Research
Interests
1.
Molecular basis of hereditary
cancer
2. Cancer
Risk Assessment:
Mutational load
distributional analysis. A novel non-invasive tool for colorectal risk
assessment
Development
and implementation of mathematical models for risk assessment.
Ductal Lavage and breast cancer risk assessment
3. Emotional Impact of Genetic Counseling
Current Projects
Title of the project / contract: ESTABLECIMIENTO DE BASES CIENTÍFICAS
PARA EL USO DE
Kind of
contract/Program:
PNAL - Programa Nacional de Alimentación
Financing Firm/administration: 3886 - MCyT
Institutions
participating: ---
Number of the project /
contract:
AGL2004-07579-04-04/ALI Amount: 70.000,00 Duration,
since: 2004 Until: 2007
Main researcher: Gabriel Capella
Number of researchers
participating: 4
Keywords:
Code of the
project / contract:
041938 Order: 001
Title of the project /
contract: Dinámica
de la progresión tumoral mediada por apc.
Kind of
contract/Program:
NSDA - Programa Nacional de Salud
Financing
Firm/administration:
PNID - Plan Nacional I+D
Institutions
participating: ---
Number of the project /
contract:
AGL2004-07579-04-04/ALI Amount: 140.000,00 Duration,
since: 2007 Until: 2009
Main researcher: Gabriel Capella
Number of researchers
participating: 4
Keywords:
Code of the
project / contract:
041940 Order: 003
Title of the project /
contract:
Crecimiento postraumático tras el diagnóstico de cáncer hereditario.
Kind of
contract/Program:
AECM - Ajuts econòmics a projectes de recerca sobre càncer de mama i càncer de
còlon
Financing
Firm/administration:
4752 - Fundació Dr.Vilardell
Institutions
participating: ---
Number of the project /
contract: FCG06001
Amount: 30.000,00 Duration, since: 2006
Until: 2008
Main researcher: Ignacio Blanco
Number of researchers
participating: 1
Keywords:
Code of the
project / contract:
041941 Order: 004
Title of the project / contract: Estudio de la expresión de APC en la poliposis adenomatosa familiar (PAF). Contribución a la tumorigénesis y aplicaciones diagnósticas.
Kind of contract/Program: AECM - Ajuts econòmics a projectes de recerca sobre càncer de mama i càncer de còlon
Financing
Firm/administration:
FUCA - Fundació Caixa de Pensions '
Institutions
participating: ---
Number of the project /
contract:
BM04/107-00 Amount: 132.950,00 Duration,
since: 2004 Until: 2006
Main researcher: Gabriel Capellà
Number of researchers
participating: 4
Keywords:
Code of the
project / contract:
041943 Order: 006
Selected
Recent Publications
1.
Screening for large rearrangements for the BRCA2
gene in Spanish families with breast / ovarian cancer.
Gutiérrez-Enríquez S, de
Breast Cancer Research
and Treatment 2006 Oct 25
2.
Polymorphisms
in genes of nucleotide and base excision repair: risk and prognosis of
colorectal cancer.
Moreno V. Gemignani F, Landi S, Gioia-Patricola
L, Chabrier A, Blanco I. Gonzalez S, Guino
E, Capella G, Canzian F.
Clin Cancer Res; 2006;
12:2101-2108
3.
Current
status of follow-up of the upper digestive tract in familial adenomatous
polyposis.
Pares,D.; Garcia-Ruiz,A.; Biondo,S.; Blanco,I.;
Llort,G.; Arriol,E.; Oca,J.; Del Rio,C.; Osorio,A.; Navarro,M.; Marti-Rague,J.;
Jaurrieta,E.
Gastroenterol Hepatol, 2006;
29:15-21
4.
Poliposis adenomatosa
familiar.
Parés D, Pera M, González
G, Pascual M, Blanco I.
Gastroeneterologia
y Hepatologia,2006; 29:625-35
5.
Información,
percepción de riesgo y ansiedad antes de recibir consejo genético en
predisposición hereditaria al cáncer.
Cabrera E, Yagüe C, Schiaffino A,
Llort G, Blanco I.
Enfermería
Clínica, 2006;16(3):112-8.
6.
Hereditary
familial polyposis and
7.
Founder mutation in familial adenomatous polyposis (FAP) in the
Balearic Islands.
Gonzláez S, Blanco I, Campos O, Julia M, Reyes J, Llompart A,
Cabeza E, Germà JR, Obrador A, Capellá G.
Cancer Genetics and Cytogenetics, 2005,
158:70–74
8.
Low levels of microsatellite instability
characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis. Alazzouzi
H, Domingo E, González S, Blanco I, Armengol M, Espín E, Plaja A, Schwartz S,
Capella G, Schwartz S Jr. Human Molecular Genetics, 2005, Vol.
14, No. 2 235–239
9.
Cáncer
Colorrectal Hereditario. Blanco I, Cabrera E, Llort G. Psicooncología,
2005; 2:213-218.
10.
Dificultad
en la comunicación del riesgo de padecer cáncer hereditario. González M, Blanco I, Bayes
R.
Psicooncología, 2005;
2:285-292.
11.
for the Bellvitge
Colorectal Cancer Study Group.Colorectal Cancer risk and
the APC D1822V variant. Menéndez M
, González S, Blanco I, Guinó E, Peris M, Peinado MA, Capellá G, Moreno V, Int J Cancer. 2004 Oct 20;112(1):161-3
12.
Perception
of breast cancer risk and surveillance behaviors of women with family history
of breast cancer: A brief report on a Spanish cohort. Gil F, Méndez I, Sirgo A, Llort G,
Blanco I, Cortés-Funes H. Psycho-oncology 2003;
12:1-7
13.
Low
Frequency of recurrent BRCA1 and BRCA2 mutations in
Llort
G, Yagüe C, Peris M, Blanco I, Germà JR, Bale A, Alvarez M.
Human Mutation 2002; 19:307
14.
Spanish
Families lacking one Amsterdam Criteria harbor the majority of MLH1 gene
mutations detected. Palicio
M, Balmaña J, Gonzalez S, Blanco I, Marcuello E, Peinado MA, Julià G, Germà JR,
Brunet J, Lopez Lopez JJ, Capellà G. J Med Genetics 2002; 39:E29
15.
What is hereditary non-polyposis colorectal cancer syndrome?. Balmaña J, Brunet J,
Pericay C, Capella G, Peinado MA, Blanco I, López JJ, Marcuello E. Rev Oncología 2000; 2:191-201
16.
Intron
Splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial
colorectal cancer. Palicio M, Blanco I, Tórtola S, González I,
Marcuello E, Brunet J, Gonzalez-Aguilera JJ, Peinado MA, Capella G.
British Journal of Cancer 2000; 82:535-537
17.
Splice
acceptor site polymorphism in the hMSH2 gene in sporadic and familial
colorectal cancer. British
Journal of Cancer 2000; 82:535-537
Analysis of FANCB and FANCN/PALB2 Fanconi Anemia genes in BRCA1/2-negative. Spanish breast cancer families.
García MJ, Fernández V, Osorio A, Barroso A, Llort G, Lázaro C, Blanco I ,Caldés T, de la Hoya M , Ramón Y Cajal T, Alonso C, Tejada MI, San Román C,Robles-Díaz L, Urioste M, Benítez J.
Breast Cancer Res Treat. 2008 Feb 27; [Epub ahead of print]
Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene.
Pineda M, Castellsagué E, Musulén E, Llort G, Frebourg T, Baert-Desurmont S,González S, Capellá G, Blanco I .
Genes Chromosomes Cancer. 2008 Apr;47(4):326-32.
Guidelines for the clinical management of familial adenomatous polyposis (FAP).
Vasen HF, Moeslein G, Alonso A, Aretz S, Bernstein I, Bertario L, Blanco I ,Bulow S, Burn J, Capella G, Colas C, Engel C, Frayling I, Friedl W, Hes F,Hodgson S, Jarvinen H, Mecklin JP, Moller P, Myrhoj T, Nagengast FM, Parc Y,Phillips R, Clark S, Ponz de Leon M, Renkonen-Sinisalo L, Sampson J, Stormorken A, Tejpar S, Thomas H, Wijnen J.
Gut. 2008 Jan 14; [Epub ahead of print]
Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis.
Menéndez M, González S, Obrador-Hevia A, Domínguez A, Pujol MJ, Valls J, Canela N, Blanco I , Torres A, Pineda-Lucena A, Moreno V, Bachs O, Capellá G.
Gastroenterology . 2008 Jan;134(1):56-64. Epub 2007 Oct 10.
22: Vasen HF, Möslein G, Alonso A, Bernstein I, Bertario L, Blanco I , Burn J, Capella G, Engel C, Frayling I, Friedl W, Hes FJ, Hodgson S, Mecklin JP, Møller P, Nagengast F, Parc Y, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Wijnen J. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet. 2007 Jun;44(6):353-62. Epub 2007 Feb 27. Review.
23: Romero-Giménez J, Dopeso H, Blanco I , Guerra-Moreno A, Gonzalez S, Vogt S,Aretz S, Schwartz S Jr, Capella G, Arango D.
Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families. Int J Cancer. 2008 Mar 15;122(6):1422-5.
24: Serra E, Pros E, García C, López E, Gili ML, Gómez C, Ravella A, Capellá G, Blanco I , Lázaro C.
Tumor LOH analysis provides reliable linkage information for prenatal genetic testing of sporadic NF1 patients. Genes Chromosomes Cancer. 2007 Sep;46(9):820-7.
25: Llort G, Peris M, Blanco I . [Hereditary breast and ovarian cancer: primary and secondary prevention for BRCA1 and BRCA2 mutation carriers] Med Clin (Barc). 2007 Mar 31;128(12):468-76. Review. Spanish
26: Lehtonen HJ, Blanco I , Piulats JM, Herva R, Launonen V, Aaltonen LA.
Conventional renal cancer in a patient with fumarate hydratase mutation. Hum Pathol. 2007 May;38(5):793-6. Epub 2007 Jan 31.