Medicinal Chemistry for Unmet Medical Needs

Bagán, A.; Abás, S.; Palà-Pujades, J.; Irisarri, A.; Griñán-Ferré, C.; Pallàs, M.; Muneta-Arrate, I.; Muguruza, C.; Callado, L. F.; Pérez, B.; Molins, E.; Morales-García, J. A.; Escolano, C. Exploring the reactivity of bicyclic α-iminophosphonates to access new imidazoline I2 receptor ligands. Bioorganic Chemistry, 2024, 142, 106935.  https://doi.org/10.1016/j.bioorg.2023.106935

Bagán, A.; Rodriguez-Arévalo, S.; Taboada-Jara, T.; Griñán-Ferré, C.; Pallàs, M.; Brocos-Mosquera, I.; Callado, L. F.; Morales-García, J. A.; Pérez, B.; Diaz, C.; Fernández-Godino, R.; Genilloud, O.; Beljkas, M.; Oljacic, S.; Nikolic, K.; Escolano, C. Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease, Pharmaceutics 2023, 15, 2381. Pharmaceutics | Free Full-Text | Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease (mdpi.com)

Bagán, A.; Morales-García, J. A.; Griñán-Ferré, C.; Díaz, C.; Pérez del Palacio, J.; Ramos, M. C.; Vicente, F.; Pérez, B.; Brea, J.; Brea, J.; Loza, M. I.; Pallàs, M.; Escolano, C. Insights into the pharmacokinetics and in vitro cell-based studies of the imidazoline I2 receptor ligands B06. Int. J. Mol. Sci. 2022, 23, 5408.  IJMS | Free Full-Text | Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06 (mdpi.com)

Rodriguez-Arévalo, S.; Bagán, A.; Griñán-Ferré, C.; Vasilopoulou, F.; Pallàs, M.; Brocos-Mosquera, I.; Callado, L.F.; Loza, M.I.; Martínez, A.L.; Brea, J.; Pérez, B.; Molins, E. De Jonghe, S.; Daelemans, D.; Radan, M.; Djikic, T.; Nikolic, K.; Hernández-Hernández, E.; García-Fuster, M. J.; García-Sevilla, J. A.; Escolano, C. Benzofuranyl-2-imidazoles as Imidazoline I2 Receptor Ligands for Alzheimer’s Disease. Eur. J. Med. Chem. 2021, 222, 113540. Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer’s disease (sciencedirectassets.com)

Abás, S.; Rodríguez-Arévalo, S.; Bagán, A.; Griñán-Ferré, C.; Vasilopoulou, F.; Brocos-Mosquera, I.; Muguruza, C.; Pérez, B.; Molins, E.; Luque, F.J.; et al. Bicyclic a-iminophosphonates as High Affinity Imidazoline I₂ Receptor Ligands for Alzheimer’s Disease. J. Med. Chem. 2020, 7, 3610–3633. Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease – PubMed (nih.gov)

Aragó, M.; Moreno-Felici, J.; Abás, S.; Rodríguez-Arévalo, S.; Hyroššová, P.; Figuras, A.; Viñals, F.; Pérez, B.; Loza, M. I.; Brea, J.; Latorrre, P.; Carrodeguas, A.; García-Rovés, P. M.; Galdeano, C.; Ginex, T.; Luque, F. J.; Escolano, C.; Perales, J. C. Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M. Biomedicine & Pharmacotherapy 2020, 121, 109601. Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M – ScienceDirect