonstrate the importance of the JNK signal transduction pathway in the processes of wound healing and regeneration after cell death.

   
Joint Seminar IBUB-Societat Catalana de Biologia "Systems biology analysis of a small bacterium; there is more than expected"
 

Date: May 6th

Time: 12:00 hours

Place: Aula Magna (Faculty of Biology)

poster

   
Joint Seminar IBUB-IRB-CSIC "Chemical Biology for the Elucidation of Structure and Funtion Strogen Receiver"
 

Date: May 5th

Time: 09:30 hours

Place: Aula Fèlix Serratosa (Parc Científic de Barcelona)

poster

   
IBUB Seminar “La vaca sagrada. Ciencia y cultura en la investigación biológica en bovinos”
 

Date: April 15th

Time: 13:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

   
IBUB Seminar“The molecular basis of inflammation and cardiovascular  diseases in aging”
 

 

Date: April 13th

Time: 12:00 hours

Place: Aula de Graus (Faculty of Biology)

poster

 

 

IBUB Seminar“Integrative genomics of ageing: New approaches for an "old" problem”
 

Date: March 26th

Time: 12:00 hours

Place: Aula 19 (Aulari) Faculty of Biology

poster

   
Open applications to attend the course BIOINFORMATICS FOR BIOLOGISTS. EASY MANAGEMENT OF GENOMICS INFORMATION organized by Consolider-Ingenio 2010 with the collaboration of IBUB.
  Find attached the program and features of the course that will take place at the Faculty of Biology, University of Barcelona the next April 14th, 15th and 16th. This course is restricted to 20 places, some of which are reserved for IBUB applicants. IBUB members interested in attending the course please send to juditagusti@ub.edu before March 26th, the following documents:
- Brief CV.
- Summary in not more than 5 lines of why are you interested in the course.
- Name of the leader of the IBUB group which the applicant is attached and the reference of the last publication of the group where IBUB is mentioned as the place where the work has been carried out.
IBUB applicants who are admitted will have a 50% reduction in the registration fee. (IBUB co-finances 100 of 200 euros of total enrollment).
   
An article on the discovery of a new pathway of thermogenesis hormonal control, carried out by research team led by Dr. Francesc  Villarroya’s from  IBUB,  on “Cell Metabolism” cover.
  The publication, edited on “ Cell Metabolism” March issue, identifies the hormonal  factor FGF21 as a new activator of brown adipose tissue and its metabolic consumption activity. FGF21 is produced by the liver that releases it into the circulation in response to the stimulation of fatty acids. The study, based on the use of neonatal mice as an experimental model which are exposed to milk fat for the first time in their development, identifies a new pathway of controlling the energy expenditure with potential therapeutic application in obesity and type II diabetes.
   
Experimental electrophysiology unit, a new scientific-technological unit promoted by IBUB
 

The IBUB , with the collaboration of the Department of Biochemistry and Molecular Biology from the Faculty of Biology, supports the creation by the laboratory of Molecular Physiology, led by Dr. Antonio Felipe, of  a scientific and technological experimental electrophysiology unit. This unit, that will operate both for research and teaching, consists of an inverted epifluorescence microscope, a pipette puller, a micro-forge, a hydraulic micro-manipulator, a Faraday cage, a digital and analog image capturing unit for TV in real time, a pneumatic anti-vibration table of compressed air and a high-end signal amplifier. This equipment, which measures electrical currents generated by the activity of membrane proteins, allows the study of membrane potential and ion movements generated by the cardiac action potential and nerve impulse transmission, among other physiological phenomena. Such technologies are of great importance in interdisciplinary research in biomedicine in the areas of cardiovascular, neurobiology, immunology and metabolism diseases. The unit is located in the Faculty of Biology, in the new building. This type of equipment is unique on campus Diagonal of the UB and adds value to the development of the Barcelona Knowledge Campus, an initiative of concentration of maximum competitiveness in research and higher education in our campus.

IBUB researchers interested in the scientific and technological benefits of this unit please contact Dr. Antonio Felipe, who is in charge of it, to this address: afelipe@ub.edu.

 

 
 
The international workshop "Channelopathies: from bench to bedside" organized by the Spanish Ion Channel Initiative and Consolider, with the support of IBUB, took place last February 2nd and 3rd.
 

The workshop, in which Dr Antonio Felipe, member of IBUB, participated as member of the organizing committee, gathered international researchers in the field of physiopathology of ion channels, and placed together the contribution from laboratories involved in basic and biomedical research in this area.

For more information

   
Professor Walter J Gehring has received the Honoris Cause Doctorate by the University of Barcelona supported by Dr Emili Saló, member of IBUB.
 

Last 21st of January, professor Walter J Gehring received the Honoris Cause doctorate by the University of Barcelona supported by Dr Emili Saló, professor of the Department of Genetics of the Faculty of Biology and member of IBUB.
Walter J. Gehring is Professor at the Biozentrum of the University of Basel, Switzerland. He obtained his Ph.D. at the University of Zurich in 1965 and after two years as a research assistant of Professor Ernst Hadorn he joined Professor Alan Garen's group at Yale University in New Haven as a postdoctoral fellow.
In 1969 he was appointed as an associate professor at the Yale Medical School and 1972 he returned to Switzerland to become a professor of developmental biology and genetics at the Biozentrum of the University of Basel. He is a Foreign Member of the National Academy of the USA, Great Britain, France, Germany and Sweden. In 2000 he received the Kyoto Prize for Basic Science, and in 2002 the Balzan Prize for Developmental Biology.
Walter Gehring has mainly been involved in studies of Drosophila genetics and development, particularly in the analysis of determination in the embryo and transdetermination of imaginal discs. He has made significant contributions to the study of the heat shock genes, various transposons and the homeotic genes which are involved in the genetic control of development.
He and his group have discovered the homeobox, a DNA segment characteristic for homeotic genes which is not only present in arthropods and their ancestors, but also in vertebrates up to man. He has been involved in the development and application of enhancer trapping methods. He and his collaborators have identified Pax-6 as a master control gene for eye development, which led to a new theory about the monophyletic origin of the eyes in evolution.

For more information

Wikipedia

Details in relation to the event of Honoris Causa Doctorate in our University

   
The IBUB research group led by Claudio Toma and Bru Cormand will develop the project "Molecular Genetics of autism: association studies, analysis of structural variants and mutational screening for identification of susceptibility genes", funded by the Marathon TV3 2008.
 
 

Thanks to the funding obtained from the “Call on Serious Mental Diseases” from Marathon 2008, they  will develop this project whose main objective is the avaluation of the contribution to autism from several genes involved in synaptogenesis and the regulation of the synaptic release of neurotransmitters in a large cohort of Spanish patients. The study's methodology will include association studies of case-control, mutational screening  and analysis of structural variants (CNVs) in candidate genes.

The project is headed by Claudio Toma, researcher CIBER-ER, and will be developed within the group led by Bru Cormand from the Department of Genetics of the University of Barcelona which belongs to the IBUB team “ Human Molecular Genetics” coordinated by Daniel Grinberg.

Good luck and success in this research !

 
Computational Biology IBUB Symposium
 

 

On the occasion of the opening of the new IBUB Unit on Computational Biology of the Institute of Biomedicine of the University of Barcelona, an International Symposium was held last 20th November with the participation of IBUB researchers and other international scientists leaders in the area.

 

Dr. Francesc Villarroya, IBUB Director, Dr. Alex Aguilar, UB Vice-Rector for Innovation and Knowledge Transfer and Dr. Joaquin Gutierrez, Dean of the Faculty of Biology of the UB opened the event with a great success of assistance.

   
IBUB Seminari “La Diabetes tipo 2 también es una enfermedad del sistema inmunológico: pérdida de células T reguladoras en el tejido adiposo de los obesos”
 


 

Date: November 13th

Time: 12:00 hours

Place: Aula 5 (Edif.A) Facultat de Farmàcia

 

poster

 

   
The team of Professor Javier Luque, IBUB member, will coordinate the international project NOstress (Unraveling the molecular mechanism of nitrosative stress resistance in tuberculosis) within the Health Area of the 7th Framework Program of the European Union.
 


The project NOstress aims to identify the molecular basis of M. Tuberculosis resistance to nitrosative stress, that is to say, to the excessive formation of radical nitric oxide (NO). This molecule, which has antibacterial activity, is one of the factors of the immune system that reduces the growth of M. tuberculosis and is produced by the macrophages during the initial process of infection. The project, in which several European laboratories are involved, pretends to improve the design of new therapies to treat tuberculosis.

For more information

   
Audiovisual on metabolic diseases (IBUB-FSJD)
 


Due to the recent collaboration in research on metabolic diseases between the Institute of Biomedicine of University of Barcelona and the Fundació Sant Joan de Déu, the University of Barcelona audiovisual department has elaborated a video which can be found in the following addressess:

Audiovisual services of UB   www.ub.edu/audiovisuals
 

   
IBUB Symposium
 

Date: September 17th

Time: 09:30 hours

Place: Aula de Graus, Biology faculty

University of Barcelona

(Free Entrance)

 

poster

 

 

   
The IBUB image design, awarded with the "LAUS National Design Awards 2009"
 

The IBUB image design, conducted by the cabinet study Natalia Cuadrado, has been awarded a bronze prize in the “LAUS design awards 2009”.

 

The challenge of an original design for IBUB within the framework of many research institutions of biomedical research in our enviroment, and its own unequivocal character of Institute of the University of Barcelona, has provided inspiration for the image of our Institute.

 

We thank to “Natalia Cuadrado” group, for their work, their understanding of the academic and nonprofit character of our Institute and their commitment to achieve a modern look which projects our character and aims.

 

1 1 1 1 1 Congratulations!

 

   
"Curso práctico de Microscopía Optimizada" for IBUB researchers
 

The IBUB has participated in the organization of the course of microscopy by computer “Curso Práctico de Microscopía Optimizada por Ordenador" that it was carried out at the beggining of September and has sponsorized some free enrolments for researchers who are members of it.

The attendance at the course has been an overwhelming success and demand has far exceeded the supply of enrolments. Due to this, many of the applications could not be studied, even though will be considered for future editions.

 

 

 

 

 

 

 
   
IBUB is in "La Vanguardia" news
 

As a part of a special supplement on "Research & Technology", La Vanguardia has published an interview with the director, Francesc Villarroya, which has reviewed the objectives and activities of the IBUB for the general public.

Complete article

   
IBUB seminari
 
Last May 13th took place in the Aula Magna of the Facultad de Biología of the Universitat de Barcelona the conference organized by IBUB titled «Proteases and their Regulation from Molecular Structures to Application» by Robert Huber, Max-Planck Institute fuer Biochemie (Germany).  Prof. Huber received the Nobel Price in Chemistry 1988, shared with Johann Deisenhoffer and Hartmut Michel, for their studies on the atomic foundations of  photosynthesis. His studies on cyanobacterial phycobilisomes, blue multi-copper oxidases, but in particular the purple bacteria reaction centre, the first 3D structure of a membrane protein ever solved, they all contributed to elucidate the structural basis for the transformation of light into chemical energy, and are already part of the History of Biology and Biochemistry. During his seminar, Prof. Huber talked about all the families of proteolytic enzymes and explained the 3D structures of a prepresentative member of each family as well as their function and regulatory mechanisms. The seminar´s host was Eva Estébanez-Perpiñá (RyC and Marie Curie fellow and member of the IBUB since 2008), who had done her PhD under Prof. Huber´s supervision. Many other ex-alumni from his lab were also present in the audience .
 




Picture legend. From right to left: Francesc Villarroya Gombau (Director of the IBUB), Eva Estébanez-Perpiñá (IBUB), Xavier Gomis-Rueth (CSIC), Robert Huber (Max-Planck-Institut), Marta Garrido-Franco (Leitat), Pablo Fuentes-Prior (Sant Pau), and Miquel Coll (IRB).
 
   
Day joint research on metabolic diseases

Sant Joan de Déu foundation and the Institute of Biomedicine of the University of Barcelona (IBUB), biomedical research centers heavily involved in the study of metabolic diseases, have began an strategic partnership to promote translational research in this field, exploiting the potential of basic and clinical research of both institutions.

The meeting "Advances in Research on Metabolic Diseases", held on last April 17th, was a first initiative in this direction, as a forum of exchange of knowledge about the state of research in this area and its prospects.

 
News from our Confocal Microscopy Courses

The demand for courses on confocal Microscopy has been a great success. Six editions have already been carried out and more than thirty of our IBUB researchers have attended them.
It has to be said that the demand for these courses has totally overcome our expectations and it has been necessary to close their continuity by now. They will surely start again from the beggining of the new academic year,  provided the necessary financial resources can be made available by the IBUB.
By next September a reminder will be sent for applications to those who have been unable to attend so far and also for new applicants.
We very much appreciate your interest and wish that this IBUB service may have been useful to your research.


 
Successfully concluded the IBUB-TEC  symposium “Real Time PCR y secuenciación masiva de DNA”, in collaboration with  Roche 

The symposium IBUB-Roche,  first symposium of the IBUB-TEC series of scientific and technological seminars promoted by  IBUB, took place last November 12th  at the Faculty of Biology with a multitudinous success. More than 500 people were attending the meeting and a peripheral site had to be established in order to provide service to the massive attendance. The experience of collaboration with the company (Roche, in this case) and with Serveis Cientifico-Tècnics has been optimal to provide the biomedical research community an updated offer for improvement and upgrading technological capacities.

Presentation of SINTEFARMA,  center of the Network of Centers of Technological Innovation Support Network (IT) of the Generalitat of Catalonia, led by an IBUB group

The Center for Research and Development in Organic Synthesis for the chemical-pharmaceutical Industry (SINTEFARMA) has been presented on 5th of December at a ceremony in Aula Magna of the Faculty of Pharmacy. SINTEFARMA, located at the Unit of Organic Chemistry, Department of Pharmacology and Therapeutics Chemistry of the Faculty of Pharmacy at the University of Barcelona, is a center of the Network of Centers of Technological Innovation Support Network (IT) of the Generalitat of Catalonia, created with the objective of promoting technology transfer and collaboration  with the industrial sector, providing advice and services in the field of organic synthesis and conducting applied research projects of technological interest for companies . The research group promoting SINTEFARMA, led by Dr. Joan Bosch, is a founding member of the IBUB, and from our institute we welcome this initiative which once again shows the momentum and dynamism of biomedical research on campus Diagonal of our University. Congratulations and many successes with this initiative from the IBUB!
Further information at  www.ub.edu/sintefarma

The Laboratory of Molecular Physiology, Department of Biochemistry and Molecular Biology- IBUB, the Spanish leader in research on ion channels  

The independent portal "Ion Channel, Patch Clamp and Electrophysiology Research led by Ion Channel Media Group Ltd. (http://www.ionchannels.org), which produces a ranking of the world laboratories and research with impact in the area of the Ion Channels has recognized the Laboratory of Molecular Physiology, Department of Biochemistry and Molecular Biology of the Institute of Biomedicine (IBUB) led by Dr.
Antonio Felipe, in the 109 worldwide position during the year 2008 for its contributions to this scientific area. This position places the Laboratory of Dr. Felipe at the first position in the ranking of the Spanish laboratories in this research field in 2008. One of the main scientific contributions leading to this recognition was the publication selected by the IBUB as “article of the month” recently (J Biol Chem. 2008; 283:8756-8764).

New IBUB laboratories in the building Helix PCB 

The IBUB, in its policy of promoting emerging research teams and encouraging biomedical research on campus, is establishing new laboratories to host such new research teams in the Helix building of  PCB. The team of Dr Eva Estébanez, emerging group of IBUB, will begin its activities in these labs next month.

IBUB-TEC, a new series of  IBUB seminaris on technology advances 

These seminars are meant to PhD students, postdocs or any lab people, in order to improve technological capacities for biomedical research.

Several already programmed IBUB-TEC Seminars are:

1.- Basic Bioinformatics Analysis (next October 17)

2.- Advances in RT-PCR and high-throughput DNA sequencing (IBUB-Roche Symposium next november 12, see below))

3.- Basics of Confocal Microscopy (December, practical-tutorial)

4.- ChIP on Chip versus ChIP-seq (January)

The first seminar  of the series will be “ Basics on Bioinformatics Analysis” by Dr. Enrique Blanco (Departament de Genetica / IBUB), next 17 October (see attached announcement).. The target audience is  PhD students and Researchers in any area of Molecular Biology.

The audience in this short talk will be in  contact with real examples that explain how to take advantage of current computational tools:   search for genes in the most  popular genome browsers, perform comparisons between related sequences, study the conservation of genes in different genomes, identify clusters of co-regulated  genes or represent graphically these results.
IBUB participates in science dissemination, article in Eureka
The IBUB undertakes activities oriented towards an improvement in the presence of biomedical research areas in non-specialized social environments. In the last issue of Eureka (the magazine of science addressed to young students) Gemma Marfany, an IBUB genetics researcher, provides a stimulating, easy accessible, view of the fascinating task of gene discovery under the title: ”The Gene Hunters” (“Caçadors de gens”).

Full text can be viewed in the following link.

Sessió IBUB-ROCHE

In line with the activities of promoting improvement in biomedical research
technologies, IBUB participates, in partnership with the company Roche, in a seminar series on recent advances in Real-time PCR and massive DNA sequencing technologies, to he held next november 12th in Facultat de Biologia.

You'll find below the anouncement including the preliminary program.
   
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Article of the month

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

Irene Sola,†,∇ Ester Aso,‡,§,∇ Daniela Frattini,† Irene López-González,‡,§ Alba Espargaró,∥ Raimon Sabaté,∥ Ornella Di Pietro,† F. Javier Luque,⊥ M. Victòria Clos,# Isidro Ferrer,*,‡,§ and Diego Muñoz-Torrero*,† Author information:
†Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain
‡Institut de Neuropatologia, Servei d’Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L’Hospitalet de Llobregat, Spain §CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto Carlos III, Spain
∥Departament de Fisicoquímica, Facultat de Farmàcia, and Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, Barcelona, Spain ⊥Departament de Fisicoquímica, Facultat de Farmàcia (Campus Torribera), and IBUB, Universitat de Barcelona, Santa Coloma de Gramenet, Spain #Departament de Farmacologia, de Terapèutica, i de Toxicologia, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain

J. Med. Chem. 2015, 58, 6018−6032

We have synthesized a series of heptamethylene-linked levetiracetam–huprine and levetiracetam–(6-chloro)tacrine hybrids to hit amyloid, tau, and cholinergic pathologies as well as β-amyloid (Aβ)-induced epileptiform activity, some of the mechanisms that eventually lead to cognitive deficits in Alzheimer’s disease patients. These hybrids are potent inhibitors of human acetylcholinesterase and butyrylcholinesterase in vitro and moderately potent Aβ42 and tau antiaggregating agents in a simple E. coli model of amyloid aggregation. Ex vivo determination of the brain acetylcholinesterase inhibitory activity of these compounds after intraperitoneal injection to C57BL6J mice has demonstrated their ability to enter the brain. The levetiracetam–huprine hybrid 10 significantly reduced the incidence of epileptic seizures, cortical amyloid burden, and neuroinflammation in APP/PS1 mice after a 4-week treatment with a 5 mg/kg dose. Moreover, the hybrid 10 rescued transgenic mice from cognitive deficits, thereby emerging as an interesting disease-modifying anti-Alzheimer drug candidate.

 

 

 

 

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