Principales publicaciones
en los últimos años:
Gryllos, I., J.G. Shaw, R. Gavín, S. Merino and J.M. Tomás (2001).
The role of the flm operon in mesophilic Aeromonas sp. adherence.
Infection and Immunity 69: 65-74.
Merino, S. and J.M. Tomás (2001).
Immune defence: microbial interference.
Encyclopedia of Life Sciences. MacMillan Reference Limited. www.els.net (Nature Scientific American Publishing Group).
Merino, S.and J.M. Tomás (2001)
Bacterial capsules and evasion of immune responses.
Encyclopedia of Life Sciences. MacMillan Reference Limited. www.els.net (Nature Scientific American Publishing Group)
Regué, M., Climent, N., Abitiu, N., Coderch, N., Merino, S., Izquierdo, L., Altarriba, M. and J. M. Tomás. (2001)
Genetic characterization of the Klebsiella pneumoniae waa gene cluster, involved in core lipopolisaccharide biosynthesis.
Journal of Bacteriology. 183: 3564- 3573.
Merino, S., Altarriba, M., Gavín, R.;,Izquierdo, L. and J. M. Tomás. (2001).
The cell division genes (ftsE and X) of Aeromonas hydrophila and their relationship with opsonophagocytosis.
FEMS Microbiological Letters. 198: 183- 188.
Merino, S., Gavín, R., Altarriba, M., Izquierdo, L, Maguire, M.E. and J. M. Tomás. (2001)
A Mg2+ transport protein (MgtE) is involved in Aeromonas hydrophila adherence.
FEMS Microbiological Letters.198: 189-195.
Gavín, R., Rabaan, A.A., Merino, S., Tomás, J. M , Grillos, I. and Shaw, J.G.(2002)
Lateral flagella of Aeromonas species are essential for epithelial cell adherence and biofilm formation.
Molecular Microbiology. 43: 383 - 397.
Knirel, Y.A., Shashkov, A.S., Senchenkova, S.N., Merino, S. and J. M. Tomás. (2002)
Structure of the O-polysaccharide of Aeromonas hydrophila O:34; a case of random O-acetylation of 6-deoxy-L-taloseA.
Carbohydrate Research.337: 1381- 1386
Izquierdo, L., Abitiu, N., Coderch, N., Hita, B., Merino, S., Gavín, R., Tomás J. M. and Regué, M. (2002).
The inner-core lipopolysaccharide biosynthetic waaE gene: function and genetic distribution among some Enterobacteriaceae
Microbiology. 148: 3485- 3496
Izquierdo, L., Merino, S., Coderch, N., Regué, M. and Tomás, J. M. (2002)
The wavB gene of Vibrio cholerae and the waaE of Klebsiella pneumoniae codify for a $-1,4- glucosyltransferase involved in the transfer of a glucose residue to the L-glycero-D-manno-heptose I in the lipopolysaccharide inner core
FEMS Microbiology Letters.216: 211-216 .
Merino, S. and J.M. Tomás (2002)
The complement activation and their biological effects on Aeromonas.
Current Trends in Immunology. 4: 177-181
Gavín, R., Merino S. and J.M. Tomás. (2002)
Molecular mechanisms of interactions between Aeromonas hydrophila and hosts.
Current Trends in the Study of Bacterial and Viral Fish Diseases (World Scientific Publishing Co). 4: 177-181.
Gavín, R., Merino, S. and J.M. Tomás. (2003)
Molecular mechanisms of bacterial pathogenesis from an emerging pathogen: Aeromonas sp
Recent Research Developments in Infection and Immunity (Transworld Research Network).1: 337-354.
Merino, S., Gavín, R., Vilches, S., Shaw, J.G. and J. M. Tomás. (2003)
A colonization factor ( production of lateral flagella) of mesophilic Aeromonas spp. Is inactive in Aeromonas salmonicida strains
Applied and Environmental Microbiology. 69: 663 -667.
Izquierdo, L., Merino, S., Regué, M., Rodríguez, F., and J.M. Tomás. (2003)
Síntesis of a Klebsiella pneumoniae O-antigen heteropolysaccharide (O12) requiring an ABC-2-transporter-dependent pathway
Journal of Bacteriology.185 : 1634-1641.
Altarriba,M, Merino, S., Gavín I., Canals R., Rabaan A., ShawJ.G. and J.M. Tomás. (2003)
A polar flagella operon (flg) of Aeromonas hydrophyla contains genes required for lateral flagella expresión
Microbial Patogénesis. 34: 249-259
Braschler T.R., Merino, S.,Tomás, J.M. and Graf J. (2003)
Complement resistance is essential for colonization of the digestive tract of Hirudo medicinalis by Aeromonas strains
Applied and Environmental Microbiology. 69 : 4268-4271
Gavin R., Merino, S., Altarriba M., Canals R., Shaw J.G. and J.M. Tomás. (2003)
Lateral flagella are required for increased cell adherence, invasión and biofilm formation by Aeromonas spp
FEMS Microbiology Letters. 224: 77-83
IzquierdoL., CoderchN., PiquéN. , BedeniE., CorsaroM. M., MerinoS., FresnoS. , Tomás J. M. and M. Regué (2003)
The Klebsiella pneumoniae wabG gene: their role in the biosynthesis of the core lipopolysaccharide and virulence.
Journal of Bacteriology.185 :7213-7221.
ReguéM., HitaB., PiquéN., IzquierdoL., MerinoS., FresnoS., Benedí V. J.and J. M. Tomás (2004)
A gene, uge, is essential for Klebsiella pneumoniae virulence.
Infection and Immunity. 72: 54-61
Coderch N. , Piqué N., LindnerB., AbitiuN., Merino S., Izquierdo L., Jimenez N., Tomás J.M. , Holst O.and M. Regué (2004)
Genetic and structural characterization of the core region of the lipopolysaccharide from Serratia marcescens N28b (serovar O4) .
Journal of Bacteriology.186: 978-988.
Yu H.B., Srinivasa Rao P.S., Lee H.C., Vilches S., Merino S., Tomás J.M., and K.Y. Leung (2004)
A type III secretion system is required for Aeromonas hydrophila AH-1 pathogenesis.
Infection and Immunity. 72: 1248-1256.
Knirel, Y.A., Vinogradov, E., Jiménez, N., Merino, S. and J.M. Tomás. (2004)
Sturctural studies on the R-type lipopolysaccharide of Aeromonas hydrophila .
Carbohydrates Research. 339 :787-793.
Vilches S., Urgell C., Merino S., Chacon M.R., Soler L., Castro-Escarpulli G., Figueras M.J., and J.M. Tomas. (2004)
Complete type III secretion system of a mesophilic Aeromonas hydrophila strain.
Applied and Environmental Microbiology.70: 6914-6919.
Esteve C., Alcaide E., Canals R., Merino S., Blasco D., Figueras M.J. and J.M. Tomas. (2004)
Pathogenic Aeromonas hydrophila serogroup O:14 and O:81 strains with an S layer.
Applied and Environmental Microbiology.70 : 5898-5904
Merino S.; Vilches S, Canals R, Ramirez S, and Tomás JM. (2005)
A C1q-binding 40KDa porin from Aeromonas salmonicida: cloning, sequencing, role in serum susceptibility and fish immunoprotection.
Microbial Pathogenesis. 38: 227- 237.
Regué M, Izquierdo L, Fresno S, Piqué N, Corsaro MM, Naldi T, De Castro C, Waidelich D, Merino S, and Tomás JM (2005)
A second outer-core region in Klebsiella pneumoniae lipopolysaccharide
Journal of Bacteriology.187: 4198 -4206
Yu HB, Zhang YL, Lau YL, Yao F, Vilches S, Merino S, Tomas JM, Howard SP, Leung KY. (2005)
Identification and characterization of putative virulence genes and gene clusters in Aeromonas hydrophila PPD134/91.
Appl Environ Microbiol. 71: 4469 -4477.
Regue M, Izquierdo L, Fresno S, Jimenez N, Pique N, Corsaro MM, Parrilli M, Naldi T, Merino S, Tomas JM. (2005)
The incorporation of glucosamine to enterobacterial core LPS: two enzymatic steps are required.
Journal Biological Chemistry.280: 36648 -36656.
Canals R.., Jiménez N., Vilches S., Regue M, Merino S, Tomas JM. (2006)
The UDP N-acetylgalactosamine 4-epimerase gene is essential for mesophilic Aeromonas hydrophila serotype O34 virulence.
Infection and Immunity.74: 537- 548.
Canals R., Ramirez S., Vilches S., Horsburg G., Shaw JG., Tomas JM and Merino S.(2006)
Polar flagellum biogenesis in Aeromonas hydrophila.
Journal of Bacteriology.188: 542-555.
Canals R., Altarriba A, Vilches S., Horsburg G., Shaw JG., Tomas JM and Merino S. (2006)
Analysis of the lateral flagella gene system of Aeromonas hydrophila AH-3
Journal of Bacteriology.188: 852 -862.
Fresno S., Jimenez N., Merino S., Corsaro MM., De Castro C., Parrilla M., Naldi T., Regue M., and Tomas JM. (2006)
The ionic interaction of Klebsiella pneumoniae K2 capsule and core lipopolysaccharide.
Microbiology.152: 1807- 1818.
Merino S., Shaw JG., and Tomas JM (2006)
Bacterial lateral flagella: an inducible flagella system.
FEMS Microbiol Lett. 2 : 127-135.
Canals R; Jiménez N; Vilches S; Regué M; Merino S. and Tomas JM (2007)
The role of Gne and GalE in the virulence of Aeromonas hydrophila O34.
Journal of Bacteriology. 189: 540-550.
Fresno S., Jiménez N., Canals R., Merino S., Corsaro M. M., Lanzetta R., Parrilli M., Pieretti G., Regué M., and Tomás J. M. (2007)
A Second Galacturonic Acid Transferase is Required for Core Lipopolysaccharide Biosynthesis and Complete Capsule Association to the Cell Surface in Klebsiella pneumoniae
Journal of Bacteriology. 189:1128-1137.
Esteve C; Alcalde E; Herraiz S; Canals R; Merino S and Tomas JM (2007)
First description of nonmotile Vibrio vulnificus strains virulent for eels
FEMS Microbiol Lett. 1: 90-97
Canals R, Vilches S, Wilhelms M, Shaw JG, Merino S, Tomas JM. (2007)
Non-structural flagella genes affecting both polar and lateral flagella-mediated motility in Aeromonas hydrophila
Microbiology.153: 1165-1175
Vilches S, Canals R, Wilhelms M, Salo MT, Knirel YA, Vinogradov E, Merino S, Tomas JM. (2007)
Mesophilic Aeromonas UDP-glucose pyrophosphorylase (GalU) mutants show two types of lipopolysaccharide structures and reduced virulence.
Microbiology.153: 2393-2404 .
Proyectos financiados en los últimos años:
Project Title :Estudio de la vulnerabilidad de Aeromonas mesófilas.....
Financiation :AECI Programa Hispano-Marroquí.
Dates : 2000 - 2002
Principal Researcher :Dr. Juan Tomás Magaña
Project Title :Genética y regulación de factores de virulencia en enterobacterias
Financiation :Generalitat de Cataluña. Grupos de Investigación Consolidados. 2000SGR00038.
Date: 2000 - 2002
Principal Researcher: Dr. Antonio Juarez Gimenez
Project Title :COST B-16 Reversal of antibiotic resistance
Financiation :European Union
Dates : 2000 - 2005
Principal Researcher :Prof. Josef Molnar
Project Title :Caracterización molecular de componentes de la superficie de bacterias Gram negativas implicados en la patogenicidad y estudio de su potencial uso immunoprofiláctico.
Financiation :D.G.I.C.Y.T. (Plan Nacional de I+D) BMC2001-3787
Dates : 2001 - 2004
Principal Researcher :Dr. Juan Tomás Magaña.
Project Title :Genética y regulación de factores de virulencia en enterobacterias
Financiation :Generalitat de Cataluña. Grupos de Investigación Consolidados. 2001SGR00100
Date: 2002 - 2004
Principal Researcher: Dr. Antonio Juarez Gimenez
Project Title : Análisis genómico y proteómico de moléculas/estructuras de la superficie de Aeromonas implicadas en su virulencia y su utilidad como immunoprofilácticos
Financiation : Ministerio de Ciencia y Tecnología. BIO2004-00412
Date: 2004 - 2007
Principal Researcher: Dra. Susana Merino Montero.
Project Title: Caracterización de mutantes en el lipopolisacárido y polisacárido extracelular de Pseudomonas aeruginosa causantes de infecciones respiratorias agudas y crónicas
Financiation : F.I.S. PI041161
Date: 2004-2007
Principal Researcher: Dr. Juán Tomás Magaña
Project Title: Genética y regulación de factores de virulencia en enterobacterias.
Financiation: Generalitat de Cataluña. Grupos de Investigación Consolidados. 2005SGR00635
Date: 2005-2008
Principal Researcher: Dr. Juán Tomás Magaña
Project Title: Lipopolisacáridos de diseño: una nueva forma de obtener vacunas en células de E. coli
Financiation :Ministerio de Ciencia y Tecnología. AGL2005-00860/GAN.
Date: 2005-2008
Principal Researcher: Dr. Juán Tomás Magaña
Project Title: Circuitos génicos que determinan estructuras superficiales de Aeromonas mesófilas e interacción de estas con el huésped.
Financiation :Ministerio de Educación y Ciencia. BIO2007-61319
Date: 2008-2010
Principal Researcher: Dra. Susana Merino Montero.
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