Ignacio Blanco Guillermo

Assistant Professor of Immunology

Professor Associat d'Immunologia

E-mail: iblanco@ub.edu

Phone: +3493 2607956

Research Interests

1. Molecular basis of hereditary cancer

2. Cancer Risk Assessment:

-Mutational load distributional analysis. A novel non-invasive tool for colorectal risk assessment.
-Development and implementation of mathematical models for risk assessment.

-Ductal Lavage and breast cancer risk assessment

3. Emotional Impact of Genetic Counseling

Current Projects

Title of the project / contract: ESTABLECIMIENTO DE BASES CIENTÍFICAS PARA EL USO DE LA FIBRA DIETÉTICA ANTIOXIDANTE POLIFENÓLICAS DE UVA EN LA PREVENCIÓN DEL CÁNCER COLORECTAL.

Kind of contract/Program: PNAL - Programa Nacional de Alimentación

Financing Firm/administration: 3886 - MCyT

Institutions participating: ---

Number of the project / contract: AGL2004-07579-04-04/ALI Amount: 70.000,00 Duration, since: 2004 Until: 2007

Main researcher: Gabriel Capella

Number of researchers participating: 4

Keywords:

Code of the project / contract: 041938 Order: 001

Title of the project / contract: Dinámica de la progresión tumoral mediada por apc.

Kind of contract/Program: NSDA - Programa Nacional de Salud

Financing Firm/administration: PNID - Plan Nacional I+D

Institutions participating: ---

Number of the project / contract: AGL2004-07579-04-04/ALI Amount: 140.000,00 Duration, since: 2007 Until: 2009

Main researcher: Gabriel Capella

Number of researchers participating: 4

Keywords:

Code of the project / contract: 041940 Order: 003

Title of the project / contract: Crecimiento postraumático tras el diagnóstico de cáncer hereditario.

Kind of contract/Program: AECM - Ajuts econòmics a projectes de recerca sobre càncer de mama i càncer de còlon

Financing Firm/administration: 4752 - Fundació Dr.Vilardell

Institutions participating: ---

Number of the project / contract: FCG06001 Amount: 30.000,00 Duration, since: 2006 Until: 2008

Main researcher: Ignacio Blanco

Number of researchers participating: 1

Keywords:

Code of the project / contract: 041941 Order: 004

Title of the project / contract: Estudio de la expresión de APC en la poliposis adenomatosa familiar (PAF). Contribución a la tumorigénesis y aplicaciones diagnósticas.

Kind of contract/Program: AECM - Ajuts econòmics a projectes de recerca sobre càncer de mama i càncer de còlon

Financing Firm/administration: FUCA - Fundació Caixa de Pensions 'La Caixa'

Institutions participating: ---

Number of the project / contract: BM04/107-00 Amount: 132.950,00 Duration, since: 2004 Until: 2006

Main researcher: Gabriel Capellà

Number of researchers participating: 4

Keywords:

Code of the project / contract: 041943 Order: 006

Selected Recent Publications

1. Screening for large rearrangements for the BRCA2 gene in Spanish families with breast / ovarian cancer.

Gutiérrez-Enríquez S, de La Hoya M, Martínez-Bouzas C, Sanchez de Abajo A, Ramón y Cajal T, Llort G, Blanco I, Beristain E, Díaz-Rubio E, Alonso C, Tejada M, Caldés T, Diez O.

Breast Cancer Research and Treatment 2006 Oct 25

2. Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.

Moreno V. Gemignani F, Landi S, Gioia-Patricola L, Chabrier A, Blanco I. Gonzalez S, Guino E, Capella G, Canzian F.

Clin Cancer Res; 2006; 12:2101-2108

3. Current status of follow-up of the upper digestive tract in familial adenomatous polyposis.

Pares,D.; Garcia-Ruiz,A.; Biondo,S.; Blanco,I.; Llort,G.; Arriol,E.; Oca,J.; Del Rio,C.; Osorio,A.; Navarro,M.; Marti-Rague,J.; Jaurrieta,E.

Gastroenterol Hepatol, 2006; 29:15-21

4. Poliposis adenomatosa familiar.

Parés D, Pera M, González G, Pascual M, Blanco I.

Gastroeneterologia y Hepatologia,2006; 29:625-35

5. Información, percepción de riesgo y ansiedad antes de recibir consejo genético en predisposición hereditaria al cáncer.

Cabrera E, Yagüe C, Schiaffino A, Llort G, Blanco I.

Enfermería Clínica, 2006;16(3):112-8.

6. Hereditary familial polyposis and Gardner’s syndrome: contribution of the odontostomatology examination in its diagnosis and a case description. Chimenos-Kustner E, Pascual M, Blanco I, Finestres F. Med Oral Patol. Oral Cir. Bucal,2006; 10:402-409

7. Founder mutation in familial adenomatous polyposis (FAP) in the Balearic Islands. Gonzláez S, Blanco I, Campos O, Julia M, Reyes J, Llompart A, Cabeza E, Germà JR, Obrador A, Capellá G.

Cancer Genetics and Cytogenetics, 2005, 158:70–74

8. Low levels of microsatellite instability characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis. Alazzouzi H, Domingo E, González S, Blanco I, Armengol M, Espín E, Plaja A, Schwartz S, Capella G, Schwartz S Jr. Human Molecular Genetics, 2005, Vol. 14, No. 2 235–239

9. Cáncer Colorrectal Hereditario. Blanco I, Cabrera E, Llort G. Psicooncología, 2005; 2:213-218.

10. Dificultad en la comunicación del riesgo de padecer cáncer hereditario. González M, Blanco I, Bayes R. Psicooncología, 2005; 2:285-292.

11. for the Bellvitge Colorectal Cancer Study Group.Colorectal Cancer risk and the APC D1822V variant. Menéndez M , González S, Blanco I, Guinó E, Peris M, Peinado MA, Capellá G, Moreno V, Int J Cancer. 2004 Oct 20;112(1):161-3

12. Perception of breast cancer risk and surveillance behaviors of women with family history of breast cancer: A brief report on a Spanish cohort. Gil F, Méndez I, Sirgo A, Llort G, Blanco I, Cortés-Funes H. Psycho-oncology 2003; 12:1-7

13. Low Frequency of recurrent BRCA1 and BRCA2 mutations in Spain.

Llort G, Yagüe C, Peris M, Blanco I, Germà JR, Bale A, Alvarez M.

Human Mutation 2002; 19:307

14. Spanish Families lacking one Amsterdam Criteria harbor the majority of MLH1 gene mutations detected. Palicio M, Balmaña J, Gonzalez S, Blanco I, Marcuello E, Peinado MA, Julià G, Germà JR, Brunet J, Lopez Lopez JJ, Capellà G. J Med Genetics 2002; 39:E29

15. What is hereditary non-polyposis colorectal cancer syndrome?. Balmaña J, Brunet J, Pericay C, Capella G, Peinado MA, Blanco I, López JJ, Marcuello E. Rev Oncología 2000; 2:191-201

16. Intron Splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer. Palicio M, Blanco I, Tórtola S, González I, Marcuello E, Brunet J, Gonzalez-Aguilera JJ, Peinado MA, Capella G. British Journal of Cancer 2000; 82:535-537

17. Splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer. British Journal of Cancer 2000; 82:535-537

Analysis of FANCB and FANCN/PALB2 Fanconi Anemia genes in BRCA1/2-negative. Spanish breast cancer families.

García MJ, Fernández V, Osorio A, Barroso A, Llort G, Lázaro C, Blanco I ,Caldés T, de la Hoya M , Ramón Y Cajal T, Alonso C, Tejada MI, San Román C,Robles-Díaz L, Urioste M, Benítez J.

Breast Cancer Res Treat. 2008 Feb 27; [Epub ahead of print]

Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene.

Pineda M, Castellsagué E, Musulén E, Llort G, Frebourg T, Baert-Desurmont S,González S, Capellá G, Blanco I .

Genes Chromosomes Cancer. 2008 Apr;47(4):326-32.

Guidelines for the clinical management of familial adenomatous polyposis (FAP).

Vasen HF, Moeslein G, Alonso A, Aretz S, Bernstein I, Bertario L, Blanco I ,Bulow S, Burn J, Capella G, Colas C, Engel C, Frayling I, Friedl W, Hes F,Hodgson S, Jarvinen H, Mecklin JP, Moller P, Myrhoj T, Nagengast FM, Parc Y,Phillips R, Clark S, Ponz de Leon M, Renkonen-Sinisalo L, Sampson J, Stormorken A, Tejpar S, Thomas H, Wijnen J.

Gut. 2008 Jan 14; [Epub ahead of print]

Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis.

Menéndez M, González S, Obrador-Hevia A, Domínguez A, Pujol MJ, Valls J, Canela N, Blanco I , Torres A, Pineda-Lucena A, Moreno V, Bachs O, Capellá G.

Gastroenterology . 2008 Jan;134(1):56-64. Epub 2007 Oct 10.

22: Vasen HF, Möslein G, Alonso A, Bernstein I, Bertario L, Blanco I , Burn J, Capella G, Engel C, Frayling I, Friedl W, Hes FJ, Hodgson S, Mecklin JP, Møller P, Nagengast F, Parc Y, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Wijnen J. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet. 2007 Jun;44(6):353-62. Epub 2007 Feb 27. Review.

23: Romero-Giménez J, Dopeso H, Blanco I , Guerra-Moreno A, Gonzalez S, Vogt S,Aretz S, Schwartz S Jr, Capella G, Arango D.

Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families. Int J Cancer. 2008 Mar 15;122(6):1422-5.

24: Serra E, Pros E, García C, López E, Gili ML, Gómez C, Ravella A, Capellá G, Blanco I , Lázaro C.

Tumor LOH analysis provides reliable linkage information for prenatal genetic testing of sporadic NF1 patients. Genes Chromosomes Cancer. 2007 Sep;46(9):820-7.

25: Llort G, Peris M, Blanco I . [Hereditary breast and ovarian cancer: primary and secondary prevention for BRCA1 and BRCA2 mutation carriers] Med Clin (Barc). 2007 Mar 31;128(12):468-76. Review. Spanish

26: Lehtonen HJ, Blanco I , Piulats JM, Herva R, Launonen V, Aaltonen LA.

Conventional renal cancer in a patient with fumarate hydratase mutation. Hum Pathol. 2007 May;38(5):793-6. Epub 2007 Jan 31.