Karst environments are characterized by the high solubility of specific bedrock lithologies, mainly carbonate or evaporites. Karst terrains show distinctive landforms and dominant subsurface drainage, which may lead to karst-related environmental and engineering problems such as subsidence (sinkholes), landslides, floods, or aquifer pollution. Karst-related hazards have been increasing because of expanding urban areas and global change in recent decades. Consequently, natural and human-induced hazards related to karst are receiving increasing attention from the scientific community and administrations. The investigation of the epigenic and hypogenic karst requires multidisciplinary research, which must integrate geomorphological mapping, remote sensing, geotechnical monitoring, geophysics exploration, trenching and retrodeformational analysis.