Josefina Liñares Louzao

Associate Professor of Microbiology
Professor Titular de Microbiologia
E-mail: fina.linares@csub.scs.es

Phone: +3493 2607930

Research Interests

Epidemiological microbiological and molecular studies of Streptococcus pneumoniae.

Mechanisms of antimicrobial resistance

Nosocomial infections

Current Projects

1. FIS 2006 (PI 06 0647): Principal Investigator

Clinical and molecular epidemiology of invasive pneumococcal disease in adult patients in the postvaccine era. Changes in the serotype distribution. Molecular typing of S. pneumoniae clones.

2. CIBER 6 (Center of Biomedical Investigation Network):Respiratory Diseases. Principal Investigator of Hospital de Bellvitge Node .

3. Marató 2006-09: Collaborator

Colonisation and Infection caused by ESBL-producing E. coli in neutropenic patients

Selected Recent Publications

Increase of the M phenotype among erythromycin-resistant Streptococcus pneumoniae isolates from Spain related to the serotype 14 variant of the Spain9V-3 clone.
Ardanuy C, Fenoll A, Berron S, Calatayud L, Linares J., and Spanish Pneumococcal Infection Study Network.
Antimicrob Agents Chemother. 2006 Sep; 50(9): 3162-5.

Pneumococcal Infection Study Network.
Streptococcus pneumoniae endophthalmitis: a study of 36 cases with special reference to antibiotic resistance and treatment options.
Soriano F, Perez-Trallero E, Pallares R, Meseguer MA, Fleites A, Gene A, Gonzalez A, Linares J, Esteban J, Baquero F, Valdes E, Munoz-Almagro C; and Spanish
Clin Microbiol Infect. 2006 Jun;12(6):519-26.

Combinations of PBPs and MurM protein variants in early and contemporary high-level penicillin-resistant Streptococcus pneumoniae isolates in Spain.
Del Campo R, Cafini F, Morosini M, Fenoll A, Liñares J, Alou L., Sevillano D, Cantón R, Prieto J, Baquero F.
J Antimicrob Chemother. 2006. March; 57: 983-986

Evaluation of fosfomycin alone and in combination with ceftriaxone or
vancomycin in an experimental model of meningitis caused by two strains of cephalosporin-resistant Streptococcus pneumoniae.
Ribes S, Taberner F, Domenech A, Cabellos C, Tubau F, Liñares J, Viladrich PF, Gudiol F.
J Antimicrob Chemother. 2006 May;57(5):931-6

Evaluation of ceftriaxone, vancomycin and rifampicin alone and combined in an experimental model of meningitis caused by highly cephalosporin-resistant Streptococcus pneumoniae ATCC 51916.
5. Ribes S, Taberner F, Domenech A, Cabellos C, Tubau F, Linares J, Fernandez Viladrich P, Gudiol F.
J Antimicrob Chemother. 2005 Nov;56(5):979-82.

Experimental study on the efficacy of combinations of glycopeptides and beta-lactams against Staphylococcus aureus with reduced susceptibility to glycopeptides.
Domenech A, Ribes S, Cabellos C, Taberner F, Tubau F, Dominguez MA, Montero A, Liñares J, Ariza J, Gudiol F.
J Antimicrob Chemother. 2005 Oct;56(4):709-16.

Epidemiologic changes in bacteremic pneumococcal disease in patients with human immunodeficiency virus in the era of highly active antiretroviral therapy.
Grau I, Pallares R, Tubau F, Schulze MH, Llopis F, Podzamczer D, Linares J, Gudiol F; Spanish Pneumococcal Infection Study Network (G03/103).
Arch Intern Med. 2005 Jul;165(13):1533-40.

New mutations and horizontal transfer of rpoB among rifampin-resistant Streptococcus pneumoniae from four Spanish hospitals.
Ferrandiz MJ, Ardanuy C, Linares J, Garcia-Arenzana JM, Cercenado E, Fleites A, de la Campa AG; Spanish Pneumococcal Infection Study Network.
Antimicrob Agents Chemother. 2005 Jun;49(6):2237-45.

Pneumococcal Infection Study Network (G03/103).
Distribution of subclasses mefA and mefE of the mefA gene among clinical isolates of macrolide-resistant (M-phenotype) Streptococcus pneumoniae, viridans group streptococci, and Streptococcus pyogenes.
Ardanuy C, Tubau F, Linares J, Dominguez MA, Pallares R, Martin R; Spanish
Antimicrob Agents Chemother. 2005 Feb;49(2):827-9.

Experimental study of teicoplanin, alone and in combination, in the therapy of cephalosporin-resistant pneumococcal meningitis.
Fernandez A, Cabellos C, Tubau F, Maiques JM, Domenech A, Ribes S, Linares J, Viladrich PF, Gudiol F.
J Antimicrob Chemother. 2005 Jan; 55(1):78-83.



A mouse peritonitis model for the study of glycopeptide efficacy in GISA infections.
Domenech A, Ribes S, Cabellos C, Dominguez MA, Montero A, Linares J, Ariza J, Gudiol F.
Microb Drug Resist. 2004 Winter;10(4):346-53.

The Spanish Pneumococcal Infection Study Network G03/103. Fluoroquinolone resistance in penicillin-resistant Streptococcus pneumoniae clones, Spain.
De La Campa AG, Balsalobre L, Ardanuy C, Fenoll A, Perez-Trallero E, Liñares J;
Emerg Infect Dis. 2004 Oct;10(10):1751-9.

Experimental study of clinafloxacin alone and in combination in the treatment of ciprofloxacin-susceptible and -resistant pneumococcal meningitis.
Domenech A, Cabellos C, Ribes S, Tubau F, Viladrich PF, Linares J, Gudiol F.
Microb Drug Resist. 2003;9 Suppl 1:S53-9.

[Experimental meningitis due to a high-level cephalosporin-resistant strain of Streptococcus pneumoniae serotype 23F]
Ribes S, Domenech A, Cabellos C, Tubau F, Linares J, Viladrich PF, Gudiol F.
Enferm Infecc Microbiol Clin. 2003 Aug-Sep;21(7):329-33.

Experimental study of LY333328 (oritavancin), alone and in combination, in therapy of cephalosporin-resistant pneumococcal meningitis.
Cabellos C, Fernandez A, Maiques JM, Tubau F, Ardanuy C, Viladrich PF, Linares J, Gudiol F.
Antimicrob Agents Chemother. 2003 Jun;47(6):1907-11.

Genetic characterization of fluoroquinolone-resistant strains Streptococcus pneumoniae isolated during ciprofloxacin therapy from a patient with bronchiectasis. Antimicrobial
De la Campa AG, Ferrándiz MJ, Tubau F, Pallares R, ManresaF, Liñares J.
Agents & Chemotherapy 2003; 47: 1419-1422.

The epidemiology of antibiotic resistance in Streptococcus pneumoniae and the clinical relevance of resistance to cephalosporins, macrolides and quinolones.
Pallarés R, Fenoll A, Liñares J; Spanish Pneumococcal Infection Study Network.
Int J Antimicrob Agents 2003;22:S15-S2

Antibacterial resistance in Streptococcus pneumoniae and Haemophilus influenzae from Italy and Spain: data from the PROTEKT surveillance study,1999-2000.
Schito AM, Schito G, Debbia E, Russo G, Liñares J., Cercenado E, Bouza E.
Journal Chemotherapy 2003,15(3):226-34.

The effect of cephalosporin resistance on mortality in adult patients with nonmeningeal systemic pneumococcal infections.
Pallares R, Capdevila O, Liñares J, Grau I, Onaga H, Tubau F, Schulze MH, Hohl P, Gudiol F.
Am J Med. 2002 Aug 1;113(2):120-6.

Experimental study of the efficacy of vancomycin, rifampicin and dexamethasone in the therapy of pneumococcal meningitis.
Martinez-Lacasa J, Cabellos C, Martos A, Fernandez A, Tubau F, Viladrich PF, Linares J, Gudiol F.
J Antimicrob Chemother. 2002 Mar;49(3):507-13.
Relationship between penicillin and cephalosporin resistance of Streptococcus pneumoniae strains and its inflammatory activity in the experimental model of meningitis.
Fernandez A, Cabellos C, Tubau F, Linares J, Viladrich PF, Gudiol F.
Med Microbiol Immunol (Berl). 2001 Dec; 190(3):135-8.

In vitro activity of linezolid and 11 other antimicrobials against 566 clinical isolates and comparison between NCCLS microdilution and Etest methods.
Tubau F, Fernandez-Roblas R, Linares J, Martin R, Soriano F.
J Antimicrob Chemother. 2001 May;47(5):675-80.

Usefulness of betalactam therapy for community-acquired pneumonia in the era of drug resistant Streptococcus pneumoniae: A randomized study of amoxicillin-clavulanic and ceftriaxone.
Rosón B, Carratalà J, Tubau F, Dorca J, Liñares J, Pallarés R, Manresa F, Gudiol F.
Microbial Drug Resistance 2001; 7: 85-96.

In vitro activities of the new ketolide HMR 3647 (Telithromycin) in comparison with those of eigth other antibiotics against viridans group streptococci isolated from blood of neutropenic patients with cancer.
Alcaide F, Benítez MA, Carratalà J, Gudiol F, Liñares J, Martín R.
Antimicrobial Agents & Chemotherapy 2001; 45: 624-626.

Pneumococcal peritonitis in adult patients: a report of 64 cases with special reference to emergence of antibiotic resistance.
Capdevila O, Pallarés R, Grau I, Tubau F, Liñares J, Ariza J, Gudiol F.
Archives of Internal Medicine 2001; 161 (14): 1472-1748.

An outbreak of hospital-acquired Klebsiella pneumoniae bacteremia, including strains producing extended-spectrum ?-lactamase.
Peña C, Pujol M, Ardanuy C, Ricart A, Pallarés R, Liñares J, Ariza J, Gudiol F.
Journal of Hospital
Infection 2001; 47: 53-59.

Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographical patterns, epidemiological features, and trends in the SENTRY. Antimicrobial Surveillance Program (1997-1999).
Gales AC, Jones RN, Forward KR, Liñares J, Sader HS, Verhoef J.
Clinical Infectious Diseases 2001; 32 (Suppl. 2): S104-S113.

Geographical differences in serogroup/types causing invasive pneumococcal disease.
Pallarés R, Moreno G, Tubau F, Liñares J.
The Lancet 2001; 358 (9279): 419.

The VISA/GISA problem: therapeutic implications.
Clinica28 Liñares J.
l Microbiology and Infection 2001; 7 (11): 8-15.