Bioorganic and Natural Products Chemistry Lab (BNP Lab)

Principal investigator: • Judit Tulla-Puche APIF predoctoral student • Ariadna Lobo-Ruiz

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Current
Research

The research at the ‘Bioorganic and Natural Products Chemistry Lab (BNPLab)’ lies in the field of bioorganic and medicinal chemistry and more specifically, it covers all aspects involving peptides, with a focus on bioactive peptides of natural origin.
The last years have witnessed increasing discoveries of naturally occurring peptide macrocycles with new structures and biological activities. This has partially prompted the re-emergence of peptides as therapeutics since, potentially, these peptides provide both the selectivity and potency of larger protein biologics but with zero or low immunogenicity, and the stability and bioavailability of small molecules.

Our research covers:

  • The discovery of novel constrained peptides which are likely to combine the advantages of therapeutic proteins with those of small molecules. These includes bioactive peptides natural products as well as designed peptides.
  • The development of new synthetic methodologies to build these complex architectures.
  • The development of new drug delivery systems based on constrained scaffolds.

Selected
Publications

Martin-Gomez, H.; Albericio F.; Tulla-Puche, J. A Lasso-​Inspired Bicyclic Peptide: Synthesis, Structure and Properties. Chem. Eur. J. 2018. doi: 10.1002/chem.201803899

Martin-Gomez, H.; Linne, U.; Albericio, F.; Tulla-Puche, J.; Hegemann, J. D. Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-​Based Production System. J. Nat. Prod. 2018, 81, 2050-2056.

Martin-Gomez, H.; Tulla-Puche, J. Lasso peptides: chemical approaches and structural elucidation. Org. Biomol. Chem. 2018, 16, 5065-5080.

Lobo-Ruiz, A.; Tulla-Puche, J. Synthetic approaches of naturally and rationally designed peptides and peptidomimetics. In ‘Peptide Applications in Biomedicine, Biotechnology and Bioengineering’ (Koutsopoulos, S., Ed.), Elsevier Ltd., UK, 2018, pp. 23-49.

Pelay-Gimeno, M.; Albericio, F.; Tulla-Puche, J. Synthesis of complex head-​to-​side-​chain cyclodepsipeptides. Nat. Protoc. 2016, 11, 1924-1947.

Selected
Publications

A Lasso- Inspired Bicyclic Peptide: Synthesis, Structure and Properties.

Author

Martin-Gomez, H.; Albericio F.; Tulla-Puche, J.

Identification

Chem. Eur. J. 2018. doi: 10.1002/chem.201803899
Investigation of the Biosynthesis

Author

Martin-Gomez, H.; Linne, U.; Albericio, F.; Tulla-Puche, J.; Hegemann, J. D.

Identification

Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-​Based Production System. J. Nat. Prod. 2018, 81, 2050-2056.

Lasso peptides

Author

Martin-Gomez, H.; Tulla-Puche, J.

Identification

Lasso peptides: chemical approaches and structural elucidation. Org. Biomol. Chem. 2018, 16, 5065-5080.

Synthetic approaches of naturally and rationally designed

Author

Lobo-Ruiz, A.; Tulla-Puche, J.

Identification

Synthetic approaches of naturally and rationally designed peptides and peptidomimetics. In ‘Peptide Applications in Biomedicine, Biotechnology and Bioengineering’ (Koutsopoulos, S., Ed.), Elsevier Ltd., UK, 2018, pp. 23-49.

Synthesis of complex head- to- side- chain cyclodepsipeptides.

Author

Pelay-Gimeno, M.; Albericio, F.; Tulla-Puche, J.

Identification

Nat. Protoc. 2016, 11, 1924-1947.