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Biologia molecular de canals iÒnics, receptors i transportadors

Responsible UPF unit in courses and seminars: Cell Signaling Unit (ADVANCED CELL COMMUNICATION) (2.5 credits)

Lecturers: Dr. Miguel A. Valverde, Dr. Carles Cantí, Dr. José M. Fernández

Lectures (1 hour)

1. Introduction to cellular receptors for extracellular signals
2. Introduction to ion channels
3. Membrane receptors with ion channel activity
4. Ion channels and cellular excitability I. Structure-function studies of Na+ channels.
5. Ion channels and cellular excitability II. Structure-function studies of K+ channels.
6. Ion channels and cellular excitability III. Structure-function studies of Cl- channels.
7. Ion channels and cellular excitability IV. Structure-function studies of Ca2+ channels.
8. Stimulus-secretion coupling. Synaptic transmission.
9. Regulation of ion channels by phosphorylation
10. Regulation of ion channels by G-protein
11. Ion channels and cellular excitability V. Structure-function studies of cationic TRP channels.
12. Cellular responses to physical stimuli: temperature, osmotic stress, mechanical stress.

Seminars (2 hours)

1. Electrophysiological techniques
2. Determination of intracellular ionic activities using microscopy with fluorescent probes.
3. Presentation/discussion of scientific papers