Josep Maria de Anta Vinyals

Associate Professor of Embriology and Human Anatomy

Professor Agregat d'Anatomia i Embriologia Humana

E-mail: janta@ub.edu

Phone: +3493 4021904

Research Interests and Current Projects

We are interested in the genetic basis of human morphology and the clinical and surgical importance of anatomical variations. Current research interest is focused on the genetic basis of coronary artery patterning and its importance in myocardial perfusion. This investigation is supported by a grant from University of Barcelona (ACESBELL 2006).

Our grup

Our group includes members experienced in anatomical dissection and also in morphology techniques and molecular biology and genetics. Our team is composed by three human anatomists and embryologists and a laboratory technician:

· Josep Maria de Anta. Ph.D. Professor of Human Anatomy and Embryology.

· Víctor J. Götzens. Ph.D. Professor of Human Anatomy and Embryology.

· María Isabel Miguel. M.D., Ph.D. Professor of Human Anatomy and Embryology.

· Eva Sánchez García. Laboratory Technician.

Selected Recent Publications

Recent past research has been focused on the study of mechanisms of resistance to antimetabolites in colon adenocarcinoma cell lines, activities supported by several competitive grants that have resulted in several publications:

Low tumor cell density environment yields survival advantage of tumor cells exposed to MTX in vitro

De Anta, J.M., Real, F.X., Mayol, X.

Biochim Biophys Acta. 2005 Jan 18;1721(1-3):98-106. Epub 2004 Nov 4.

Methotrexate resistance in vitro is achieved by a dynamic selection process of tumor cell variants emerging during treatment.

De Anta, J.M., Real, F.X., Mayol, X.

Int J Cancer. 2006 Oct 1;119(7):1607-15.

The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance.

De Anta, J.M., Pérez-Castro, A.J., Real, F.X., Freire, R. and Mayol, X.

Anticancer Drugs. 2006 Nov;17(10):1171-1177.