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Neuropsicologia de l’envelliment i demÈncies (optativa, 2.5 crÈdits)

Professors Coordinadors:

David Bartrés i Imma C. Clemente

Classes magistrals (15h)

Tema 1. Funcions cognitives i envelliment (David Bartrés).

Referències
Park DC, Schwarz N (eds). Envejecimiento cognitivo. Madrid : Médica Panoamericana, cop. 2002

Hedden T, Gabrieli DE. Insights into the aging mind: a view from cognitive neuroscience. Nat Rev Neurosci 2004; 5: 87-97

Hedden T, Gabrieli DE. Healthy and pathological processes in adult development: new evidence from neuroimaging in the brain. Curr Opin Neurol 2005; 18:740-747

Reuter-Lorenz PA, Lustig C. Brain aging: reorganization discoveries about the aging mind. Curr Opin Neurobiol 2005; 15:245-251

Bartrés-Faz D, Clemente IC, Junqué C. Cambios en la substancia y rendimiento cognitivo en el envejecimiento. Rev Neurol 2001; 33:347-353.

Tema 2. Característiques cerebrals en l’envelliment (M. Antònia Poca).

Referències
Naftali Raz, Ulman Lindenberger, Karen M. Rodrigue, Kristen M. Kennedy, Denise Head, Adrienne Williamson, Cheryl Dahle, Denis Gerstorf, James D. Acker. Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers. Cerebral Cortex doi:10.1093/cercor/bhi044

Mortamet B, Zeng D, Gerig G, Prastawa M, Bullitt E. Effects of healthy aging measured by intracranial compartment volumes using a designed MR brain database. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2005;8(Pt 1):383-91. PMID: 16685869 [PubMed - in process]

Louis ED, Luchsinger JA. History of vascular disease and mild parkinsonian signs in community-dwelling elderly individuals. Arch Neurol. 2006 May;63(5):717-22. PMID: 16682541 [PubMed - in process]

Nunes LM, Salge AK, Oliveira FA, Teixeira VD, Reis MA. Cerebral and cardiac amyloidosis in autopsied elderly individuals. Clinics. 2006 Apr;61(2):113-118. Epub 2006 Apr 25. PMID: 16680327 [PubMed - as supplied by publisher]

Tema 3. Neurogenètica de l’envelliment cognitiu (Imma C. Clemente).

Referències
Balaban RS, Nemoto S, Finkel T (2005) .Mitochondria, Oxidants, and Aging. Cell. 120(4):483-95.

Curtis R, Geesaman BJ, DiStefano PS. (2005) Ageing and metabolism: drug discovery opportunities.Nat Rev Drug Discov. (7):569-80.

Kaare Christensen K, Johnson TE, Vaupel JW (2006). The quest for genetic determinants of human longevity: challenges and insights. Nature Reviews Genetics (2006) 7, 436-448

Mark P. Mattson MP and MagnusT. (2006). Ageing and neuronal vulnerability. Nature Reviews Neuroscience 7, 278-294

Partridge L, Gems D. (2002). Mechanisms of ageing: public or private?
Nat Rev Genet. 2002 Mar;3(3):165-75.

Tema 4. Evidencies psicobiològiques sobre l’entitat ‘Mild Cognitive Impairment’ (David Bartrés).

Referències
Chételat G, Desgranges B, de la Sayette V, Viader F, Eustache F. Aux frontières de l’Alzheimer. Rev Neurol (Paris) 2004; 160:2S1-7S9

Davis HS, Rockwood K. Conceptualization of mild cognitive impairment: a review. International Journal of Geriatric Psychiatry 2004; 19:313-319.

DeCarli C. Mild cognitive impairment: prevalence, prognosis, aetiology and treatment. Lancet Neurol 2003; 2:15-21.

Meltzer CC, Bell-McGinty S, Scanlon JM. Exploración del deterioro cognitivo leve por neuroimagen. Rev Neurol 2003; 37:145-149.

Portet F, Ousset PJ, Visser PJ, et al. Mild Cognitive Impairment in medical practive: a critical review of the concept and new diagnostic procedure: Report of the MCI working group of the European Consortium on Alzheimer’s Disease. J Neurol Neurosurg Psychiatry 2006; 77:714-718.

Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256:183-194.

Tema 5. Demències: definició i classificacions (David Bartrés).

Referències
Cummings LJ. The neuropsychiatry of Alzheimer’s diseas and related dementias. London: Martin Dunitz 2003

Savage CR. Neuropsychology of subcortical dementias. Psychiatr Clin North Am 1997; 20:911-931

Alberca R . Demencias: diagnóstico y tratamiento. Barcelona: Masson, 1998; cap 10:243-289.

Junque C, Jurado MA. Envejecimiento y demencias. Barcelona: Martínez Roca 1994.

Tema 6. Neuropsicologia de la Malaltia d’Alzheimer (Lorena Rami).

Referències
Alberca R . Demencias: diagnóstico y tratamiento. Barcelona: Masson, 1998; cap 10:243-289.

Junque C, Jurado MA. Envejecimiento y demencias. Barcelona: Martínez Roca 1994.

Chui HC, Teng EL, Hendersin VW, Moy AC. Clinical subtypes of dementia of Alzheimer's Type. Neurology 1985;35:1544-1550.

Tema 7. Neuropsicologia de la Malaltia de Parkinson i la Demència per cossos de Lewy (Montse Alegret).

Referències
Emre M. What causes mental dysfunction in Parkinson’s disease? Mov Disord 2003; 18:S63-S71.

Pahwa R, Paolo A, Tröster A, Koller W. Cognitive impairment in Parkinson’s disease. Eur J Neurol 1998; 5:431-441.

Zgaljardic DJ, Borod JC, Foldi NS, Mattis P. A review of the cognitive and behavioral sequelae of Parkinson’s disease: relationship to frontostriatal circuitry. Cog Behav Neurol 2003; 16:193-210.

Calderon J, Perry RJ, Erzinclioglu SW, Berrios GE, Dening TR, Hodges JR. Perception, atention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer´s disease. J Neurol Neurosurg Psychiatry 2001;70:157-64.

Rippon GA, Marder KS. Dementia in Parkinson’s disease. Adv Neurol 2005; 96:95-113.

Buracchio T, Arvanitakis Z, Gorbien M. Dementia with Lewy bodies: current concepts. Dement Geriatr Cogn Disord 2005; 20:306-320.

Owen AM. Cognitive dysfunction in Parkinson’s disease: the role of frontostriatal circuitry. Neuroscientist 2005; 10:525-537.

Tema 8. Neuropsicologia de la Malaltia de Huntington i la Paràlisi Supranuclear Progressiva (David Bartrés).

Referències
Paulsen JS, Conybeare RA. Cognitive changes in Huntington’s disease. Adv Neurol 2005; 96:209-225.

Deus-Yela J, Pujol J, Espert R. Deterioro neuropsicológico en la enfermedad de Huntington. Rev Neurol 1997; 25:1257-1268.

Anderson KE, Marder KS. An overview of psychiatric symptoms n Huntington’s disese. Curr Psychiatry Rep 2001; 3:379-388.

Magherini A, Litvan I. Cognitive and behavioral aspects of PSP since Steele, Richardson and Olszewski's description of PSP 40 years ago and Albert's delineation of the subcortical dementia 30 years ago. Neurocase 2005; 11: 250-262.

Tema 9. Neuropsicologia de la demencia frontotemporal (Lorena Rami)

Referències
Thompson JC, Stopford CL, Snowden JS, Neary D. Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2005;76:920-927.

Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, et al. Frontotemporal lobar degeneration. A consensus on clinical diagnostic criteria. Neurology 1998;52:1546-1554.

Diehl J, Monsch AU, Aebi C, Wagenpfeil S, Krapp S, Grimmer T, et al. Frontotemporal Dementia, Semantic Dementia, and Alzheimer's Disease: the contribution of standard Neuropsychological Test to Differential Diagnosis. J Geriatr Psychiatry Neurol 2005;18:39-44.

Thompson SA, Patterson K, Hodges JR. Left/right asymmetry of atrophy in semantic dementia. Behavioural-cognitive implications. Neurology 2003;61:1196-1202.

Tema 10. Neuropsicologia de les demències vascular i afectació cognitiva d’origen vascular (David Bartrés).

Referències
Junqué C, Vendrell P. Exploración neuropsicológica. En: Métodos diagnósticos en las enfermedades vasculares cerebrales. Arboix A. (ed). Madrid: Ergon 2006.

Frisoni GB, Galluzzi S, Bresciani L, Zanetti O, Geroldi C. Mild Cognitive Impairment with subcortical vascular features. J Neurol 2002; 249:1423-1432.

O’Brien JT, Erkinjuntti T, Reisberg B, et al. Vascular Cognitve Impairment. Lancet Neurol 2003; 2:69-96.

Roman GC. Vascular dementia prevention: a risk factor analysis. Cerevrobasc Dis 2005;20 Suppl 2:91-100.

Garret KD, Paul RH, Libon DJ, Cohen RA. Defining the diagnosis of vascular dementia. Appl Neuropsychol 2004; 11:204-209.

Roman GC. Vascular dementia: distinguishing characteristics, treatment, and prevention. J Am Geriatr Soc 2003; 51(5 Suppl Dementia):S296-304.

Tema 11. Demències reversibles. Actualitzacions sobre la hidrocefàlia de pressió normal, un tipus de demència tractable cada cop més prevalent (M.Antònia Poca).

Referències
Poca MA, Mataro M, Matarin M, Arikan F, Junque C, Sahuquillo J. Good outcome in patients with normal-pressure hydrocephalus and factors indicating poor prognosis. J Neurosurg. 2005 Sep;103(3):455-63. PMID: 16235677 [PubMed - indexed for MEDLINE]

Poca MA, Mataro M, Del Mar Matarin M, Arikan F, Junque C, Sahuquillo J. Is the placement of shunts in patients with idiopathic normal-pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure. J Neurosurg. 2004 May;100(5):855-66. PMID: 15137605 [PubMed - indexed for MEDLINE]

Poca MA, Sahuquillo J, Mataro M. [Update on diagnosis and treatment of normotensive hydrocephalus (chronic hydrocephalus of the adult)] Neurologia. 2001 Oct;16(8):353-69. Spanish. PMID: 11738013 [PubMed - indexed for MEDLINE]

Marmarou A, Young HF, Aygok GA, Sawauchi S, Tsuji O, Yamamoto T, Dunbar J. Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients. J Neurosurg. 2005 Jun;102(6):987-97. PMID: 16028756 [PubMed - indexed for MEDLINE]

Tema 12. Alteracions neuropsicològiques en la demència per hidrocefàlia de pressió normal. Aspectes diferencials i proposta d'un protocol d'avaluació per aquests malalts (Bessy Benejam)

Referències
Thomas G, McGirt MJ, Woodworth GF, Heidler J, Rigamonti D, Hillis AE, Williams MA. Baseline neuropsychological profile and cognitive response to cerebrospinal fluid shunting idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Disord 2005; 20:163-168.

Miyoshi N, Kazui H, Ogino A, Ishikawa M, Miyake H, Tokunaga H, Ikejiri Y, Takeda M. Association between cognitive impairment and gait disturbance in patients with idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Disord 2005; 20:71-76.

Duinkerke A, Williams MA, Rigamonti D, Hillis AE. Cognitive recovery in idiopathic normal pressure hydrocephalus after shunt. Cog Behav Neurol 2004; 17:179-184.

Iddon JL, Picard JD, Cross JJL, Griffiths PD, Czosnyka M, Sahakian BJ. Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer’s disease: a pilot study. J Neurol Neurosurg Psychiatry 1999; 67:723-732.

Tema 13. Depressió major senil: balanç neuropsicològic entre aprenentatge associatiu i planificació, com indicador de resposta terapèutica (Teodor Marcos)

Referències
Alexopoulos GS, Meyers BS, Young RC, et al., Executive dysfunction and long-term outcomes of geriatric depression. Arch Gen Psychiatry, 2000; 57: 285-290.

Portella MJ, Marcos T, Rami L, et al. Residual cognitive impairment in late-life depression after a 12-month period follow-up. Int J Geriatr Psych, 2003; 18: 571-576.

Marcos T, Portella MJ, Navarro V, et al. Neuropsychological prediction of recovery in late-onset major depression. Int J Geriatr Psych, 2005; 20: 790-795.

Tema 14. Efecte diferencial dels fàrmacs en l’envelliment (Ana Adan)

Referències
Dementia and Geriatric Cognitive Disorders (2004), 17. Volum dedicat a la prescripció farmacològica en l’envellimnet (no només demència).

www.acnp.org American College of Neuropsychopharmacology. Permite consultar la edición on-line de “Psychopharmacology, the Fourth Generation of Progress”

www.vh.org/providers/conferences/CPS Virtual Hospital

Tema 15. Estimulació cognitiva en l’envelliment i les demències (Sara Doménech)

Referències
Baltes, M.M. & Baltes, B.M. (1997). Normal versus pathological cognitive functioning in old-age: Plasticity and testing the limits of cognitive/brain reserve capacity. In P.B. Baltes (Ed.), Demence et longevité. Berlin: DTB.- Becker, J., Huff, F., Nebes, R., Holland, A. & Boller, F. (1988). Neuropsychological function in Alzheimer's disease: pattern of impairment and rate of progression. Archives of Neurology, 45, 263-268.

Grandmaison, E.. & Simard, M. (2003). A Critical Review of memory stimulation programs in Alzheimer's Disease. J Neuropsychiatry Clin Neurosci, 15, 130-144.
Isräel, L., De Rotrou, J.Y. & Chappaz, M. (1982). Une thérapeuthique non médicamenteuse nouvelle: la stimulation de la mémoire chez les personnes agées. La revue de gériatrie, 7 (8), 387-390.

De Vreese, L.P. & Neri, M. (1999). Ecological impact of combined cognitive training programs and drug treatment in Alzheimer's disease. Int Psychogeirat, 11 (supl. 1), 187.

Doménech, S. (2004). Aplicación de un programa estructurado de memoria aplicado a enfermos de Alzheimer con demencia leve. Tesis Doctoral, Facultad de Psicologia, Universidad de Barcelona

Quayhagen, M.P., Quayhagen, M., Corbeil, R. et al. (2000). Coping with dementia: evaluation of four nonpharmacological interventions. Int Psychogeriatr, 12, 249-265.

Classes presencials (5h)

Presentació de casos i discussió (2 h. David Bartrés)
Journal Club (1.5 h. I. Clemente)
Journal Club (1.5 h. D. Bartrés)

Pàgina web del grup

http://www.ub.es/neuropsychology/