Technology Transfer Opportunities
Biochemical and Biomedical
Transfer Opportunities
services
Animal Models:
Cancer
Cardiovascular diseases
Diabetes and Obesity
Drosophila and CNS diseases
Inflammation
Intrapancreatic PDAC models
PPARbeta/delta knock out models
In Vivo Studies:
Anti-inflammatory and toxicology drug validation
Cardiovascular performance, ecocardiography, treadmill
Impact of drugs on development using Drosophila
Infrared thermography
Metabolic phenotyping of rodent models Stereotaxis
Cell-Based Studies:
Analysis of the mechanisms of action of anticancer drugs
Barrier models for drug absorption screening and drug-transporter interactions
Cell immortalization (fibroblasts, adipocytes,…)
In vitro assays of bacterial infection and immunosuppression
Mitochondrial metabolism and respiration
Structural Approaches and “OMICS” Services:
Biophysics assays: surface plasmon resonance/Biacore studies and competition assays
Computational biology and bioinformatics applied to genomes and gene/protein networks
Generation of high-quality leads for drug discovery
Metabolomics and computational analysis of metabolic fluxes
Protein crystallography, lead identification and validation
know-how
Gene-protein networks integration, data management and visualization
Infrared thermography for metabolic studies
Mechanisms of action of anticancer drugs
Mitochondrial metabolism and respiration
Multiomics modelling
Pharmacogenetics of anticancer drugs
Pharmacological evaluation of drugs in metabolic-related diseases
Protein structure-function relationship analysis and structural biology
Signal transduction pathways and disease
Targeted metabolomics
*Conventional cell, biochemical, protein and molecular biology approaches available in most laboratories at IBUB.
Chemistry and Pharmacy
Transfer Opportunities
services
Biophysical characterization of ligand-protein complexes
Computational structure-based drug discovery: druggability, virtual screening, hit/lead optimisation
Design and synthesis of chemical libraries and scaffolds
Design and synthesis of prodrugs
Experimental determination of physicochemical properties
Expert advice on new synthetic routes for organic compounds
Expert advice on the determination of ADMET properties
Expert opinion about chemical patents, infractions risks, etc.
Expert opinion on chemical manufacturing sites
Fragment-based drug discovery: fragment screening, fragment evolution
Hit to lead optimization
HPLC and/or HPLC/MS of APIs, drugs and mixtures
Molecular modelling of biomolecules for structure-function relationships
Optimization and scale-up of routes of synthesis for APIs
Search of molecules in libraries of compounds
Structural elucidation and synthesis of metabolites
Structural elucidation, isolation and synthesis of impurities of active pharmaceutical ingredients (APIs)
Synthesis and conjugation of Fluorophores and Small molecule Bioprobes
Synthesis of labelled compounds
Synthesis of peptides and oligonucleotides (DNA, RNA)
Synthesis of peptides-oligonucleotides conjugates
Theoretical studies in structure-activity relationships
Primary cultures of specialized cell types (adipocytes, hepatocytes, neurons, intestinal barrier, macrophages, cardiomyocites…)
know-how
Synthesis of bioactive compounds
Assays for the physicochemical characterization of compounds: lipophilicity / hydrophilicity (log Po/w, log D, log D7.4, CHI, log D vs pH, CHI vs pH); Acidity (pKa), isoelectric point; solubility (log S0, log Sk, pH-dependent solubility), interactions with proteins (Kb, DHB).
Biophysical methods for ligand-protein characterization (DSF, SPR, ITC, fluorescence). Chromatographical estimation of biological properties: aquatic toxicity (LC50, CNAR), skin permeability (kp), and soil-water distribution (log KOC).
Computational determination of physicochemical properties of bioactive drugs
Computational methods for drug discovery Design and development of “high throughput” methods for the determination of physicochemical parameters (log Po/w, log D, CHI, pKa, log S).
Flow-chemistry (hydrogenation, coupling-reactions)
Freeze-drying
Patented compounds with biological activity
Reactions under special conditions (Flow, Microwave irradiation, Photoredox, High dilution, etc.)
Reactions with gas (H2, CO, NH3, O3, etc.)
Solid-phase synthesis of peptides and oligonucleotides (DNA, RNA): synthesis and isolation.
Synthesis of antibiotics, antivirals and antitumor compounds
