Miquel Viñas Ciordia

Professor of Microbiology

Catedràtic de Microbiologia

E-mail: mvinyas@ub.edu

Phone: +3493 402 4265

Research Interests

Our group is interested in the molecular mechanisms of resistance to antimicrobials (antibiotics and disinfectants) in Gram negative bacteria. This includes characterization of Outer membrane proteins, efflux machinery and eventually others. We are also interested in the mechanism of spread in bacterial populations of such mechanisms and the search for new strategies to fight against bacterial infections. Particular interest focuses the interaction between proteins and lipid bilayer by means of AFM and other biophysical methods. The Biology of Biofilms and the application of nanotechnologies to its study is also a major topic of activity of our group.

Current Projects

TERFIQEC. Impacto program.

FJF11.1

FJF 10.32

Publications

* Zalacain, A.; Obrador, C.; Martínez, J.P.; Viñas, M.; Vinuesa, T.Characterization of the antimicrobial susceptibility of fungi responsible for onychomycosis in Spain . Med Mycol. (2011) 49:495-9

* Veiga-Crespo, P.; Fuste, E.; Vinuesa, T.; Vinas, M.; Villa, T.G.Synergism between outer membrane proteins and antimicrobials. Antimicrobial Agents and Chemotherapy (2011).55 2206 – 2211

* Ruiz-Martínez, L.; López-Jiménez, L.; Fusté, E.; Vinuesa, T.; Martínez, J.P.; Viñas, M .Clas I integrons in environmental and clinical Pseudomonas aeruginosa .909264 - International Journal of Antimicrobial Agents. ( 2011)38:398-402.

* López-Jornet MP; García-Teresa G; Viñas M; Vinuesa T. Clinical and antimicrobial evaluation of a mouthwash and toothpaste for xerostomia: A randomized, double-blind, crossover study. Journal of Dentistry. (2011)39:757-63

* Lidia Ruiz-Martínez; Lidia López-Jiménez; Valeria d"Ostuni; Ester Fusté; Teresa Vinuesa; Miguel Viñas*.A mechanism of carbapenem resistance due to a new insertion element (ISPa133) in Pseudomonas aeruginosa .913188 - International Microbiology (2011) .14,. 21 – 58

* Lucía Blasco; Miquel Viñas; Tomás G.Villa1; .Proteins influencing foam formation in wine and beer: the role of yeast.- International Microbiology (2011).14. 61 - 71

* Pérez-Tomás R, Viñas M.New insights on the antitumoral properties of prodiginines.909463 - Current Medicinal Chemistry (2010).17 2222 – 2231

*Fenosa, A.; Fusté, E.; Ruiz, L.; Veiga-Crespo, P.; Vinuesa, T.; Guallar, V.; Villa, T.G.; Viñas, M.Role of TolC in the Klebsiella oxytoca resistance to antibiotics.903144 - Journal of Antimicrobial Chemotherapy. (2009) 297. 187 -195..

* Arnabat, J.; Escribano, C.; Fenosa, A.; Vinuesa, T.; Gay, C.; Berini, L.; Viñas, M.Bactericidal activity of erbium, chromium:yttrium-scandium-gallium-garnet laser in root canals. - Lasers in Medical Science. (2009) 25. 805 – 810.

* Veiga-Crespo, P.; Ruiz, L.; Viñas, M.; Villa, T.G.Fragment of the ancient RBCL gene from de Miocene. Scholarly Research Exchange.2008,( United States of America ): Hindawi,2008.

* Martinez-Garriga B, Vinuesa T, Hernandez-Borrell J, Vinas M. The contribution of efflux pumps to quinolone resistance in Streptococcus pneumoniae clinical isolates. International Journal of Medical Microbiology 287: 187- 195 (2007)

* Ruiz L, López L Fenosa A, Veiga-Crespo P, Villa TG, Viñas M and Vinuesa T. Enrichment Cultures should be performed in the detection of Bacterial Oral Human Pathogens in DUWLs. Bull Group Int Rech Sci Stomatol Odontol. 48: 15-21 (2007)

* Rojas L, Vinuesa T, Tubau F, Truchero C, Benz R, Viñas M. Integron presence in Morganella morgani International Journal of Antimicrobial Agents 27: 505-512 (2006)

* Merino, S.; Doménech, O.; Viñas, M.; Montero, T.; Hernández Borrell, J. Effects of Lactose Permease on the Phospholipid Environment in which it is reconstituted: A fluorescence and Atomic Force Microscopy Study. Langmuir 21: 4642- 4647 (2005)

* Berlanga, M.; Montero, M. T.; Hernández-Borrell, J.; Viñas, M. Influence of the cell wall on ciprofloxacin susceptibility in selected wild-type Gram-negative and Gram-positive bacteria International Journal of Antimicrobial Agents 23: 627- 630 (2004)

* Ruiz, L.; Dominguez, A.; Ruiz, N.; Viñas, M. Relationship between clinical and environmental isolates of Pseudomonas aeruginosa in the hospital setting. Archives of Medical Research. 35: 251 - 257 (2004)

* Ruiz, N.; Merino, S.; Viñas, M.; Doménech, O.; Montero, T.; Hernandez-Borrell, J. Preliminary studies of the 2D crystallization of Omp1 of Serratia marcescens : Observation by atomic force microscopy in native membranes, environment and reconstituted in proteolipid sheets. Biophysical Chemistry 111: 1-7 (2004)

* Serra, J.; Viñas, M. Laboratory diagnosis of Brucellosis in a rural endemic area International Microbiology 7: 53- 58 (2004)

* Merino, S.; Domènech, Ò.; Díez, I.; Sanz, F.; Viñas, M.; Montero, M.T.; Hernández-Borrell, J. Effects of ciprofloxacin on Escherichia coli Lipid Bilayers: An Atomic Force Microscopy Study Langmuir 19: 6922- 6927 (2004)

* Ruíz, N.; Montero, M.T.; Hernández-Borrell, J.; Viñas, M. The role of Serratia marcescen porins in antibiotic resistance. Microbial Drug Resistance-Mechanisms Epidemiology and Disease 9: 257- 264 (2003)

* Ruiz, N.; Maier, E.; Andersen, C.; Benz, R.; Viñas, M. Molecular and functional characterisation of the Serratia marcescens Omp1. Biophysical Chemistry. 109 : 215- 227 (2003)

* Dalmau M, Maier E, Mulet N, Viñas M, Benz R. Bacterial membrane injuries induced by lactacin F and nisin. International Microbiology: 18 : 73-80 (2002) * Merino, S.; Vázquez, J.L.; Domènech, Ò.; Berlanga, M.; Viñas, M.; Montero, M.T.; Hernández-Borrell, J. Fluoroquinolone-Biomembrane Interaction at the DPPC/PG Lipid-Bilayer Interface Langmuir. 18: 3288- 3292 (2002)

* Grancelli, A.; Morros, A.; Cabañas, M.; Domènech, Ò.; Merino, S.; Vázquez, J.L.; Montero, M.T.; Viñas, M.; Hernández-Borrell, J. Interaction of 6-fluoroquinolones with dipalmitoylphosphatidylcholine monolayers and liposomes. Langmuir 18: 9177- 9182 (2002)

* Vázquez, J.L.; Montero, M.T.; ; Merino, S.; Doménech, O.; Berlanga, M. Viñas, M.; Hernández-Borrell, J. Location and nature of the surface membrane binding site of the antibiotic ciprofloxacin: a fluorescence study. Langmuir 17: 1009-1014 (2001).

* Vázquez, J.L.; Berlanga, M.; Merino, S.; Doménech, O.; Viñas, M.; Montero, M.T.; Hernández-Borrell, J. Determination by fluorimetric titration of the ionization constants of ciprofloxacin in solution and in the presence of liposomes Photochemistry and Photobiology 73:1-14 (2001)

* Orús, P.; Viñas, M. Transfer of penicillin-resistance between neisseriae in microcosm. Microbial Drug Resistance-Mechanisms Epidemiology and Disease 6:99-106 (2000)

* Berlanga, M. Viñas, M. Salycilate induction of phenotypic resistance to quinolones. Journal of Antimicrobial Chemotherapy 46: 278-282 (2000)

* Berlanga, M.; Montero, T.; Hernandez, J.; Viñas, M. Correlation between thermodynamic partition coefficients and antimicrobial activity of a homologous series of ciprofloxacin. International Journal of Pharmaceutics 220: 53-62 (2000)

* Orús, P.; Viñas, M. Other mechanisms than PBP2 alterations may contribute to moderate penicillin resistance in Neisseria meningitidis . International Journal of Antimicrobial Agents 18: 113-119 (2000)

* Gautier, G.; Noguer, M.; Costa, N.; Canela, J.; Viñas, M. Mouthrinses a comparative microbiological study. Bulletin du Group. Int. Rech. Sci. Stomatologie Odontologie 42 . 23 - 29 (2000)

* Berlanga, M.; Ruiz, N.; Hernández-Borrell, J.; Montero, T.; Viñas, M. Role of outer membrane in the accumulation of quinolones by Serratia marcescens . Canadian Journal of Microbiology 46:716-722 (2000)

* Berlanga, M.; Vázquez, J.L.; Hernández-Borrell, J.; Montero, M.T.; Viñas, M. Evidence of an efflux pump in Serratia marcescens . Microbial Drug Resistance-Mechanisms Epidemiology and Disease 6: 111-117 (2000)

* Mulet-Powell, N.; Lacoste-Armynot A.M.; Viñas, M.; Simeon de Buochberg, M. Interactions between pairs of bacteriocins from lactic. Journal of Food Protection, 61:1210- 1212 (1999)

* Martínez-Gomis, J.; Fernández, A.; Viñas, M.; González, P.; Planas, M.E.; Sánchez, S. Effects of topical application of free and liposome-encapsulated lactoferrin and lactoperoxidase on oral microbiota and dental caries in rats. Archives of Oral Biology. 44 : 901- 906 (1999)

* Viñas M. Pérez R. Resinas Epoxi y alimentación Humana. Investigación y Ciencia Nov.99 (1999)

* Sanchez-Planas, L.; Viñas, M. Non-Typable Haemophilus influenzae from a single Hospital: epidemiological markers. Microbios 93: 55 - 68 (1998)

* Fuste, M.C.; Pineda, A.; Palomar, J.; Viñas, M.; Lorén, J.G. Clonality of Multidrug resistant nontypeable strains of Haemophilus influenzae . Journal of Clinical Microbiology 34:2760-2765 (1997)

* Leranoz, S.; Orús, P.; Berlanga, M.; Dalet, F.; Viñas, M. New fimbrial adhesins of S. marcescens isolated from UTI: description and properties Journal of Urology. 157: 694 698 (1997)

* Sanchez-Planas, L.; Pan, W.; Viñas, M.; Nikaido, H. The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. Journal of Bacteriology 179: 6855- 6857 (1997)

* Viñas M. Frontiers in Antimicrobial Resistance. Microbiología-SEM 13: 271- 272 (1997)

* Sanchez, L.; Ruiz, N; Leranoz, S.; Viñas , M. The role of outer membrane in Serratia marcescens intrinsic resistance to antibiotics. Microbiología-SEM, 13: 315- 320 (1997)

* Sanchez, L.; Leranoz, S.; Puig, M.; Lorén, J.G.; Nikaido, H.; Viñas, M. Molecular basis of Antimicrobial Resistance in non-typable Haemophilus influenzae . Microbiología-SEM, 13: 309- 314 (1997)

* Sánchez, L.; Puig, M.; Fusté, M.C.; Loren, J.G.; Viñas, M. Outer membrane permeability of non-typable Haemophilus influenzae . Journal of Antimicrobial Chemotherapy : 341-344 (1996)