Integrative Systems Biology, Metabolomics and Cancer

Universitat de Barcelona
Faculty of Biology (IBUB)

Dept Biochemistry and Molecular Biomedicine

Prof. Marta Cascante

Av/ Diagonal 643, 08028 Barcelona, Spain
martacascante@ub.edu
http://www.bq.ub.es/bioqint/principaleng.html

 

Principal investigator: Dr. Marta Cascante  Senior researchers: Dr Josep J. Centelles • Dr Vitaly Selivanov Post-doc researchers • Dr Pedro de Atauri • Dr Silvia Marín • Dr Ibrahim Halil Polat • Dr Míriam Tarrado PhD students: Cristina Balcells • Inés Baptista • Miriam Contreras • Carles Foguet • Effrosyni Karakitsou • Josep Tarragó • Erika Zodda

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Current
Research

Our group performs a multidisciplinary research, combining techniques from the fields of biochemistry, cellular and molecular biology and bioinformatics for an integrated analysis of biological samples within a Systems Biology and Systems Medicine approach. Our main research line is the study of metabolism and metabolic networks for therapeutic and industrial purposes. We have pioneered the development and application of 13C-based fluxomics and omics integration with a new generation of genome scale metabolic models to characterize metabolic alterations underlying human diseases. We focus on the role of metabolic reprogramming in two key players of tumorigenesis: metastasis and resistance to chemotherapy, to identify vulnerabilities exploitable as therapeutic metabolic targets efficient for both processes.

Our team is partner in several international projects aimed at precision medicine (EC FP7 and H2020 programs). Thus, we contribute to: i) An Europe-driven international effort to develop a robust data infrastructure to exchange standards for metabolomics (PHENOMENAL-H2020); ii) the training of young researchers in the fields of metabolomics and systems medicine (Marie Curie Training Networks H2020 MOGLYNET and HAEMMETABOLOME). We lead the consolidated SGR group on Integrative Biochemistry, that also integrates the Microbiota and intestinal epithelium IBUB group, leaded by Dr. Laura Baldomà, with which we collaborate in the framework of industry and international projects. Our group is a node of the Biomedical Research Network Center in Hepatic and Digestive Diseases (CIBEREHD) and a core node of the Spanish Institute of Bioinformatics (INB), both supported by ISCIII-Spanish Ministry of Health. INB is the Spanish node of the inter-governmental organization ELIXIR. As UB node of INB, we contribute to develop and sustain software tools in the field of metabolomics and fluxomics and to establish Europe-wide standards in these fields.

Selected
Publications

Marín de Mas I;…, Cascante M. Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells. PLoS Comput Biol. 2;14(1):e1005914, 2018
doi: 10.1371/journal.pcbi.1005914

Tarrado M; de Atauri P; …; Yuneva M; Thomson T; Cascante M. De novo Myc addiction as an adaptive response of cancer cells to CDK4/6 inhibition. Mol Syst Biol. 13(10), 940, 2017. doi: 10.15252/msb.20167321

Chong, M; Jayaraman A; Marin S; Selivanov V; de Atauri PR; Tennant DA; Cascante M*; Günther UL; Ludwig C*. Combined Analysis of NMR and MS Spectra (CANMS). Angew Chem Int Ed Engl., 56(15):4140-4144, 2017 (*co-corresponding) doi: 10.1002/anie.201611634

Diaz-Moralli S; Aguilar E; Marin S; Coy JF; Dewerchin M; Antoniewicz MR; Meca-Cortés O; Notebaert L; Ghesquière B; Eelen G; Thomson TM; Carmeliet P; Cascante M. A key role for transketolase-like 1 in tumor metabolic reprogramming. Oncotarget 7(32):51875-51897, 2016. doi: 10.18632/oncotarget.10429

Aguilar E; …Hockenbery D; Thomson TM; Cascante M. Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program. Stem Cells 34(5):1163-76, 2016 doi: 10.1002/stem.2286

Selected
Publications

Author

Identification

Marín de Mas I;…, Cascante M. Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells. PLoS Comput Biol. 2;14(1):e1005914, 2018
doi: 10.1371/journal.pcbi.1005914

Author

Identification

Tarrado M; de Atauri P; …; Yuneva M; Thomson T; Cascante M. De novo Myc addiction as an adaptive response of cancer cells to CDK4/6 inhibition. Mol Syst Biol. 13(10), 940, 2017. doi: 10.15252/msb.20167321

Author

Identification

Chong, M; Jayaraman A; Marin S; Selivanov V; de Atauri PR; Tennant DA; Cascante M*; Günther UL; Ludwig C*. Combined Analysis of NMR and MS Spectra (CANMS). Angew Chem Int Ed Engl., 56(15):4140-4144, 2017 (*co-corresponding) doi: 10.1002/anie.201611634

 

Author

Identification

Diaz-Moralli S; Aguilar E; Marin S; Coy JF; Dewerchin M; Antoniewicz MR; Meca-Cortés O; Notebaert L; Ghesquière B; Eelen G; Thomson TM; Carmeliet P; Cascante M. A key role for transketolase-like 1 in tumor metabolic reprogramming. Oncotarget 7(32):51875-51897, 2016. doi: 10.18632/oncotarget.10429

 

Author

Identification

Aguilar E; …Hockenbery D; Thomson TM; Cascante M. Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program. Stem Cells 34(5):1163-76, 2016 doi: 10.1002/stem.2286