Research
Interests
Current
Projects
Selected
Recent Publications
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.
Perez-Tomas R.
Curr Med Chem. 2006;13(16):1859-76. Review.
Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line.
Monge M, Vilaseca M, Soto-Cerrato V, Montaner B, Giralt E, Perez-Tomas R.
Invest New Drugs. 2006 Apr 5; [Epub ahead of print]
Cell cycle arrest and proapoptotic effects of the anticancer cyclodepsipeptide serratamolide (AT514) are independent of p53 status in breast cancer cells.
Soto-Cerrato V, Montaner B, Martinell M, Vilaseca M, Giralt E, Perez-Tomas R.
Biochem Pharmacol. 2005 Dec 19;71(1-2):32-41. Epub 2005 Nov 18.
Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells.
Castillo-Avila W, Abal M, Robine S, Perez-Tomas R.
Life Sci. 2005 Nov 26;78(2):121-7. Epub 2005 Aug 29.
Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica.
Nogi T, Yuan YE, Sorocco D, Perez-Tomas R, Levin M.
Laterality. 2005 May;10(3):193-205.
DNA interaction and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin.
Montaner B, Castillo-Avila W, Martinell M, Ollinger R, Aymami J, Giralt E, Perez-Tomas R.
Toxicol Sci. 2005 Jun;85(2):870-9. Epub 2005 Mar 23.
High cytotoxic sensitivity of the human small cell lung doxorubicin-resistant carcinoma (GLC4/ADR) cell line to prodigiosin through apoptosis activation.
Llagostera E, Soto-Cerrato V, Joshi R, Montaner B, Gimenez-Bonafe P,Perez-Tomas R.
Anticancer Drugs. 2005 Apr;16(4):393-9.
AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway.
Escobar-Diaz E, Lopez-Martin EM, Hernandez del Cerro M, Puig-Kroger A,Soto-Cerrato V, Montaner B, Giralt E, Garcia-Marco JA, Perez-Tomas R, Garcia-Pardo A.
Leukemia. 2005 Apr;19(4):572-9.
Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin.
Soto-Cerrato V, Llagostera E, Montaner B, Scheffer GL, Perez-Tomas R.
Biochem Pharmacol. 2004 Oct 1;68(7):1345-52.
The role of fibroblast growth factor (FGF) and type beta transforming growth factor (TGF-beta 1-beta 2-beta 3) during rat craniofacial development.
Garcia-Molina JA, Vallespi-Miro G, Greco-Machado Y, Perez-Tomas R,Ustrell-Torrent JM, Carvalho-Lobato P, Belmonte-Calderon AM, Serra-Renom I,Manzanares-Cespedes MC.
Bull Group Int Rech Sci Stomatol Odontol. 2003 May-Dec;45(2-3):66-78. Review.
Prodigiosin induces apoptosis by acting on mitochondria in human lung cancer cells.
Llagostera E, Soto-Cerrato V, Montaner B, Perez-Tomas R.
Ann N Y Acad Sci. 2003 Dec;1010:178-81.
The prodigiosins, proapoptotic drugs with anticancer properties.
Perez-Tomas R, Montaner B, Llagostera E, Soto-Cerrato V.
Biochem Pharmacol. 2003 Oct 15;66(8):1447-52. Review.
Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia.
Campas C, Dalmau M, Montaner B, Barragan M, Bellosillo B, Colomer D, Pons G, Perez-Tomas R, Gil J.
Leukemia. 2003 Apr;17(4):746-50.
Effects of the proapoptotic drug prodigiosin on cell cycle-related proteins in Jurkat T cells.
Perez-Tomas R, Montaner B.
Histol Histopathol. 2003 Apr;18(2):379-85.
The prodigiosins: a new family of anticancer drugs.
Montaner B, Perez-Tomas R.
Curr Cancer Drug Targets. 2003 Feb;3(1):57-65. Review.
Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells.
Montaner B, Perez-Tomas R.
Ann N Y Acad Sci. 2002 Nov;973:246-9.
Peptide dendrimers based on polyproline helices.
Crespo L, Sanclimens G, Montaner B, Perez-Tomas R, Royo M, Pons M, Albericio F, Giralt E.
J Am Chem Soc. 2002 Jul 31;124(30):8876-83.
The cytotoxic prodigiosin induces phosphorylation of p38-MAPK but not of SAPK/JNK.
Montaner B, Perez-Tomas R.
Toxicol Lett. 2002 Mar 24;129(1-2):93-8.
Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin.
Ramoneda BM, Perez-Tomas R.
Biochem Pharmacol. 2002 Feb 1;63(3):463-9.
Transforming growth factor-alpha precursors in human colon carcinoma cells.
Asbert M, Montaner B, Perez-Tomas R.
Dig Dis Sci. 2001 Jun;46(6):1157-62.