IBUB team to expand frontiers of multicomponent reaction-based molecular synthesis

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The synthesis of complex molecules such as drugs, requires a process that sometimes involves several phases that increase its cost and harden the access to the product. Now, a team of the UB has designed a new methodological approach that combines multicomponent reactions with domino type processes –continuous transformations on an only compound– to ease the synthesis of high structural complex molecules.

The study, published in the journal Angewandte Chemie International Edition, is led by Professor Rodolfo Lavilla, from the Faculty of Pharmacy and Food Sciences and the Institute of Biomedicine (IBUB) of the University of Barcelona. The study, whose first signatories are researchers Ouldouz Ghasghaei and Marina Pedrola (UB-IBUB), counts on the participation of experts from Masaryk University (Czech Republic) and the Leibniz Research Institute for Environmental Medicine (Germany).

Reference article:

Ghashghaei, O.; Pedrola, M.; Seghetti, F.; Martin, V.V.; Zavarce, R.;Babiak, M.; Novacek, J.; Hartung, F.; Rolfes, K.M.; Haarmann-Stemmann, T.; Lavilla, R. “Extended Multicomponent Reactions with Indole Aldehydes: Access to Unprecedented Polyheterocyclic Scaffolds, Ligands of the Aryl Hydrocarbon Receptor”. Angewandte Chemie International Edition, October 2020. DOI: 10.1002/anie.202011253